Find all hotels by Extended Stay America in Defiance, MO
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Compare rooms and suites by Extended Stay America in Defiance with rates, reviews, and availability. Most hotels are fully refundable.
Top Defiance Hotel Reviews

Drury Plaza Hotel St. Louis Creve Coeur
10/10 Excellent
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Defiance Hotels by Brand
Hotels near popular St. Louis Attractions
- Hotels near August A. Busch Memorial Conservation Area
- Hotels near Chandler Hill Vineyards
- Hotels near Historic Daniel Boone Home and Heritage Center
- Hotels near Sugar Creek Winery
- Hotels near Yellow Farmhouse Winery
- Hotels near Broemmelsiek Park
- Hotels near Six Flags St. Louis
- Hotels near Mississippi River
- Hotels near Hollywood Casino Amphitheatre
- Hotels near Ameristar Casino St. Charles
More Accommodation Types in Defiance
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- The Wildwood Hotel
- La Quinta Inn & Suites by Wyndham St. Louis Westport
- Days Inn and Suites by Wyndham St. Louis/Westport Plaza
- Wingate by Wyndham St. Louis/Fenton Route 66
- Drury Plaza Hotel St. Louis Chesterfield
- Sonesta ES Suites St. Louis - Chesterfield
- Holiday Inn St. Louis - Creve Coeur by IHG
- Drury Inn & Suites Southwest St. Louis
- DoubleTree by Hilton St. Louis - Westport
- Best Western Plus St. Louis West-Westport
- Hyatt Place St. Louis/Chesterfield
- Elimwood Hotel, a Ramada by Wyndham
- Comfort Inn St. Louis - Westport Event Center
- Comfort Suites St Charles - St Louis
- Marriott St. Louis West
- Best Western Plus Fenton
- Sonesta Simply Suites St Louis Earth City
- Country Inn & Suites by Radisson, St. Charles Historic District
- Best Western Plus The Charles Hotel
- Relax Inn Saint Charles