$119 Cheap Flights from Amarillo (AMA) to Des Moines (DSM)

View $119 flight on Thu, Sep 4, 2025Opens in a new window

Popular airlines from Amarillo, TX (AMA-Rick Husband Amarillo Intl.) to Des Moines International Airport (DSM)

Cheap Flights from Amarillo to Des Moines (AMA-DSM)

Prices were available within the past 7 days and start at $119 for one-way flights and $279 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Sep 17 - Tue, Sep 23
AMA
Amarillo
DSM
Des Moines
$279 Roundtrip, found 6 days ago
$279
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Sep 17 from Amarillo to Des Moines, returning Tue, Sep 23, priced at $279 found 6 days ago
American Airlines
Fri, Sep 19 - Sun, Sep 21
AMA
Amarillo
DSM
Des Moines
$334 Roundtrip, found 4 days ago
$334
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Sep 19 from Amarillo to Des Moines, returning Sun, Sep 21, priced at $334 found 4 days ago
Southwest Airlines
Mon, Dec 22 - Fri, Jan 2
AMA
Amarillo
DSM
Des Moines
$377 Roundtrip, found 13 hours ago
$377
Roundtrip
found 13 hours ago
Select Southwest Airlines flight, departing Mon, Dec 22 from Amarillo to Des Moines, returning Fri, Jan 2, priced at $377 found 13 hours ago
Southwest Airlines
Mon, Dec 22 - Fri, Jan 2
AMA
Amarillo
DSM
Des Moines
$382 Roundtrip, found 13 hours ago
$382
Roundtrip
found 13 hours ago
Select Southwest Airlines flight, departing Mon, Dec 22 from Amarillo to Des Moines, returning Fri, Jan 2, priced at $382 found 13 hours ago
Southwest Airlines
Mon, Dec 22 - Fri, Jan 2
AMA
Amarillo
DSM
Des Moines
$382 Roundtrip, found 13 hours ago
$382
Roundtrip
found 13 hours ago
Select Southwest Airlines flight, departing Mon, Dec 22 from Amarillo to Des Moines, returning Fri, Jan 2, priced at $382 found 13 hours ago
United
Mon, Dec 22 - Fri, Jan 2
AMA
Amarillo
DSM
Des Moines
$384 Roundtrip, found 13 hours ago
$384
Roundtrip
found 13 hours ago
Select United flight, departing Mon, Dec 22 from Amarillo to Des Moines, returning Fri, Jan 2, priced at $384 found 13 hours ago
Southwest Airlines
Mon, Dec 22 - Fri, Jan 2
AMA
Amarillo
DSM
Des Moines
$388 Roundtrip, found 13 hours ago
$388
Roundtrip
found 13 hours ago
Select Southwest Airlines flight, departing Mon, Dec 22 from Amarillo to Des Moines, returning Fri, Jan 2, priced at $388 found 13 hours ago
United
Mon, Dec 22 - Fri, Jan 2
AMA
Amarillo
DSM
Des Moines
$390 Roundtrip, found 13 hours ago
$390
Roundtrip
found 13 hours ago
Select United flight, departing Mon, Dec 22 from Amarillo to Des Moines, returning Fri, Jan 2, priced at $390 found 13 hours ago
Southwest Airlines
Mon, Dec 22 - Fri, Jan 2
AMA
Amarillo
DSM
Des Moines
$397 Roundtrip, found 13 hours ago
$397
Roundtrip
found 13 hours ago
Select Southwest Airlines flight, departing Mon, Dec 22 from Amarillo to Des Moines, returning Fri, Jan 2, priced at $397 found 13 hours ago
American Airlines
Fri, Sep 19 - Sun, Sep 21
AMA
Amarillo
DSM
Des Moines
$404 Roundtrip, found 4 days ago
$404
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Sep 19 from Amarillo to Des Moines, returning Sun, Sep 21, priced at $404 found 4 days ago

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $318
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $318
Flights from Amarillo (AMA) to Des Moines (DSM)
Origin airport
Rick Husband Amarillo Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Southwest Airlines, United
Roundtrip price
$278
Distance
616 mi

Amarillo to Des Moines Flights

The cheapest times to fly from Amarillo to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Amarillo to Des Moines are during the month of September. You can find some of the cheapest flights from Amarillo to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Amarillo to Des Moines

Sunday is one of the best days to book for cheap flights from Amarillo to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Amarillo to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Amarillo to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $119 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Amarillo to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Amarillo to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Rick Husband Amarillo Intl. Airport (AMA) to Des Moines Intl. Airport (DSM) cost?
Snag a cheap one-way flight from $119 or cheap return flight from $279 from Rick Husband Amarillo Intl. Airport (AMA) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Rick Husband Amarillo Intl. Airport (AMA) to Des Moines Intl. Airport (DSM)?
September is the most affordable month to fly from AMA to DSM. Planning your trip for the off-season is often the key to finding better fares.
What is the cheapest airline that flies from Rick Husband Amarillo Intl. Airport (AMA) to Des Moines Intl. Airport (DSM)?
To find the cheapest airline flying from AMA to DSM, use Expedia's filter tool. Customize your search based on your travel style, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to see the cheapest flights first.
How many flights per day from Rick Husband Amarillo Intl. Airport (AMA) to Des Moines Intl. Airport (DSM)?
Direct flights from Rick Husband Amarillo Intl. Airport (AMA) to Des Moines Intl. Airport (DSM) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your travel details and click on either "1 Stop" or "2+ Stops."
What day of the week has the most flights from AMA to DSM?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can vary depending on various factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Rick Husband Amarillo Intl. Airport (AMA) to Des Moines Intl. Airport (DSM)?
Select a flight from Rick Husband Amarillo Intl. Airport (AMA) to Des Moines Intl. Airport (DSM) that leaves before 3 PM to reduce the risk of cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Rick Husband Amarillo Intl. Airport (AMA) to Des Moines Intl. Airport (DSM) last-minute?
Booking your ticket from AMA to DSM right before your getaway is usually more expensive. However, if you're flexible with your departure times and dates, you could grab a cheap last-minute fare.
Is it cheaper to book an AMA to DSM flight and hotel package?
You can save money by booking an AMA to DSM flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one convenient place. After choosing your preferred accommodations and flights, consider adding extras like activities, car rentals and tours.
Can I cancel or change the date of my flight from Rick Husband Amarillo Intl. Airport (AMA) to Des Moines Intl. Airport (DSM)?
Usually, it's possible to cancel or reschedule your AMA to DSM flight. However, for bookings made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.