$381 Cheap Flights from La Crosse (LSE) to Portland (PWM)

View $381 flight on Sat, Nov 22, 2025Opens in a new window

Popular airlines from La Crosse, WI (LSE-La Crosse Municipal) to Portland Intl. Jetport Airport (PWM)

  • Plan, book, fly with confidence

  • trending down icon

    Be in the know

    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon

    Book smarter

    Save up to 30% on select hotels after you book a flight*
  • one key icon

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from La Crosse to Portland (LSE-PWM)

Prices were available within the past 7 days and start at $381 for one-way flights and $482 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Oct 21 - Tue, Oct 28
LSE
La Crosse
PWM
Portland
$482 Roundtrip, found 1 day ago
$482
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Oct 21 from La Crosse to Portland, returning Tue, Oct 28, priced at $482 found 1 day ago
American Airlines
Tue, Oct 21 - Tue, Oct 28
LSE
La Crosse
PWM
Portland
$488 Roundtrip, found 1 day ago
$488
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Oct 21 from La Crosse to Portland, returning Tue, Oct 28, priced at $488 found 1 day ago
American Airlines
Tue, Sep 23 - Sat, Sep 27
LSE
La Crosse
PWM
Portland
$493 Roundtrip, found 1 day ago
$493
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 23 from La Crosse to Portland, returning Sat, Sep 27, priced at $493 found 1 day ago
American Airlines
Tue, Sep 23 - Sat, Oct 11
LSE
La Crosse
PWM
Portland
$497 Roundtrip, found 1 day ago
$497
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 23 from La Crosse to Portland, returning Sat, Oct 11, priced at $497 found 1 day ago
American Airlines
Tue, Sep 23 - Tue, Oct 7
LSE
La Crosse
PWM
Portland
$503 Roundtrip, found 1 day ago
$503
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 23 from La Crosse to Portland, returning Tue, Oct 7, priced at $503 found 1 day ago
American Airlines
Thu, Oct 23 - Mon, Oct 27
LSE
La Crosse
PWM
Portland
$507 Roundtrip, found 1 day ago
$507
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Oct 23 from La Crosse to Portland, returning Mon, Oct 27, priced at $507 found 1 day ago
American Airlines
Thu, Oct 9 - Tue, Oct 14
LSE
La Crosse
PWM
Portland
$513 Roundtrip, found 4 days ago
$513
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Oct 9 from La Crosse to Portland, returning Tue, Oct 14, priced at $513 found 4 days ago
American Airlines
Tue, Oct 21 - Thu, Oct 30
LSE
La Crosse
PWM
Portland
$520 Roundtrip, found 1 day ago
$520
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Oct 21 from La Crosse to Portland, returning Thu, Oct 30, priced at $520 found 1 day ago
American Airlines
Wed, Oct 8 - Wed, Oct 15
LSE
La Crosse
PWM
Portland
$523 Roundtrip, found 4 days ago
$523
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Oct 8 from La Crosse to Portland, returning Wed, Oct 15, priced at $523 found 4 days ago
American Airlines
Thu, Oct 23 - Tue, Oct 28
LSE
La Crosse
PWM
Portland
$526 Roundtrip, found 1 day ago
$526
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Oct 23 from La Crosse to Portland, returning Tue, Oct 28, priced at $526 found 1 day ago
Flights from La Crosse (LSE) to Portland (PWM)
Origin airport
La Crosse Municipal
Destination airport
Portland Intl. Jetport
Airlines serving
American Airlines
Roundtrip price
$482
Distance
1042 mi

La Crosse to Portland Flights

The cheapest times to fly from La Crosse to Portland

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from La Crosse to Portland are during the month of October. You can find some of the cheapest flights from La Crosse to Portland with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from La Crosse to Portland

Sunday is one of the best days to book for cheap flights from La Crosse to Portland: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from La Crosse to Portland

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from La Crosse to Portland in 2025. You can also book with separate airlines for your outbound and return journeys, from $381 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap La Crosse to Portland flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your La Crosse to Portland airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from La Crosse Municipal Airport (LSE) to Portland Intl. Jetport Airport (PWM) cost?
Discover the latest flight deals from LSE to PWM by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from LSE to PWM?
The cheapest flights from LSE to PWM are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from LSE to PWM?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from LSE to PWM. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from La Crosse Municipal Airport (LSE) to Portland Intl. Jetport Airport (PWM)?
You'll need to hop on a flight with a layover when traveling from La Crosse Municipal Airport (LSE) to Portland Intl. Jetport Airport (PWM). Direct flights don't operate daily on this route. However, just filter your search to include one or more stops to find the best option for your trip.
What day of the week has the most flights from LSE to PWM?
Friday is usually the busiest day for flights, while Tuesday is often the quietest.* Just remember that flight schedules can change based on a range of factors, including the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from La Crosse Municipal Airport (LSE) to Portland Intl. Jetport Airport (PWM)?
To arrive at Portland Intl. Jetport Airport (PWM) without delays, opt for a flight that leaves La Crosse Municipal Airport (LSE) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from La Crosse Municipal Airport (LSE) to Portland Intl. Jetport Airport (PWM) last-minute?
Booking your flight from LSE to PWM right before your journey is usually more expensive. But if you're flexible with your departure times and dates, you could bag a cheap last-minute fare.
Is it cheaper to book a LSE to PWM flight and hotel package?
You'll generally save money by securing a LSE to PWM flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one convenient place. After choosing your ideal accommodations and flights, consider adding extras such as activities, car rentals and tours.
Can I cancel or change the date of my flight from La Crosse Municipal Airport (LSE) to Portland Intl. Jetport Airport (PWM)?
Generally, it's possible to reschedule or cancel your LSE to PWM flight. However, if it's been more than 24 hours since booking, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find more information on our Customer Service portal.

Explore a world of travel with Expedia

*Available to One Key members.