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$269 Cheap Flights from Mobile (MOB) to Des Moines (DSM)

View $269 flight on Sun, Nov 8, 2026Opens in a new window

Popular airlines from Mobile Regional Airport (MOB) to Des Moines International Airport (DSM)

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Cheap Flights from Mobile to Des Moines (MOB-DSM)

Prices were available within the past 7 days and start at $269 for one-way flights and $309 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Sep 15 - Sun, Sep 27
MOB
Mobile
DSM
Des Moines
$309 Roundtrip, found 6 hours ago
$309
Roundtrip
found 6 hours ago
Select Delta flight, departing Tue, Sep 15 from Mobile to Des Moines, returning Sun, Sep 27, priced at $309 found 6 hours ago
American Airlines
Tue, Sep 15 - Tue, Sep 29
MOB
Mobile
DSM
Des Moines
$324 Roundtrip, found 6 hours ago
$324
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Tue, Sep 15 from Mobile to Des Moines, returning Tue, Sep 29, priced at $324 found 6 hours ago
United
Tue, Sep 15 - Tue, Sep 29
MOB
Mobile
DSM
Des Moines
$329 Roundtrip, found 6 hours ago
$329
Roundtrip
found 6 hours ago
Select United flight, departing Tue, Sep 15 from Mobile to Des Moines, returning Tue, Sep 29, priced at $329 found 6 hours ago
American Airlines
Tue, Sep 15 - Tue, Sep 29
MOB
Mobile
DSM
Des Moines
$333 Roundtrip, found 6 hours ago
$333
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Tue, Sep 15 from Mobile to Des Moines, returning Tue, Sep 29, priced at $333 found 6 hours ago
American Airlines
Tue, Sep 15 - Tue, Sep 29
MOB
Mobile
DSM
Des Moines
$339 Roundtrip, found 6 hours ago
$339
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Tue, Sep 15 from Mobile to Des Moines, returning Tue, Sep 29, priced at $339 found 6 hours ago
American Airlines
Tue, Sep 15 - Tue, Sep 29
MOB
Mobile
DSM
Des Moines
$348 Roundtrip, found 6 hours ago
$348
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Tue, Sep 15 from Mobile to Des Moines, returning Tue, Sep 29, priced at $348 found 6 hours ago
Delta
Tue, Sep 15 - Sun, Sep 27
MOB
Mobile
DSM
Des Moines
$354 Roundtrip, found 6 hours ago
$354
Roundtrip
found 6 hours ago
Select Delta flight, departing Tue, Sep 15 from Mobile to Des Moines, returning Sun, Sep 27, priced at $354 found 6 hours ago
United
Tue, Sep 15 - Tue, Sep 29
MOB
Mobile
DSM
Des Moines
$366 Roundtrip, found 6 hours ago
$366
Roundtrip
found 6 hours ago
Select United flight, departing Tue, Sep 15 from Mobile to Des Moines, returning Tue, Sep 29, priced at $366 found 6 hours ago
United
Tue, Sep 15 - Sun, Sep 27
MOB
Mobile
DSM
Des Moines
$372 Roundtrip, found 6 hours ago
$372
Roundtrip
found 6 hours ago
Select United flight, departing Tue, Sep 15 from Mobile to Des Moines, returning Sun, Sep 27, priced at $372 found 6 hours ago
American Airlines
Thu, Sep 17 - Tue, Sep 29
MOB
Mobile
DSM
Des Moines
$374 Roundtrip, found 6 hours ago
$374
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Thu, Sep 17 from Mobile to Des Moines, returning Tue, Sep 29, priced at $374 found 6 hours ago

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $656
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $656

What you need to know for your flight from Mobile Regional to Des Moines Intl.

Mobile (MOB) to Des Moines (DSM) at a glance

Travel from Mobile (MOB) to Des Moines (DSM) with a selection of airlines on this domestic short-haul route. Explore options from both full-service airlines to find the flight that fits your budget, schedule, and travel plans as you discover the iconic sights and neighborhoods of Des Moines. Check out the essential details for flights departing from Mobile Regional Airport (MOB) to Des Moines International Airport (DSM).

  • Fastest flight duration: around 4 hours in-flight, plus roughly 1 hour layover with one stop
  • Route distance: roughly 800 miles (1,290 km)
  • Flights per week: around 7 departures on average
  • Typical fares (one-way): economy tickets often range from $125–$400, depending on seasonality and how far ahead you book

Flights from Mobile Regional Airport (MOB) to Des Moines International Airport (DSM)

Based on recent traveler bookings, here are the top airlines preferred for flights from Mobile to Des Moines, typically offering one-stop services. Common layover points include Hartsfield-Jackson Atlanta International Airport (ATL) with a layover of about 1 hour and 15 minutes, Dallas-Fort Worth International Airport (DFW) at approximately 1 hour and 30 minutes, and George Bush Intercontinental Airport (IAH) with a 1-hour layover. These options provide you the flexibility to balance price, total travel time, and cabin class for your ideal itinerary.

  • American Airlines: This comprehensive airline provides one-stop service, with one-way ticket prices generally falling between $125 and $330. It comprises about 36% of departures on this route, featuring an in-flight duration of 4 hours and a total travel time of around 5 hours, including layover time.
  • Delta: Another full-service option, Delta offers one-stop flights with one-way fares usually ranging from $125 to $425. This airline also accounts for roughly 36% of departures on this route, with an airborne time of 4 hours and an overall journey time close to 5 hours, factoring in layovers.
  • United: Known for its full-service offerings, United provides one-stop flights with one-way fares typically between $165 and $480. It makes up approximately 28% of departures on this route, with a flight time of about 4 hours and a total travel duration nearing 5 hours, including layover time.

Alternative routes from Mobile (MOB) to Des Moines (DSM)

  • Pensacola to Des Moines (PNS-DSM): Located approximately 64 miles from Mobile Regional Airport (MOB), Pensacola International Airport (PNS) offers one-way economy fares that generally fall between $120 and $375, influenced by travel season and booking time. This route features a mix of one-stop and multi-stop flights, with common layovers at Hartsfield-Jackson Atlanta International Airport (ATL) and Dallas-Fort Worth International Airport (DFW). The leading airlines for this route include American Airlines and Delta, with first-class service also available.
  • Gulfport to Des Moines (GPT-DSM): Gulfport - Biloxi International Airport (GPT) is located roughly 53 miles from Mobile Regional Airport (MOB). One-way economy ticket prices on this route usually range from $120 to $405, depending on the season and how early you book. Flights typically involve one-stop options, with frequent layovers at Hartsfield-Jackson Atlanta International Airport (ATL) and Dallas-Fort Worth International Airport (DFW). Delta and American Airlines are the primary carriers for this route.

How to find the best prices for flights from Mobile (MOB) to Des Moines (DSM)

Getting some of the best deals on flights from Mobile to Des Moines is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually available when booking 2-8 weeks in advance, which coincides with when most travelers make their reservations. Afternoon departures (12pm-6pm) generally offer lower prices, while morning flights (5am-12pm) are the most popular. Additionally, Saturday is both the cheapest and most favored travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Des Moines International Airport from Mobile Regional Airport

Des Moines welcomes travelers from Mobile with a range of transport options based on price, convenience, and proximity. Here's how to reach Des Moines efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Des Moines, with private rides that can be arranged in advance.
  • Car rental: Renting a car from Des Moines International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Des Moines International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.

Frequently asked questions

How much does a flight from Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.) cost?
You can find cheap one-way flights from $269 and cheap return flights from $309 Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.) with Expedia. One-way flights usually range from $241 to $686, and return flights typically cost between $371 and $1228. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
The cheapest month to fly from MOB to DSM is September when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
Enter MOB to DSM and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
American Airlines is one of the cheapest airlines offering connecting flights from Mobile Regional (MOB) to Des Moines Intl. (DSM), with round-trip tickets starting from around $278.37. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
To find a cheap flight from Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
The earliest flight from Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.) typically departs at around 5:05 AM, operated by American Airlines. This seasonal service is available in November, giving you an early start to your travels. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
The most popular departure times for flights from Mobile, AL (MOB) to Des Moines, IA (DSM) are in the early morning, from 6am to 9am. About 26% of passengers prefer this time window. Many major carriers, including Delta Airlines and United Airlines, offer flights during this window. This timing works well because it lets you start your day early and arrive in Des Moines with time to spare.
How long does it take to fly from Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
A flight from MOB to DSM with a layover takes around 7 hours 20 minutes, with the route covering approximately 808 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
First class seats are offered on the MOB to DSM route. First class cabins are available on:

  • American Airlines
  • Delta Air Lines
  • United Airlines

How do I earn miles on a Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.) flight with Expedia?
It's easy to earn miles on a Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Des Moines from Mobile Regional (MOB)?
From Mobile Regional (MOB), you can fly into Des Moines Intl. (DSM) to reach Des Moines. Some flights may connect through major hubs like George Bush Intercontinental (IAH), Washington Dulles Intl. (IAD), Hartsfield-Jackson Atlanta Intl. (ATL) before reaching Des Moines. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.) at the last minute?
Typically, booking a last minute flight from Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.) flight and hotel package?
Securing a Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.) Des Moines Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.)?
If you booked your Mobile, AL (MOB-Mobile Regional) to Des Moines, IA (DSM-Des Moines Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Mobile Regional
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$308
Distance
807 mi

Book with confidence

Mobile to Des Moines Flights

The cheapest times to fly from Mobile to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Mobile to Des Moines are during the month of September. You can find some of the cheapest flights from Mobile to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Mobile to Des Moines

Sunday is one of the best days to book for cheap flights from Mobile to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Mobile to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Mobile to Des Moines in 2026. You can also book with separate airlines for your outbound and return journeys, from $269 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Mobile to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Mobile to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Mobile to Des Moines Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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