Title: The Best 5 Star Hotels in Murphysboro, IL from $169 | Expedia.com [Murphysboro Travel Guide](https://expedia.com/Murphysboro.dx55857)[Hotels in Murphysboro](https://expedia.com/Murphysboro-Hotels.d55857.Travel-Guide-Hotels)[Vacation Rentals in Murphysboro](https://expedia.com/Murphysboro-Vacation-Rentals.d55857.Travel-Guide-VacationRentals)[Flights to Murphysboro](https://expedia.com/Cheap-Flights-To-Murphysboro.d55857.Travel-Guide-Flights)[Car Rentals in Murphysboro](https://expedia.com/Car-Rentals-In-Murphysboro.d55857.Car-Rental-Guide)[Murphysboro Vacation Packages](https://expedia.com/Murphysboro.d55857.Destination-Travel-Guides) ![Lake Murphysboro State Park which includes autumn leaves, picnicing and forests](https://images.trvl-media.com/place/6186677/108d6e6a-45bc-4623-a9ba-f3146d9aa969.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Southernmost Illinois Tourism Bureau ![](https://images.trvl-media.com/place/6186677/108d6e6a-45bc-4623-a9ba-f3146d9aa969.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Murphysboro 5 Star Hotels Tonight [Mar 2 - Mar 3](https://www.expedia.com/Hotel-Search?regionId=55857&startDate=2026-03-02&endDate=2026-03-03&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 3 - Mar 4](https://www.expedia.com/Hotel-Search?regionId=55857&startDate=2026-03-03&endDate=2026-03-04&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=55857&startDate=2026-03-06&endDate=2026-03-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=55857&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Murphysboro-Hotels.s50-0-d55857.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Murphysboro-Hotels.s50-0-d55857.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Murphysboro. ![Walker's Bluff Casino Resort](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/1aec7f72_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Walker's Bluff Casino Resort 777 Walkers Bluff Way Carterville IL $152 nightly $169 total Mar 9 - Mar 10 Total with taxes and fees 9.4/10 Exceptional! (419 reviews) [](https://expedia.com/Carterville-Hotels-Walkers-Bluff-Casino-Resort.h97064786.Hotel-Information) Still don't see what you're looking for? [See all properties in Murphysboro.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F4%2F2026&endDate=3%2F5%2F2026®ionId=55857&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F4%2F2026&endDate=3%2F5%2F2026®ionId=55857&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F4%2F2026&endDate=3%2F5%2F2026®ionId=55857&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F4%2F2026&endDate=3%2F5%2F2026®ionId=55857&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F4%2F2026&endDate=3%2F5%2F2026®ionId=55857&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F4%2F2026&endDate=3%2F5%2F2026®ionId=55857&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Murphysboro Barbecue enthusiasts flock to the Apple Festival and award-winning 17th Street BBQ for Southern Illinois' most celebrated smoked meats. Outdoor adventurers can explore nearby Kinkaid Lake's fishing spots or take a short drive to Shawnee National Forest's hiking trails. [See all hotels in Murphysboro](https://www.expedia.com/Hotel-Search?startDate=2026-03-17&endDate=2026-03-18&adults=2®ionId=55857) ![Lake Murphysboro State Park which includes autumn leaves, picnicing and forests](https://images.trvl-media.com/place/6186677/108d6e6a-45bc-4623-a9ba-f3146d9aa969.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) Photo by Southernmost Illinois Tourism Bureau ## Top Murphysboro Hotel Reviews ## Find out more about Murphysboro You enjoy the finer things in life, both at home and on vacation. Why not demand complete opulence on your excursion to Murphysboro? There's no reason to delay a getaway to Murphysboro any longer. You'll join the multitudes of vacationers who have made Murphysboro so fashionable recently. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. What are you waiting for? Reserve one of our 5-star hotels in Murphysboro and indulge in the finer things in life for a while. ### Book the Best Murphysboro 5-Star Hotels A stay in one of these hotels is bound to be special. Exceptional customer care, granite-tiled bathrooms, and fabulous spa offerings are all on offer. You're sure to find exactly the accommodation you need. You can also look forward to an outstanding experience and fantastic customer care, so get ready to kick back and indulge. How do you want to relax? A concierge to help you plan every detail of your day? A rejuvenating facial treatment to help your cares fall away? Fluffy down pillows, lip-smacking main courses, and even a hot tub in the bathroom...these hotels will astonish you. Don't want to take our word for it? Plenty of visitors recommend this location. Yearning for experiences outside your hotel room? We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Murphysboro are the perfect place to relax after an exciting day. ### Make Your Escape The results are in, and Murphysboro 5-star hotels are the place to be when you book your next vacation. These beautiful hotels are highly rated by the guests who stay in them, and you're about to join their ranks. It's time to plan your next great escape -- Expedia can help you land a great deal on accommodation. Pick out one of the 5-star hotels in Murphysboro today and relax in the lap of luxury when you're ready. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Murphysboro? > - Search for the lowest price per night from $169 ### What makes a hotel 5 stars in Murphysboro? ### Are there any 5-star all-inclusive resorts in Murphysboro? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - [Jackson County Hotels ](https://www.expedia.com/Destinations-In-Jackson-County.d553248635976432038.Hotel-Destinations) - [Cabin Rentals in Jackson County ](https://www.expedia.com/Jackson-County-Cabins.d553248635976432038-aaCabins.Travel-Guide-Accommodation) - [Hotels near General John A. 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