Name: 21C Museum Hotel St Louis
Price range: $172 total
Rating: 9

Where to stay in Northeast Missouri

Clayton

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

Berkeley

Visitors highly recommend Berkeley for its abundant dining options, and you can make a stop by James S. McDonnell Prologue Room while you're in town.

"The first St. Charles Borromeo Church, like this one, was constructed of vertical, hewn logs placed directly in the ground: an architectural style unique to the French in the New World during the 17th and 18th centuries. The church has been rebuilt on its original location. Jesse Francis, a local preservationist with 20 years experience restoring 18th French log buildings, directed the reconstruction. The work was done completely by with period tools in the manner of the 18th century. The church is part of an on-going historical interpretive program based on a re-creation of daily activities in this old French village."

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Saint Louis Abbey while you're in town.

Downtown West

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

Central West End

4.5/5(450 area reviews)

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

See our Where To Stay guide

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

421 N 8th St St. Louis MO

$89 nightly

$106 total

Dec 28 - Dec 29

Total with taxes and fees

Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...

8.6/10 Excellent! (1,155 reviews)

All went well.

Reviewed on Dec 19, 2025

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO

$94 nightly

$110 total

Dec 28 - Dec 29

Total with taxes and fees

Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...

8.8/10 Excellent! (3,035 reviews)

The stay was nice the staff were nice but there was hair and staining in the tub

Reviewed on Dec 19, 2025

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

$147 nightly

$172 total

Jan 1 - Jan 2, 2026

Total with taxes and fees

Book a stay at this luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...

9/10 Wonderful! (1,510 reviews)

The entire hotel was fantastic. Beautifully decorated, so much to see. The art gallery was fantastic, the servers at the bar were friendly and phenomenal and just made for a great evening. The food was fantastic. Every inch of the building was well styled and the room was fantastic. Can’t wait to ...

Reviewed on Dec 22, 2025

See all 2,779 properties in Northeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

White House at Grand Central

3805 Lindell Blvd St. Louis MO

Stay at this apartment in St. Louis. Enjoy free WiFi, a 24-hour front desk, and a garden. Popular attractions St. Louis Union Station and Gateway Arch are located ...

8.4/10 Very Good! (124 reviews)

The property was wonderful, perfect, beautiful. We loved it

Reviewed on Nov 25, 2025

Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!

St. Louis MO

Stay at this vacation home in St. Louis. Enjoy free breakfast, free WiFi, and a water park. Popular attractions St. Louis Union Station and Gateway Arch are ...

9.6/10 Exceptional! (160 reviews)

The host was very friendly. The property is in a great area of the neighborhood, clean, and equipped with everything you need.

Reviewed on Dec 7, 2025

Luxury 2BEDROOM LOFT near Bush Stadium

St. Louis MO

Stay at this apartment in St. Louis. Enjoy laundry facilities, in-room jetted tubs, and air conditioning. Popular attractions Busch Stadium and Gateway Arch ...

9.4/10 Exceptional! (6 reviews)

Excellent

Reviewed on Dec 15, 2025

See all properties in Northeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

St. Louis Union Station

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's fascinating museums or attend a baseball game.

Busch Stadium

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's great live music or attend a baseball game.

St. Louis Zoo

In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.

City Museum

This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.

Forest Park

Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.

Fox Theater

Enjoy an evening of comedic, dramatic and musical entertainment at this grand theater. Delve into its history on a guided tour, including behind-the-scenes details.