A large eye sculpture in a park surrounded by trees.

Find hotels in Northeast Missouri, MO from $78

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Oct 13 - Oct 14
Tomorrow
Oct 14 - Oct 15
This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

Filter by

Star rating

Guest rating

Our top choices for Northeast Missouri hotels

An indoor swimming pool with a view of the outside, a sign reading 'Depot Inn,' and a 'RAILROAD CROSSING' sign on the wall.
A hotel lobby with a reception desk, a coffee station, and seating areas.
A hotel lobby with a reception desk, seating area, and a sign for the general store.
A living room with a flat-screen TV, fireplace, and a couch with pillows.

1. Depot Inn and Suites

Depot Inn and Suites
La Plata
Guest highlights
  • Pool with billiard table
  • Short walk to nearby playground
  • Continental breakfast with new hot options
$84 nightly
$91 total
Oct 25 - Oct 26
Total with taxes and fees
Depot Inn and Suites
A living room with a sofa, coffee table, and patterned rug. There are large windows with blinds, a chandelier, and a view of the outside.
A building with a covered entrance, American flag, and a sign indicating it's open.
A hotel room with two beds, a television, a lamp, and a painting on the wall.
A hotel hallway with a patterned carpet, doors, and a sign indicating room number 101.

2. FairBridge Inn Express, Monroe City

FairBridge Inn Express, Monroe City
Monroe City
Guest highlights
  • Short walk to nearby restaurants
  • Clean and inviting guest rooms
  • Comfortable bed with fresh linens
$86 nightly
$93 total
Nov 11 - Nov 12
Total with taxes and fees
FairBridge Inn Express, Monroe City
A hotel room with a bed, a sofa, a desk, a chair, and a small table.
A Super 8 hotel with a covered entrance and multiple windows.
A kitchenette with a coffee maker, toaster, microwave, and various kitchen utensils.
A bathroom with a sink, toilet, and bathtub. There is a towel rack with towels, a mirror, and a ceiling light.

3. Super 8 by Wyndham Macon

Super 8 by Wyndham Macon
Macon
Guest highlights
  • Safe and plentiful parking available
  • Extremely clean bathroom with great shower
  • Quiet location with comfortable rooms
$78 nightly
$85 total
Oct 18 - Oct 19
Total with taxes and fees
Super 8 by Wyndham Macon
A stainless steel ice dispenser with a blue button labeled 'PUSH FOR ICE' in a kitchen setting.
A kitchen counter with fruits, a blender, and a refrigerator with a game display.
A reception area with a counter, a trash bin, and a seating area with chairs.
A hotel room with two beds, green walls, and artwork.

4. Travelier Motel

Travelier Motel
Macon
Guest highlights
  • Friendly and helpful staff on hand
  • Comfortable beds for a restful night
  • Clean and affordable rooms available
$77 nightly
$83 total
Oct 14 - Oct 15
Total with taxes and fees
Travelier Motel
A compact kitchen with wooden cabinets, a coffee machine, and a dining area with metal chairs.
A neatly made bed with a brown quilted bedspread, a decorative pillow with a heart-shaped towel, and a bedside table with a lamp.
A living room with a black leather sofa, two black chairs, a potted plant, and a small table.
A hotel lobby with a black leather sofa, two bar stools, a reception desk, and a sign indicating no refund policy.

5. Americas Best Value Inn & Suites Macon at Sunset Dr

Americas Best Value Inn & Suites Macon at Sunset Dr
Macon
Guest highlights
  • Close to local coffee shops
  • Fresh-smelling bedding and bed
  • Clean and comfortable room
$66 nightly
$70 total
Oct 28 - Oct 29
Total with taxes and fees
Americas Best Value Inn & Suites Macon at Sunset Dr
A neatly made bed with a white quilt, a dark wooden headboard, a bedside lamp, a red chair, and a wall decoration.
A room with a large window, a red chair, and a wall-mounted air conditioner.
A building with a brick facade, a wooden door, and a neon 'OPEN' sign.
A long, narrow hallway with carpeted floors, doors on both sides, and a red chair in the distance.

6. Prairie View Inn

Prairie View Inn
Shelbina
$95 nightly
$104 total
Oct 14 - Oct 15
Total with taxes and fees
Prairie View Inn
A wooden bridge with a rope railing in a forested area.
A building with a covered porch, stone pillars, and a gravel driveway.
A wooden staircase with a railing, a door, and a ceiling with fluorescent lights.
A spacious living room with a high ceiling, wooden beams, a fireplace, and a dining area with a table and chairs.

7. Lost Branch Lodge. Complete exterior remodel, spring 2026!

Lost Branch Lodge. Complete exterior remodel, spring 2026!
Brashear
Guest highlights
  • Perfect for family gatherings with space
  • Very well stocked kitchen with supplies
  • Extra spacious with games for all ages
Lost Branch Lodge. Complete exterior remodel, spring 2026!
View all properties

Vacation Rentals in Northeast Missouri

Cabin
A park with a pond, picnic tables, and a gazebo.
A small, well-lit kitchen with a dining table, chairs, a refrigerator, a microwave, and a television mounted on the wall.
A pool with a 5 FT depth marker.
A grassy area with a picnic table and a dog.

Cannon Dam Cabins

Cannon Dam Cabins
Perry
"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"
Cannon Dam Cabins
Aparthotel
A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.
A spacious bathroom with a large bathtub, a walk-in shower, and a vanity with a mirror.
A swimming pool with lounge chairs and a covered seating area.
A modern living room with a grey sofa, a white armchair, a coffee table, and a patterned rug. There is a kitchen in the background with white cabinets and a black door.

Lighthouse Inn & Suites

Lighthouse Inn & Suites
Hannibal
"The room was very clean. It had a hot tub in it and it was also very clean and worked properly. We enjoyed our stay there."
Lighthouse Inn & Suites
Aparthotel
A compact living space with a sofa, a TV, a kitchen area with a fridge, microwave, and coffee maker, and a dining table.
A modern kitchen with a wooden island, bar stools, and a flat-screen TV.
A black building with large windows, a covered porch with a flag, and potted plants.
A compact kitchen with a marble backsplash, a refrigerator, a washing machine, and a dining area with chairs.

The Mercantile on the Katy Trail

The Mercantile on the Katy Trail
Hermann
"We loved this place- very unique! Clean and great communication from hosts."
The Mercantile on the Katy Trail
Cottage
A covered porch with a white door, two folding chairs, and a concrete walkway.
A living room with a sofa, a table, a TV, and a dining area with chairs.
A modern kitchen with white cabinets, a black refrigerator, and a dining area with a blue table runner.
A kitchen with white cabinets, a granite countertop, a stainless steel refrigerator, a microwave, a toaster, and a coffee maker.

Peaceful Missouri Cabin Rental on 55 Acres!

Peaceful Missouri Cabin Rental on 55 Acres!
Canton
"This is a great place to stay if you want to get away from the city. Rural enough to be quiet, but within easy driving distance to a city. Also perfect if you just want to stay on the property and really get away from city life, just bring your groceries. "
Peaceful Missouri Cabin Rental on 55 Acres!
Treehouse
Private kitchen
A cozy room with a wooden ladder, a sofa with cushions, a small table with a lamp, and a dining area with chairs.
A room with a bed, white walls, and windows with brown blinds.
A wooden deck with a railing, a chair, and a view of a forest.

The Cottage

The Cottage
Hermann
"Our host mentioned he does not receive messages from Expedia postings. So if you are not receiving check-in information, you might want to find another way to contact them. The property is lovely. The Treehouse was perfect for my granddaughter and me."
The Cottage
Apartment
A spacious foyer with a grand staircase, a piano, and a large rug.
A spacious living room with a beige sofa, a dining area with a table and chairs, large windows, and a chandelier.
A backyard with a stone fire pit, two Adirondack chairs, and a hammock.
A spacious dining area with a round glass table, black metal chairs, and a wooden staircase leading to an upper level.

White House at Grand Central

White House at Grand Central
Grand Center
"Nice find in the city"
White House at Grand Central
Apartment
A spacious room with a wooden dining table, chairs, a chandelier, and a bed with white bedding.
A red deck with wicker furniture and a blue umbrella, overlooking a residential area with houses and a dome-shaped building.
A modern living room with a blue sofa, a coffee table, and a ceiling fan.
A spacious living area with a blue sofa, wooden flooring, and a chandelier.

Spacious 3-Bedroom with King Bed

Spacious 3-Bedroom with King Bed
Central West End
"Clean room nice area "
Spacious 3-Bedroom with King Bed
Vacation Home
A two-story building with a balcony, outdoor seating area, and string lights.
A gym with exercise equipment, a dining area with a table and chairs, and a painting of oranges on the wall.
A living room with a sofa, a coffee table, a chair, and a potted plant.
A dining area with a round table, chairs, and artwork on the wall.

StayAtlas Retreat w/ Pool, Gym, Games, BBQ

StayAtlas Retreat w/ Pool, Gym, Games, BBQ
Mount Pleasant
"The property was such a fun surprise- the neighborhood was a little sketchy, but it was great on the inside and the backyard... Great experience, fun complimentary toiletries, etc"
StayAtlas Retreat w/ Pool, Gym, Games, BBQ
Apartment
A modern hotel lobby with a marble reception desk, a TV mounted on the wall, and a seating area with chairs and a sofa.
A modern living area with a grey sofa, a glass coffee table, and a black leather sofa. There are large windows and a visible interior space beyond.
A modern living room with a pool table, a seating area, and a large window offering a view of the outdoors.
A modern gym with treadmills, ellipticals, and weight machines. Large windows offer views of a swimming pool and greenery.

Landing Furnished Apartments - Central West End

Landing Furnished Apartments - Central West End
Central West End
"Parking was behind a large mechanical gate which did not always work. Could sometimes be noisy outside in the evening due to college clientele. Had to park on the street most of the time because of gate issues."
Landing Furnished Apartments - Central West End
Cottage
A covered porch with a white door, two folding chairs, and a concrete walkway.
A modern kitchen with white cabinets, a granite countertop, a built-in stove, a microwave, and a stainless steel refrigerator.
A single-story building with a covered porch and a gravel driveway.
A living room with a beige sofa, a coffee table, a TV mounted on the wall, and a chair.

Updated Missouri Cabin Rental on Large Farm

Updated Missouri Cabin Rental on Large Farm
Canton
"The cabin rental was a great stay. Had some connection problems with the t.v. couldn't get past the check out date. The wifi was easy to hook up. The cabin was clean and smelled fresh. Did have some problems with ants on the countertop. Great place to stay, enjoyed our visit."
Updated Missouri Cabin Rental on Large Farm
Apartment
A wooden dock extending into a calm lake surrounded by lush greenery.
A dining area with a wooden table, chairs, and a fruit basket.
A room with a wooden floor, a patterned chair, a television mounted on the wall, and a kitchen area visible through an open door.
A white two-story house with a wooden deck and a staircase leading to the front door.

Charming Berger Apt on 42-acre Farm w/ Pool Access

Charming Berger Apt on 42-acre Farm w/ Pool Access
Berger
Charming Berger Apt on 42-acre Farm w/ Pool Access
Apartment
A wooden deck with a rope fence, overlooking a lake and surrounded by trees.
A room with a large window, a microwave, a cabinet, and a sofa.
A spacious living area with a sofa, a coffee table, and a dining table with a bench. There is a ceiling fan and a chandelier.
A two-story house with a covered porch and a detached garage.

Lakefront Studio Guest Home on Hermann Wine Trail!

Lakefront Studio Guest Home on Hermann Wine Trail!
New Haven
"Loved this property, very clean and well kept! Very pretty, lovely view. "
Lakefront Studio Guest Home on Hermann Wine Trail!
Apartment
A red building with a sign for 'Catala House' and a 'Massage House' sign.
A kitchen with white cabinets, a wooden door, and a window.
A red building with a balcony, a staircase, and outdoor seating with a blue umbrella.
A cozy loft-style living room with a brown leather sofa, a blue ottoman, and a patterned rug.

New Melle Apartment Near Missouri Wine Country

New Melle Apartment Near Missouri Wine Country
Wentzville
"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...
New Melle Apartment Near Missouri Wine Country
Apartment
A modern kitchen with a wooden ceiling, a dining area with stools, and a seating area with a bench.
A compact kitchen with a wooden ceiling, a small seating area, and a dining table.
An outdoor patio with wooden benches and a covered seating area, surrounded by a gravel path and a fence.
A modern kitchen with a built-in stove, a sink, and a countertop. There is a window with blinds, a ceiling fan, and a small stool.

The Merlot Bungalow Defiance Tiny Home on Trail

The Merlot Bungalow Defiance Tiny Home on Trail
Defiance
"We enjoyed our stay very much! The place was very cute and conveniently located to explore Defiance! We will look to stay here again in the future!"
The Merlot Bungalow Defiance Tiny Home on Trail
Cottage
A spacious room with a wooden interior, a staircase, a sofa, a table, and a cabinet.
A kitchen with wooden cabinets, a refrigerator, a dishwasher, a stove, and a microwave.
A spacious living area with a staircase, a fireplace, and a cozy seating arrangement.
A wooden interior with a dining table, chairs, a staircase, and framed pictures on the walls.

Hillside Cabin on 43 Acres w/ Private Lake & View!

Hillside Cabin on 43 Acres w/ Private Lake & View!
Defiance
"We had a wonderful stay. The property is beautiful and well maintained, and the cabin is cute, comfortable, and well equipped. Nick is a very courteous host. We couldn’t have hoped for a better Thanksgiving getaway!"
Hillside Cabin on 43 Acres w/ Private Lake & View!
See all vacation rentals
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Northeast Missouri attractions

The Saint Louis Zoo sign with vines on the wall.

St. Louis Zoo

9.2/10 (4,367 reviews)
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
See properties
A baseball stadium with a large crowd, a prominent arch structure, and various advertisements.
Photo by Carl Guttovz

Busch Stadium

9.4/10 (4,850 reviews)
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
See properties
A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.

Enterprise Center

8.8/10 (1,597 reviews)
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
See properties
A cityscape with a prominent arch structure, various high-rise buildings, and a large government building.

Dome at America’s Center

8.4/10 (1,229 reviews)
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's fascinating museums and acclaimed art scene.
See properties
A stone fountain with water cascading down a tiered structure, surrounded by a pond and a grassy area with a building in the background.

Forest Park

9.2/10 (3,389 reviews)
Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.
See properties
A historic building with a large lawn, a flagpole with flags, and a clear blue sky.

St. Louis University

8.6/10 (526 reviews)
Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its acclaimed theater scene.
See properties
A tightrope walker balancing on a wire between buildings.

City Museum

9.0/10 (3,209 reviews)
This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.
See properties

America's Center Convention Complex

8.8/10 (306 reviews)
Learn about the events happening at America's Center Convention Complex during your trip to St. Louis. Experience the area's acclaimed art scene and great live music.
See properties

Learn more about Northeast Missouri

Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.

See all hotels in Northeast Missouri
A large eye sculpture in a park surrounded by trees.
Photo by Andrew Hershfeld

Top Northeast Missouri Hotel Reviews

Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

10/10 Excellent
"Great!"
Melissa 3-night trip
Posted 8 hours ago
Pear Tree Inn St. Louis Near Union Station
Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown

8/10 Good
"A"
Anton 1-night trip
Posted 10 hours ago
Tru By Hilton St. Louis Downtown
Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

8/10 Good
"The location is excellent! Walking distance to the aquarium and union station. There is garage parking. There is free breakfast and dinner. The only thing I would have liked a slightly bigger room. But the rooms were clean and quiet."
Nicole 3-night trip
Posted 10 hours ago
Drury Plaza Hotel St. Louis Union Station
Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center

10/10 Excellent
"The whole staff was amazing"
TaKeela 1-night trip
Posted 11 hours ago
Courtyard by Marriott St. Louis Downtown/Convention Center
Home2 Suites by Hilton St. Louis Downtown

Home2 Suites by Hilton St. Louis Downtown

10/10 Excellent
"Location, location, location! Booked based on proximity to the Enterprise Center. VERY clean, courteous staff, comfortable bed, full size toiletries. Would stay again."
Jennifer 3-night trip
Posted 12 hours ago
Home2 Suites by Hilton St. Louis Downtown
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

10/10 Excellent
"Very nice place. We enjoyed the roomy room."
Harold 1-night trip
Posted 13 hours ago
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
21C Museum Hotel St Louis

21C Museum Hotel St Louis

10/10 Excellent
"It was the best stay ever. I highly recommend this hotel. It has everything you would need for your vacation stay and more."
George 1-night trip
Posted 14 hours ago
21C Museum Hotel St Louis
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

10/10 Excellent
"The Renaissance was very nice. It was clean and well maintained. You can tell it's an older hotel but it has been well maintained. Very convenient to the airport if you have an early flight."
Jim 1-night trip
Posted 15 hours ago
Renaissance St. Louis Airport Hotel
The Westin St. Louis

The Westin St. Louis

10/10 Excellent
"The Westin is a lovely hotel, great location for our trip. Staff was friendly and helpful, we didn't use any of the amenities, but they are nice. The bar is great, and the rooms are very large."
JOHNA 1-night trip
Posted 21 hours ago
The Westin St. Louis

More cheap stays in Northeast Missouri

Best Western St. Louis Inn

Best Western St. Louis Inn

6224 Heimos Industrial Park Dr St. Louis MO
$68 nightly
$78 total
Oct 25 - Oct 26
Total with taxes and fees
Best Western St. Louis Inn
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10810 Pear Tree Ln St. Ann MO
$90 nightly
$107 total
Oct 18 - Oct 19
Total with taxes and fees
Pear Tree Inn St. Louis Airport
Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown

1221 Locus Street St. Louis MO
$93 nightly
$108 total
Nov 1 - Nov 2
Total with taxes and fees
7.8/10 Good! (1,013 reviews)
Tru By Hilton St. Louis Downtown
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO
$119 nightly
$136 total
Oct 25 - Oct 26
Total with taxes and fees
Hampton Inn St. Charles St. Peters
The West End

The West End

4215 Lindell Blvd St. Louis MO
$121 nightly
$138 total
Oct 25 - Oct 26
Total with taxes and fees
The West End
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

227 South Central Ave St. Louis MO
$135 nightly
$158 total
Oct 18 - Oct 19
Total with taxes and fees
9.2/10 Wonderful! (412 reviews)
AC Hotel St. Louis Clayton

Hotels in Northeast Missouri with star-rating

Explore a world of travel with Expedia