Santa Cruz Vacation Rentals

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Check prices for these dates

In two weeks
Nov 27 - Nov 29
In two months
Jan 8 - Jan 10
In three months
Feb 5 - Feb 7
In four months
Mar 5 - Mar 7

Our top choices for Santa Cruz vacation rentals

A hotel sign with the text "Apart Hotel Premium Suites Santa Cruz".

1. Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz
3.5 star property
Santa Cruz
8.6 out of 10, Excellent, (107 reviews)
"Great location."
United States
Ruben
$25 nightly
The price is $25
Nov 11 - Nov 12
Apart Hotel Premium Suites Santa Cruz
A rooftop pool with a water feature, surrounded by modern buildings and a clear sky.

2. Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
8.8 out of 10, Excellent, (121 reviews)
"great place to stay!"
United States
Luisa
$46 nightly
The price is $46
Nov 10 - Nov 11
Premium Suites Deluxe Aparthotel Equipetrol
A modern rooftop pool with a city view, wooden flooring, and a seating area.

3. AMERICA APARTMENTS

AMERICA APARTMENTS
3.0 star property
Santa Cruz
10.0 out of 10, Exceptional, (3 reviews)
"Clean room, great staff "
Canada
Peter
$27 nightly
The price is $27
Nov 10 - Nov 11
AMERICA APARTMENTS
An outdoor dining area with tables and chairs, surrounded by plants and palm trees.

4. Terranova Suites

Terranova Suites
3.5 star property
Santa Cruz
8.0 out of 10, Very good, (91 reviews)
"Easy to access"
United States
Dorothy
$47 nightly
The price is $47
Nov 10 - Nov 11
Terranova Suites
A modern hotel room with a bed, a nightstand, a lamp, a painting, a kitchen area, and a bathroom.

5. Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel
2.5 star property
Santa Cruz
8.8 out of 10, Excellent, (13 reviews)
"Perfect hotel"
Turkey
Yener
$56 nightly
The price is $56
Nov 10 - Nov 11
Equipetrol Suites Apart Hotel
A modern building with a glass facade, a pool area with sun loungers, and a clear blue sky.

6. POX: 24th Floor, Green Tower | Luxury and Panoramic Views

POX: 24th Floor, Green Tower | Luxury and Panoramic Views
Santa Cruz de la Sierra
10.0 out of 10, Exceptional, (1 review)
"Very comfortable and nice view and the super clean"
United States
Carlos
$95 nightly
The price is $95
Nov 10 - Nov 11
POX: 24th Floor, Green Tower | Luxury and Panoramic Views
A hotel with multiple floors, a pool area with lounge chairs, and palm trees.

7. Apart Hotel Toborochi

Apart Hotel Toborochi
3.0 star property
Equipetrol
8.8 out of 10, Excellent, (61 reviews)
"Very comfortable and quiet place and very good location. "
United States
Luis
$73 nightly
The price is $73
Nov 10 - Nov 11
Apart Hotel Toborochi
A modern kitchen with a black countertop, stainless steel appliances, and a built-in oven.

8. Comfort in the best neighborhood in Santa Cruz—perfect for business travelers and tourists!!

Comfort in the best neighborhood in Santa Cruz—perfect for business travelers and tourists!!
Santa Cruz de la Sierra
$48 nightly
The price is $48
Nov 16 - Nov 17
Comfort in the best neighborhood in Santa Cruz—perfect for business travelers and tourists!!
A rooftop pool with lounge chairs and a cityscape view at sunset.

9. 58" TV / Swimming Pool / Coworking Space / Fitness Center / Queen-Size Bed

58" TV / Swimming Pool / Coworking Space / Fitness Center / Queen-Size Bed
Equipetrol
8.0 out of 10, Very good, (2 reviews)
$48 nightly
The price is $48
Nov 30 - Dec 1
58" TV / Swimming Pool / Coworking Space / Fitness Center / Queen-Size Bed
A rooftop swimming pool with a clear view of the city skyline and a partly cloudy sky.

10. Menacho Apartment - Mangales Blue - Norte

Menacho Apartment - Mangales Blue - Norte
Santa Cruz de la Sierra
10.0 out of 10, Exceptional, (1 review)
"We arrived at 12:30 am due to our flight and I let the host know of our late arrival time. He had no problem. When checking in I made an error and I couldn’t figure out how to get there. I called the host as late as it was, he answered no problem and was super nice and helpful. He was very communicative although out our stay. Room was fully functional. Had a kitchen with all the necessary utensils, living room area with a tv and a couch that became a bed for our kids. Private master bedroom...
Canada
Evelyn
$26 nightly
The price is $26
Nov 10 - Nov 11
Menacho Apartment - Mangales Blue - Norte
A modern kitchen with dark cabinetry, a dining area with a black table and chairs, and a living room with a sofa and a large abstract painting.

11. Aqua: Loft Artistico Urbano

Aqua: Loft Artistico Urbano
Santa Cruz de la Sierra
10.0 out of 10, Exceptional, (1 review)
"Excellent atencion todo muy comodo bonito limpio gracias"
United States
Nestor C.
$59 nightly
The price is $59
Nov 30 - Dec 1
Aqua: Loft Artistico Urbano
A rooftop pool with clear blue water, surrounded by palm trees and plants, overlooking a cityscape with modern buildings.

12. Apartment with a Balcony & View / Pool / Gym at Equipe

Apartment with a Balcony & View / Pool / Gym at Equipe
Equipetrol
$53 nightly
The price is $53
Nov 16 - Nov 17
Apartment with a Balcony & View / Pool / Gym at Equipe
A modern office space with glass walls, a long table with chairs, and several round ottomans.

13. Enchanting studio with AC in Santa Cruz de la Sierra

Enchanting studio with AC in Santa Cruz de la Sierra
Equipetrol
$39 nightly
The price is $39
Nov 10 - Nov 11
Enchanting studio with AC in Santa Cruz de la Sierra
A modern outdoor kitchen area with a built-in oven, seating, and a view of the city skyline.

14. COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!

COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!
Equipetrol
$58 nightly
The price is $58
Nov 10 - Nov 11
COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!
A rooftop pool with lounge chairs and a cityscape view at sunset.

15. Apartment with a balcony, pool, fitness center, and coworking space at Equipe

Apartment with a balcony, pool, fitness center, and coworking space at Equipe
Equipetrol
$46 nightly
The price is $46
Nov 16 - Nov 17
Apartment with a balcony, pool, fitness center, and coworking space at Equipe
A modern living room with a dining area, a sofa, a red chair, a coffee table, and a bookshelf.

16. Beautiful Loft in a brand new Condo, 10 minutes from business center.

Beautiful Loft in a brand new Condo, 10 minutes from business center.
Santa Cruz de la Sierra
2.0 out of 10, (1 review)
$48 nightly
The price is $48
Nov 10 - Nov 11
Beautiful Loft in a brand new Condo, 10 minutes from business center.
A rooftop pool with clear blue water, surrounded by palm trees and a cityscape in the background.

17. Cozy studio in enchanting Santa Cruz de la Sierra with WiFi, AC

Cozy studio in enchanting Santa Cruz de la Sierra with WiFi, AC
Equipetrol
$40 nightly
The price is $40
Nov 14 - Nov 15
Cozy studio in enchanting Santa Cruz de la Sierra with WiFi, AC
A rooftop pool with clear blue water, surrounded by lounge chairs and potted plants.

18. Inspiring Views • Enveloping Comfort

Inspiring Views • Enveloping Comfort
Equipetrol
$46 nightly
The price is $46
Nov 16 - Nov 17
Inspiring Views • Enveloping Comfort
A modern living room with a sofa, a dining table with chairs, and a bed with a white canopy.

19. Elegante departamento Sirari Equipetrol

Elegante departamento Sirari Equipetrol
Santa Cruz de la Sierra
$58 nightly
The price is $58
Nov 10 - Nov 11
Elegante departamento Sirari Equipetrol
A reception desk with a marble top and a sign that reads "MACOROROE 8".

20. Patio-style apartment with a private garage

Patio-style apartment with a private garage
Santa Cruz de la Sierra
$49 nightly
The price is $49
Nov 16 - Nov 17
Patio-style apartment with a private garage
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Find vacation rentals that suit your style

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Aparthotels
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Top Santa Cruz Hotel Reviews

The exterior of the ECO HOTEL with illuminated signage and a wooden canopy.
Chairú Eco Hotel

Chairú Eco Hotel

Chairú Eco Hotel
Santa Cruz

10/10 Excellent

Nice and clean
United States
Brian
Reviewed October 28, 2026
Chairú Eco Hotel

Find out more about Santa Cruz

Everything you need to know about Santa Cruz vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Cruz vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Cruz vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santa Cruz vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santa Cruz. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Cruz in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $24 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santa Cruz rentals

At Expedia, we put the best Santa Cruz vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santa Cruz rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Cruz vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Cruz. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently Asked Questions

Can I find a vacation rental in Santa Cruz?

Yes, we have vacation rentals in Santa Cruz near Santa Cruz Zoo, or you can go with a secluded option if you're looking for a relaxing stay. Discover why Santa Cruz is known for its shops. Make sure you have time to check out the cafes and zoo during your trip.

What are some of the best vacation home rentals in Santa Cruz?

Casa Vida: This highly rated vacation home rental in Santa Cruz is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a private yard and a selection of games. Some other top choices in Santa Cruz are Cozy 1-bedroom house in beautiful Santa Cruz de la Sierra with WiFi, AC and Seasonal House.

How many vacation rentals will I find in Santa Cruz?

With 23 Expedia vacation rentals, you're sure to find just the right place for your Santa Cruz stay.

What can I see and do in Santa Cruz?

Enjoy the outdoors at Arenal Park and Guembe Biocenter, or simply take in cultural attractions like Ethno-folkloric Museum and Cine Center. Plaza 24 de Septiembre and Blacutt Square are other places to visit while you're in town.

What are vacation rentals like in Santa Cruz?

Vacation rentals are private accommodations you can stay in for several days or more in Santa Cruz. Vacation rentals provide amenities such as laundry facilities and kitchens so you'll have everything you want. If you're concerned about a sanitized environment, a vacation rental can offer a sense of privacy away from shared hotel elevators and busy reception areas while still allowing you the enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a popular option for a family trip.

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