A colonial-style building with a bell tower, palm trees, and a paved walkway.

Santa Cruz Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your Santa Cruz Vacation

With one of our vacation packages to Santa Cruz, you'll find countless opportunities for adventure and relaxation. There's so much to experience, including its beaches and lively atmosphere. If taking in sights is part of the program during your trip to Santa Cruz, check out major attractions like Plaza 24 de Septiembre, Guembe Biocenter and Ventura Mall. Whoever you're heading away with and whatever the size of your budget, your dream Santa Cruz vacation is just clicks away with Expedia.

Where to stay in and around Santa Cruz

Santa Cruz offers a vibrant blend of culture and outdoor adventures. Explore the stunning views and friendly atmosphere while visiting the jungle in Rurrenabaque. With its great location, Santa Cruz is perfect for family vacations and excursions, especially during the lively months of Santa Cruz.

Warnes

For travelers seeking a blend of adventure and relaxation, Warnes offers a vibrant escape just a short drive from Santa Cruz. This city is perfect for families and business visitors alike, featuring attractions like the lively Play Land Amusement Park and the serene botanical garden. With bustling shopping centers and the historic Palestina Church nearby, Warnes provides a rich urban experience. It's about a 19-mile drive from Santa Cruz, making it a smart choice for your stay in Bolivia.

Colinas del Urubo

Plan your stay in Colinas del Urubo, an ideal choice for adventure-seeking families and luxury travelers eager to explore Santa Cruz, Bolivia. This vibrant village offers easy access to attractions like the botanical garden, Plaza 24 de Septiembre, and the Ethno-folkloric Museum, ensuring a rich cultural experience. Nestled in Santa Cruz, Colinas del Urubo provides a strategic base for both leisure and business travelers looking to enjoy shopping centers and resorts nearby. Choosing Colinas del Urubo for your stay is a smart way to embrace the local charm and excitement.

La Guardia

Make the most of your visit by staying in La Guardia, a haven for adventure and cultural enthusiasts thanks to its proximity to captivating venues like the Lomas de Arena Regional Park and the vibrant Artecampo arts center. Families will appreciate the local attractions, including the scenic botanical garden and Blacutt Square. Located about 13 miles by car from Santa Cruz, La Guardia makes for a smart choice for travelers seeking an engaging experience in Bolivia.

Hamacas

Immerse yourself in Hamacas, where adventure enthusiasts and cultural explorers can easily access the vibrant heart of Santa Cruz. This lively neighborhood is perfect for those looking to discover local gems like the bustling Plaza 24 de Septiembre, the captivating Ethno-folkloric Museum, and the insightful Municipal Library. Located around Santa Cruz, Hamacas offers a seamless gateway for travelers eager to delve into the rich cultural tapestry of Bolivia. Choosing to stay here ensures a memorable and engaging experience.

La Cruceña

Travelers seeking a blend of culture and adventure will find La Cruceña an ideal base for their vacation, featuring easy access to attractions like the Municipal Botanical Garden of Santa Cruz, the Catedral de Santa Cruz, and the Ethno-folkloric Museum. With visitor numbers peaking in March and September to October, this vibrant city offers year-round experiences without significant seasonal fluctuation. Located about 19 miles by car from Santa Cruz, La Cruceña makes for a smart choice for your stay, ensuring memorable explorations await.

Discover the most popular places to visit in Santa Cruz

What to do in Santa Cruz

Santa Cruz Hotel Deals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Santa Cruz

Things to do in Santa Cruz

Santa Cruz offers a vibrant mix of city-themed and cultural experiences perfect for families. Visitors can explore shopping centers and malls, unwind at resorts, and enjoy outdoor adventures like hiking and standup paddleboarding. For those looking for leisure, there's plenty of window shopping and long strolls to enjoy. Thrill-seekers can also find exciting roller coasters to experience, making Santa Cruz a well-rounded destination for all types of tourists.

Shopping

In Santa Cruz, visit Ventura Mall for a vibrant shopping experience with entertainment and family-friendly vibes. La Recova Artisan Walk offers a unique market atmosphere perfect for local crafts. If you're up for a drive, check out Patio Design LifeStyle Center for a stylish shopping environment.

Recreation

Experience the vibrant atmosphere at Ramon Tahuichi Aguilera Stadium, where you can enjoy local sports events. For a family-friendly outing, catch a movie at Cine Center. Don't miss the cultural richness at Casa Municipal de Cultura Raúl Otero Reiche, featuring captivating performances and artistic events.

Adventure

Parque Nacional Amboró offers thrilling hiking trails through diverse ecosystems, where you can spot unique wildlife. For adrenaline seekers, the nearby Chapare region features exhilarating white-water rafting experiences amidst stunning landscapes, perfect for adventure enthusiasts looking for an unforgettable experience.

Nightlife

In Santa Cruz, Bolivia, experience vibrant nightlife at Plaza 24 de Septiembre, filled with lively bars and clubs. Visit the trendy Equipetrol neighborhood for upscale lounges and dance the night away at popular venues like La Casa de la Cerveza and Club Level, where the energy is electric.

Find the best attractions in Santa Cruz

Santa Cruz, Bolivia, is perfect for city-themed and family vacations, offering rich cultural experiences. Explore popular attractions like the piazza, cathedral, and various landmarks that cater to diverse interests, including culture and outdoor activities. Don't miss out on discovering local gems and immersing yourself in the vibrant atmosphere of Santa Cruz for an unforgettable experience.

  • Plaza 24 de Septiembre: This vibrant square serves as the heart of Santa Cruz, where locals and visitors gather to enjoy cultural events, music, and lively street performances. Its lush gardens and historical significance make it a perfect spot to soak in the city's atmosphere and people-watch.
  • San Lorenzo Cathedral: A stunning example of colonial architecture, San Lorenzo Cathedral features intricate designs and a serene ambiance. Visitors can appreciate its artistic beauty and rich history while attending mass or exploring its peaceful surroundings.
  • Blacutt Square: Known for its unique excursions, Blacutt Square is a popular gathering place for locals and tourists alike. The square often hosts cultural fairs and events, offering a glimpse into the region's traditions and local crafts.

Best time to go to Santa Cruz

The best time to visit Santa Cruz can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Santa Cruz falls in October, when visitor numbers are slightly low and weather is mostly sunny with light rain. The coolest average temperature in Santa Cruz falls in June, visitor numbers are average and weather is mostly sunny with light rain.

Tips to save on your trip to Santa Cruz

  • Take advantage of package deals on Expedia and combine flights, hotels, or car rentals for a convenient and cost-effective trip to Santa Cruz.
  • Consider traveling during the off-peak season (typically June, August and November) for more affordable package holidays to Santa Cruz.
  • Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
  • Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.