Title: Top 10 Hotels in Scott City, MO from $69 - Competitive Prices | Expedia.com [Vacation Rentals in Scott City](https://expedia.com/Scott-City-Vacation-Rentals.d553248634983544376.Travel-Guide-VacationRentals)[Flights to Scott City](https://expedia.com/Cheap-Flights-To-Scott-City.d553248634983544376.Travel-Guide-Flights)[Car Rentals in Scott City](https://expedia.com/Car-Rentals-In-Scott-City.d553248634983544376.Car-Rental-Guide)[Scott City Vacation Packages](https://expedia.com/Scott-City.d553248634983544376.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Scott City Cabin [](https://www.expedia.com/Hotel-Search?destination=Scott+City%2C+Missouri%2C+United+States+of+America®ionId=553248634983544376&latLong=37.216718%2C-89.524534&adults=2&startDate=2026-04-05&d1=2026-04-05&endDate=2026-04-07&d2=2026-04-07&lodging=CABIN) Family friendly [](https://www.expedia.com/Hotel-Search?destination=Scott+City%2C+Missouri%2C+United+States+of+America®ionId=553248634983544376&latLong=37.216718%2C-89.524534&adults=2&startDate=2026-04-05&d1=2026-04-05&endDate=2026-04-07&d2=2026-04-07&travelerType=family_friendly) Pet friendly [](https://www.expedia.com/Hotel-Search?destination=Scott+City%2C+Missouri%2C+United+States+of+America®ionId=553248634983544376&latLong=37.216718%2C-89.524534&adults=2&startDate=2026-04-05&d1=2026-04-05&endDate=2026-04-07&d2=2026-04-07&amenities=PETS) Pool [](https://www.expedia.com/Hotel-Search?destination=Scott+City%2C+Missouri%2C+United+States+of+America®ionId=553248634983544376&latLong=37.216718%2C-89.524534&adults=2&startDate=2026-04-05&d1=2026-04-05&endDate=2026-04-07&d2=2026-04-07&amenities=POOL) Apart­ment [](https://www.expedia.com/Hotel-Search?destination=Scott+City%2C+Missouri%2C+United+States+of+America®ionId=553248634983544376&latLong=37.216718%2C-89.524534&adults=2&startDate=2026-04-05&d1=2026-04-05&endDate=2026-04-07&d2=2026-04-07&lodging=APARTMENT) Hot tub [](https://www.expedia.com/Hotel-Search?destination=Scott+City%2C+Missouri%2C+United+States+of+America®ionId=553248634983544376&latLong=37.216718%2C-89.524534&adults=2&startDate=2026-04-05&d1=2026-04-05&endDate=2026-04-07&d2=2026-04-07&amenities=HOT_TUB) ## Check prices for these dates Tonight [Mar 22 - Mar 23](https://www.expedia.com/Hotel-Search?regionId=553248634983544376&startDate=2026-03-22&endDate=2026-03-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 23 - Mar 24](https://www.expedia.com/Hotel-Search?regionId=553248634983544376&startDate=2026-03-23&endDate=2026-03-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=553248634983544376&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=553248634983544376&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Scott City hotels ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/f27091ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/53cb7546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Jackpot Suite | Living area | LED TV, Netflix, Hulu, first-run movies](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/e87009c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Riverview [](https://www.expedia.com/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (531 reviews) "Room was perfect" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Derrick $95 nightly $108 total Mar 25 - Mar 26 Total with taxes and fees [](https://www.expedia.com/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/f90ef358.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/95135562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Sikeston, MO [](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) Sikeston 9.4/10 Exceptional (1,004 reviews) "Very nice for overnight stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Scott $94 nightly $108 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/f1c41457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds, Non Smoking | Iron/ironing board, free cribs/infant beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/96f1c1e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/9d3e181d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking | Iron/ironing board, free cribs/infant beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/e2b2c624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Cairo I-57 [](https://www.expedia.com/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information) Cairo 6.6/10 (282 reviews) "Amenities, microwave, refrigerator,iron and iron board,Shower soap options " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maurice $72 nightly $80 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/a42cb957.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/15abbdc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/7fdae22d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking | Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/d0a59214.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Riverstone Hotel Charleston-Sikeston [](https://www.expedia.com/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information) Charleston 6.8/10 (409 reviews) "The staff was very friendly and accommodating " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Arturo $70 nightly $78 total Mar 23 - Mar 24 Total with taxes and fees [](https://www.expedia.com/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/8bb15ffe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/266a85bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/6cd5cd8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/ac6f4af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Cape Girardeau [](https://www.expedia.com/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (167 reviews) "Nearby Mexican restaurant, clean room, pleasant staff, good breakfast choices " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Larry $93 nightly $105 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) ![Snack bar](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/2f374258.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/2e166a9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/0aa802d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible, Bathtub (Mobility & Hearing)](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/1ca0c293.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Cape Girardeau [](https://www.expedia.com/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (116 reviews) "Hotel was very clean, quiet and has a great location! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dustin $89 nightly $102 total Apr 9 - Apr 10 Total with taxes and fees [](https://www.expedia.com/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/13d95c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/327b8d22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/42667f54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Sikeston I-55 [](https://www.expedia.com/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) Sikeston 8.4/10 Very Good (1,000 reviews) "nice and covenant have stay here a few times, staff always has a smile. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roger $93 nightly $106 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/679acee6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/bbf96e9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/a5038447.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/1ca277a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Charleston/Sikeston East MO [](https://www.expedia.com/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) Charleston 6.8/10 (625 reviews) "Affordable for a quick one night stay. Restaurant and gas station next to hotel." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Annette $62 nightly $69 total Mar 23 - Mar 24 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) ![Desk, laptop workspace, blackout drapes, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/71011e95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/dba6fd48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible (Tub) | Desk, laptop workspace, blackout drapes, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/86c003aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/fe0d924e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Cape Girardeau West [](https://www.expedia.com/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) Cape Girardeau 9.0/10 Wonderful (1,000 reviews) "Very clean and updated bathroom, clean room; outstanding hot breakfast and friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Colleen $72 nightly $81 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Individually decorated, individually furnished, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/bf40a512.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/d5d0cfa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) [](https://www.expedia.com/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) Sikeston 8.4/10 Very Good (752 reviews) "The room was clean and comfortable. Check in staff was friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer $65 nightly $75 total Mar 23 - Mar 24 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/4abadc7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, free WiFi, bed sheets](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/cbe2898d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/432f7137.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Sikeston [](https://www.expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) Sikeston 9.0/10 Wonderful (509 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) grant $97 nightly $110 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/b5f01af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/132cb18c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/d0828685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Jackson MO [](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) Jackson 9.6/10 Exceptional (1,004 reviews) "The staff is so nice here" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura $80 nightly $85 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/ccad2677.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/23518830.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/dc7dee1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau [](https://www.expedia.com/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) Jackson 9.0/10 Wonderful (726 reviews) "Very clean and staff was very nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nastassia $89 nightly $96 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![1 bedroom, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/717baff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/8fe9a2cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/7335ffbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn and Suites by Wyndham Sikeston [](https://www.expedia.com/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) Sikeston 7.4/10 Good (1,001 reviews) "Business friendly, clean room staff very friendly, accommodating." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janice $68 nightly $78 total Mar 24 - Mar 25 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/27c728aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/c790aa73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/e959f8b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Sikeston [](https://www.expedia.com/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) Sikeston 9.4/10 Exceptional (63 reviews) "Nice quiet hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steven $101 nightly $114 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) ![Room, 1 King Bed, Non Smoking | View from room](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/183a17d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/ec6ce079.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/8720ff7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, alarm clocks](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/228b486a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Eagle Inn Charleston [](https://www.expedia.com/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information) Charleston 6.6/10 (105 reviews) "The hotel needs a renovation. For the price I didn’t expect much, but it feels neglected." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Britani $64 nightly $71 total Mar 23 - Mar 24 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 8 AM to 11 PM, sun loungers](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/65f9cbe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/3aa729da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, down comforters, desk, iron/ironing board](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/4b95ba78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Sikeston Southwest by IHG [](https://www.expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) Sikeston 8.6/10 Excellent (449 reviews) "Stay was excellent " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kourtney $93 nightly $105 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c65fb6ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/6f9bce18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/db8c9491.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Cape Girardeau Conference Center [](https://www.expedia.com/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (1,007 reviews) "My favorite place tpstay when in the area." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jack $100 nightly $113 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/dc836bc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/44b66206.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking | Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/4ac4ba46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Cape Girardeau North [](https://www.expedia.com/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) Cape Girardeau 7.2/10 Good (712 reviews) "Room was clean. Staff was friendly. Hotel itself is due for a renovation. You get what you pay for. 2.5 out of 5 for this place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robin $67 nightly $75 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/84598bf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/5b2269be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Accessible (Sofa Sleeper, Tub, 2 Rooms) | Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/0f190cb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Cape Girardeau [](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (1,006 reviews) "The room was great and the staff was friendly as always. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) LuAnne $92 nightly $104 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-05&endDate=2026-04-06®ionId=553248634983544376&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FScott-City-Hotels.d553248634983544376.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FScott-City-Hotels.d553248634983544376.Travel-Guide-Hotels) ## Top Scott City Hotel Reviews ![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed_y.jpg) ### Drury Inn & Suites Cape Girardeau 10/10 Excellent "LOVED EVERYTHING ABOUT THIS PLACE" [](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg) ### Hampton Inn Sikeston 10/10 Excellent "Very nice property. Staff friendly, check in easy, room clean well appointed. Price was very reasonable." [](https://expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg) ### Drury Inn & Suites Jackson MO 10/10 Excellent "We have never stayed at a Drury hotel before and we were pleasantly surprised by amenities that are different from the usual hotel chains. Such as complimentary supper along with breakfast. Definitely a great deal when traveling with a family! Since we travel through the area often, we’ll definitely make this hotel our usual overnight stop." [](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 8/10 Good "Beds were clean and well made however carpet in room was stained. There was a chicken nugget on the floor in the elevator upon arrival and was still there the next morning. Breakfast was good except for preparer wiping her nose with her plastic serving gloves on. Good coffee and easy check in." [](https://expedia.com/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Candlewood Suites Cape Girardeau by IHG](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85_y.jpg) ### Candlewood Suites Cape Girardeau by IHG 6/10 Okay "Yes" [](https://expedia.com/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information) ![Quality Inn Cape Girardeau North](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781_y.jpg) ### Quality Inn Cape Girardeau North 8/10 Good "The office chair did not move up or down. The water in the shower was just lukewarm when it was hot at the sink. The drain mechanism didn't let the water drain out." [](https://expedia.com/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33_y.jpg) ### Days Inn and Suites by Wyndham Sikeston 10/10 Excellent "Business friendly, clean room staff very friendly, accommodating." [](https://expedia.com/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg) ### Best Western Plus Sikeston I-55 10/10 Excellent "Room was clean, the bathroom had a good vent and nice lighting which we've had a problem with with other hotels. Very satisfied with our stay and breakfast was gold. " [](https://expedia.com/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "Pool not too cold and it was even snowing at one point. Staff was very friendly and helpful. Never had to wait for elevator. Breakfast waffles were excellent. Room was spacious. I’ve stayed in a lot of hotels, and this is one of the best. They get a 100/10 for amenities! " [](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ## More cheap stays in Scott City ![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 100 Matthews Lane Sikeston MO $65 nightly $75 total Mar 23 - Mar 24 Total with taxes and fees 8.4/10 Very Good! (752 reviews) [](https://expedia.com/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![Quality Inn Cape Girardeau North](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Quality Inn Cape Girardeau North 2011 North Kingshighway Cape Girardeau MO $67 nightly $75 total Mar 29 - Mar 30 Total with taxes and fees 7.2/10 Good! (712 reviews) [](https://expedia.com/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn and Suites by Wyndham Sikeston 220 S Interstate Dr Sikeston MO $68 nightly $78 total Mar 24 - Mar 25 Total with taxes and fees 7.4/10 Good! (1,001 reviews) [](https://expedia.com/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/71011e95_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Pear Tree Inn Cape Girardeau West 103 Cape West Pkwy Cape Girardeau MO $72 nightly $81 total Mar 29 - Mar 30 Total with taxes and fees 9/10 Wonderful! (1,000 reviews) [](https://expedia.com/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn Sikeston 1240 Commerce Drive Sikeston MO $97 nightly $110 total Apr 12 - Apr 13 Total with taxes and fees 9/10 Wonderful! (509 reviews) [](https://expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG 3253 William Street Cape Girardeau MO $103 nightly $116 total Apr 5 - Apr 6 Total with taxes and fees 9.4/10 Exceptional! (1,001 reviews) [](https://expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ## Hotels in Scott City with star-rating ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 2 properties [](https://expedia.com/4Star-Scott-City-Hotels.s40-0-d553248634983544376.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 7 properties [](https://expedia.com/3Star-Scott-City-Hotels.s30-0-d553248634983544376.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 37 properties [](https://expedia.com/2Star-Scott-City-Hotels.s20-0-d553248634983544376.Travel-Guide-Filter-Hotels) ## Frequently asked questions ### What is the best area to stay in Scott City? > This area is the heart of Scott City, offering a central location for exploring. Main Street itself features a collection of local businesses, including diners and shops that provide a glimpse into the community life. It's a straightforward area, making navigation easy for visitors. > > > For solo travelers or couples looking for a practical and central base, staying near Main Street is ideal. ### When is the best time to go to Scott City? > During spring, the temperatures are mild, and the natural scenery comes alive with blooming flowers and lush greenery. This makes it a great time for couples to enjoy scenic walks along the Mississippi River or visit local parks without the discomfort of summer heat or winter cold. > > > Similarly, the fall season in Scott City provides comfortable temperatures and beautiful autumn foliage, which is superb for solo travelers looking for a relaxing getaway. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Scott City hotel booking with Expedia? > \*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo. ### How much is the nightly rate at a Scott City hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Cars - [Hotels near Cape Girardeau Municipal ](https://www.expedia.com/Cape-Girardeau-Municipal-Airport-Hotels.0-aCGI-0.Travel-Guide-Filter-Hotels) - [Flights from Cape Girardeau Municipal ](https://www.expedia.com/lp/airports/cgi/flights-from-cape-girardeau-municipal-airport) - [Flights from Nashville (BNA) to Cape Girardeau (CGI) ](https://www.expedia.com/lp/flights/bna/cgi/nashville-to-cape-girardeau) - [Flights from St. Louis (STL) to Cape Girardeau (CGI) ](https://www.expedia.com/lp/flights/stl/cgi/st-louis-to-cape-girardeau) - [Flights from Dallas (DFW) to Cape Girardeau (CGI) ](https://www.expedia.com/lp/flights/dfw/cgi/dallas-to-cape-girardeau) - [Flights from Chicago (ORD) to Cape Girardeau (CGI) ](https://www.expedia.com/lp/flights/ord/cgi/chicago-to-cape-girardeau) - 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