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Our top choices for Commerce hotels

Standard Room, 1 Queen Bed, Non Smoking, Garden View | Free WiFi
Rockwood Inn

Rockwood Inn

Rockwood Inn
2.0 star property
Cape Girardeau
10.0 out of 10, Exceptional, (19)
"My stay was cozy, warm and inviting, and absolutely wonderful shower. I will definitely be returning! "
United States
Kim
$156 nightly
The price is $177
Jan 5 - Jan 6, 2026
Total with taxes and fees
Rockwood Inn
Desk, free WiFi
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
Cape Girardeau
6.0 out of 10, (206)
"Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors."
United States
Gary
$57 nightly
The price is $64
Jan 4 - Jan 5, 2026
Total with taxes and fees
Town House Inn Cape Giradreau
Business center
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1003)
"Awesome stay!"
United States
Breckin
$90 nightly
The price is $102
Jan 5 - Jan 6, 2026
Total with taxes and fees
Drury Inn & Suites Cape Girardeau
Room, 2 Queen Beds
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (104)
"It was a nice stay"
United States
Douglas
$89 nightly
The price is $102
Jan 7 - Jan 8, 2026
Total with taxes and fees
Tru By Hilton Cape Girardeau
Exterior
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.2 out of 10, Very Good, (886)
"Room was clean and spacious."
United States
George
$70 nightly
The price is $84
Jan 11 - Jan 12, 2026
Total with taxes and fees
Candlewood Suites Cape Girardeau by IHG
Courtyard
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (785)
"Excellent stay"
United States
Christina
$106 nightly
The price is $119
Jan 8 - Jan 9, 2026
Total with taxes and fees
Hampton Inn Cape Girardeau I 55 East
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (145)
"Lovely staff clean hotel comfortable beds "
United States
Kastriot
$88 nightly
The price is $99
Jan 8 - Jan 9, 2026
Total with taxes and fees
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1003)
"Nice place for a stay at a reasonable price."
United States
Arthur
$70 nightly
The price is $79
Jan 5 - Jan 6, 2026
Total with taxes and fees
Pear Tree Inn Cape Girardeau Near the Medical Center
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
$91 nightly
The price is $103
Jan 11 - Jan 12, 2026
Total with taxes and fees
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lobby sitting area
The Riverview

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (480)
" Excellent stay. Will come again"
United States
joydeep
$95 nightly
The price is $108
Jan 4 - Jan 5, 2026
Total with taxes and fees
The Riverview
Lobby
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
Cape Girardeau
7.2 out of 10, Good, (689)
"The room was clean and nice. The breakfast was really good."
United States
Kalani
$59 nightly
The price is $67
Jan 8 - Jan 9, 2026
Total with taxes and fees
Quality Inn Cape Girardeau North
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (471)
"Very nice hotel within walking distance to many good restaurants "
United States
Vicky
$114 nightly
The price is $129
Jan 25 - Jan 26, 2026
Total with taxes and fees
Courtyard by Marriott Cape Girardeau Downtown
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
"This Drury is our preferred place to stay when visiting family in Cape Girardeau. The hotel Staff is always warm and small town friendly! The hotel is nice and the breakfast buffet is outstanding!! "
United States
Michael
$90 nightly
The price is $102
Jan 5 - Jan 6, 2026
Total with taxes and fees
Drury Plaza Hotel Cape Girardeau Conference Center
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (680)
"Conveniently located, clean, friendly staff."
United States
Philip
$81 nightly
The price is $87
Jan 4 - Jan 5, 2026
Total with taxes and fees
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
"Great place. Friendly staff clean"
United States
Jeff
$90 nightly
The price is $103
Jan 5 - Jan 6, 2026
Total with taxes and fees
Drury Inn & Suites Sikeston, MO
Lobby
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
2.5 star property
Jackson
8.2 out of 10, Very Good, (740)
"Room was clean and affordable for one night. The morning person could have been more attentive to me being there for breakfast. No greeting at all and sat on her phone. I was the only one down in the breakfast area. Be more aware of her surroundings while working alone. "
United States
Lori
$80 nightly
The price is $86
Jan 4 - Jan 5, 2026
Total with taxes and fees
Comfort Suites Jackson-Cape Girardeau
Iron/ironing board, free WiFi, bed sheets
Country Yard Inn and Suite

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (121)
"Great spot en route home from Mississippi. Staff put me in a room that ended up being in a quiet section of the hotel. Great sleep."
United States
Andrew
$56 nightly
The price is $64
Jan 1 - Jan 2, 2026
Total with taxes and fees
Country Yard Inn and Suite
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
"Very clean and updated bathroom, clean room; outstanding hot breakfast and friendly staff."
United States
Colleen
$70 nightly
The price is $79
Jan 5 - Jan 6, 2026
Total with taxes and fees
Pear Tree Inn Cape Girardeau West
Front of property - evening/night
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (615)
"Staff was great! Room was nice. "
United States
Lana
$62 nightly
The price is $69
Jan 1 - Jan 2, 2026
Total with taxes and fees
Super 8 by Wyndham Charleston/Sikeston East MO
Lobby
Quality Inn Cairo I-57

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (275)
"The quality was not what I expected for a "Quality Inn". It felt more light a Motel 6. I was not satisfied at all."
United States
ReShena
$71 nightly
The price is $79
Jan 17 - Jan 18, 2026
Total with taxes and fees
Quality Inn Cairo I-57
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Commerce Hotel Reviews

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

10/10 Excellent
"Lovely staff clean hotel comfortable beds "
Kastriot 1-night trip
Posted 1 day ago
Fairfield Inn & Suites by Marriott Cape Girardeau

More cheap stays in Commerce

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO
$70 nightly
The price is $79 total per night from Jan 5 to Jan 6
$79 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
9/10 Wonderful! (1,002 reviews)

Hotels in Commerce with star-rating

Frequently asked questions

Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Commerce.
How can I save on a Commerce hotel booking with Expedia?
One Key™ - Expedia's free travel rewards program - gives you instant access to perks and Member Prices on Commerce hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings.

*OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Commerce hotel?
Prices for hotels in Commerce often vary, but you can find a great deal from $64 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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