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Browse Select Sikeston Vacation Homes

Little Blue Cottage on Spanish
The price is $60 per night from May 2 to May 3
Situated in Cape Girardeau, this vacation home is 0.2 mi (0.2 km) from Shawnee National Forest and 1.1 mi (1.7 km) from Isle Casino Cape Girardeau. Southeast ...
4.9/5Exceptional! (8 reviews)
"Private, adorable and so quiet. Location was awesome, walked downtown for dinner and drinks, slept late and it was quiet until after 9. Amazing hosts, quick communication. Definitely will stay again"

Reviewed on Mar 27, 2021

Little Blue Cottage on Spanish
Serenity South -- Gardens, River-Views, and Refreshing Space
The price is $150 per night from Apr 19 to Apr 20
This family-friendly Cape Girardeau vacation home is located on a river, within 2 mi (3 km) of Shawnee National Forest and Isle Casino Cape Girardeau. Southeast ...
5/5Exceptional! (26 reviews)
Long weekend
"My husband and I stayed with my parents for my brother's wedding weekend. The place was wonderful even though we weren't there all that often. There was some excitement with a water main break and a boil order. The hosts were awesome and brought us tons of bottled water to use. We didn't even use ..."

Reviewed on Apr 16, 2021

Serenity South -- Gardens, River-Views, and Refreshing Space
Hilltop Retreat, a Modernly-rustic Getaway!
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Situated in Murphysboro, this vacation home is 1.4 mi (2.3 km) from Shawnee National Forest and within 6 mi (10 km) of General John A. Logan Museum and Lake ...
5/5Exceptional! (9 reviews)
Extended weekend in the wilderness
"We really enjoyed the house and the time we spent together with family. I would definitely choose this location again in the future! The host made everything easy and communicated thoroughly and in a timely manner - everything was as advertised."

Reviewed on Nov 20, 2020

Hilltop Retreat, a Modernly-rustic Getaway!
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Cozy House Within Walking Distance of the Historic Downtown District
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This family-friendly Cape Girardeau vacation home is located on a river, within 1 mi (2 km) of Southeast Missouri Hospital, Shawnee National Forest, and Isle ...
5/5Exceptional! (3 reviews)
VRBO Cape Girardeau
"What a beautiful place to stay, the house was immaculate, had everything we needed and more. Perfect location for the visit. The owners communicated often and I never had a worry. I now have a place to stay when I am visiting my son who lives in Cape. We will be back for sure!"

Reviewed on Mar 22, 2021

Cozy House Within Walking Distance of the Historic Downtown District
Notting Hill Guest Cottage
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Situated in Alto Pass, this vacation home is 0.1 mi (0.1 km) from Shawnee National Forest and within 9 mi (15 km) of Cave Hollow Trailhead and Little Grand Canyon ...
4.6/5Exceptional! (100 reviews)
Perfect location
"This house was absolutely perfect for our getaway to the Shawnee wine trail. The hot tub was such a nice bonus!! We’ll definitely be back!!"

Reviewed on Apr 14, 2021

Notting Hill Guest Cottage
Williams Parkview Flat Upper
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Situated in Cape Girardeau, this vacation home is 0.2 mi (0.4 km) from Shawnee National Forest and 1 mi (1.6 km) from Isle Casino Cape Girardeau. Southeast Missouri ...
Williams Parkview Flat Upper
You Have the Entire House
Cape Girardeau, MO
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Located in the heart of Cape Girardeau, this vacation home is within 2 mi (3 km) of Southeast Missouri Hospital, Isle Casino Cape Girardeau, and Shawnee National ...
4.9/5Exceptional! (7 reviews)
Close to SportsPlex
"Nice, clean property. Location close to the SportsPlex."

Reviewed on Feb 14, 2021

You Have the Entire House
Betty's Vineyard House - On the Shawnee Wine Trail
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This family-friendly Alto Pass vacation home is located in a rural location, 0.1 mi (0.1 km) from Shawnee National Forest, and within 9 mi (15 km) of Cave Hollow ...
5/5Exceptional! (19 reviews)
Lovely home, great location!
"We had a great stay at Betty's Vineyard House! It was clean and stylish, and just a few steps from Alto Vineyards' tasting room. We also enjoyed all the beautiful hiking nearby. Would definitely stay again!"

Reviewed on Apr 8, 2021

Betty's Vineyard House - On the Shawnee Wine Trail
The Cottage at Eden
Cape Girardeau, MO
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Situated in Cape Girardeau, this vacation home is 0.1 mi (0.2 km) from Shawnee National Forest and 1 mi (1.7 km) from Isle Casino Cape Girardeau. Southeast Missouri ...
4.7/5Exceptional! (17 reviews)
"Couldn’t figure out the heat but other than that amazing place 10/10 recommended"

Reviewed on Dec 19, 2020

The Cottage at Eden
Spacious 2 BR, 1 1/2 Baths, hot Tub, Pool Table, Outside Room, Full Kitchen
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Located in the center of Anna, this family-friendly vacation home is within a 15-minute walk of Shawnee Community College, Anna City Park, and Union County Hospital. ...
4.9/5Exceptional! (29 reviews)
Lovely property
"Kathleen was a very responsive host and we enjoyed our stay here. She was very helpful about things to do with our young kids and had some great suggestions, which we loved. The home is vey well-organized, clean and well-maintained. Lots of info about the winery trail and other area attractions. ..."

Reviewed on Apr 7, 2021

Spacious 2 BR, 1 1/2 Baths, hot Tub, Pool Table, Outside Room, Full Kitchen
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Other property types in Sikeston

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
The price is $108 per night from Apr 22 to Apr 23
4.8/5Exceptional! (553 reviews)
"Great place to stay. The gentlemen that were in charge of the breakfast area were outstanding...Just wished they were able to use the griddle to make omelets in the morning. Very Clean!"

Reviewed on Apr 13, 2021

Drury Plaza Hotel Cape Girardeau Conference Center
Auburn Place Hotel And Suites

Auburn Place Hotel And Suites

2.5 out of 5
3265 William St, Cape Girardeau, MO
The price is $69 per night from Apr 19 to Apr 20
4.4/5Excellent! (979 reviews)
"I like the friendless and cleaness .. I didnt like cause pool was closed"

Reviewed on Apr 5, 2021

Auburn Place Hotel And Suites
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St., Cape Girardeau, MO
The price is $135 per night from May 6 to May 7
4.7/5Exceptional! (145 reviews)
"Beautiful old building refitted for hotel. Loved the vibe, clean, wonderful view, and friendly service"

Reviewed on Mar 27, 2021

Courtyard by Marriott Cape Girardeau Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.