East Prairie, MO

Travel Guide

A tree-lined landscape with a river and fields.
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
$94 nightly
The price is $108 total per night from Nov 15 to Nov 16
$108 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,002 reviews)
"The hotel was very clean. Room was spacious and bed was comfortable. Staff were friendly"

Reviewed on Nov 6, 2026

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
$66 nightly
The price is $76 total per night from Nov 8 to Nov 9
$76 total
Nov 8 - Nov 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Days Inn and Suites by Wyndham Sikeston
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
$100 nightly
The price is $114 total per night from Nov 22 to Nov 23
$114 total
Nov 22 - Nov 23
Total with taxes and fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
Hampton Inn Sikeston
See all 91 properties in East Prairie
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Come and relax at the Refuge at beautiful Reelfoot Lake!

Come and relax at the Refuge at beautiful Reelfoot Lake!

Hornbeak TN
Enjoy free WiFi, laundry facilities, and patios. Popular attractions Willow Towhead and Rat Island are located nearby.
9.4/10 Exceptional! (37 reviews)
"The place was nice, however the air-conditioning was out and the refrigerator did not work. It's early September in the south, no a/c means a miserable experience. After some time and several calls/messages I was able to reach the host. He said there was nothing he could do about it other than a ..."

Reviewed on Sep 7, 2026

Come and relax at the Refuge at beautiful Reelfoot Lake!
3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters

3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters

Hornbeak TN
Stay at this vacation home in Hornbeak. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Willow Towhead and Rat Island are located ...
10/10 Exceptional! (16 reviews)
"Great property! Highly recommend! We travel all the time and loved this place! Host was wonderful very helpful and communicative! Thanks for the wonderful experience!"

Reviewed on Nov 3, 2026

3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters
The Dragonfly - Sleeps up to 8, Lake views.

The Dragonfly - Sleeps up to 8, Lake views.

Hornbeak TN
Stay at this vacation home in Hornbeak. Enjoy laundry facilities, an in-room coffeemaker, and air conditioning. Popular attractions Willow Towhead and Rat Island ...
The Dragonfly - Sleeps up to 8, Lake views.
See all properties in East Prairie
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
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Frequently asked questions

When is the best time to visit East Prairie?
The best time to visit East Prairie is from June through August, when the weather is typically warm and popular for travelers. For fewer crowds and better value, the quieter months of October through December are a good bet, offering a more relaxed experience with cooler temperatures.
What is East Prairie known for?
East Prairie is known for Big Oak Tree State Park, a prominent natural attraction. Travelers can explore this park to experience its unique ecosystem and impressive oak trees, offering a peaceful setting for outdoor exploration and enjoying nature.
What is a good itinerary length for East Prairie?
A good itinerary length for East Prairie is one day to explore Big Oak Tree State Park. For travelers who want to enjoy the local North American, Italian, and Latin American dining options at a leisurely pace, a two-day visit provides a more relaxed experience.
What are the top things to do in and around East Prairie?
In East Prairie, travelers can explore Big Oak Tree State Park, a scenic natural area.
Can I book a refundable hotel in East Prairie?
Yes, Expedia offers many flexible booking options, and you can look for refundable hotels in East Prairie by entering your dates and using the refundable or fully refundable filter. Always check the hotel's cancellation policy before you book, since terms can vary by hotel, and visit Expedia help center for further details.
Why book a trip to East Prairie with Expedia?
Expedia makes it easier to plan your East Prairie trip with travel tools, flexible search options, and bookable trip components all in one place. You can organize your plans in one account and use Expedia to help build a trip that fits your budget and travel style. Find out more about how by visiting Expedia's Trip Planner page.
Should I stay in a hotel or vacation rental in East Prairie?
The best choice depends on your travel style. Hotels in East Prairie can be a good fit for convenience, on-site amenities, and shorter stays, while vacation rentals may offer more space, privacy, and home-style amenities for longer trips, families, or groups. With Expedia, you can compare both options side by side, read traveler reviews, and filter by amenities to find the right fit for your trip.
How can I manage my East Prairie trip on Expedia?
Once you've booked your East Prairie trip, you can manage it through your Expedia account or the Expedia app. You can view your itinerary, access booking details, make eligible changes, and check for updates in My Trips. The Expedia app can also help you stay organized while you travel.
What if I need help during my East Prairie trip?
Expedia offers customer support before, during, and after your East Prairie trip. If your plans change or something unexpected happens, you can review your booking in My Trips and use Expedia help center channels for help with eligible changes, cancellations, or travel issues.
How can Expedia help me plan my first trip to East Prairie?
If it's your first trip to East Prairie, Expedia can help you plan by bringing together stays, flights, activities, traveler reviews, and trip-planning tools in one place. With Expedia's Trip Planner you can compare options, read reviews from other travelers, and build an itinerary that matches your interests and budget.
How can I save on my East Prairie hotel booking with Expedia?
Join One Key™ for free to unlock instant discounts with Member Prices on select hotels. You can also earn and use OneKeyCash™* on eligible bookings on Expedia. Booking in advance is usually another great way to save on your East Prairie hotel.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

Cities near East Prairie

A sunset over a calm lake with tall trees reflected in the water.

Charleston

A tree with sunlight filtering through its leaves, creating a warm glow.

Sikeston

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