Sikeston Vacations from $316

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Your Sikeston Vacation

There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston vacation packages will be perfect for you. Fill your spare time with visits to Sikeston Depot Museum, The Book Bug and Central Park, some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston vacation is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style.

The Latest Sikeston vacation packages

Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

3 out of 5
Save 100% on your flight
Price was $500, price is now $316 per person
$316
per person
Oct 27 - Oct 31
found 5 hours ago
Roundtrip non-stop flight included
Atlanta (ATL) to St. Louis (STL)
8.2/10 Very Good! (760 reviews)
I booked online and paid via the app. When I arrived on site they explained they had overbooked and had no rooms available. The staff was amazing and went above and beyond and secured a room at another location. Thank you to the staff for taking care of us.

Reviewed on Jul 26, 2025

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
Price was $610, price is now $333 per person
$333
per person
Oct 27 - Oct 31
found 5 hours ago
Roundtrip non-stop flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,561 reviews)
Lots of restaurants in the area within walking distance.

Reviewed on Aug 22, 2025

Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center

3 out of 5
Downtown St. Louis
Save 100% on your flight
Price was $494, price is now $334 per person
$334
per person
Oct 27 - Oct 31
found 9 hours ago
Roundtrip non-stop flight included
Atlanta (ATL) to St. Louis (STL)
9/10 Wonderful! (1,004 reviews)
I was very surprised at how empty the streets were but I asked a local policeman and he said it usually is. The streets were very clean. However like most big cities just be careful

Reviewed on Aug 20, 2025

Marriott St. Louis West

Marriott St. Louis West

3.5 out of 5
Save 100% on your flight
Price was $622, price is now $431 per person
$431
per person
Oct 27 - Oct 31
found 9 hours ago
Roundtrip non-stop flight included
Atlanta (ATL) to St. Louis (STL)
8.6/10 Excellent! (1,005 reviews)
Ample free self parking. Friendly staff. Clean. Free bottled water.

Reviewed on Aug 16, 2025

WorldMark Lake of the Ozarks

WorldMark Lake of the Ozarks

3 out of 5
Save 100% on your flight
Price was $803, price is now $561 per person
$561
per person
Oct 31 - Nov 4
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
9.4/10 Exceptional! (401 reviews)
Great property! Your balcony view is directly on the water. This property offers a dock unused just for guests. I would bring your own raft or float to enjoy the water. The pools and hot tube area are nice, and offer grills for cooking in the pool area and another location. Check in was great except our room wasn’t ready until 5, the check in time was 4, however they made accommodations to us to offset the delay. It’s close to many fun things to do at the Lake of the Ozarks!! We will be back and will stay here again.

Reviewed on Aug 10, 2025

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Discover the most popular places to visit in Sikeston

Sikeston Depot Museum

You can spend time exploring the galleries in Sikeston Depot Museum in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.

Sikeston Depot Museum

Central Park

Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.

Central Park

Sikeston Hotel Deals

Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
$84 nightly
The price is $96 total per night from Sep 14 to Sep 15
$96 total
Sep 14 - Sep 15
Total with taxes and fees
8.2/10 Very Good! (1,004 reviews)
Two Thumbs Up
"It was awesome we would stay here again. The room was clean and the breakfast was pretty good for a continental the eggs weren’t great but everything else’s was good. We had a room that dogs were allowed in and it was very clean. Clean bathroom too. I even slept in the sheets so that’s telling you ..."

Reviewed on Aug 19, 2025

Best Western Plus Sikeston
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $103 total per night from Aug 28 to Aug 29
$103 total
Aug 28 - Aug 29
Total with taxes and fees
9.4/10 Exceptional! (1,000 reviews)
"The food options were great, the hotel was very clean, the staff were nice and friendly. The room was perfect and the bed was comfortable."

Reviewed on Aug 18, 2025

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr, Sikeston, MO
Fully refundableReserve now, pay when you stay
$63 nightly
The price is $72 total per night from Aug 26 to Aug 27
$72 total
Aug 26 - Aug 27
Total with taxes and fees
7.2/10 Good! (1,000 reviews)
"The staff were all great and happy to accommodate us when we asked to switch rooms due to an AC issue in our original room. The beds were comfortable and clean. No bugs in sight, which is a big thing for me when staying in hotels. Everything was very outdated, the rooms could definitely benefit from ..."

Reviewed on Aug 8, 2025

Days Inn and Suites by Wyndham Sikeston
See all 257 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How much does a Sikeston vacation package cost?
You'll find cheap prices from $316 on Expedia for your Sikeston getaway. However, a range of factors like the season, length of stay and your choice of hotel will determine how much your vacation to Sikeston costs.
What are the cheapest months to go to Sikeston?
If you're hoping to score a cheap Sikeston vacation package, consider planning a trip in November, December and January. You'll typically find lower rates on hotels and flights during these months — ideal for travelers wishing to save money.
How many days is enough for Sikeston?
Usually, a handful of days is great for a Sikeston vacation. With a well-planned itinerary, you can go to all the popular sights such as The Book Bug, as well as explore some hidden treasures along the way.
Is it worth booking a vacation package to Sikeston?
Sikeston offers everything you need for an unforgettable getaway. Get your Sikeston vacation off to a flying start by visiting major attractions like Sikeston Depot Museum.
How to find the best Sikeston package deals?
Use Expedia's filters to find some great Sikeston package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or look for Sikeston package deals in the off-season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's usually best to lock in your vacation package as soon as possible.
Is it cheaper to book a Sikeston vacation as a package?
An Expedia vacation package could land you significant savings when compared to booking stays and flights separately. Better still, you can tailor your Sikeston escape to fit your exact style. Pick your preferred flight time, select the hotel type and add a car rental. Browse our bundle deals and find out how much you can save.
When to book a vacation package to Sikeston?
Enjoy incredible bargains by booking your flights in advance with Expedia. If spontaneity is more your thing, snap up one of our last-minute deals for a spur-of-the-moment Sikeston trip.
Does Expedia offer Book Now, Pay Later Sikeston vacation packages?
If you're like us, you love traveling the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the total cost of your Sikeston vacation over 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can secure great vacation packages with payment plans as soon as you see them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.