Title: Sikeston Vacation Packages 2026 from $499 | Expedia.com [Sikeston Travel Guide](https://expedia.com/Sikeston.dx6058766)[Hotels in Sikeston](https://expedia.com/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)[Vacation Rentals in Sikeston](https://expedia.com/Sikeston-Vacation-Rentals.d6058766.Travel-Guide-VacationRentals)[Flights to Sikeston](https://expedia.com/Cheap-Flights-To-Sikeston.d6058766.Travel-Guide-Flights)[Car Rentals in Sikeston](https://expedia.com/Car-Rentals-In-Sikeston.d6058766.Car-Rental-Guide) ![](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Sikeston Vacations from $499 ## Book a Hotel + Flight or Car together to unlock savings ## Your Sikeston Vacation There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston vacation packages will be perfect for you. Fill your spare time with visits to [Sikeston Depot Museum](https://www.expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction), [The Book Bug](https://www.expedia.com/The-Book-Bug-Sikeston.d553248621532655751.Vacation-Attraction) and [Central Park](https://www.expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction), some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston vacation is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style. ## The Latest Sikeston vacation packages Price found within the past 48 hours. Click for updated prices. ![The Knight Center at Washington University](https://images.trvl-media.com/lodging/39000000/38720000/38711900/38711810/a9bf89ab_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Knight Center at Washington University $499 per person Jun 12 - Jun 15 found 1 day ago Roundtrip flight included Denver (DEN) to St. Louis (STL) 9.4/10 Exceptional! (496 reviews) Great place to stay on campus. Extremely helpful and friendly staff you don’t typically find at the chain hotels. Reviewed on Mar 14, 2026 ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/035dee6c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Wildwood Hotel Save 100% on your flight $614 per person Jun 12 - Jun 15 found 1 day ago Roundtrip flight included Denver (DEN) to St. Louis (STL) 9.2/10 Wonderful! (1,620 reviews) Very nice, clean and there is a pool, a small gym and access to good things in the area Reviewed on Mar 18, 2026 ![Sonesta ES Suites St. Louis - Chesterfield](https://images.trvl-media.com/lodging/1000000/10000/500/422/6f160867_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Sonesta ES Suites St. Louis - Chesterfield $553 per person May 21 - May 26 found 8 hours ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to St. Louis (STL) 8/10 Very Good! (1,029 reviews) Clean and comfortable Reviewed on Mar 15, 2026 ![Angad Arts Hotel St. Louis, Tapestry Collection by Hilton](https://images.trvl-media.com/lodging/28000000/27620000/27617000/27616925/25bc97a8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Angad Arts Hotel St. Louis, Tapestry Collection by Hilton Grand Center $636 per person May 8 - May 11 found 1 day ago Roundtrip flight included Baltimore (BWI) to St. Louis (STL) 8.8/10 Excellent! (1,065 reviews) Super close to the center. Great Breakfast. Clean room and very friendly staff. However, it would be most likely cheaper to buy breakfast the day off then prepay while booking. I got vouchers because I paid for breakfast in advance but could see what my bill would have been and I paid more when booking the room. Reviewed on Mar 16, 2026 ![Holiday Inn Express Troy by IHG](https://images.trvl-media.com/lodging/16000000/15050000/15041300/15041234/f837c869_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Holiday Inn Express Troy by IHG $634 per person May 21 - May 26 found 1 day ago Roundtrip flight included Newark Liberty Intl. Airport (EWR) to St. Louis (STL) 9.4/10 Exceptional! (742 reviews) Shower was amazing, clean room, nice staff, decent breakfast Reviewed on Feb 18, 2026 Don't see what you're looking for? See all available trips from Columbus to Sikeston [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-19/2026-04-26/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=STL&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ### Discover the most popular places to visit in Sikeston #### Central Park Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this relaxing area, you can savor the top-notch restaurants. [](https://expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction) #### Sikeston Depot Museum You can spend time exploring the galleries in Sikeston Depot Museum in Sikeston. While in this relaxing area, you can savor the top-notch restaurants. [](https://expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction) ## Sikeston Hotel Deals ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Sikeston, MO 2608 East Malone Ave, Miner Sikeston MO Fully refundableReserve now, pay when you stay $94 nightly $108 total Mar 26 - Mar 27 Total with taxes and fees 9.4/10 Exceptional! (1,003 reviews) Pool not too cold and it was even snowing at one point. Staff was very friendly and helpful. Never had to wait for elevator. Breakfast waffles were excellent. Room was spacious. I’ve stayed in a lot of hotels, and this is one of the best. They get a 100/10 for amenities! Reviewed on Mar 18, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F26%2F2026&endDate=3%2F27%2F2026&selected=24210&PinnedHotelID=24210&HadPinnedHotel=true®ionId=6058766) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn Sikeston 1240 Commerce Drive Sikeston MO Fully refundableReserve now, pay when you stay $97 nightly $110 total Apr 12 - Apr 13 Total with taxes and fees 9/10 Wonderful! (506 reviews) We wished we could have stayed longer. Reviewed on Mar 17, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=25178175&PinnedHotelID=25178175&HadPinnedHotel=true®ionId=6058766) ![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Best Western Plus Sikeston I-55 120 S Interstate Drive Sikeston MO Fully refundableReserve now, pay when you stay $87 nightly $99 total Mar 26 - Mar 27 Total with taxes and fees 8.4/10 Very Good! (1,006 reviews) Room was clean, the bathroom had a good vent and nice lighting which we've had a problem with with other hotels. Very satisfied with our stay and breakfast was gold. Reviewed on Mar 19, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F26%2F2026&endDate=3%2F27%2F2026&selected=8420572&PinnedHotelID=8420572&HadPinnedHotel=true®ionId=6058766) [See all 287 properties in Sikeston](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F20%2F2026&endDate=3%2F21%2F2026®ionId=6058766) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Sikeston Vacation Packages ## Sikeston Essential Information | Language | English | | --------------- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ | | Currency | U.S dollars | | Closest Airport | Cape Girardeau Municipal Airport (CGI) | | Population | 16,400 | | Max Temp Winter | 45ºF | | Max Temp Summer | 85ºF | | Top Sights | [Sikeston Depot Museum](https://www.expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction), [Central Park](https://www.expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction) and [The Book Bug](https://www.expedia.com/The-Book-Bug-Sikeston.d553248621532655751.Vacation-Attraction) | ## More vacations you might like 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Bloomfield ](https://www.expedia.com/Cheap-Flights-To-Bloomfield.d6351829.Travel-Guide-Flights) - [Flights from Stoddard County ](https://www.expedia.com/lp/flights/553248635976432323/flights-from-stoddard-county) - [Sikeston Depot Museum ](https://www.expedia.com/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction) - [Central Park ](https://www.expedia.com/Central-Park-Sikeston.d6305608.Vacation-Attraction) - [Boot Heel Golf Club ](https://www.expedia.com/Boot-Heel-Golf-Club-Sikeston.d6305606.Vacation-Attraction) - [Bertrand Vacations ](https://www.expedia.com/Bertrand.d3000349285.Destination-Travel-Guides) - [Visit Bertrand ](https://www.expedia.com/Bertrand.dx3000349285) - [Visit Blodgett ](https://www.expedia.com/Blodgett.dx3000349291) - [Visit Canalou ](https://www.expedia.com/Canalou.dx3000349311) - [Visit East Prairie ](https://www.expedia.com/East-Prairie.dx3000349349) - [Charleston Vacations ](https://www.expedia.com/Charleston.d7182.Destination-Travel-Guides) - [Visit 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