Sikeston Vacations from $567

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Your Sikeston Vacation

There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston vacation packages will be perfect for you. Fill your spare time with visits to Sikeston Depot Museum, The Book Bug and Central Park, some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston vacation is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style.

The Latest Sikeston vacation packages

Price found within the past 48 hours. Click for updated prices.
The Cheshire

The Cheshire

4 out of 5
Price was $682, price is now $567 per person
$567
per person
Dec 3 - Dec 6
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,011 reviews)
Roach in room. They don’t clean room at all you need to ask for clean towels and toilet paper. For the price it’s a two or three star place.

Reviewed on Oct 26, 2026

Remodeled and Inviting Free EV

Remodeled and Inviting Free EV

2 out of 5
Price was $1,096, price is now $804 per person
$804
per person
Jan 7 - Jan 11
just found
Roundtrip non-stop flight included
Portland (PDX) to St. Louis (STL)
9.4/10 Exceptional! (3 reviews)
We had a great time with my family ❤️ thank you

Reviewed on Oct 12, 2026

River City Casino & Hotel

River City Casino & Hotel

4 out of 5
Price was $703, price is now $579 per person
$579
per person
Dec 3 - Dec 6
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9/10 Wonderful! (1,820 reviews)

Spacious 3-Bedroom with King Bed

Spacious 3-Bedroom with King Bed

4 out of 5
Central West End
Price was $1,064, price is now $881 per person
$881
per person
Dec 3 - Dec 6
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (11 reviews)
Clean room nice area

Reviewed on Feb 1, 2026

The Westin St. Louis

The Westin St. Louis

4.5 out of 5
Downtown St. Louis
Price was $811, price is now $679 per person
$679
per person
Dec 3 - Dec 6
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.6/10 Excellent! (1,012 reviews)

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Stay near popular Sikeston attractions

Sikeston Depot Museum

7.6/10 (57 reviews)
Housed in a restored 1916 train depot, this museum showcases Sikeston's cotton-growing heritage and local art. Explore regional history through rotating exhibits while admiring the building's National Register status.
See properties

Sikeston Hotel Deals

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from Nov 1 to Nov 2
$108 total
Nov 1 - Nov 2
Total with taxes and fees
9.6/10 Exceptional! (1,003 reviews)
"We had a two-room room king suite. The only complaint I had was that it took 5-10 minutes for the hot water to get hot. They did offer to give me points for a free stay if I wanted to sign-up for their rewards program. We will there next year when we go through Sikeston MO."

Reviewed on Oct 27, 2026

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
$66 nightly
The price is $76 total per night from Nov 1 to Nov 2
$76 total
Nov 1 - Nov 2
Total with taxes and fees
Days Inn and Suites by Wyndham Sikeston
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $108 total per night from Nov 22 to Nov 23
$108 total
Nov 22 - Nov 23
Total with taxes and fees
9/10 Wonderful! (649 reviews)
"Great hotel, clean spacious room, good breakfast choice"

Reviewed on Oct 22, 2026

Hampton Inn Sikeston
See all 319 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Sikeston Vacation Packages

Sikeston Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Cape Girardeau Municipal Airport (CGI)
Population
16,400
Max Temp Winter
45ºF
Max Temp Summer
85ºF
Top Sights
Sikeston Depot Museum, Central Park and The Book Bug

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Frequently asked questions

What's the best vacation package for Sikeston?
For families looking to book the best vacation packages in Sikeston, a stay at Drury Inn & Suites Sikeston, MO is a strong choice. This property is rated 9.3 out of 10 and offers family rooms, an indoor pool, and an outdoor pool, with travelers often highlighting the spacious rooms and great food, including the free breakfast.

Couples seeking a comfortable stay might consider a Sikeston vacation package featuring Fairfield Inn & Suites by Marriott Sikeston. Rated 8.6 out of 10, it provides amenities like an indoor pool and a bar/lounge, creating a relaxing atmosphere.

If you're looking for a budget-friendly option, Comfort Inn & Suites Sikeston I-55 offers a good value. Rated 7.9 out of 10 and costing around $110 per night, this hotel includes free breakfast and an indoor pool, and travelers frequently praise the great breakfast and friendly staff.

*Package availability and prices may change depending on dates and demand.
How can I save money on a Sikeston vacation package?
When you bundle, you can save up to 30%*. To save money on a Sikeston package, consider traveling during the quieter months or be flexible with your dates to find more options. Bundling your flights and hotel together often unlocks savings compared to booking separately. *Members only. Savings vary.
Is Sikeston a good choice for a family vacation package?
Sikeston is a strong choice for family vacation packages, offering attractions and accommodations suitable for all ages.

Drury Inn & Suites Sikeston, MO, rated 9.3 out of 10 by travelers, is a family-friendly hotel about 3 miles from Central Park, featuring family rooms, free breakfast, and both indoor and outdoor pools. Travelers frequently praise the excellent staff and great food.

For activities, families can visit Central Park, about a 10-minute walk from central Sikeston, or explore the natural beauty of Reelfoot Lake State Park, about 17 miles away. Happy Hollow Park, about 8 miles from central Sikeston, also provides a pleasant outdoor space. Your Sikeston vacation package can be customized around these family-friendly activities.
What are the top things to do in Sikeston?
Sikeston, an outdoor and nature destination, offers a variety of attractions for your Sikeston vacation:

Browse and book things to do in Sikeston on Expedia.
Do you need to rent a car in Sikeston, or is public transport enough?
For a Sikeston vacation package, renting a car is highly recommended to fully explore the area, as it is an outdoor and nature destination with attractions spread out. While some central attractions like Central Park are about a 10-minute walk from the city center, many other points of interest, such as Trail of Tears State Park (about 12 miles away) or Reelfoot Lake State Park (about 17 miles away), are best reached by car.

Sikeston is served by several regional airports, including Jackson, TN (MKL-McKellar-Sipes Regional), Paducah, KY (PAH-Barkley Regional), and Cape Girardeau, MO (CGI-Cape Girardeau Municipal). A rental car provides flexibility for travel from these airports and for day trips to surrounding natural areas. Opting for Sikeston vacation packages with flights and a rental car will give you the most freedom to discover the region.
Are Sikeston vacation package hotels conveniently located?
Sikeston vacation package hotels are generally well-located, with many properties situated close to the city center. For example, Holiday Inn Express & Suites Sikeston Southwest by IHG is about 1 mile from central Sikeston, while Hampton Inn Sikeston and Fairfield Inn & Suites by Marriott Sikeston are both about 2 miles away. Drury Inn & Suites Sikeston, MO is also conveniently located about 3 miles from the center. These locations offer convenient access to local attractions and dining, making it easy to explore Sikeston during your stay.
Can I change or cancel my Sikeston vacation package if my plans change?
Yes, you can cancel your vacation package via your itinerary page on Expedia or by contacting customer service. Remember that some packages are fully refundable, but the details vary based on each unique booking. A fully refundable package may depend on how far out from the travel dates you're canceling and what airline you are traveling with.
Do One Key members get extra savings when booking Sikeston vacation packages?
Yes, members who join our free One Key™ travel rewards program can instantly unlock additional savings and save 10% or more on over 500,000 stays worldwide with Member Prices and over 1 million car rentals.
Does Expedia offer Book Now, Pay Later Sikeston vacation packages?
Yes, with Expedia's Book Now, Pay Later option, powered by Affirm, you can spread the cost of your Sikeston vacation over 3, 6, or 12 months. With no late payment fees or hidden costs, it's easy to secure your ideal vacation package as soon as you spot it.
How do I find last-minute vacation packages to Sikeston?
To find last-minute vacation packages to Sikeston, explore the last-minute deals section for the latest package offers, including flights, departing in the coming weeks. Being flexible with your travel dates and hotel preferences can help you secure the best prices.
How does free cancellation work on Sikeston vacation packages?
Free cancellation on a Sikeston vacation package depends on the specific hotel and rate combination you book. Many bookings allow free cancellation up to a stated deadline (often a few days before travel) where eligible. Read the cancellation terms carefully when reviewing the package, and visit Expedia help center for further details.
Is it cheaper to book a Sikeston vacation as a package or separately?
Booking flights and hotels together can unlock lower overall prices. Better still, you can tailor your Sikeston getaway to match your exact preference. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
Why should I book my Sikeston vacation package with Expedia?
Booking your vacation package on Expedia makes it easier to get more out of your trip from the start. With a wide choice of hotels, you can compare prices, reviews and amenities all in one place, then bundle your hotel with flights which could help you save even more. Flexible booking options on selected stays also make it easier to plan with confidence.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.