
Sikeston Vacations from $288
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Your Sikeston Vacation
There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston vacation packages will be perfect for you. Fill your spare time with visits to Sikeston Depot Museum, The Book Bug and Central Park, some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston vacation is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style.
The Latest Sikeston vacation packages



Hilton Garden Inn Chesterfield
Reviewed on Jul 26, 2025

Ameristar Casino Resort and Spa
Reviewed on Aug 4, 2025

Discover the most popular places to visit in Sikeston
Sikeston Depot Museum
You can spend time exploring the galleries in Sikeston Depot Museum in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.
Central Park
Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.
Sikeston Hotel Deals

Best Western Plus Sikeston
Reviewed on Aug 2, 2025

Drury Inn & Suites Sikeston, MO
Reviewed on Jul 19, 2025

Days Inn and Suites by Wyndham Sikeston
Reviewed on Jul 26, 2025
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