Sikeston Vacations from $288

Book a Hotel + Flight or Car together to unlock savings

Photo by Ryan Coleman

Your Sikeston Vacation

There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston vacation packages will be perfect for you. Fill your spare time with visits to Sikeston Depot Museum, The Book Bug and Central Park, some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston vacation is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style.

The Latest Sikeston vacation packages

Price found within the past 48 hours. Click for updated prices.
The Principal Hotel

The Principal Hotel

3.5 out of 5
Save 100% on your flight
per person
Oct 16 - Oct 19
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9.8/10 Exceptional! (105 reviews)
Very clean quiet , room excellent ,mattress very comfortable, extra towels Overall experience awesome.

Reviewed on Jul 26, 2025

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
per person
Oct 16 - Oct 19
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9.2/10 Wonderful! (1,550 reviews)
Great place! Super safe and quiet

Reviewed on Aug 4, 2025

Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

3 out of 5
Save 100% on your flight
per person
Oct 16 - Oct 19
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
8.2/10 Very Good! (756 reviews)
I booked online and paid via the app. When I arrived on site they explained they had overbooked and had no rooms available. The staff was amazing and went above and beyond and secured a room at another location. Thank you to the staff for taking care of us.

Reviewed on Jul 26, 2025

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
Save 100% on your flight
per person
Oct 16 - Oct 19
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
8.4/10 Very Good! (1,003 reviews)
We love staying at the hotel for its great service, clean rooms and awesome restaurant food. BUT, THE CASINO HAS BEEN PAYING LESS AND LESS. WE WOULD NOT RECOMMEND THE CASINO...THE PAYOUTS ARE TERRIBLE ESPECIALLY FOR A HOLIDAY WEEKEND LIKE THE 4TH OF JULY

Reviewed on Aug 4, 2025

The Knight Center at Washington University

The Knight Center at Washington University

2.5 out of 5
Save 100% on your flight
per person
Oct 16 - Oct 19
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9.4/10 Exceptional! (361 reviews)
Great location and staff!

Reviewed on Aug 3, 2025

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Discover the most popular places to visit in Sikeston

Sikeston Depot Museum

You can spend time exploring the galleries in Sikeston Depot Museum in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.

Sikeston Depot Museum

Central Park

Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.

Central Park

Sikeston Hotel Deals

Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $100 total per night from Aug 10 to Aug 11
$100 total
Aug 10 - Aug 11
Total includes taxes and fees
8.2/10 Very Good! (1,001 reviews)
"Staff was excellent. Pool was nice and warm too!"

Reviewed on Aug 2, 2025

Best Western Plus Sikeston
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $103 total per night from Aug 17 to Aug 18
$103 total
Aug 17 - Aug 18
Total includes taxes and fees
9.4/10 Exceptional! (1,001 reviews)
"Enjoyed everything"

Reviewed on Jul 19, 2025

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr, Sikeston, MO
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $82 total per night from Aug 18 to Aug 19
$82 total
Aug 18 - Aug 19
Total includes taxes and fees
7.2/10 Good! (1,001 reviews)
Nice, comfortable
"The staff and room were nice. I did not like that they actually took a deposit out of my account and put it back instead of just held it like other hotels I've been at."

Reviewed on Jul 26, 2025

Days Inn and Suites by Wyndham Sikeston
See all 263 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How much does a Sikeston vacation package cost?
You'll find cheap prices from $288 on Expedia for your Sikeston getaway. However, a range of factors like the season, length of stay and your choice of hotel will determine how much your vacation to Sikeston costs.
What are the cheapest months to go to Sikeston?
If you're hoping to score a cheap Sikeston vacation package, consider planning a trip in November, December and January. You'll typically find lower rates on hotels and flights during these months — ideal for travelers wishing to save money.
How many days is enough for Sikeston?
Usually, a handful of days is great for a Sikeston vacation. With a well-planned itinerary, you can go to all the popular sights such as The Book Bug, as well as explore some hidden treasures along the way.
Is it worth booking a vacation package to Sikeston?
Sikeston offers everything you need for an unforgettable getaway. Get your Sikeston vacation off to a flying start by visiting major attractions like Sikeston Depot Museum.
How to find the best Sikeston package deals?
Use Expedia's filters to find some great Sikeston package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or look for Sikeston package deals in the off-season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's usually best to lock in your vacation package as soon as possible.
Is it cheaper to book a Sikeston vacation as a package?
An Expedia vacation package could land you significant savings when compared to booking stays and flights separately. Better still, you can tailor your Sikeston escape to fit your exact style. Pick your preferred flight time, select the hotel type and add a car rental. Browse our bundle deals and find out how much you can save.
When to book a vacation package to Sikeston?
Enjoy incredible bargains by booking your flights in advance with Expedia. If spontaneity is more your thing, snap up one of our last-minute deals for a spur-of-the-moment Sikeston trip.
Does Expedia offer Book Now, Pay Later Sikeston vacation packages?
If you're like us, you love traveling the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the total cost of your Sikeston vacation over 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can secure great vacation packages with payment plans as soon as you see them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.