Photo by Linda Cronan

Find hotels in Medical Center District, San Antonio from $56

    Plan, book, stay with confidence
    bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    one key icon
    Treat yourself
    Save instantly and earn perks with One Key
    Learn about One Key
    today icon
    Change your mind
    Book hotels with free cancellation

Filter by

Popular filters
Popular filters
Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility
Traveler experience
Traveler experience

Discover 4,148 Medical Center District hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

QuBed San Antonio
Reception
QuBed San Antonio
2.5 star property
6.4 out of 10, (1000)
"Before staying here we stayed at La Quinta that’s around the corner from here and it was bad there with drug selling all hours of the night, couldn’t get really get any sleep while there but now I’m able to sleep. Don’t see no drug selling, it’s quiet and very comfortable and convenient to fast food restaurants."
The price is $56
$67 total
includes taxes & fees
Jun 29 - Jun 30
QuBed San Antonio
Riverwalk Plaza
Game room
Riverwalk Plaza
4.0 star property
8.2 out of 10, Very Good, (3698)
"First and foremost, the staff at this property are AMAZING, and they make you feel like family from the moment you arrive. The lobby is beautiful, and Niche (coffe shop) and The Gavel (restaurant and bar) are neighborhood gems! So nice to be able to walk downstairs and have wonderful coffee/ breakfast / drinks. The room was very clean and comfortable; however, it could use a bit of an update. The AC unit was a bit noisy, but in fairness, it was trying to keep up with 100 degree weather. The...
The price is $119
$141 total
includes taxes & fees
Jun 30 - Jul 1
Riverwalk Plaza
Menger Hotel
Lobby
Menger Hotel
3.5 star property
9.0 out of 10, Wonderful, (2859)
"First time there, entire experience was a great one . "
The price is $122
$146 total
includes taxes & fees
Jun 27 - Jun 28
Menger Hotel
Crockett Hotel
Outdoor pool
Crockett Hotel
3.0 star property
8.8 out of 10, Excellent, (1779)
"This hotel is clean & comfortable. "
The price is $105
$124 total
includes taxes & fees
Jun 27 - Jun 28
Crockett Hotel
Hyatt Regency San Antonio Riverwalk
View from property
Hyatt Regency San Antonio Riverwalk
4.0 star property
8.8 out of 10, Excellent, (1604)
"My husband, son and I had a wonderful time. The hotel is beautiful and you can’t beat the location, right on the river walk. Walking distance to the Alamo. It was just wonderful, will definitely recommend to all my family and friends who visit San Antonio."
The price is $186
$223 total
includes taxes & fees
Jun 30 - Jul 1
Hyatt Regency San Antonio Riverwalk
Hotel Contessa
Exterior
Hotel Contessa
4.0 star property
8.8 out of 10, Excellent, (2753)
"Perfect..!!!"
The price is $170
$216 total
includes taxes & fees
Jul 8 - Jul 9
Hotel Contessa
Omni La Mansion del Rio
Outdoor pool
Omni La Mansion del Rio
4.0 star property
9.2 out of 10, Wonderful, (2168)
"Spacious, cozy room. Comfy Beds. Beautiful atmosphere. Lovely balcony with river view. Easy access to riverwalk. Room service is amazing with fresh hot food.Staff is so welcoming and helpful. Pool and pool service is awesome."
The price is $188
$226 total
includes taxes & fees
Jul 10 - Jul 11
Omni La Mansion del Rio
The Gunter Hotel San Antonio Riverwalk
Lobby
The Gunter Hotel San Antonio Riverwalk
3.5 star property
8.2 out of 10, Very Good, (1004)
"Can’t make a fair statement the property was under construction. I loved the location."
The price is $97
$116 total
includes taxes & fees
Jul 2 - Jul 3
The Gunter Hotel San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Exterior
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3.0 star property
7.6 out of 10, Good, (2774)
"The convenience and walking distance to downtown SA. Parking was additional, which was fine since I did not have to drive anywhere and car was safe from theft as there is a guarded entry. "
The price is $98
$116 total
includes taxes & fees
Jun 26 - Jun 27
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Grand Hyatt San Antonio River Walk
Miscellaneous
Grand Hyatt San Antonio River Walk
4.0 star property
8.8 out of 10, Excellent, (1059)
"Over priced mattress's are no to good for sleeping more than one night "
The price is $174
$209 total
includes taxes & fees
Jun 30 - Jul 1
Grand Hyatt San Antonio River Walk
Drury Plaza Hotel San Antonio Riverwalk
Exterior
Drury Plaza Hotel San Antonio Riverwalk
3.0 star property
9.2 out of 10, Wonderful, (2601)
"The best service we have ever experienced. The Employees we interacted with were extremely knowledgeable, friendly and treated us like special guests that they were expecting. "
The price is $108
$128 total
includes taxes & fees
Jul 2 - Jul 3
Drury Plaza Hotel San Antonio Riverwalk
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Seasonal outdoor pool
Sonesta ES Suites San Antonio Downtown Alamo Plaza
3.0 star property
8.4 out of 10, Very Good, (1323)
"Our stay was great! It's a clean and quiet place and close to everything. The only thing that was annoying was they said our room was ready early for us but would charge us $39 to check in early...not cool "
The price is $98
$116 total
includes taxes & fees
Jul 14 - Jul 15
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Hampton Inn San Antonio-Downtown (River Walk)
Outdoor pool, sun loungers
Hampton Inn San Antonio-Downtown (River Walk)
2.5 star property
8.2 out of 10, Very Good, (2594)
"Great location for downtown entertainment. "
The price is $93
$110 total
includes taxes & fees
Jun 30 - Jul 1
Hampton Inn San Antonio-Downtown (River Walk)
La Cantera Resort & Spa
Private pool
La Cantera Resort & Spa
4.0 star property
8.8 out of 10, Excellent, (1034)
"The view and resort are beautiful but if you're not there for golf or an event, after a day of the view, there isn't much to do except lay by the pool. Pool is nice, well maintained w/ choices of areas for kids and adult only and the main combined pool. The pool water was perfect, not too cold nor too warm. They "upgraded" our room to a King w/ pullout queen in order to be close to the second room we got for family. The pullout queen is a sofa bed, it was horrible! Thin mattress and you could...
The price is $311
$409 total
includes taxes & fees
Jul 14 - Jul 15
La Cantera Resort & Spa
Hotel Gibbs Downtown Riverwalk
Frette Italian sheets, premium bedding, pillowtop beds, in-room safe
Hotel Gibbs Downtown Riverwalk
4.5 star property
9.0 out of 10, Wonderful, (2950)
"Beautiful "
The price is $116
$136 total
includes taxes & fees
Jun 26 - Jun 27
Hotel Gibbs Downtown Riverwalk
The Westin Riverwalk, San Antonio
Breakfast, lunch, dinner served; Italian cuisine
The Westin Riverwalk, San Antonio
4.0 star property
8.6 out of 10, Excellent, (1004)
"Everything was great. Front lobby doors could use automatic handicap entrance. Likewise with bathrooms. Doors are too heavy to push or pull for elderly."
The price is $165
$196 total
includes taxes & fees
Jun 28 - Jun 29
The Westin Riverwalk, San Antonio
Homewood Suites by Hilton San Antonio Riverwalk/Downtown
Exterior
Homewood Suites by Hilton San Antonio Riverwalk/Downtown
3.0 star property
8.4 out of 10, Very Good, (1004)
"Perfect "
The price is $136
$163 total
includes taxes & fees
Jul 9 - Jul 10
Homewood Suites by Hilton San Antonio Riverwalk/Downtown
La Quinta Inn & Suites by Wyndham San Antonio Downtown
Exterior
La Quinta Inn & Suites by Wyndham San Antonio Downtown
2.5 star property
8.6 out of 10, Excellent, (2359)
"Good place "
The price is $103
$122 total
includes taxes & fees
Jul 7 - Jul 8
La Quinta Inn & Suites by Wyndham San Antonio Downtown
La Quinta Inn & Suites by Wyndham San Antonio Airport
Outdoor pool, sun loungers
La Quinta Inn & Suites by Wyndham San Antonio Airport
2.5 star property
7.6 out of 10, Good, (2621)
"Good stay for the price. Worth it."
The price is $80
$95 total
includes taxes & fees
Jun 30 - Jul 1
La Quinta Inn & Suites by Wyndham San Antonio Airport
Hotel Valencia Riverwalk
Terrace/patio
Hotel Valencia Riverwalk
4.0 star property
9.2 out of 10, Wonderful, (1731)
"Very nice place, will stay there again. "
The price is $158
$192 total
includes taxes & fees
Jun 23 - Jun 24
Hotel Valencia Riverwalk
Don't see what you're looking for?
See all available properties in Medical Center District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Medical Center District

Hotels in top San Antonio neighborhoods Learn more about Medical Center District
Downtown - Riverwalk which includes heritage architecture, boating and a river or creek

Downtown San Antonio

4 out of top 10 points of interest in this area
4/5(9,525 area reviews)

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

Find hotels in Downtown San Antonio

Medical Center District Travel Info

Number of reviews
39,815
Location
San Antonio, United States of America
Similar neighborhoods
Downtown San Antonio, North Central and Uptown
Accommodation
4,148 hotels
Known landmarks
San Antonio Aquarium, University of Texas Health and Science Center at San Antonio and Oak Hills Country Club
Hotels with nearby historical attractions
?SA STUDIO? Private Entry , Medical Center Condo for Medical Students, Professionals and Small Families. and Spacious Family Home Near San Antonio Hotspots!
Lowest price
$56
Highest price
$311

Frequently asked questions

What is Medical Center District like?

Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighborhood.

What's a favorite place to stay in Medical Center District?

Based on Expedia customer reviews, Drury Inn & Suites San Antonio Northwest Medical Center is the highest ranked property in Medical Center District. This hotel offers free breakfast and an indoor pool. Other favorite options in the area include SpringHill Suites by Marriott San Antonio Medical Center/NW and Fairfield Inn & Suites by Marriott San Antonio Medical Center.

How many hotels will I be able to find in Medical Center District?

Expedia has 126 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.

Where can I learn more about changing or cancelling my trip to Medical Center District?

For more information about changing or cancelling your trip to Medical Center District, go to https://www.expedia.com/service/.

What can I see and do in this San Antonio neighborhood?

A few attractions you might want to check out while you're in Medical Center District are USAA Corporate Office Headquarters and The San Antonio Art Institute. Wonderland of the Americas Mall and First Unitarian Universalist Church are also worth a visit when you're out sightseeing in San Antonio.

Recent reviews of Medical Center District hotels

Hotel Contessa

Hotel Contessa

5/5 Excellent
"Perfect..!!!"
A verified traveler stayed at Hotel Contessa
Posted 7 hours ago
Hotel Contessa