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Find 4 Star Hotels in Medical Center District, TX from $99

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Check availability on Medical Center District 4 Star Hotels

Tonight
Aug 23 - Aug 24
Tomorrow
Aug 24 - Aug 25
Next weekend
Aug 29 - Aug 31
In two weeks
Sep 5 - Sep 7

Compare Medical Center District 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Riverwalk Plaza
Game room

Riverwalk Plaza

4.0 star property
8.2 out of 10, Very Good, (5715)
"Amazing place to visit "
$89 nightly
The price is $105
Sep 10 - Sep 11
Total with taxes and fees
Riverwalk Plaza
Hotel Contessa
Terrace/patio

Hotel Contessa

4.0 star property
9.0 out of 10, Wonderful, (3196)
"Great place and location "
$161 nightly
The price is $190
Sep 1 - Sep 2
Total with taxes and fees
Hotel Contessa
Omni La Mansion del Rio
Balcony view

Omni La Mansion del Rio

4.0 star property
9.4 out of 10, Exceptional, (2689)
"Great stay!"
$166 nightly
The price is $196
Sep 7 - Sep 8
Total with taxes and fees
Omni La Mansion del Rio
Hotel Valencia Riverwalk
Terrace/patio

Hotel Valencia Riverwalk

4.5 star property
9.4 out of 10, Exceptional, (1979)
"It was a great stay! Best hotel we've stayed at in San Antonio. "
$182 nightly
The price is $214
Aug 24 - Aug 25
Total with taxes and fees
Hotel Valencia Riverwalk
Plaza San Antonio Hotel & Spa, Autograph Collection
Outdoor pool, open 9:00 AM to 10:00 PM, cabanas (surcharge)

Plaza San Antonio Hotel & Spa, Autograph Collection

4.0 star property
9.2 out of 10, Wonderful, (573)
"Second year staying here for a quick weekend getaway. Ticks the boxes for my husband and I and really convenient distance from Yamagata park and splash pad for our toddler. "
$170 nightly
The price is $200
Aug 28 - Aug 29
Total with taxes and fees
Plaza San Antonio Hotel & Spa, Autograph Collection
JW Marriott San Antonio Hill Country Resort & Spa
4 outdoor pools, cabanas (surcharge), pool umbrellas

JW Marriott San Antonio Hill Country Resort & Spa

4.5 star property
9.0 out of 10, Wonderful, (1003)
"Great family oriented place !"
$409 nightly
The price is $478
Aug 28 - Aug 29
Total with taxes and fees
JW Marriott San Antonio Hill Country Resort & Spa
The Westin Riverwalk, San Antonio
Breakfast, lunch, dinner served; Italian cuisine

The Westin Riverwalk, San Antonio

4.0 star property
8.8 out of 10, Excellent, (1299)
"Wonderful stay"
$151 nightly
The price is $179
Sep 11 - Sep 12
Total with taxes and fees
The Westin Riverwalk, San Antonio
La Cantera Resort & Spa
Property grounds

La Cantera Resort & Spa

4.0 star property
9.0 out of 10, Wonderful, (1002)
"We had a great stay. "
$387 nightly
The price is $458
Aug 24 - Aug 25
Total with taxes and fees
La Cantera Resort & Spa
InterContinental San Antonio Riverwalk by IHG
Exterior

InterContinental San Antonio Riverwalk by IHG

4.5 star property
9.4 out of 10, Exceptional, (527)
"Great place to stay! "
$173 nightly
The price is $204
Aug 31 - Sep 1
Total with taxes and fees
InterContinental San Antonio Riverwalk by IHG
Hyatt Regency Hill Country Resort & Spa
3 outdoor pools, cabanas (surcharge), sun loungers

Hyatt Regency Hill Country Resort & Spa

4.0 star property
8.8 out of 10, Excellent, (1005)
"Great place for the price "
$243 nightly
The price is $288
Aug 24 - Aug 25
Total with taxes and fees
Hyatt Regency Hill Country Resort & Spa
Element San Antonio Riverwalk
Restaurant

Element San Antonio Riverwalk

4.0 star property
9.0 out of 10, Wonderful, (975)
"Wonderful hotel with excellent staff and amenities. "
$111 nightly
The price is $131
Sep 1 - Sep 2
Total with taxes and fees
Element San Antonio Riverwalk
AC Hotel by Marriott San Antonio Riverwalk
Rooftop terrace

AC Hotel by Marriott San Antonio Riverwalk

4.0 star property
9.0 out of 10, Wonderful, (888)
"Love you San Antonio "
$119 nightly
The price is $141
Aug 26 - Aug 27
Total with taxes and fees
AC Hotel by Marriott San Antonio Riverwalk
Kimpton Santo San Antonio - Riverwalk by IHG
Outdoor pool

Kimpton Santo San Antonio - Riverwalk by IHG

4.5 star property
9.2 out of 10, Wonderful, (452)
"Amazing stay!"
$171 nightly
The price is $202
Aug 31 - Sep 1
Total with taxes and fees
Kimpton Santo San Antonio - Riverwalk by IHG
Canopy by Hilton San Antonio Riverwalk
Terrace/patio

Canopy by Hilton San Antonio Riverwalk

4.0 star property
9.2 out of 10, Wonderful, (1526)
"Great location, right on the riverwalk. Walkable to shopping and dining and the staff was wonderful! Would definitely stay there again."
$158 nightly
The price is $187
Sep 1 - Sep 2
Total with taxes and fees
Canopy by Hilton San Antonio Riverwalk
The Westin San Antonio North
Indoor pool, outdoor pool

The Westin San Antonio North

4.0 star property
8.6 out of 10, Excellent, (1055)
"Great place to stay."
$84 nightly
The price is $99
Aug 29 - Aug 30
Total with taxes and fees
The Westin San Antonio North
Hyatt Regency San Antonio Riverwalk
View from property

Hyatt Regency San Antonio Riverwalk

4.0 star property
9.2 out of 10, Wonderful, (1791)
"We love and enjoyed our stay!"
$164 nightly
The price is $194
Sep 1 - Sep 2
Total with taxes and fees
Hyatt Regency San Antonio Riverwalk
The St. Anthony, A Luxury Collection Hotel, San Antonio
2 restaurants, breakfast, lunch, dinner served; American cuisine

The St. Anthony, A Luxury Collection Hotel, San Antonio

4.5 star property
8.8 out of 10, Excellent, (1000)
"Really enjoyed stay!! Staff was super friendly!! We d"
$159 nightly
The price is $188
Aug 24 - Aug 25
Total with taxes and fees
The St. Anthony, A Luxury Collection Hotel, San Antonio
Hilton San Antonio Hill Country
Exterior

Hilton San Antonio Hill Country

4.0 star property
8.4 out of 10, Very Good, (1001)
"The staff was friendly and knowledgeable."
$127 nightly
The price is $151
Aug 28 - Aug 29
Total with taxes and fees
Hilton San Antonio Hill Country
Grand Hyatt San Antonio River Walk
Premium bedding, pillowtop beds, in-room safe, desk

Grand Hyatt San Antonio River Walk

4.0 star property
9.0 out of 10, Wonderful, (1236)
"Great food !"
$194 nightly
The price is $229
Aug 24 - Aug 25
Total with taxes and fees
Grand Hyatt San Antonio River Walk
Hilton Garden Inn San Antonio Downtown Riverwalk
Reception

Hilton Garden Inn San Antonio Downtown Riverwalk

4.0 star property
8.4 out of 10, Very Good, (1005)
"I felt welcome and the hotel was clean."
$84 nightly
The price is $99
Sep 1 - Sep 2
Total with taxes and fees
Hilton Garden Inn San Antonio Downtown Riverwalk
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Medical Center District.
Thompson San Antonio - Riverwalk, by Hyatt

Thompson San Antonio - Riverwalk, by Hyatt

115 Lexington Avenue, San Antonio, TX
$223 nightly
The price is $264 total per night from Aug 24 to Aug 25
$264 total
Aug 24 - Aug 25
Total with taxes and fees
9/10 Wonderful! (827 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Medical Center District Hotel Reviews

Omni La Mansion del Rio

Omni La Mansion del Rio

10/10 Excellent
"Lovely place"
Katelyn 3-night trip
Posted 15 hours ago
Omni La Mansion del Rio

Frequently asked questions

What are the best 4-star hotels in Medical Center District?
The Westin San Antonio North is highly praised by Expedia guests. This 4-star hotel located around Medical Center District guarantees a warm and inviting atmosphere and plenty of handy amenities.
How much does it cost to stay in a 4-star hotel in Medical Center District?
To book a 4-star hotel in Medical Center District that's within your budget, make use of Expedia's filters. Take a look at the availability during your travel dates and use our pricing filter to set your maximum rate. You can also list your results by the most budget-friendly retreat first.

  • Search for the lowest price from $264

What's the difference between 5-star and 4-star hotels in Medical Center District?
Treat yourself to refined living during your Medical Center District vacation by checking in to a 4-star hotel. As well as featuring upscale accommodations, these properties are typically packed with amenities like large beds, complimentary bathrobes and more. A 5-star hotel will go the extra mile to make your stay an even more indulgent and unforgettable one. 24-hour front desk, on-site spas and gourmet dining are a few of the exclusive services and conveniences you'll likely have access to.