Santee Vacations from $431

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Your Santee Vacation

Enjoy unforgettable adventures when you book a vacation package to Santee. Whether you're a foodie, art buff or just a traveler who loves discovering new places, there's something for everyone in this lively city. If your trip to Santee includes some sightseeing, don't miss famous attractions like Santee State Park, Santee Cooper Country Club and Santee Outlets. Stop daydreaming and start traveling. Browse the many options on Expedia today and put your Santee vacation plans into action!

The Latest Santee vacation packages

Price found within the past 48 hours. Click for updated prices.
Hilton Columbia Center

Hilton Columbia Center

3.5 out of 5
Downtown Columbia
Price was $501, price is now $431 per person
$431
per person
Jul 16 - Jul 18
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to Columbia (CAE)
8.8/10 Excellent! (1,001 reviews)
They should at least have coffee available in the mornings. It was provided at one time - but now they have a sign up that the machine is out of order - which it has been for over year now.

Reviewed on May 14, 2026

LivSmart Studios by Hilton Columbia Greystone

LivSmart Studios by Hilton Columbia Greystone

2 out of 5
Price was $800, price is now $654 per person
$654
per person
Jul 22 - Jul 29
found 14 hours ago
Roundtrip flight included
Chicago (CHI) to Columbia (CAE)
No reviews
Quality Inn Columbia Airport

Quality Inn Columbia Airport

2.5 out of 5
Price was $552, price is now $470 per person
$470
per person
Jul 22 - Jul 29
found 14 hours ago
Roundtrip flight included
Chicago (CHI) to Columbia (CAE)
6.6/10 (1,004 reviews)
Yummy breakfast Clean and spacious room

Reviewed on Apr 30, 2026

Comfort Suites Columbia at Harbison

Comfort Suites Columbia at Harbison

2.5 out of 5
Price was $740, price is now $638 per person
$638
per person
Jul 22 - Jul 29
found 14 hours ago
Roundtrip flight included
Chicago (CHI) to Columbia (CAE)
8.2/10 Very Good! (1,005 reviews)
The pool was closed all weekend

Reviewed on May 14, 2026

Hyatt Place Columbia/Downtown/The Vista

Hyatt Place Columbia/Downtown/The Vista

3 out of 5
Downtown Columbia
Price was $502, price is now $433 per person
$433
per person
Jul 16 - Jul 18
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to Columbia (CAE)
8.6/10 Excellent! (1,007 reviews)
Great location and comfort for my stay.

Reviewed on May 5, 2026

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Discover the most popular places to visit in Santee

Santee State Park

4/5(43 reviews)

You can take time to visit Santee State Park during your travels to Santee. While you're here, you can savor the top-notch restaurants.

Santee State Park

Santee Cooper Country Club

4/5(12 reviews)

Enjoy a round of golf in Santee at Santee Cooper Country Club. While you're here, you can savor the top-notch restaurants.

Santee Cooper Country Club

Santee National Golf Club

3.5/5(19 reviews)

Enjoy a round of golf in Santee at Santee National Golf Club. While you're here, you can savor the top-notch restaurants.

Santee National Golf Club

Santee Hotel Deals

Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $83 total per night from May 17 to May 18
$83 total
May 17 - May 18
Total with taxes and fees
8/10 Very Good! (1,463 reviews)
The room was very clean. The staff was extremely nice. The only thing that I would suggest is bring your own pillow the bed was very comfortable, but the pillow bring your own.

Reviewed on May 15, 2026

Baymont by Wyndham Santee
Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $118 total per night from May 27 to May 28
$118 total
May 27 - May 28
Total with taxes and fees
9.2/10 Wonderful! (828 reviews)
The staff went out of their way to help me. I had just gotten out of hospital and driven from charlotte

Reviewed on May 15, 2026

Tru By Hilton Santee
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
Fully refundable
$114 nightly
The price is $126 total per night from May 25 to May 26
$126 total
May 25 - May 26
Total with taxes and fees
8/10 Very Good! (1,001 reviews)
This property is right off the interstate with no traffic. The staff was very friendly and the hotel was clean. Breakfast and coffee were delicious. Highly recommend

Reviewed on May 16, 2026

Comfort Inn & Suites Santee
See all 307 properties in Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santee Vacation Packages

Santee Essential Information

Language
English
Currency
U.S dollars
Population
940
Max Temp Winter
55ºF
Max Temp Summer
90ºF
Top Sights
Santee State Park, Santee Cooper Country Club and Santee National Golf Club

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Frequently asked questions

How much does a Santee vacation package cost?
Offering excellent value package deals from $431 on Expedia, you'll be surprised at how little a vacation to Santee costs! Our packages make travel planning easier and your savings go further.
What are the cheapest months to go to Santee?
If you're hoping to snag a cheap Santee vacation package, consider visiting in January, September and October. You're likely to find better prices on accommodations and flights during these quieter months — ideal for budget-conscious travelers.
How many days is enough for Santee?
The ideal length for your Santee vacation depends on what you'd like to see and do. Usually, a few days to a week will give you time to hit all the leading attractions and explore some hidden treasures along the way.
Is it worth booking a vacation package to Santee?
It's no wonder a Santee vacation is on the to-do list of many travelers. Major attractions like Santee State Park are just the beginning of things to see and do here.
How to find the best Santee package deals?
Use Expedia's handy filters to help you find some fabulous Santee package deals. When you begin your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your break for midweek, or search for Santee package deals in the low season. Switch up your travel dates and you may land even better discounts. As a rule of thumb, it's typically best to lock in your vacation package as early as possible.
Is it cheaper to book a Santee vacation as a package?
An Expedia vacation package could land you considerable savings when compared to booking stays and flights individually. Better still, you can customize your Santee trip to match your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Browse our great deals to see how much you can save.
When to book a vacation package to Santee?
If you have your Santee vacation dates locked in, book as soon as you can to score some incredible deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spur-of-the-moment adventures? Our last-minute deals are perfect for quick escapes.
Does Expedia offer Book Now, Pay Later Santee vacation packages?
If you're anything like us, you love discovering new places but don't love the price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With help from online lender Affirm, you can spread the total cost of your Santee trip across 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can snap up cheap vacation packages with payment plans as soon as you spot them.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.