$169 Cheap Flights from Gainesville (GNV) to Des Moines (DSM)

View $169 flight on Wed, Dec 24, 2025Opens in a new window

Popular airlines from Gainesville Regional Airport (GNV) to Des Moines International Airport (DSM)

  • Plan, book, fly with confidence

  • trending down icon
    Be in the know
    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon
    Book smarter
    Save up to 30% on select hotels after you book a flight*
  • one key icon
    Earn twice
    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Gainesville to Des Moines (GNV-DSM)

Prices were available within the past 7 days and start at $169 for one-way flights and $337 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Nov 4 - Sat, Nov 8
GNV
Gainesville
DSM
Des Moines
$337 Roundtrip, found 2 days ago
$337
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Nov 4 from Gainesville to Des Moines, returning Sat, Nov 8, priced at $337 found 2 days ago
American Airlines
Tue, Jul 29 - Sat, Aug 2
GNV
Gainesville
DSM
Des Moines
$337 Roundtrip, found 19 hours ago
$337
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Tue, Jul 29 from Gainesville to Des Moines, returning Sat, Aug 2, priced at $337 found 19 hours ago
Delta
Sat, Jul 5 - Tue, Jul 15
GNV
Gainesville
DSM
Des Moines
$365 Roundtrip, found 4 days ago
$365
Roundtrip
found 4 days ago
Select Delta flight, departing Sat, Jul 5 from Gainesville to Des Moines, returning Tue, Jul 15, priced at $365 found 4 days ago
Delta
Sat, Jul 5 - Sat, Jul 12
GNV
Gainesville
DSM
Des Moines
$366 Roundtrip, found 4 days ago
$366
Roundtrip
found 4 days ago
Select Delta flight, departing Sat, Jul 5 from Gainesville to Des Moines, returning Sat, Jul 12, priced at $366 found 4 days ago
Delta
Tue, Nov 4 - Mon, Nov 10
GNV
Gainesville
DSM
Des Moines
$372 Roundtrip, found 2 days ago
$372
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Nov 4 from Gainesville to Des Moines, returning Mon, Nov 10, priced at $372 found 2 days ago
Delta
Mon, Nov 10 - Tue, Nov 11
GNV
Gainesville
DSM
Des Moines
$379 Roundtrip, found 2 days ago
$379
Roundtrip
found 2 days ago
Select Delta flight, departing Mon, Nov 10 from Gainesville to Des Moines, returning Tue, Nov 11, priced at $379 found 2 days ago
Delta
Sat, Jul 5 - Thu, Jul 17
GNV
Gainesville
DSM
Des Moines
$382 Roundtrip, found 4 days ago
$382
Roundtrip
found 4 days ago
Select Delta flight, departing Sat, Jul 5 from Gainesville to Des Moines, returning Thu, Jul 17, priced at $382 found 4 days ago
Delta
Tue, Jul 8 - Tue, Jul 15
GNV
Gainesville
DSM
Des Moines
$393 Roundtrip, found 3 days ago
$393
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Jul 8 from Gainesville to Des Moines, returning Tue, Jul 15, priced at $393 found 3 days ago
Delta
Tue, Jul 8 - Sat, Jul 12
GNV
Gainesville
DSM
Des Moines
$394 Roundtrip, found 3 days ago
$394
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Jul 8 from Gainesville to Des Moines, returning Sat, Jul 12, priced at $394 found 3 days ago
Delta
Sat, Jul 12 - Sat, Jul 19
GNV
Gainesville
DSM
Des Moines
$395 Roundtrip, found 4 days ago
$395
Roundtrip
found 4 days ago
Select Delta flight, departing Sat, Jul 12 from Gainesville to Des Moines, returning Sat, Jul 19, priced at $395 found 4 days ago

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $441
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $441
Flights from Gainesville (GNV) to Des Moines (DSM)
Origin airport
Gainesville Regional
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta
Roundtrip price
$336
Distance
1036 mi

Gainesville to Des Moines Flights

The cheapest times to fly from Gainesville to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Gainesville to Des Moines are during the month of November. You can find some of the cheapest flights from Gainesville to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Gainesville to Des Moines

Sunday is one of the best days to book for cheap flights from Gainesville to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Gainesville to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Gainesville to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $169 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Gainesville to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Gainesville to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Gainesville Regional Airport (GNV) to Des Moines Intl. Airport (DSM) cost?
Discover the latest flight deals from GNV to DSM by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from GNV to DSM?
The cheapest flights from GNV to DSM are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from GNV to DSM?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from GNV to DSM. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Gainesville Regional Airport (GNV) to Des Moines Intl. Airport (DSM)?
There aren't any daily nonstop flights from Gainesville Regional Airport (GNV) to Des Moines Intl. Airport (DSM). But you can choose flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be on your way before you know it.
What day of the week has the most flights from GNV to DSM?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change based on various factors, including the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Gainesville Regional Airport (GNV) to Des Moines Intl. Airport (DSM)?
Select a flight from Gainesville Regional Airport (GNV) to Des Moines Intl. Airport (DSM) that leaves before 3 PM to reduce the likelihood of delays. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Gainesville Regional Airport (GNV) to Des Moines Intl. Airport (DSM) last-minute?
Last-minute bookings from GNV to DSM are usually more expensive. For the lowest prices, start searching for flights ahead of time. That said, if you can play around with your travel dates, you may score a cheap ticket just before your departure.
Is it cheaper to book a GNV to DSM flight and hotel package?
Opting for a GNV to DSM flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Pick from our impressive range of hotels and then add activities, flights and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Gainesville Regional Airport (GNV) to Des Moines Intl. Airport (DSM)?
If you reserved your GNV to DSM flight in the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of ticket you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for further details.

Explore a world of travel with Expedia

*Available to One Key members.