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Compare 338 hotels in Perry County with room rates, reviews, and availability. Most hotels are fully refundable.

Exterior
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
Perryville
9.2 out of 10, Wonderful, (537)
"Clean room and pleasant staff"
United States
David
$87 nightly
The price is $100
Dec 14 - Dec 15
Total with taxes and fees
Holiday Inn Express & Suites Perryville by IHG
Exterior
Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville

2.0 star property
Perryville
8.4 out of 10, Very Good, (937)
"The room was spotless, and the staff was extremely patient. Each one was very helpful. It was easy to get a good night's sleep - the building was very quiet."
United States
Cynthia
$63 nightly
The price is $72
Dec 22 - Dec 23
Total with taxes and fees
Super 8 by Wyndham Perryville
Lobby
Quality Inn Perryville I-55

Quality Inn Perryville I-55

2.5 star property
Perryville
6.6 out of 10, (124)
"Nice place would recommend Mary Jane’s if you’re looking for good food "
United States
Andrew
$69 nightly
The price is $79
Dec 14 - Dec 15
Total with taxes and fees
Quality Inn Perryville I-55
Seasonal outdoor pool
Days Inn by Wyndham Perryville

Days Inn by Wyndham Perryville

2.0 star property
Perryville
6.8 out of 10, (415)
"Was a nice place."
United States
Lesliee
$62 nightly
The price is $71
Dec 8 - Dec 9
Total with taxes and fees
Days Inn by Wyndham Perryville
Property grounds
The Weber Farm - Enjoy a beautiful 100 acre farm!

The Weber Farm - Enjoy a beautiful 100 acre farm!

Frohna
10.0 out of 10, Exceptional, (32)
"Hosts were great. I just wish they had a second bath or atleast a larger bathroom. "
United States
Dennis H.
$178 nightly
The price is $184
Dec 8 - Dec 9
Total with taxes and fees
The Weber Farm - Enjoy a beautiful 100 acre farm!
Exterior
Hot Tub & Creek Views: Secluded Perryville Cabin

Hot Tub & Creek Views: Secluded Perryville Cabin

Perryville
9.8 out of 10, Exceptional, (8)
"We enjoyed our stay! Peaceful and relaxing.John and Bambi"
United States
Bambi and John B.
Hot Tub & Creek Views: Secluded Perryville Cabin
Property grounds
TreeLoft at BaseCamp

TreeLoft at BaseCamp

2.0 star property
Perryville
10.0 out of 10, Exceptional, (5)
"This place is perfect if you want a private upscale experience that is immersed in natural beauty. The treehouse is luxurious and so comfortable. We loved every minute of our stay. "
United States
joel r.
$417 nightly
The price is $439
Dec 9 - Dec 10
Total with taxes and fees
TreeLoft at BaseCamp
Interior
Urban Loft #1 RED · Urban Loft Downtown above BrewCo & Restaurant

Urban Loft #1 RED · Urban Loft Downtown above BrewCo & Restaurant

Perryville
10.0 out of 10, Exceptional, (1)
"Everything was perfect!"
United States
Thor L.
$277 nightly
The price is $317
Dec 7 - Dec 8
Total with taxes and fees
Urban Loft #1 RED · Urban Loft Downtown above BrewCo & Restaurant
House (3 Bedrooms) | Interior
Hot Tub & Creek Views: Secluded Perryville Cabin

Hot Tub & Creek Views: Secluded Perryville Cabin

3.0 star property
Perryville
Hot Tub & Creek Views: Secluded Perryville Cabin
Interior
Gorgeous, downtown house!

Gorgeous, downtown house!

Perryville
10.0 out of 10, Exceptional, (1)
"Our stay was excellent and our host Carisa was a Great person to work with. The house was beautiful. The house worked out great for us. We had 6 people staying and we all had very comfortable beds and our own bathrooms. Great for a large family. "
United States
Doyle or Cheryl D.
$771 nightly
The price is $875
Dec 8 - Dec 9
Total with taxes and fees
Gorgeous, downtown house!
House (Multiple Bedrooms) | Interior
Missouri Castle w/ Private Lake, Pool & 100 Acres!

Missouri Castle w/ Private Lake, Pool & 100 Acres!

3.0 star property
St Mary
Missouri Castle w/ Private Lake, Pool & 100 Acres!
Dining
Peaceful 4BR ranch w/ hot tub, fire pit & quick access to Ste. Genevieve’s wineries & shops.

Peaceful 4BR ranch w/ hot tub, fire pit & quick access to Ste. Genevieve’s wineries & shops.

Saint Mary
9.8 out of 10, Exceptional, (7)
"Large space which was great. Big bedrooms. "
United States
Robin
Peaceful 4BR ranch w/ hot tub, fire pit & quick access to Ste. Genevieve’s wineries & shops.
55-inch Smart TV with digital channels, TV, streaming services
Urban Lofts

Urban Lofts

3.0 star property
Perryville
9.2 out of 10, Wonderful, (17)
"Great place to stay! "
United States
Eric
$208 nightly
The price is $238
Dec 31 - Jan 1, 2026
Total with taxes and fees
Urban Lofts
1 bedroom, desk, iron/ironing board, WiFi
Downtown Loft w/ Amazing Bath Tub & Shower

Downtown Loft w/ Amazing Bath Tub & Shower

Perryville
10.0 out of 10, Exceptional, (6)
"Amazing place. "
United States
Brandy P.
Downtown Loft w/ Amazing Bath Tub & Shower
Property grounds
Historic House in heart of Altenburg

Historic House in heart of Altenburg

2.0 star property
Altenburg
10.0 out of 10, Exceptional, (1)
"Great place to stay Quite and clean"
United States
Catherine M.
Historic House in heart of Altenburg
Microwave, oven, stovetop, dishwasher
Tranquil and relaxing living quarters surrounded by nature.

Tranquil and relaxing living quarters surrounded by nature.

2.0 star property
Frohna
Tranquil and relaxing living quarters surrounded by nature.
House (0 Bedroom) | Interior
'the Brewer Guesthouse' Tiny Home w/ Patio & Yard!

'the Brewer Guesthouse' Tiny Home w/ Patio & Yard!

3.0 star property
Perryville
10.0 out of 10, Exceptional, (2)
"The house and host were just awesome, enjoyed our stay Toni even helped me Extend!! Would def stay again:)"
United States
Shandese
'the Brewer Guesthouse' Tiny Home w/ Patio & Yard!
Outdoor spa tub
New! Luxury Meets Nature - TreeRise at BaseCamp

New! Luxury Meets Nature - TreeRise at BaseCamp

2.0 star property
Perryville
10.0 out of 10, Exceptional, (1)
"Our visit was short but so special. Waylon and Kaci have created a sweet haven of rest in the woods of Missouri. We so appreciated the chance to unplug for a bit. Can’t recommend enough! "
United States
Amber S.
New! Luxury Meets Nature - TreeRise at BaseCamp
Fridge, microwave, stovetop, coffee/tea maker
'The Brewer Guesthouse' Tiny Home w/ Patio & Yard!

'The Brewer Guesthouse' Tiny Home w/ Patio & Yard!

Perryville
10.0 out of 10, Exceptional, (9)
"Clean, quiet, and conveniently located near Perryville. I would definitely stay again."
United States
Matthew
'The Brewer Guesthouse' Tiny Home w/ Patio & Yard!
Property grounds
Entire Private Home in Perryville, MO

Entire Private Home in Perryville, MO

Perryville
10.0 out of 10, Exceptional, (2)
"Clean and comfortable it was everything we needed. The property manager was very pleasant to talk to. I would recommend others to stay here."
United States
David T.
Entire Private Home in Perryville, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Perry County Hotel Reviews

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
Brian 1-night trip
Posted 4 days ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

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