$157 Cheap Flights from Charleston (CHS) to Des Moines (DSM)

View $157 flight on Sun, Jan 18, 2026Opens in a new window

Popular airlines from Charleston Intl. Airport (CHS) to Des Moines International Airport (DSM)

Cheap Flights from Charleston to Des Moines (CHS-DSM)

Prices were available within the past 7 days and start at $157 for one-way flights and $313 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Thu, Jan 1 - Sun, Jan 18
CHS
Charleston
DSM
Des Moines
$313 Roundtrip, found 2 days ago
$313
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Jan 1 from Charleston to Des Moines, returning Sun, Jan 18, priced at $313 found 2 days ago
United
Mon, Nov 24 - Tue, Dec 2
CHS
Charleston
DSM
Des Moines
$315 Roundtrip, found 2 days ago
$315
Roundtrip
found 2 days ago
Select United flight, departing Mon, Nov 24 from Charleston to Des Moines, returning Tue, Dec 2, priced at $315 found 2 days ago
Delta
Sat, Dec 13 - Wed, Dec 17
CHS
Charleston
DSM
Des Moines
$317 Roundtrip, found 18 hours ago
$317
Roundtrip
found 18 hours ago
Select Delta flight, departing Sat, Dec 13 from Charleston to Des Moines, returning Wed, Dec 17, priced at $317 found 18 hours ago
American Airlines
Mon, Nov 24 - Tue, Dec 2
CHS
Charleston
DSM
Des Moines
$320 Roundtrip, found 2 days ago
$320
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Nov 24 from Charleston to Des Moines, returning Tue, Dec 2, priced at $320 found 2 days ago
United
Mon, Nov 24 - Tue, Dec 2
CHS
Charleston
DSM
Des Moines
$320 Roundtrip, found 2 days ago
$320
Roundtrip
found 2 days ago
Select United flight, departing Mon, Nov 24 from Charleston to Des Moines, returning Tue, Dec 2, priced at $320 found 2 days ago
United
Mon, Nov 24 - Tue, Dec 2
CHS
Charleston
DSM
Des Moines
$325 Roundtrip, found 2 days ago
$325
Roundtrip
found 2 days ago
Select United flight, departing Mon, Nov 24 from Charleston to Des Moines, returning Tue, Dec 2, priced at $325 found 2 days ago
United
Mon, Nov 24 - Tue, Dec 2
CHS
Charleston
DSM
Des Moines
$325 Roundtrip, found 2 days ago
$325
Roundtrip
found 2 days ago
Select United flight, departing Mon, Nov 24 from Charleston to Des Moines, returning Tue, Dec 2, priced at $325 found 2 days ago
American Airlines
Sun, Dec 7 - Wed, Dec 10
CHS
Charleston
DSM
Des Moines
$328 Roundtrip, found 5 hours ago
$328
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Sun, Dec 7 from Charleston to Des Moines, returning Wed, Dec 10, priced at $328 found 5 hours ago
United
Sun, Dec 7 - Wed, Dec 10
CHS
Charleston
DSM
Des Moines
$333 Roundtrip, found 5 hours ago
$333
Roundtrip
found 5 hours ago
Select United flight, departing Sun, Dec 7 from Charleston to Des Moines, returning Wed, Dec 10, priced at $333 found 5 hours ago
Southwest Airlines
Thu, Jan 8 - Mon, Jan 12
CHS
Charleston
DSM
Des Moines
$339 Roundtrip, found 4 days ago
$339
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Thu, Jan 8 from Charleston to Des Moines, returning Mon, Jan 12, priced at $339 found 4 days ago

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $390
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $390

Frequently asked questions

How much does a flight from Charleston Intl. Airport (CHS) to Des Moines Intl. Airport (DSM) cost?
Grab a cheap one-way flight from $157 or cheap return flight from $313 from Charleston Intl. Airport (CHS) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Charleston Intl. Airport (CHS) to Des Moines Intl. Airport (DSM)?
January is the most affordable month to fly from CHS to DSM. Traveling during an off-peak travel window is often the key to scoring lower fares.
What is the cheapest airline that flies from Charleston Intl. Airport (CHS) to Des Moines Intl. Airport (DSM)?
Use the filters on Expedia to compare different airlines and find the cheapest carrier that'll fly you from CHS to DSM. Then, sort your results by "Price (lowest to highest)" to snap up the best deal available.
How many flights per day from Charleston Intl. Airport (CHS) to Des Moines Intl. Airport (DSM)?
You'll have to book a flight with a layover when traveling from Charleston Intl. Airport (CHS) to Des Moines Intl. Airport (DSM). There are no daily direct flights on this route. However, simply filter your search to include one or two stops to find the best option for your trip.
What day of the week has the most flights from CHS to DSM?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can change depending on a number of factors, including the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Charleston Intl. Airport (CHS) to Des Moines Intl. Airport (DSM)?
To avoid possible delays on the Charleston Intl. Airport (CHS) to Des Moines Intl. Airport (DSM) route, aim to travel before 3 PM. Later flights have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Charleston Intl. Airport (CHS) to Des Moines Intl. Airport (DSM) last-minute?
Last-minute bookings from CHS to DSM are generally more expensive. For the best rates, start looking for flights well in advance. That being said, if your travel plans are flexible, you may find a cheap ticket just before your departure.
Is it cheaper to book a CHS to DSM flight and hotel package?
Opting for a CHS to DSM flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip all in one place. Select from our extensive range of hotels and then add flights, car rentals and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Charleston Intl. Airport (CHS) to Des Moines Intl. Airport (DSM)?
If you booked your CHS to DSM flight in the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for further details.

Travel information

Origin airport
Charleston Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$312
Distance
956 mi

Book with confidence

Charleston to Des Moines Flights

The cheapest times to fly from Charleston to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Charleston to Des Moines are during the month of January. You can find some of the cheapest flights from Charleston to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Charleston to Des Moines

Sunday is one of the best days to book for cheap flights from Charleston to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Charleston to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Charleston to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $157 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Charleston to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Charleston to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Charleston to Des Moines Flights

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*Available to One Key members.