$131 Cheap Flights from Portland (PDX) to Des Moines (DSM)

View $131 flight on Wed, Dec 3, 2025Opens in a new window

Popular airlines from Portland International Airport (PDX) to Des Moines International Airport (DSM)

Cheap Flights from Portland to Des Moines (PDX-DSM)

Prices were available within the past 7 days and start at $131 for one-way flights and $261 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Dec 3 - Sat, Dec 6
PDX
Portland
DSM
Des Moines
$261 Roundtrip, found 1 day ago
$261
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Dec 3 from Portland to Des Moines, returning Sat, Dec 6, priced at $261 found 1 day ago
Southwest Airlines
Sat, Dec 13 - Tue, Dec 16
PDX
Portland
DSM
Des Moines
$266 Roundtrip, found 5 days ago
$266
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Sat, Dec 13 from Portland to Des Moines, returning Tue, Dec 16, priced at $266 found 5 days ago
Delta
Thu, Nov 27 - Wed, Dec 3
PDX
Portland
DSM
Des Moines
$271 Roundtrip, found 5 days ago
$271
Roundtrip
found 5 days ago
Select Delta flight, departing Thu, Nov 27 from Portland to Des Moines, returning Wed, Dec 3, priced at $271 found 5 days ago
Southwest Airlines
Wed, Nov 19 - Sat, Dec 13
PDX
Portland
DSM
Des Moines
$287 Roundtrip, found 2 days ago
$287
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Wed, Nov 19 from Portland to Des Moines, returning Sat, Dec 13, priced at $287 found 2 days ago
American Airlines
Tue, Dec 16 - Thu, Jan 1
PDX
Portland
DSM
Des Moines
$300 Roundtrip, found 5 days ago
$300
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Dec 16 from Portland to Des Moines, returning Thu, Jan 1, priced at $300 found 5 days ago
Southwest Airlines
Tue, Dec 16 - Thu, Jan 1
PDX
Portland
DSM
Des Moines
$301 Roundtrip, found 5 days ago
$301
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Tue, Dec 16 from Portland to Des Moines, returning Thu, Jan 1, priced at $301 found 5 days ago
American Airlines
Sat, Dec 13 - Tue, Dec 16
PDX
Portland
DSM
Des Moines
$306 Roundtrip, found 5 days ago
$306
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sat, Dec 13 from Portland to Des Moines, returning Tue, Dec 16, priced at $306 found 5 days ago
Delta
Mon, Dec 15 - Tue, Dec 16
PDX
Portland
DSM
Des Moines
$306 Roundtrip, found 5 days ago
$306
Roundtrip
found 5 days ago
Select Delta flight, departing Mon, Dec 15 from Portland to Des Moines, returning Tue, Dec 16, priced at $306 found 5 days ago
United
Sat, Dec 13 - Tue, Dec 16
PDX
Portland
DSM
Des Moines
$314 Roundtrip, found 5 days ago
$314
Roundtrip
found 5 days ago
Select United flight, departing Sat, Dec 13 from Portland to Des Moines, returning Tue, Dec 16, priced at $314 found 5 days ago
Alaska Airlines
Thu, Dec 18 - Mon, Jan 5
PDX
Portland
DSM
Des Moines
$507 Roundtrip, found 7 hours ago
$507
Roundtrip
found 7 hours ago
Select Alaska Airlines flight, departing Thu, Dec 18 from Portland to Des Moines, returning Mon, Jan 5, priced at $507 found 7 hours ago

Find the cheapest month to fly from Portland (PDX) to Des Moines (DSM)

November is typically the cheapest month to fly

From $138 - $646 per traveler.

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $357
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $357

Frequently asked questions

How much does a flight from Portland Intl. Airport (PDX) to Des Moines Intl. Airport (DSM) cost?
Grab a cheap one-way flight from $131 or cheap return flight from $261 from Portland Intl. Airport (PDX) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Portland Intl. Airport (PDX) to Des Moines Intl. Airport (DSM)?
December is the most affordable month to fly from PDX to DSM. Avoiding peak travel times is often the key to scoring lower fares.
What is the cheapest airline that flies from Portland Intl. Airport (PDX) to Des Moines Intl. Airport (DSM)?
To find the cheapest airline flying from PDX to DSM, use Expedia's filter tool. Customize your search based on what matters most to you, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to see the cheapest fares upfront.
How many flights per day from Portland Intl. Airport (PDX) to Des Moines Intl. Airport (DSM)?
There aren't any daily nonstop flights from Portland Intl. Airport (PDX) to Des Moines Intl. Airport (DSM). But you can book flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be cruising above the clouds before you know it.
What day of the week has the most flights from PDX to DSM?
Generally you'll find the widest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* But this can vary depending on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Portland Intl. Airport (PDX) to Des Moines Intl. Airport (DSM)?
To touch down at Des Moines Intl. Airport (DSM) on time, choose a flight that leaves Portland Intl. Airport (PDX) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Portland Intl. Airport (PDX) to Des Moines Intl. Airport (DSM) last-minute?
Last-minute bookings from PDX to DSM are typically more expensive. For the lowest rates, start looking for flights early. That said, if your travel plans are flexible, you may score a cheap ticket right before your journey.
Is it cheaper to book a PDX to DSM flight and hotel package?
Booking a PDX to DSM flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our wide range of accommodations and then add car rentals, flights and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Portland Intl. Airport (PDX) to Des Moines Intl. Airport (DSM)?
If you booked your PDX to DSM flight in the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of fare you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal if you want more information.

Travel information

Origin airport
Portland Intl.
Destination airport
Des Moines Intl.
Airlines serving
Alaska Airlines, American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$260
Distance
1467 mi

Book with confidence

Portland to Des Moines Flights

The cheapest times to fly from Portland to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Portland to Des Moines are during the month of December. You can find some of the cheapest flights from Portland to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Portland to Des Moines

Sunday is one of the best days to book for cheap flights from Portland to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Portland to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Portland to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $131 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Portland to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Portland to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Portland to Des Moines Flights

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*Available to One Key members.