$149 Cheap Flights from Fort Myers (RSW) to Des Moines (DSM)

View $149 flight on Wed, Dec 31, 2025Opens in a new window

Popular airlines from Southwest Florida Intl. Airport (RSW) to Des Moines International Airport (DSM)

Cheap Flights from Fort Myers to Des Moines (RSW-DSM)

Prices were available within the past 7 days and start at $149 for one-way flights and $297 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Fri, Sep 12 - Wed, Sep 17
RSW
Fort Myers
DSM
Des Moines
$297 Roundtrip, found 2 days ago
$297
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Sep 12 from Fort Myers to Des Moines, returning Wed, Sep 17, priced at $297 found 2 days ago
American Airlines
Thu, Aug 28 - Mon, Sep 1
RSW
Fort Myers
DSM
Des Moines
$297 Roundtrip, found 7 hours ago
$297
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Thu, Aug 28 from Fort Myers to Des Moines, returning Mon, Sep 1, priced at $297 found 7 hours ago
Delta
Thu, Aug 28 - Mon, Sep 1
RSW
Fort Myers
DSM
Des Moines
$297 Roundtrip, found 7 hours ago
$297
Roundtrip
found 7 hours ago
Select Delta flight, departing Thu, Aug 28 from Fort Myers to Des Moines, returning Mon, Sep 1, priced at $297 found 7 hours ago
Delta
Wed, Dec 10 - Thu, Dec 11
RSW
Fort Myers
DSM
Des Moines
$299 Roundtrip, found 3 days ago
$299
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Dec 10 from Fort Myers to Des Moines, returning Thu, Dec 11, priced at $299 found 3 days ago
United
Wed, Sep 3 - Mon, Sep 8
RSW
Fort Myers
DSM
Des Moines
$302 Roundtrip, found 3 days ago
$302
Roundtrip
found 3 days ago
Select United flight, departing Wed, Sep 3 from Fort Myers to Des Moines, returning Mon, Sep 8, priced at $302 found 3 days ago
Delta
Sun, Aug 31 - Mon, Sep 8
RSW
Fort Myers
DSM
Des Moines
$307 Roundtrip, found 10 hours ago
$307
Roundtrip
found 10 hours ago
Select Delta flight, departing Sun, Aug 31 from Fort Myers to Des Moines, returning Mon, Sep 8, priced at $307 found 10 hours ago
United
Wed, Sep 3 - Mon, Sep 8
RSW
Fort Myers
DSM
Des Moines
$312 Roundtrip, found 3 days ago
$312
Roundtrip
found 3 days ago
Select United flight, departing Wed, Sep 3 from Fort Myers to Des Moines, returning Mon, Sep 8, priced at $312 found 3 days ago
Southwest Airlines
Tue, Oct 7 - Fri, Oct 10
RSW
Fort Myers
DSM
Des Moines
$312 Roundtrip, found 13 hours ago
$312
Roundtrip
found 13 hours ago
Select Southwest Airlines flight, departing Tue, Oct 7 from Fort Myers to Des Moines, returning Fri, Oct 10, priced at $312 found 13 hours ago
United
Tue, Oct 7 - Fri, Oct 10
RSW
Fort Myers
DSM
Des Moines
$314 Roundtrip, found 13 hours ago
$314
Roundtrip
found 13 hours ago
Select United flight, departing Tue, Oct 7 from Fort Myers to Des Moines, returning Fri, Oct 10, priced at $314 found 13 hours ago
United
Wed, Sep 3 - Mon, Sep 8
RSW
Fort Myers
DSM
Des Moines
$316 Roundtrip, found 3 days ago
$316
Roundtrip
found 3 days ago
Select United flight, departing Wed, Sep 3 from Fort Myers to Des Moines, returning Mon, Sep 8, priced at $316 found 3 days ago

Find the cheapest month to fly from Fort Myers (RSW) to Des Moines (DSM)

August is typically the cheapest month to fly

From $214 - $752 per traveler.

Graph displaying average flight prices per month

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $372
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $372
Flights from Fort Myers (RSW) to Des Moines (DSM)
Origin airport
Southwest Florida Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$296
Distance
1237 mi

Fort Myers to Des Moines Flights

The cheapest times to fly from Fort Myers to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Fort Myers to Des Moines are during the month of September. You can find some of the cheapest flights from Fort Myers to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Fort Myers to Des Moines

Sunday is one of the best days to book for cheap flights from Fort Myers to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Fort Myers to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Fort Myers to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $149 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Fort Myers to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Fort Myers to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Southwest Florida Intl. Airport (RSW) to Des Moines Intl. Airport (DSM) cost?
Discover the latest flight deals from RSW to DSM by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from RSW to DSM?
The cheapest flights from RSW to DSM are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Southwest Florida Intl. Airport (RSW) to Des Moines Intl. Airport (DSM)?
You can't fly direct from Fort Myers, FL (RSW-Southwest Florida Intl.) to Des Moines Intl. Airport (DSM). However, you can easily reach Des Moines without any layovers by taking off from Charlotte County Airport (PGD).
What is the cheapest airline that flies from RSW to DSM?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from RSW to DSM. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Southwest Florida Intl. Airport (RSW) to Des Moines Intl. Airport (DSM)?
You'll need to catch a flight with a layover if you're traveling from Southwest Florida Intl. Airport (RSW) to Des Moines Intl. Airport (DSM). Direct flights don't operate daily on this route. However, just filter your search to include one or more stops to find an option that works for you.
What day of the week has the most flights from RSW to DSM?
Usually you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* However, this can vary depending on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Southwest Florida Intl. Airport (RSW) to Des Moines Intl. Airport (DSM)?
To avoid possible delays on the Southwest Florida Intl. Airport (RSW) to Des Moines Intl. Airport (DSM) route, fly before 3 PM. Later flights have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Southwest Florida Intl. Airport (RSW) to Des Moines Intl. Airport (DSM) last-minute?
Last-minute fares from RSW to DSM are usually more expensive. To secure the lowest rates, start looking for flights early. That said, if you're flexible with your travel plans, you may land a cheap ticket right before your journey.
Is it cheaper to book a RSW to DSM flight and hotel package?
Compared with arranging hotels and flights separately, booking a RSW to DSM flight and hotel package with Expedia could lead to significant savings. What's more, having everything in one easy place will take the stress out of planning your trip. Just pick your flights and select from our extensive range of hotels, then personalize your trip with other add-ons like tours, activities and car rentals.
Can I cancel or change the date of my flight from Southwest Florida Intl. Airport (RSW) to Des Moines Intl. Airport (DSM)?
Usually, it's possible to reschedule or cancel your RSW to DSM flight. However, for bookings made more than 24 hours ago, additional fees may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find more information on our Customer Service portal.

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*Available to One Key members.