$308 Cheap Flights from Memphis (MEM) to Florence (FLO)

View $308 flight on Wed, Jan 14, 2026Opens in a new window

Popular airlines from Memphis International Airport (MEM) to Florence, SC (FLO-Florence Regional)

Cheap Flights from Memphis to Florence (MEM-FLO)

Prices were available within the past 7 days and start at $308 for one-way flights and $407 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, Oct 25 - Sat, Nov 1
MEM
Memphis
FLO
Florence
$407 Roundtrip, found 1 day ago
$407
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Oct 25 from Memphis to Florence, returning Sat, Nov 1, priced at $407 found 1 day ago
American Airlines
Mon, Nov 24 - Mon, Dec 8
MEM
Memphis
FLO
Florence
$411 Roundtrip, found 13 hours ago
$411
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Mon, Nov 24 from Memphis to Florence, returning Mon, Dec 8, priced at $411 found 13 hours ago
American Airlines
Thu, Mar 12 - Tue, Mar 17
MEM
Memphis
FLO
Florence
$432 Roundtrip, found 6 days ago
$432
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Mar 12 from Memphis to Florence, returning Tue, Mar 17, priced at $432 found 6 days ago
American Airlines
Thu, Mar 12 - Tue, Mar 17
MEM
Memphis
FLO
Florence
$442 Roundtrip, found 6 days ago
$442
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Mar 12 from Memphis to Florence, returning Tue, Mar 17, priced at $442 found 6 days ago
American Airlines
Mon, Nov 24 - Mon, Dec 8
MEM
Memphis
FLO
Florence
$456 Roundtrip, found 13 hours ago
$456
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Mon, Nov 24 from Memphis to Florence, returning Mon, Dec 8, priced at $456 found 13 hours ago
American Airlines
Tue, Dec 16 - Tue, Dec 30
MEM
Memphis
FLO
Florence
$457 Roundtrip, found 5 days ago
$457
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Dec 16 from Memphis to Florence, returning Tue, Dec 30, priced at $457 found 5 days ago
American Airlines
Tue, Nov 4 - Sat, Nov 22
MEM
Memphis
FLO
Florence
$467 Roundtrip, found 5 days ago
$467
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Nov 4 from Memphis to Florence, returning Sat, Nov 22, priced at $467 found 5 days ago
American Airlines
Wed, Oct 22 - Wed, Oct 29
MEM
Memphis
FLO
Florence
$477 Roundtrip, found 1 day ago
$477
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 22 from Memphis to Florence, returning Wed, Oct 29, priced at $477 found 1 day ago
American Airlines
Mon, Nov 24 - Mon, Dec 8
MEM
Memphis
FLO
Florence
$481 Roundtrip, found 13 hours ago
$481
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Mon, Nov 24 from Memphis to Florence, returning Mon, Dec 8, priced at $481 found 13 hours ago
American Airlines
Tue, Nov 4 - Thu, Nov 20
MEM
Memphis
FLO
Florence
$491 Roundtrip, found 5 days ago
$491
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Nov 4 from Memphis to Florence, returning Thu, Nov 20, priced at $491 found 5 days ago

Alternative airports near Florence

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Florence Regional FLO. Cheapest and Closest option available. Average driving time to city center is 5 minutes. Flights from $512
FLO
Florence Regional
CheapestClosest
Average driving time to city center5 min
Flights from $512

Frequently asked questions

How much does a flight from Memphis Intl. Airport (MEM) to Florence Regional Airport (FLO) cost?
Secure a cheap one-way flight from $308 or cheap return flight from $407 from Memphis Intl. Airport (MEM) to Florence Regional Airport (FLO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Memphis Intl. Airport (MEM) to Florence Regional Airport (FLO)?
Planning your getaway for October is a great way to save, as it's the cheapest month for flights between MEM and FLO. You'll usually find the lowest fares during the off-season.
What is the cheapest airline that flies from Memphis Intl. Airport (MEM) to Florence Regional Airport (FLO)?
Use the filters on Expedia to compare airlines and find the most affordable carrier that'll fly you from MEM to FLO. Then, sort your results by "Price (lowest to highest)" to snag a great deal.
How many flights per day from Memphis Intl. Airport (MEM) to Florence Regional Airport (FLO)?
There aren't any daily nonstop flights from Memphis Intl. Airport (MEM) to Florence Regional Airport (FLO). But you can choose flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be on your way before you know it.
What day of the week has the most flights from MEM to FLO?
You'll usually find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Memphis Intl. Airport (MEM) to Florence Regional Airport (FLO)?
Opt for a flight from Memphis Intl. Airport (MEM) to Florence Regional Airport (FLO) that takes off before 3 PM to reduce the risk of delays and cancellations. Departures after this hour are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Memphis Intl. Airport (MEM) to Florence Regional Airport (FLO) last-minute?
Last-minute fares from MEM to FLO are usually more expensive. To lock in the best prices, start looking for flights as early as possible. That said, if you're flexible with your travel dates, it's possible to land a cheap fare right before you leave.
Is it cheaper to book a MEM to FLO flight and hotel package?
You'll typically save money by booking a MEM to FLO flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one place. Once you've chosen your ideal accommodations and flights, consider adding extras like car rentals, tours and activities.
Can I cancel or change the date of my flight from Memphis Intl. Airport (MEM) to Florence Regional Airport (FLO)?
Generally, it's possible to cancel or reschedule your MEM to FLO flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find more information on our Customer Service portal.

Travel information

Origin airport
Memphis Intl.
Destination airport
Florence Regional
Airlines serving
American Airlines
Roundtrip price
$406
Distance
585 mi

Book with confidence

Memphis to Florence Flights

The cheapest times to fly from Memphis to Florence

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Memphis to Florence are during the month of October. You can find some of the cheapest flights from Memphis to Florence with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Memphis to Florence

Sunday is one of the best days to book for cheap flights from Memphis to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Memphis to Florence

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Memphis to Florence in 2025. You can also book with separate airlines for your outbound and return journeys, from $308 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Memphis to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Memphis to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Memphis to Florence Flights

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*Available to One Key members.