Find 5 Star Hotels in Florence, SC
Upfront pricingOur total price for your stay includes taxes and fees
Treat yourselfSave 10% or more on over 100,000 hotels worldwide with Member Prices
Be pickySearch almost a million properties worldwide
Check availability on Florence 5 Star Hotels
Our top choices for Florence 5-star hotels
8. Days Inn by Wyndham Florence Near Civic Center
Days Inn by Wyndham Florence Near Civic Center
Florence and related destinations
Stroll through the West Broad Street Historic District to soak up local history before exploring the Florence Museum's diverse exhibits. Catch a show at the Florence Civic Center or hunt for bargains at Magnolia Mall for a taste of modern entertainment.
Top Florence Hotel Reviews
Find out more about Florence
Ready to experience the next standard in luxury? We know you are thinking about it. Add further enjoyment on your next trip to Florence by treating yourself to the best of the best when it comes to lodging. It's an ideal combination. There's no reason to delay a getaway to Florence any longer. You'll join the multitudes of vacationers who have made Florence so fashionable in the last year. We should also mention, the hotels in this area receive high marks for guest services, so you know you'll be well cared for during your getaway. You deserve the great vacation you're dreaming about. Reserve one of our 5-star hotels in Florence and indulge in the finer things in life for a while.
5-Star Hotels in Florence
Don't be afraid to be pampered during your trip. Michelin-starred restaurants, excellent customer care, and deeply relaxing spa offerings are all on offer. Our numerous hotels in the area will ensure you find the perfect space to kick back after a long day. Besides that, you'll find that these hotels are kept in great shape and provide a fine place to lay your head at night. What creature comforts do you want in your lodging? 24-hour room service, so you can order that berry tart in the wee hours of the morning? A reflexology treatment that will leave you feeling great? Butler services? No matter what you want on a perfect getaway, you're bound to find it here.
You won't sleep and order room service the entire time, though. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Florence are waiting for you to relax after a busy day. Ready to learn more? Then explore the 560 reviews various guests have left on Expedia and get to know these places.
Make Your Escape
The results are in, and Florence 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Expedia can help you land a great deal on accommodation. It's time to plan your next great escape. Select one of the 5-star hotels in Florence today and settle down in total tranquility tomorrow.
Frequently asked questions
Explore a world of travel with Expedia
- Flights from Florence Regional
- Flights from New York (JFK) to Florence (FLO)
- Flights from Charlotte (CLT) to Florence (FLO)
- Flights from Boston (BOS) to Florence (FLO)
- Flights from Charleston (CHS) to Florence (FLO)
- Flights from St. Louis (STL) to Florence (FLO)
- Flights from Myrtle Beach (MYR) to Florence (FLO)
- Flights from Atlanta (ATL) to Florence (FLO)
- Flights from Nashville (BNA) to Florence (FLO)
- Flights from Las Vegas (LAS) to Florence (FLO)
- Flights from Washington (DCA) to Florence (FLO)
- Flights from Houston (IAH) to Florence (FLO)
- Flights from New York (LGA) to Florence (FLO)
- Flights from Columbia (CAE) to Florence (FLO)
- Flights from Jacksonville (JAX) to Florence (FLO)
- Flights from Chicago (ORD) to Florence (FLO)
- Flights from Baltimore (BWI) to Florence (FLO)
- Flights from Philadelphia (PHL) to Florence (FLO)
- Flights from Hartford (BDL) to Florence (FLO)
- Flights from Tampa (TPA) to Florence (FLO)
- Flights from Greenville (GSP) to Florence (FLO)
- Flights from Dallas (DFW) to Florence (FLO)
- Flights from Rochester (ROC) to Florence (FLO)
- Flights from Orlando (MCO) to Florence (FLO)
- Flights from Oklahoma City (OKC) to Florence (FLO)
- Flights from Huntsville (HSV) to Florence (FLO)
- Flights from Los Angeles (LAX) to Florence (FLO)
- Flights from Phoenix (PHX) to Florence (FLO)
- Flights from Fort Lauderdale (FLL) to Florence (FLO)
- Flights from Miami (MIA) to Florence (FLO)
- Flights from Wilmington (ILM) to Florence (FLO)
- Flights from Raleigh (RDU) to Florence (FLO)
- Flights from Savannah (SAV) to Florence (FLO)
- Flights from Memphis (MEM) to Florence (FLO)
- Flights from San Diego (SAN) to Florence (FLO)
- Flights from Sarasota (SRQ) to Florence (FLO)
- Flights from Denver (DEN) to Florence (FLO)
- Flights from Seattle (SEA) to Florence (FLO)
- Flights from Pittsburgh (PIT) to Florence (FLO)
- Flights from Detroit (DTW) to Florence (FLO)
- Flights from Albany (ALB) to Florence (FLO)
- Flights from Buffalo (BUF) to Florence (FLO)
- Flights from Lexington (LEX) to Florence (FLO)
- Flights from Louisville (SDF) to Florence (FLO)
- Flights from Cleveland (CLE) to Florence (FLO)
- Flights from Austin (AUS) to Florence (FLO)
- Flights from San Francisco (SFO) to Florence (FLO)
- Flights from Greensboro (GSO) to Florence (FLO)
- Flights from Columbus (CMH) to Florence (FLO)
- Flights from Richmond (RIC) to Florence (FLO)
- Flights from Augusta (AGS) to Florence (FLO)
- Flights from Tucson (TUS) to Florence (FLO)
- Flights from Birmingham (BHM) to Florence (FLO)
- Flights from Syracuse (SYR) to Florence (FLO)
- Flights from Chattanooga (CHA) to Florence (FLO)
- Flights from Dayton (DAY) to Florence (FLO)
- Flights from Indianapolis (IND) to Florence (FLO)
- Flights from Norfolk (ORF) to Florence (FLO)
- Flights from Little Rock (LIT) to Florence (FLO)
- Flights from Minneapolis (MSP) to Florence (FLO)
- Flights from Knoxville (TYS) to Florence (FLO)
- Flights from Newburgh (SWF) to Florence (FLO)
- Flights from London (LHR) to Florence (FLO)
- Flights from Daytona Beach (DAB) to Florence (FLO)
- Flights from Milwaukee (MKE) to Florence (FLO)
- Flights from Sacramento (SMF) to Florence (FLO)
- Flights from Colorado Springs (COS) to Florence (FLO)
- Flights from Kansas City (MCI) to Florence (FLO)
- Flights from Providence (PVD) to Florence (FLO)
- Flights from El Paso (ELP) to Florence (FLO)
- Flights from Cincinnati (CVG) to Florence (FLO)
- Flights from West Palm Beach (PBI) to Florence (FLO)
- Flights from New Orleans (MSY) to Florence (FLO)
- Flights from Asheville (AVL) to Florence (FLO)
- Flights from Gainesville (GNV) to Florence (FLO)
- Flights from Missoula (MSO) to Florence (FLO)
- Flights from Lancaster (LNS) to Florence (FLO)
- Flights from Nairobi (NBO) to Florence (FLO)
- Flights from New Haven (HVN) to Florence (FLO)
- Flights from Tallahassee (TLH) to Florence (FLO)
- Flights from Harrisburg (MDT) to Florence (FLO)
- Flights from Washington (IAD) to Florence (FLO)
- Flights from Boise (BOI) to Florence (FLO)
- Flights from Allentown (ABE) to Florence (FLO)
- Flights from Salt Lake City (SLC) to Florence (FLO)
- Flights from Montgomery (MGM) to Florence (FLO)
- Flights from Eugene (EUG) to Florence (FLO)
- Flights from Fayetteville (FAY) to Florence (FLO)