$362 Cheap Flights from Syracuse (SYR) to Florence (FLO)

View $362 flight on Tue, Dec 9, 2025Opens in a new window

Popular airlines from Hancock Intl. Airport (SYR) to Florence, SC (FLO-Florence Regional)

Cheap Flights from Syracuse to Florence (SYR-FLO)

Prices were available within the past 7 days and start at $362 for one-way flights and $413 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Jul 7 - Tue, Sep 1
SYR
Syracuse
FLO
Florence
$413 Roundtrip, found 4 days ago
$413
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Jul 7 from Syracuse to Florence, returning Tue, Sep 1, priced at $413 found 4 days ago
American Airlines
Tue, Nov 25 - Tue, Dec 2
SYR
Syracuse
FLO
Florence
$469 Roundtrip, found 21 hours ago
$469
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Tue, Nov 25 from Syracuse to Florence, returning Tue, Dec 2, priced at $469 found 21 hours ago
American Airlines
Sat, Dec 13 - Wed, Dec 24
SYR
Syracuse
FLO
Florence
$479 Roundtrip, found 3 days ago
$479
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Dec 13 from Syracuse to Florence, returning Wed, Dec 24, priced at $479 found 3 days ago
American Airlines
Mon, Nov 24 - Wed, Dec 10
SYR
Syracuse
FLO
Florence
$483 Roundtrip, found 3 days ago
$483
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Nov 24 from Syracuse to Florence, returning Wed, Dec 10, priced at $483 found 3 days ago
American Airlines
Wed, Dec 24 - Tue, Jan 13
SYR
Syracuse
FLO
Florence
$488 Roundtrip, found 3 days ago
$488
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Dec 24 from Syracuse to Florence, returning Tue, Jan 13, priced at $488 found 3 days ago
American Airlines
Wed, Dec 24 - Wed, Dec 31
SYR
Syracuse
FLO
Florence
$491 Roundtrip, found 3 days ago
$491
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Dec 24 from Syracuse to Florence, returning Wed, Dec 31, priced at $491 found 3 days ago
American Airlines
Tue, Jul 7 - Tue, Sep 1
SYR
Syracuse
FLO
Florence
$492 Roundtrip, found 4 days ago
$492
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Jul 7 from Syracuse to Florence, returning Tue, Sep 1, priced at $492 found 4 days ago
American Airlines
Mon, Nov 24 - Fri, Dec 12
SYR
Syracuse
FLO
Florence
$494 Roundtrip, found 3 days ago
$494
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Nov 24 from Syracuse to Florence, returning Fri, Dec 12, priced at $494 found 3 days ago
American Airlines
Tue, Nov 25 - Tue, Dec 2
SYR
Syracuse
FLO
Florence
$504 Roundtrip, found 21 hours ago
$504
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Tue, Nov 25 from Syracuse to Florence, returning Tue, Dec 2, priced at $504 found 21 hours ago
American Airlines
Sat, Dec 13 - Mon, Dec 22
SYR
Syracuse
FLO
Florence
$508 Roundtrip, found 3 days ago
$508
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Dec 13 from Syracuse to Florence, returning Mon, Dec 22, priced at $508 found 3 days ago

Alternative airports near Florence

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Florence Regional FLO. Cheapest and Closest option available. Average driving time to city center is 5 minutes. Flights from $518
FLO
Florence Regional
CheapestClosest
Average driving time to city center5 min
Flights from $518

Frequently asked questions

How much does a flight from Hancock Intl. Airport (SYR) to Florence Regional Airport (FLO) cost?
Get a cheap one-way flight from $362 or cheap return flight from $413 from Hancock Intl. Airport (SYR) to Florence Regional Airport (FLO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Hancock Intl. Airport (SYR) to Florence Regional Airport (FLO)?
Flying in July is a good way to save, as it's the cheapest month for flights between SYR and FLO. You'll usually find the lowest prices during off-peak months.
What is the cheapest airline that flies from Hancock Intl. Airport (SYR) to Florence Regional Airport (FLO)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest SYR to FLO flight.
How many flights per day from Hancock Intl. Airport (SYR) to Florence Regional Airport (FLO)?
There are no daily nonstop flights departing from Hancock Intl. Airport (SYR) to Florence Regional Airport (FLO). But you can choose flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be cruising above the clouds before you know it.
What day of the week has the most flights from SYR to FLO?
You'll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Hancock Intl. Airport (SYR) to Florence Regional Airport (FLO)?
To avoid possible delays on the Hancock Intl. Airport (SYR) to Florence Regional Airport (FLO) route, aim to travel before 3 PM. Later flights have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Hancock Intl. Airport (SYR) to Florence Regional Airport (FLO) last-minute?
Last-minute fares from SYR to FLO are generally more expensive. To lock in the best prices, start looking for flights well ahead of time. That said, if your travel plans are flexible, it's possible to find a cheap ticket right before your trip.
Is it cheaper to book a SYR to FLO flight and hotel package?
Compared with arranging flights and hotels separately, booking a SYR to FLO flight and hotel package with Expedia could lead to significant savings. What's more, having everything in one convenient place will take the stress out of travel planning. Simply pick your flights and select from our wide range of hotels, then customize your trip with other add-ons like activities and car rentals.
Can I cancel or change the date of my flight from Hancock Intl. Airport (SYR) to Florence Regional Airport (FLO)?
In most instances, you can cancel or modify your SYR to FLO flight. However, there may be additional fees, especially if you booked more than 24 hours ago. Double-check your itinerary for the airline's fees and guidelines on flight changes, or if you'd like further information, go to our Customer Service portal.

Travel information

Origin airport
Hancock Intl.
Destination airport
Florence Regional
Airlines serving
American Airlines
Roundtrip price
$412
Distance
646 mi

Book with confidence

Syracuse to Florence Flights

The cheapest times to fly from Syracuse to Florence

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Syracuse to Florence are during the month of July. You can find some of the cheapest flights from Syracuse to Florence with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Syracuse to Florence

Sunday is one of the best days to book for cheap flights from Syracuse to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Syracuse to Florence

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Syracuse to Florence in 2025. You can also book with separate airlines for your outbound and return journeys, from $362 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Syracuse to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Syracuse to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Syracuse to Florence Flights

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*Available to One Key members.