Florida Keys Adults Only Vacations 2026

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Top Adults Only vacation packages in Florida Keys

Price found within the past 48 hours. Click for updated prices.

Cheeca Lodge & Spa

Matecumbe

$549

per person

Oct 19 - Oct 22

found 1 day ago

Roundtrip flight included

Philadelphia (PHL) to Miami (MIA)

9.2/10 Wonderful! (1,360 reviews)

Southernmost House - Adult Exclusive

Old Town Key West

Save 100% on your flight

$1,178

per person

Oct 19 - Oct 22

found 1 day ago

Roundtrip non-stop flight included

Hartford (BDL) to Key West (EYW)

9.4/10 Exceptional! (1,002 reviews)

Excellent place to stay and will absolutely stay there again! The staff was so helpful and friendly! The restaurant on the property has delicious food! I highly recommend staying at he Southern Most House, great pool, great location, great vacation!

Reviewed on Aug 16, 2026

The Marker Key West Harbor Resort

Key West Historic District

Save 100% on your flight

$1,221

per person

Oct 19 - Oct 22

found 1 day ago

Roundtrip non-stop flight included

Hartford (BDL) to Key West (EYW)

9.2/10 Wonderful! (1,002 reviews)

The fact they have an EV charger in their garage was a HUGE PLUS! The property is really nice and the staff was awesome!

Reviewed on Aug 18, 2026

Southernmost Beach Resort and Guesthouses

Old Town Key West

$787

per person

Oct 19 - Oct 22

found 1 day ago

Roundtrip non-stop flight included

Hartford (BDL) to Key West (EYW)

8.8/10 Excellent! (3,469 reviews)

Super clean room! So many things to do- pool, beach, restaurants!! Staff was super awesome and friendly. We loved it!!!

Reviewed on Aug 19, 2026

Hawks Cay Resort

$817

per person

Sep 18 - Sep 20

found 1 day ago

Roundtrip non-stop flight included

Flint (FNT) to Miami (MIA)

8.2/10 Very Good! (1,009 reviews)

So relaxing now need to do anything but relax

Reviewed on Aug 18, 2026

Don't see what you're looking for?

See all available trips from Columbus to Florida Keys

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5* Adults Only vacations in Florida Keys

Price found within the past 48 hours. Click for updated prices.

Cheeca Lodge & Spa

Matecumbe

$549

per person

Oct 19 - Oct 22

found 1 day ago

Roundtrip flight included

Philadelphia (PHL) to Miami (MIA)

9.2/10 Wonderful! (1,360 reviews)

Don't see what you're looking for?

See all available trips from Columbus to Florida Keys

View all trips

3 Night Adults Only vacations in Florida Keys

Price found within the past 48 hours. Click for updated prices.

Hawks Cay Resort

Save 100% on your flight

$628

per person

Sep 18 - Sep 21

found 9 hours ago

Roundtrip flight included

Atlanta (ATL) to Miami (MIA)

8.2/10 Very Good! (1,009 reviews)

So relaxing now need to do anything but relax

Reviewed on Aug 18, 2026

Southernmost House - Adult Exclusive

Old Town Key West

Save 100% on your flight

$1,178

per person

Oct 19 - Oct 22

found 1 day ago

Roundtrip non-stop flight included

Hartford (BDL) to Key West (EYW)

9.4/10 Exceptional! (1,002 reviews)

Reviewed on Aug 16, 2026

The Marker Key West Harbor Resort

Key West Historic District

Save 100% on your flight

$1,221

per person

Oct 19 - Oct 22

found 1 day ago

Roundtrip non-stop flight included

Hartford (BDL) to Key West (EYW)

9.2/10 Wonderful! (1,002 reviews)

The fact they have an EV charger in their garage was a HUGE PLUS! The property is really nice and the staff was awesome!

Reviewed on Aug 18, 2026

Don't see what you're looking for?

See all available trips from Columbus to Florida Keys

View all trips

4 Night Adults Only vacations in Florida Keys

Price found within the past 48 hours. Click for updated prices.

Hawks Cay Resort

Save 100% on your flight

$790

per person

Oct 22 - Oct 26

found 1 day ago

Roundtrip non-stop flight included

New York (NYC) to Miami (MIA)

8.2/10 Very Good! (1,009 reviews)

So relaxing now need to do anything but relax

Reviewed on Aug 18, 2026

Southernmost House - Adult Exclusive

Old Town Key West

Save 100% on your flight

$1,914

per person

Oct 19 - Oct 23

found 1 day ago

Roundtrip non-stop flight included

Hartford (BDL) to Key West (EYW)

9.4/10 Exceptional! (1,002 reviews)

Reviewed on Aug 16, 2026

The Marker Key West Harbor Resort

Key West Historic District

Save 100% on your flight

$1,915

per person

Oct 19 - Oct 23

found 1 day ago

Roundtrip non-stop flight included

Hartford (BDL) to Key West (EYW)

9.2/10 Wonderful! (1,002 reviews)

The fact they have an EV charger in their garage was a HUGE PLUS! The property is really nice and the staff was awesome!

Reviewed on Aug 18, 2026

Don't see what you're looking for?

See all available trips from Columbus to Florida Keys

View all trips

Why choose an adults-only resort for my vacation in Florida Keys?

Book adults-only accommodation for your Florida Keys getaway to enjoy privacy and tranquility. With no little ones running around, the atmosphere at an adults-only resort tends to be more sophisticated. These types of resorts are especially popular among couples. The intimacy of adults-only hotels is ideal for a romantic escape and honeymoons. On Expedia, you'll encounter a vast array of affordable adults-only vacations to Florida Keys.

What amenities are typically included in adults-only resort packages for Florida Keys?

As they're geared toward relaxation, adults-only vacation packages to Florida Keys usually include resorts with amenities like swimming pools, spas, and on-site restaurants. If you book an all-inclusive vacation package to Florida Keys, you'll have all meals and drinks included, too. All-inclusive adults-only resorts typically offer a tempting mix of local cuisine and international favorites. When searching for packages, you can take advantage of the filters to pin down adults-only resorts you desire.

Are there any age restrictions for staying at adults-only resorts in Florida Keys?

Typically, you'll need to be over the age of 18 to go on an adults-only vacation to Florida Keys. Each resort has its own policy, though. Some consider 16 and 17-year-olds to be adults, while others even accept those over 13 years of age. In other cases, you may need to be over 21. Given that there are lots of differences, it's a good idea to double-check before booking. Luckily, Expedia makes this information clear so there are no surprises.

Can I expect a more romantic atmosphere at adults-only resorts in Florida Keys compared to other accommodations?

Yes, if you're seeking a romantic adults-only Florida Keys vacation, you'll enjoy more intimate vibes in adult-only resorts. That's because they include amenities that are ideal for couples. The look and feel is often more sophisticated too, and you'll find amenities are usually spread out to create a feeling of privacy. You may also enjoy a more personalized service, with concierge and masseurs on hand. Take your pick from Expedia's plethora of romantic adults-only resorts in Florida Keys.

Are there any special events or activities tailored for adults at adults-only resorts in Florida Keys?

When you stay at an adults-only resort on your Florida Keys vacation, you can expect romantic activities like candle-lit dinners under the stars. Adult-only hotels typically offer fine dining, with talented chefs preparing exquisite meals. Adults-only resorts in Florida Keys often boast indulgent spas, too. Here, you can pamper yourself with rejuvenating treatments and unwind with relaxing massages. Before booking your Florida Keys vacation package on Expedia, you'll be able to view what each property offers.

How to find last-minute deals for adults-only packages on Expedia?

Wizz over to Expedia's last-minute deals page to view some of the best last-minute deals for an affordable Florida Keys vacation from $549. Remember, you're more likely to land a last-minute saving during the low season when fewer people travel. It's also a good idea to be flexible with your dates. That's because prices can vary by day. Luckily, Expedia's easy-to-use search wizard and nifty filters make booking a last-minute escape quick and easy.

Can I cancel my adults-only vacation booking easily?

Yes, as many of Expedia's adult-only vacation packages to Florida Keys are flexible, you can often cancel for free. Simply log in to your account and head to the “Trips” section and follow the steps. Not all packages are flexible, however, so you should read the cancellation policy before booking your 2026 trip. The good news is you'll see this displayed on Expedia before you reach the booking page. The free cancellation search filter is handy, too.

Why book my adults-only vacation with Expedia?

Thanks to exclusive offers, you'll get some of the best-priced deals for adults-only Florida Keys vacations when booking with Expedia. With a wide selection of flights and hotels, you'll easily find the right trip for you. The One Key reward program lets you earn points on select stays that you can then cash in to save on future trips, on top of exclusive member-only discounts. Best of all, joining One Key is free. On top of these benefits, the 24/7 support and booking protection gives you peace of mind when booking with Expedia.

Top Adults Only Florida Keys Hotels

The Southernmost Inn - Adults Only

525 United Street Key West FL

9 min walk from Duval Street

Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...

8.4/10 Very Good! (1,427 reviews)

"I traveled solo and stayed in the Attic Room. The room I stayed in is bigger than it looks in the pictures. There is a small private bathroom with shower stall. The room doesn't get super cold but the AC keeps it comfortable. (I think a table fan would be a great addition to the room) There is a ..."

Reviewed on Aug 18, 2026

Paradise Inn Key West - Adults Only

819 Simonton Street Key West FL

4 min walk from Duval Street

Book a stay at this business-friendly hotel in Key West. Enjoy free breakfast, parking (surcharge), and a garden. Our guests praise the breakfast and the pool ...

Heron House - Adult Only

512 Simonton St Key West FL

3 min walk from Duval Street

Stay at this B&B in Key West. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the breakfast and the pool in our reviews. Popular attractions ...

See all 8,271 properties in Florida Keys

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.