Plan your trip

A river with a bridge, autumn foliage, and a clear sky.

Find Resorts & Hotels with Spas in Canton, MO

Check prices for these dates

Check prices for these dates, December 15 – 16, 2026

View in a map

Our top choices for Canton hotels with a spa

1. Holiday Inn Quincy East by IHG

A modern reception area with a marble counter, a wooden panel with a light fixture, a fireplace, and a seating area with a sofa and chairs.

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

View all properties

Choose what matters most at spa hotels in Canton

Pool

Breakfast included

Hot tub

4 stars

5 stars

Find out more about Canton

Top Canton attractions for a relaxing vacation

Canton, Missouri, offers a quaint and charming experience for travelers seeking relaxation and rejuvenation at hotels with spas. Begin your exploration at the historic Canton Square, where you can enjoy local boutiques and cafes, perfect for a leisurely afternoon. Just a short drive away, the scenic Mark Twain Lake provides opportunities for serene nature walks, fishing, and picnicking, ideal for unwinding before indulging in spa treatments. For a touch of culture, visit the nearby Canton Museum, showcasing local art and history, which can inspire a sense of calm and creativity. After a day of exploration, retreat to one of the area's spa hotels situated near the lake, where you can enjoy lakeside views and soothing treatments that cater to your every need. The combination of natural beauty and luxurious accommodations ensures a delightful stay, where attentive service makes every moment feel special.

Frequently Asked Questions

Looking for a spa hotel in Canton?

Book one of our fantastic spa hotels and pamper yourself from the moment you arrive. Check out the museums and restaurants in Canton—your day trip starts here. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your holiday.

What's there to see and do in Canton?

Enjoy all that Canton has to offer when you visit Golden Age Toys, Mississippi River, and Mark Twain Casino. If you have spare time during your trip, you might want to make a stop at Wakonda State Park and Oakley Lindsay Center.

What is a Canton spa hotel?

Spa hotels in Canton provide lodging and have an on-site spa offering services like therapies and body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.

Explore a world of travel with Expedia