A river with a bridge, a town, and a forested hillside.

Find 4 Star Hotels in Hannibal, MO from $219

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Check availability on Hannibal 4 Star Hotels

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Sep 1 - Sep 2
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Sep 2 - Sep 3
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Sep 4 - Sep 6
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Sep 11 - Sep 13

Our top choices for Hannibal 4-star hotels

A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.
A modern living room with a grey sofa, a white armchair, a coffee table, and a patterned rug. There is a kitchen in the background with white cabinets and a black door.
A compact kitchen with white cabinets, a microwave, a coffee maker, and a sink.
A swimming pool with lounge chairs and a covered seating area.

1. Lighthouse Inn & Suites

Lighthouse Inn & Suites
Hannibal
United States
Kari
$190 nightly
$219 total
Sep 5 - Sep 6
Total with taxes and fees
Lighthouse Inn & Suites
A large, historic mansion with a grand entrance, multiple windows, and a well-maintained lawn.
A spacious room with large windows, a wooden bed, two armchairs, and a white shag rug.
A spiral staircase with ornate wooden balusters and patterned carpet.
A two-story building with a symmetrical facade, large windows, and a central entrance.

2. Garth Woodside Mansion B&B

Garth Woodside Mansion B&B
Hannibal
United States
Shannon
Garth Woodside Mansion B&B
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Hannibal and related destinations

Mark Twain's boyhood home invites you to step into the world that inspired Tom Sawyer and Huckleberry Finn. Explore limestone caves, take a riverboat cruise, or hike to Lover's Leap for spectacular Mississippi River views when morning fog lifts.

See all hotels in Hannibal
A white building with green window boxes and a green door, number 206, with a brick wall and a stone building to the left.
Photo by Daydreams and Discoveries

Top Hannibal Hotel Reviews

Lighthouse Inn & Suites

Lighthouse Inn & Suites

10/10 Excellent
"It's so amazing to stay they're very helpful room look amazing clean we love staying again next time"
Mary Ann 1-night trip
Posted 4 days ago
Lighthouse Inn & Suites

Find out more about Hannibal

Hannibal Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Hannibal, Missouri are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Hannibal 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Hannibal. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Hannibal, Missouri, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Hannibal hotels offer everything your heart desires.

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Hannibal?
To book a 4-star hotel in Hannibal that's within your budget, make use of Expedia's handy filters. Take a look at the availability during your chosen dates and use our pricing filter to set your maximum rate. You can also list your results by the most budget-friendly retreat first.
  • Search for the lowest price from $219
What's the difference between 5-star and 4-star hotels in Hannibal?
Treat yourself to refined living during your Hannibal escape by staying at a 4-star hotel. As well as featuring upscale accommodations, these properties are usually filled with amenities such as bathrobes, large beds and plenty more. A 5-star hotel will go above and beyond to make your stay an even more indulgent and unforgettable one. 24-hour concierge assistance, luxurious spas and gourmet dining are just the start of the first-rate conveniences and services you'll likely have access to.
Does Hannibal have any 4-star all-inclusive resorts?
Use our "All inclusive" filter to find your next dream escape in Hannibal where just about everything is taken care of, from your accommodations to your food, activities and entertainment. We can also help you find standard 4-star stays in and around this sought-after destination.

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