Apartments in Defiance for Rent

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals

  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings

  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

In two weeks
May 22 - May 24
In two months
Jul 3 - Jul 5
In three months
Jul 31 - Aug 2
In four months
Aug 28 - Aug 30

Our top choices for Defiance apartments

Terrace/patio

Newly Reno! 11 Sleeps, Game Room, Picturable walls

Newly Reno! 11 Sleeps, Game Room, Picturable walls
Maryland Heights
10.0 out of 10, Exceptional, (2 reviews)
"This was an awesome place for 9 of us- plenty of rooms to sleep and bathrooms. The renter was very kind"
United States
Janet
$462 nightly
The price is $462
May 10 - May 11
Total with taxes and fees
Newly Reno! 11 Sleeps, Game Room, Picturable walls
1 bedroom, free WiFi

1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed

1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed
St. Louis MO
10.0 out of 10, Exceptional, (38 reviews)
"Great spot!"
United States
Anonymous traveler
$85 nightly
The price is $98
Jun 1 - Jun 2
Total with taxes and fees
1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed
Dining

Great for Business Travelers! Studio Suite Near Edward Jones! Free Breakfast!

Great for Business Travelers! Studio Suite Near Edward Jones! Free Breakfast!
Maryland Heights
9.6 out of 10, Exceptional, (4 reviews)
"It was an easy experience renting this place"
United States
Dominic M.
$190 nightly
The price is $217
May 10 - May 11
Total with taxes and fees
Great for Business Travelers! Studio Suite Near Edward Jones! Free Breakfast!
Interior

3BR Family+Game Retreat 8 min STL Airport/Westport

3BR Family+Game Retreat 8 min STL Airport/Westport
Maryland Heights
9.0 out of 10, Wonderful, (8 reviews)
"Great stay! We had everything we needed and the communication was perfect!"
United States
Melodie B.
$399 nightly
The price is $399
May 10 - May 11
Total with taxes and fees
3BR Family+Game Retreat 8 min STL Airport/Westport
Interior

Family Home: Game Room & Huge Yard, Airport

Family Home: Game Room & Huge Yard, Airport
Maryland Heights
$441 nightly
The price is $441
May 10 - May 11
Total with taxes and fees
Family Home: Game Room & Huge Yard, Airport
Exterior

Stay on Main Historic Studio

Stay on Main Historic Studio
St. Charles Historic District
9.0 out of 10, Wonderful, (34 reviews)
"From the welcome email with clear concise directions on how to enter with door codes to a dwelling that had everything I needed with a very comfortable bed, it was a great stay and I wanted for nothing."
United States
Jacob G.
$186 nightly
The price is $205
May 10 - May 11
Total with taxes and fees
Stay on Main Historic Studio
Interior

Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (59 reviews)
"Lovely accommodations, very clean, well equipped, great location. "
United States
Emily B.
$259 nightly
The price is $277
May 11 - May 12
Total with taxes and fees
Amazing Renovated Historic Loft on Main Street
1 bedroom, WiFi, bed sheets

Duplex Hideaway in St. Charles, MO

Duplex Hideaway in St. Charles, MO
St. Charles Historic District
10.0 out of 10, Exceptional, (5 reviews)
"I will stay here again. It was a great location for my visit. Lots of room and amenities. Highly recommend this location if you are visiting the St Louis area. Barely a mile to get to Hwy 70, so easy access to St Louis, St Peter's, Wentzville etc. Maybe two blocks from Historic St Charles and Ameristar Casino."
United States
Karen M.
$228 nightly
The price is $251
May 10 - May 11
Total with taxes and fees
Duplex Hideaway in St. Charles, MO
Interior

The Historic Bricks on Main

The Historic Bricks on Main
St. Charles Historic District
9.0 out of 10, Wonderful, (17 reviews)
"Had a wonderful stay. Host was very responsive. Great stay in the middle of everything- so we could walk out and shop or grab a bite to eat. "
United States
Alison C.
$209 nightly
The price is $230
May 10 - May 11
Total with taxes and fees
The Historic Bricks on Main
TV

Main Street Balcony Apartment

Main Street Balcony Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (36 reviews)
"Great location for shopping and a lot of restaurants nearby. Beds were very comfortable. "
United States
Brooke I.
$394 nightly
The price is $434
May 10 - May 11
Total with taxes and fees
Main Street Balcony Apartment
Interior

2 Queen Beds | Non-Smoking, Kitchen

2 Queen Beds | Non-Smoking, Kitchen
St. Louis MO
10.0 out of 10, Exceptional, (36 reviews)
"Awesome place to stay!"
United States
Anonymous traveler
$90 nightly
The price is $104
Jun 1 - Jun 2
Total with taxes and fees
2 Queen Beds | Non-Smoking, Kitchen
Interior

2 Queen Beds | Mobil Access Tub Nsmk Kitchen

2 Queen Beds | Mobil Access Tub Nsmk Kitchen
St. Louis MO
10.0 out of 10, Exceptional, (43 reviews)
"Great place to stay!"
United States
Anonymous traveler
$90 nightly
The price is $104
Jun 1 - Jun 2
Total with taxes and fees
2 Queen Beds | Mobil Access Tub Nsmk Kitchen
Interior

The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (169 reviews)
"Host was very responsive and location was perfect"
United States
Peggy K.
$242 nightly
The price is $259
May 10 - May 11
Total with taxes and fees
The Lofts of North Main Street
Interior

The Brick & Beam 3rd Floor Apartment

The Brick & Beam 3rd Floor Apartment
St. Charles Historic District
$287 nightly
The price is $316
May 10 - May 11
Total with taxes and fees
The Brick & Beam 3rd Floor Apartment
Fridge, microwave, oven, stovetop

Historic Main St. Customs House Upstairs Apartment

Historic Main St. Customs House Upstairs Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (37 reviews)
"Great Stay and great location! "
United States
Angela
$323 nightly
The price is $356
May 11 - May 12
Total with taxes and fees
Historic Main St. Customs House Upstairs Apartment
TV

1st Capitol Mansion - Suite 401

1st Capitol Mansion - Suite 401
St. Charles Historic District
7.6 out of 10, Good, (8 reviews)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
United States
Emily L.
$266 nightly
The price is $299
May 13 - May 14
Total with taxes and fees
1st Capitol Mansion - Suite 401
1 bedroom, free WiFi

1 Queen Bed | Non-Smoking, Kitchen

1 Queen Bed | Non-Smoking, Kitchen
St. Louis MO
10.0 out of 10, Exceptional, (39 reviews)
"I really enjoy it here!"
United States
Anonymous traveler
$80 nightly
The price is $92
Jun 1 - Jun 2
Total with taxes and fees
1 Queen Bed | Non-Smoking, Kitchen
Smart TV

Prime Loft of Main Street

Prime Loft of Main Street
St. Charles Historic District
9.8 out of 10, Exceptional, (110 reviews)
"This was a wonderful place for our St Charles stay - right in the heart of the historic downtown. Very clean and with nice character (exposed brick walls, tastefully decorated, etc). We had plenty of room fo the three of us, and our almost 12 year old kiddo LOVED having the loft upstairs to herself. If you are looking for a place to stay outside of St Louis, I highly recommend this location."
United States
Julie
$257 nightly
The price is $275
May 10 - May 11
Total with taxes and fees
Prime Loft of Main Street
Fridge, microwave, stovetop, toaster

Charming Duplex on Main

Charming Duplex on Main
St. Charles Historic District
9.8 out of 10, Exceptional, (18 reviews)
"We had an AMAZING time here and you can't beat the close walking distance to main st!! Absolutely loved our stay. "
United States
Wendy K.
$223 nightly
The price is $246
May 10 - May 11
Total with taxes and fees
Charming Duplex on Main
TV

6th street 101 - Walk to Main St

6th street 101 - Walk to Main St
St. Charles Historic District
10.0 out of 10, Exceptional, (2 reviews)
"Excellent"
United States
Scott N.
$252 nightly
The price is $283
May 10 - May 11
Total with taxes and fees
6th street 101 - Walk to Main St
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Defiance Hotel Reviews

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

10/10 Excellent
"Room was clean. Staff was very friendly. Hotel is close to the highway and reasturants."
Sarah 1-night trip
Posted 3 hours ago
Wingate by Wyndham St. Louis/Fenton Route 66

Find out more about Defiance

Defiance Apartments information

Number of reviews
566
Accommodation
104 Apartments
Lowest Price
$92
Highest Price
$462

Frequently asked questions

What's it like to stay at an apartment in Defiance?
You'll find 10 apartments to choose from in Defiance for your stay.
Why choose an apartment versus a traditional hotel?
Often more spacious than a traditional hotel room, an apartment includes a kitchen for convenient home-cooked meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want something in a quieter part of town.
What's a favorite apartment for a stay in Defiance?
Here are some of the top apartments in the area: The Lofts of North Main Street: Located in St. Charles, 19.2 mi/30.8 km from the heart of Defiance. Includes free WiFi, sofa beds, and Smart TVs. Access to onsite laundry facilities is available on site. Stay on Main Historic Studio: Located 19.1 mi/30.8 km away in St. Charles. Pet Friendly, Scenic, Eureka, St Louis, Nurse, Insurance, Contractor spec. rates: Located in High Ridge, 16 mi/25.8 km away. Includes free WiFi, private patios, and fireplaces. Access to onsite laundry facilities is available on site. 2 Queen Beds | Non-Smoking, Kitchen: 18.7 mi/30.1 km away in Maryland Heights. Free WiFi and Smart TVs are included. Remodeled Kirkwood Guest house: Located in Kirkwood, 20 mi/32.2 km from Defiance. Includes private balconies, sofa beds, and Smart TVs. Onsite laundry facilities and a hot tub are on site.
How many apartments will I be able to find in Defiance?
Expedia has 10 apartments to book in Defiance.
What can I expect from the weather during my trip to Defiance?
Weather is only one factor, but it can really affect your travel plans, especially if you're planning an extended stay in Defiance. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.
What are the must-see places to visit in Defiance?
August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Chandler Hill Vineyards and Sugar Creek Winery are other places worth a visit.
What's the best way to get to and around Defiance?
Knowing a bit about the transportation options can save you time when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. You can also search for flights into St. Louis Lambert Intl. Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to explore around the area, you may want a rental car for your journey.

Explore a world of travel with Expedia