A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Apartments in Defiance for Rent

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Our top choices for Defiance apartments

2nd Street -Deck Suite (back entrance)

2nd Street -Deck Suite (back entrance)
Washington
10.0 out of 10, Exceptional, (6 reviews)
"Great comfortable mini apartment style."
United States
Ozzy
$166 nightly
The price is $186
Jul 6 - Jul 7
Total with taxes and fees
2nd Street -Deck Suite (back entrance)

1 Queen Bed | Non-Smoking, Kitchen

1 Queen Bed | Non-Smoking, Kitchen
Westport
10.0 out of 10, Exceptional, (39 reviews)
"I really enjoy it here!"
United States
Anonymous traveler
$86 nightly
The price is $100
Jul 12 - Jul 13
Total with taxes and fees
1 Queen Bed | Non-Smoking, Kitchen

Great for Business Travelers! Pool + Gym

Great for Business Travelers! Pool + Gym
O'Fallon
$151 nightly
The price is $174
Jul 6 - Jul 7
Total with taxes and fees
Great for Business Travelers! Pool + Gym

Back Door Guest Suite, Zia My Retreat

Back Door Guest Suite, Zia My Retreat
New Haven
10.0 out of 10, Exceptional, (6 reviews)
"Very comfortable, spacious, great location for canoe trip. "
United States
Carolyn B.
$211 nightly
The price is $230
Jul 6 - Jul 7
Total with taxes and fees
Back Door Guest Suite, Zia My Retreat

Chic 1- Queen Bed, Non Smoking-Near Airport, Kitchen, Twin Bed

Chic 1- Queen Bed, Non Smoking-Near Airport, Kitchen, Twin Bed
St. Louis
8.8 out of 10, Excellent, (11 reviews)
"This was absolutely perfect and reasonable pricing I surely will be back "
United States
David G.
$101 nightly
The price is $107
Aug 1 - Aug 2
Total with taxes and fees
Chic 1- Queen Bed, Non Smoking-Near Airport, Kitchen, Twin Bed

2 Bdr Upstairs Apt Walking Distance to Main St

2 Bdr Upstairs Apt Walking Distance to Main St
Saint Charles
8.0 out of 10, Very Good, (5 reviews)
"The best price-value ratio. Quiet neighborhood, close to the city center."
United States
Tamas P.
$266 nightly
The price is $293
Jul 12 - Jul 13
Total with taxes and fees
2 Bdr Upstairs Apt Walking Distance to Main St

The Driftwood Den | Boho-Inspired 2-Bedroom

The Driftwood Den | Boho-Inspired 2-Bedroom
St. Charles Historic District
10.0 out of 10, Exceptional, (3 reviews)
$265 nightly
The price is $292
Jul 6 - Jul 7
Total with taxes and fees
The Driftwood Den | Boho-Inspired 2-Bedroom

Main Street Apartment

Main Street Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (39 reviews)
"Great location for shopping and a lot of restaurants nearby. Beds were very comfortable. "
United States
Brooke I.
$376 nightly
The price is $415
Jul 6 - Jul 7
Total with taxes and fees
Main Street Apartment

6th street 101 - Walk to Main St

6th street 101 - Walk to Main St
St. Charles Historic District
10.0 out of 10, Exceptional, (2 reviews)
"Excellent"
United States
Scott N.
$253 nightly
The price is $284
Jul 9 - Jul 10
Total with taxes and fees
6th street 101 - Walk to Main St

The Historic Bricks on Main

The Historic Bricks on Main
St. Charles Historic District
9.0 out of 10, Wonderful, (18 reviews)
"Great place, very fun. I’d stay again for sure. "
United States
Michael C.
$208 nightly
The price is $229
Jul 8 - Jul 9
Total with taxes and fees
The Historic Bricks on Main

1st Capitol Mansion - Suite 401

1st Capitol Mansion - Suite 401
St. Charles Historic District
7.4 out of 10, Good, (9 reviews)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
United States
Emily L.
$225 nightly
The price is $253
Jul 6 - Jul 7
Total with taxes and fees
1st Capitol Mansion - Suite 401

Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (65 reviews)
"Lovely accommodations, very clean, well equipped, great location. "
United States
Emily B.
$261 nightly
The price is $279
Jul 12 - Jul 13
Total with taxes and fees
Amazing Renovated Historic Loft on Main Street

Walk to Main St | Pet-Friendly Apt

Walk to Main St | Pet-Friendly Apt
St. Charles Historic District
8.6 out of 10, Excellent, (16 reviews)
"Property was as advertised. Perfect for my needs, clean, quiet and convenient. Loved Historic St. Charles. Would recommend anytime! Thank you! "
United States
Brian B.
$269 nightly
The price is $297
Jul 6 - Jul 7
Total with taxes and fees
Walk to Main St | Pet-Friendly Apt

Historic Main St. Customs House Upstairs Apartment

Historic Main St. Customs House Upstairs Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (38 reviews)
"Lovely place to stay!"
United States
Margaret A.
$331 nightly
The price is $365
Jul 8 - Jul 9
Total with taxes and fees
Historic Main St. Customs House Upstairs Apartment

Stay on Main Historic Studio

Stay on Main Historic Studio
St. Charles Historic District
9.0 out of 10, Wonderful, (34 reviews)
"From the welcome email with clear concise directions on how to enter with door codes to a dwelling that had everything I needed with a very comfortable bed, it was a great stay and I wanted for nothing."
United States
Jacob G.
$208 nightly
The price is $229
Aug 3 - Aug 4
Total with taxes and fees
Stay on Main Historic Studio

Family Home: Game Room & Huge Yard, Airport

Family Home: Game Room & Huge Yard, Airport
Maryland Heights
10.0 out of 10, Exceptional, (1 review)
"Very nice"
United States
Steven S.
$454 nightly
The price is $454
Jul 12 - Jul 13
Total with taxes and fees
Family Home: Game Room & Huge Yard, Airport

Charming Duplex on Main

Charming Duplex on Main
St. Charles Historic District
10.0 out of 10, Exceptional, (21 reviews)
"We had an AMAZING time here and you can't beat the close walking distance to main st!! Absolutely loved our stay. "
United States
Wendy K.
$247 nightly
The price is $272
Jul 21 - Jul 22
Total with taxes and fees
Charming Duplex on Main

Prime Loft of Main Street

Prime Loft of Main Street
St. Charles Historic District
9.8 out of 10, Exceptional, (112 reviews)
"Really liked the location, lots to do within walking distance. Very good check in process - easy to follow.Well maintained place."
United States
William H.
$259 nightly
The price is $277
Jul 6 - Jul 7
Total with taxes and fees
Prime Loft of Main Street

Duplex Hideaway in St. Charles, MO

Duplex Hideaway in St. Charles, MO
St. Charles Historic District
9.8 out of 10, Exceptional, (6 reviews)
"I will stay here again. It was a great location for my visit. Lots of room and amenities. Highly recommend this location if you are visiting the St Louis area. Barely a mile to get to Hwy 70, so easy access to St Louis, St Peter's, Wentzville etc. Maybe two blocks from Historic St Charles and Ameristar Casino."
United States
Karen M.
$251 nightly
The price is $276
Jul 16 - Jul 17
Total with taxes and fees
Duplex Hideaway in St. Charles, MO

Historic Main St Apt | Private Garage

Historic Main St Apt | Private Garage
St. Charles Historic District
9.2 out of 10, Wonderful, (18 reviews)
"The location is excellent. The appartment is nice, spacious, comfortable, and practical. The parking spot is a big plus. Everything was perfect with our stay. Would stay again and highly recommedn."
United States
Bettina I.
$307 nightly
The price is $338
Jul 20 - Jul 21
Total with taxes and fees
Historic Main St Apt | Private Garage
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Find out more about Defiance

Defiance Apartments information

Number of reviews
326
Accommodation
115 Apartments
Lowest Price
$100
Highest Price
$454

Frequently asked questions

What's it like to stay at an apartment in Defiance?
You'll find 10 apartments to choose from in Defiance for your stay.
Why choose an apartment versus a traditional hotel?
Often more spacious than a traditional hotel room, an apartment includes a kitchen for convenient home-cooked meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want something in a quieter part of town.
What's a favorite apartment for a stay in Defiance?
Here are some of the top apartments in the area: Chic 1- Queen Bed, Non Smoking-Near Airport, Kitchen, Twin Bed: Situated in Overland, 20.7 mi/33.2 km from the heart of Defiance. Includes free WiFi, private balconies, and Smart TVs. 1 Queen Bed | Non-Smoking, Kitchen: Located 18.7 mi/30.1 km away in Maryland Heights. Free WiFi and Smart TVs are included. 2 Queen Beds | Non-Smoking, Kitchen: It's situated in Maryland Heights, 18.7 mi/30.1 km away. Includes free WiFi and Smart TVs. The Lofts of North Main Street: Located 19.2 mi/30.8 km away in St. Charles. Free WiFi, sofa beds, and Smart TVs are included. Access to onsite laundry facilities is available on site. 1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed: It's located in Maryland Heights, 18.7 mi/30.1 km from Defiance. Includes free WiFi and Smart TVs.
How many apartments will I be able to find in Defiance?
Expedia has 10 apartments to book in Defiance.
What can I expect from the weather during my trip to Defiance?
Weather is only one factor, but it can really affect your travel plans, especially if you're planning an extended stay in Defiance. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.
What are the must-see places to visit in Defiance?
August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Chandler Hill Vineyards and Sugar Creek Winery are other places worth a visit.
What's the best way to get to and around Defiance?
Knowing a bit about the transportation options can save you time when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. You can also search for flights into St. Louis Lambert Intl. Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to explore around the area, you may want a rental car for your journey.

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