Uptown - Upper Duval, FL
Key West
Visit Uptown - Upper Duval
Popular places to visit
Southernmost Point
4.5/5(3,246 reviews)
Snap a memorable photograph from the edge of North America at this monumental landmark.
South Beach
4/5(999 reviews)
Head to the southernmost beach of the continental United States to relax and swim in the waters where famous writer Tennessee Williams once took his daily swim.
Key West Butterfly and Nature Conservatory
4.5/5(770 reviews)
With about 60 species of butterfly, an indoor waterfall and a tropical rainforest, this nature conservatory is one of the most popular attractions in Key West.
Things to do
Dolphin Watch Catamaran Sunset Sail w/ Tapas and Open Bar
$79
per adult
94% of travellers recommend
Miami to Key West Day Trip with Activity Options
$39
per adult
82% of travellers recommend
Key West Rum & Reggae: Snorkel & Sunset Sail Combo
$55
per adult
88% of travellers recommend
Sunset Dinner Cruise in Key West with Live Music & Unlimited Open Bar!
$76
per adult
88% of travellers recommend
Shipwreck Treasure Museum Tickets
$19
per adult
78% of travellers recommend
Uptown - Upper Duval Hotel Deals
Southernmost Beach Resort and Guesthouses
1319 Duval Street Key West FL
Fully refundableReserve now, pay when you stay
$330 nightly
The price is $372 total per night from May 19 to May 20
$372 total
May 19 - May 20
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.8/10 Excellent! (3,220 reviews)
Very nice property, great location, right near the beach(which is rare in Key West). Our only issue was the housekeeping services. We took the privacy sign off the door and were expecting to get the room cleaned while we were gone for the whole morning. Usually, thats when the cleaning is done. We ...
Reviewed on Apr 19, 2026
The Reach Key West, Curio Collection by Hilton
1435 Simonton Street Key West FL
$326 nightly
The price is $367 total per night from May 20 to May 21
$367 total
May 20 - May 21
Total with taxes and fees
Book a stay at this beach resort in Key West. Enjoy a full-service spa, a private beach, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.6/10 Excellent! (1,005 reviews)
The rooms and property were clean and comfortable. The staff were respectful, kind, and accommodating. The beach and pool were close and made it convenient for kids to jump from pool to beach. We loved our stay
Reviewed on Apr 16, 2026
Southwinds Motel
1321 Simonton Street Key West FL
$236 nightly
The price is $266 total per night from Apr 21 to Apr 22
$266 total
Apr 21 - Apr 22
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,306 reviews)
Clean room close the bathroom and everything
Reviewed on Apr 18, 2026
The Southernmost Inn - Adults Only
525 United Street Key West FL
$199 nightly
The price is $224 total per night from Apr 22 to Apr 23
$224 total
Apr 22 - Apr 23
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.4/10 Very Good! (1,318 reviews)
Room and location were good - we had the end unit facing the street and Parking lot so it was never dark at night. Should consider black out shades for this room. A/C unit is super loud as well - didn't sleep very well all three nights. Otherwise the location is on the quieter side of Duval Street ...
Reviewed on Apr 19, 2026
Douglas House - Adults Only
419 Amelia St Key West FL
$247 nightly
The price is $277 total per night from May 4 to May 5
$277 total
May 4 - May 5
Total with taxes and fees
Stay at this guesthouse in Key West. Enjoy free WiFi, daily housekeeping, and a garden. Popular attractions Duval Street and Ernest Hemingway Home and Museum ...
9.6/10 Exceptional! (359 reviews)
Perfect for an anniversary get away. We stayed in room 11, which is on the first floor and has its own private patio. The patio was perfect to enjoy our morning coffee, an evening glass of wine, or kicking back to relax and read a book out of the sun during the day. They sell a small selection of ...
Reviewed on Apr 19, 2026
Santa Maria Suites
1401 Simonton St Key West FL
$499 nightly
The price is $561 total per night from May 11 to May 12
$561 total
May 11 - May 12
Total with taxes and fees
Stay at this resort in Key West. Enjoy free WiFi, 2 outdoor pools, and a fitness center. Our guests praise the pool and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (1,001 reviews)
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Reviewed on Apr 18, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check Uptown - Upper Duval hotel availability
Other neighborhoods around Uptown - Upper Duval
Old Town Key West
4.5/5(229 area reviews)
Old Town, the historic heart of Key West, boasts a central business district and numerous tourist attractions. Explore the Key West Aquarium, Ernest Hemingway House, Mallory Square, and more in this vibrant area.
Bahama Village
5/5(39 area reviews)
Bahama Village is noteworthy for its historic sites, and you can make a stop at top attractions like Duval Street and Key West Lighthouse and Keeper's Quarters Museum.
Downtown Key West
If you're spending some time in Downtown Key West, Duval Street and Ernest Hemingway Home and Museum are top sights worth seeing.
Key West Historic District
4.5/5(4,090 area reviews)
Old Town Key West boasts a rich history with 2485 historic buildings, and is home to popular attractions like Ernest Hemingway House and Mallory Square. Enjoy the lively atmosphere in the central business district.
Casa Marina
While visiting Casa Marina, you might make a stop by sights like Florida Keys Beaches and Clarence S. Higgs Memorial Beach Park.
White Street Gallery District
When in White Street Gallery District, you can plan a visit to Duval Street and Clarence S. Higgs Memorial Beach Park, some noteworthy sights in the nearby area.
Uptown - Upper Duval, FL
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