Uptown - Upper Duval, FL
Key West
Visit Uptown - Upper Duval
Popular places to visit
Southernmost Point
4.5/5(3,244 reviews)
Snap a memorable photograph from the edge of North America at this monumental landmark.
South Beach
4/5(999 reviews)
Head to the southernmost beach of the continental United States to relax and swim in the waters where famous writer Tennessee Williams once took his daily swim.
Key West Butterfly and Nature Conservatory
4.5/5(770 reviews)
With about 60 species of butterfly, an indoor waterfall and a tropical rainforest, this nature conservatory is one of the most popular attractions in Key West.
Things to do
Dolphin Watch Catamaran Sunset Sail w/ Tapas and Open Bar
$79
per adult
94% of travellers recommend
Miami to Key West Day Trip with Activity Options
$39
per adult
82% of travellers recommend
Key West Rum & Reggae: Snorkel & Sunset Sail Combo
$55
per adult
88% of travellers recommend
Shipwreck Treasure Museum Tickets
$19
per adult
78% of travellers recommend
Sunset Dinner Cruise in Key West with Live Music & Unlimited Open Bar!
$76
per adult
88% of travellers recommend
Uptown - Upper Duval Hotel Deals
Southernmost Beach Resort and Guesthouses
1319 Duval Street Key West FL
$415 nightly
The price is $467 total per night from May 10 to May 11
$467 total
May 10 - May 11
Total with taxes and fees
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.8/10 Excellent! (3,195 reviews)
Enjoyed the resort. We experienced 2 of the pools.
Reviewed on Apr 9, 2026
The Reach Key West, Curio Collection by Hilton
1435 Simonton Street Key West FL
$331 nightly
The price is $373 total per night from May 3 to May 4
$373 total
May 3 - May 4
Total with taxes and fees
Book a stay at this beach resort in Key West. Enjoy a full-service spa, a private beach, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.6/10 Excellent! (1,004 reviews)
Resort was beautiful and rooms were spacious and clean. We had an issue with housekeeping one day, but Annie took care of it for us. Everyone was wonderful. Would DEFINITELY return.
Reviewed on Apr 7, 2026
Southwinds Motel
1321 Simonton Street Key West FL
$252 nightly
The price is $284 total per night from May 10 to May 11
$284 total
May 10 - May 11
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,300 reviews)
The room was very clean and the staff was great. I really enjoyed the heated pool.
Reviewed on Apr 8, 2026
The Southernmost Inn - Adults Only
525 United Street Key West FL
$269 nightly
The price is $303 total per night from May 10 to May 11
$303 total
May 10 - May 11
Total with taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.2/10 Very Good! (1,303 reviews)
Easy to walk to everywhere! Staff was amazing and the beds were comfortable! Very spacious room!
Reviewed on Apr 8, 2026
Douglas House - Adults Only
419 Amelia St Key West FL
$286 nightly
The price is $322 total per night from Apr 15 to Apr 16
$322 total
Apr 15 - Apr 16
Total with taxes and fees
Stay at this guesthouse in Key West. Enjoy free WiFi, daily housekeeping, and a garden. Popular attractions Duval Street and Ernest Hemingway Home and Museum ...
9.6/10 Exceptional! (343 reviews)
The only inconvenience was parking. Otherwise, the stay was perfect!
Reviewed on Apr 9, 2026
Santa Maria Suites
1401 Simonton St Key West FL
$609 nightly
The price is $685 total per night from May 4 to May 5
$685 total
May 4 - May 5
Total with taxes and fees
Stay at this resort in Key West. Enjoy free WiFi, 2 outdoor pools, and a fitness center. Our guests praise the pool and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (1,000 reviews)
The resort was so nice and perfect for our family of 5. We were in walking distance of restaurants and a small grocery store that has amazing breakfast. The lady that works the day shift ( I believe her name was Matilda) was so helpful and also helped us schedule a golf cart and an excursion making ...
Reviewed on Mar 30, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check Uptown - Upper Duval hotel availability
Other neighborhoods around Uptown - Upper Duval
Old Town Key West
4.5/5(229 area reviews)
Old Town, the historic heart of Key West, boasts a central business district and numerous tourist attractions. Explore the Key West Aquarium, Ernest Hemingway House, Mallory Square, and more in this vibrant area.
Bahama Village
5/5(39 area reviews)
Bahama Village is noteworthy for its historic sites, and you can make a stop at top attractions like Duval Street and Key West Lighthouse and Keeper's Quarters Museum.
Downtown Key West
If you're spending some time in Downtown Key West, Duval Street and Ernest Hemingway Home and Museum are top sights worth seeing.
Key West Historic District
4.5/5(4,090 area reviews)
Old Town Key West boasts a rich history with 2485 historic buildings, and is home to popular attractions like Ernest Hemingway House and Mallory Square. Enjoy the lively atmosphere in the central business district.
Casa Marina
While visiting Casa Marina, you might make a stop by sights like Clarence S. Higgs Memorial Beach Park and Florida Keys Beaches.
White Street Gallery District
When in White Street Gallery District, you can plan a visit to Duval Street and Clarence S. Higgs Memorial Beach Park, some noteworthy sights in the nearby area.
Uptown - Upper Duval, FL
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