Title: Visit Uptown - Upper Duval: 2026 Uptown - Upper Duval, Key West Travel Guide | Expedia.com [Hotels in Uptown - Upper Duval](https://expedia.com/Uptown-Upper-Duval-Key-West-Hotels.0-n553248635976473524-0.Travel-Guide-Filter-Hotels)[Flights to Key West](https://expedia.com/Cheap-Flights-To-Key-West.d1187.Travel-Guide-Flights)[Things to do in Key West](https://expedia.com/Things-To-Do-In-Key-West.d1187.Travel-Guide-Activities)[Car Rentals in Uptown - Upper Duval](https://expedia.com/Car-Rentals-In-Uptown-Upper-Duval.d553248635976473524.Car-Rental-Guide)[Uptown - Upper Duval Vacations](https://expedia.com/Uptown-Upper-Duval.d553248635976473524.Destination-Travel-Guides) # Uptown - Upper Duval, FL ## Key West ![Uptown - Upper Duval](https://images.trvl-media.com/place/1187/48023594-76b8-4930-a4a9-06a0f12911a4.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Uptown - Upper Duval](https://images.trvl-media.com/place/1187/bf123656-e1f1-4311-8c95-2b851a4b8721.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Uptown - Upper Duval](https://images.trvl-media.com/place/1187/ca919e5f-361f-4129-b171-77d34c9b6791.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Uptown - Upper Duval](https://images.trvl-media.com/place/1187/5d488261-cf7f-43ce-a448-690eeb186cd2.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Uptown - Upper Duval](https://images.trvl-media.com/place/1187/c8f3d3ca-f3d1-4ec7-8539-65db27bcc943.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Uptown - Upper Duval Things to do Hotels Where to stay --- ### Popular places to visit ![Southernmost Point](https://images.trvl-media.com/place/501380/97e2b26c-38ce-483b-b59e-7a017404ab35.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Southernmost Point Snap a memorable photograph from the edge of North America at this monumental landmark. [](https://expedia.com/Southernmost-Point-Old-Town-Key-West.d501380.Vacation-Attraction) ![South Beach](https://images.trvl-media.com/place/6246827/42d13a3e-a933-4e9f-b857-cde9f4314a24.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### South Beach Head to the southernmost beach of the continental United States to relax and swim in the waters where famous writer Tennessee Williams once took his daily swim. [](https://expedia.com/South-Beach-Old-Town-Key-West.d6246827.Vacation-Attraction) ![Key West Butterfly and Nature Conservatory](https://images.trvl-media.com/place/6068597/40321a43-d7c0-4ff6-bffa-8178a19d9be2.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Key West Butterfly and Nature Conservatory With about 60 species of butterfly, an indoor waterfall and a tropical rainforest, this nature conservatory is one of the most popular attractions in Key West. [](https://expedia.com/Key-West-Butterfly-And-Nature-Conservatory-Old-Town-Key-West.d6068597.Vacation-Attraction) ### Things to do ![Miami to Key West Day Trip with Activity Options](https://mediaim.expedia.com/localexpert/1344154/127def52-afdb-470f-97fc-ba484b15a753.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Miami to Key West Day Trip with Activity Options $39 per adult **82%** of travellers recommend [](https://expedia.com/things-to-do/miami-to-key-west-day-trip-with-activity-options.a1344154.activity-details) ![Key West Premium Sunset Sail with Champagne, Wine & Tapas](https://mediaim.expedia.com/localexpert/2190809/50f64266-172c-47ec-a3dd-1abdcf45ef8c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Dolphin Watch Catamaran Sunset Sail w/ Tapas and Open Bar $79 per adult **94%** of travellers recommend [](https://expedia.com/things-to-do/dolphin-watch-catamaran-sunset-sail-w-tapas-and-open-bar.a2190809.activity-details) ![Combo image of activity in Key West](https://mediaim.expedia.com/localexpert/191571/36bcc364-ce77-4331-a7d9-4330818bfbfa.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Key West Rum & Reggae: Snorkel & Sunset Sail Combo $55 per adult **88%** of travellers recommend [](https://expedia.com/things-to-do/key-west-rum-reggae-snorkel-sunset-sail-combo.a191571.activity-details) ![Key West Half-Day Fishing Charter](https://mediaim.expedia.com/localexpert/5299343/671745e1-9724-45ed-9f6d-20286eca548a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Key West Half-Day Fishing Charter $95 per adult **90%** of travellers recommend [](https://expedia.com/things-to-do/key-west-half-day-fishing-charter.a5299343.activity-details) ![Entertainer in character at the Shipwreck Treasure Museum in Key West](https://mediaim.expedia.com/localexpert/191533/0194ef1a-54dc-4244-9dae-801c2ad37537.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Shipwreck Treasure Museum Tickets $19 per adult **78%** of travellers recommend [](https://expedia.com/things-to-do/shipwreck-treasure-museum-tickets.a191533.activity-details) ![Sunset Dinner Cruise in Key West with Live Music & Unlimited Open Bar!](https://mediaim.expedia.com/localexpert/588408/c7a7cff0-8d80-4d7c-9dd4-6dd2dd79a519.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Sunset Dinner Cruise in Key West with Live Music & Unlimited Open Bar! $76 per adult **88%** of travellers recommend [](https://expedia.com/things-to-do/sunset-dinner-cruise-in-key-west-with-live-music-unlimited-open-bar.a588408.activity-details) [See all activities in Key West](https://expedia.com/Things-To-Do-In-Key-West.d1187.Travel-Guide-Activities) --- ## Uptown - Upper Duval Hotel Deals ![Southernmost Beach Resort and Guesthouses](https://images.trvl-media.com/lodging/1000000/870000/863400/863329/546caf1e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Southernmost Beach Resort and Guesthouses 1319 Duval Street Key West FL $393 nightly $442 total May 6 - May 7 Total with taxes and fees Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ... 8.8/10 Excellent! (3,170 reviews) Wonderful beach views, clean rooms and property, great food Reviewed on Apr 5, 2026 [](https://expedia.com/Hotel-Search?startDate=5%2F6%2F2026&endDate=5%2F7%2F2026&selected=863329&PinnedHotelID=863329&HadPinnedHotel=true®ionId=553248635976473524) ![The Reach Key West, Curio Collection by Hilton](https://images.trvl-media.com/lodging/1000000/460000/457900/457821/bc3021c3_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Reach Key West, Curio Collection by Hilton 1435 Simonton Street Key West FL $367 nightly $413 total May 4 - May 5 Total with taxes and fees Book a stay at this beach resort in Key West. Enjoy a full-service spa, a private beach, and breakfast (surcharge). Our guests praise the helpful staff and the ... 8.6/10 Excellent! (1,003 reviews) Hotel was very clean and staff was attentive. The location was great with direct beach access and close to duval street. The food service on the beach from Stephanie was great! It was our first trip to key west and it won’t be our last. Reviewed on Apr 4, 2026 [](https://expedia.com/Hotel-Search?startDate=5%2F4%2F2026&endDate=5%2F5%2F2026&selected=457821&PinnedHotelID=457821&HadPinnedHotel=true®ionId=553248635976473524) ![Southwinds Motel](https://images.trvl-media.com/lodging/9000000/8990000/8984500/8984451/45887e0a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Southwinds Motel 1321 Simonton Street Key West FL $251 nightly $282 total Apr 12 - Apr 13 Total with taxes and fees Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ... 8.6/10 Excellent! (1,295 reviews) Yes yes Reviewed on Apr 3, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F12%2F2026&endDate=4%2F13%2F2026&selected=8984451&PinnedHotelID=8984451&HadPinnedHotel=true®ionId=553248635976473524) ![The Southernmost Inn - Adults Only](https://images.trvl-media.com/lodging/5000000/4290000/4280800/4280752/a8250942_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Southernmost Inn - Adults Only 525 United Street Key West FL $259 nightly $291 total Apr 6 - Apr 7 Total with taxes and fees Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ... 8.2/10 Very Good! (1,294 reviews) The other guests were very noisy throughout the night. The light from the pool area shone so brightly through the blinds and curtains it was almost daylight all night in the bedroom. No storage space for clothes and parking was off site. On the plus side the staff were all very friendly and helpful ... Reviewed on Apr 3, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F6%2F2026&endDate=4%2F7%2F2026&selected=4280752&PinnedHotelID=4280752&HadPinnedHotel=true®ionId=553248635976473524) ![Douglas House - Adults Only](https://images.trvl-media.com/lodging/111000000/110490000/110488200/110488130/ba6b4821_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Douglas House - Adults Only 419 Amelia St Key West FL $266 nightly $300 total Apr 13 - Apr 14 Total with taxes and fees Stay at this guesthouse in Key West. Enjoy free WiFi, daily housekeeping, and a garden. Popular attractions Duval Street and Ernest Hemingway Home and Museum ... 9.6/10 Exceptional! (340 reviews) The room was fantastic! We loved it and will be sure to book it again! Reviewed on Apr 4, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F13%2F2026&endDate=4%2F14%2F2026&selected=110488130&PinnedHotelID=110488130&HadPinnedHotel=true®ionId=553248635976473524) ![Santa Maria Suites](https://images.trvl-media.com/lodging/1000000/920000/911000/910922/069776b3_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Santa Maria Suites 1401 Simonton St Key West FL $609 nightly $685 total May 4 - May 5 Total with taxes and fees Stay at this resort in Key West. Enjoy free WiFi, 2 outdoor pools, and a fitness center. Our guests praise the pool and the helpful staff in our reviews. Popular ... 9.6/10 Exceptional! (1,000 reviews) The resort was so nice and perfect for our family of 5\. We were in walking distance of restaurants and a small grocery store that has amazing breakfast. The lady that works the day shift ( I believe her name was Matilda) was so helpful and also helped us schedule a golf cart and an excursion making ... Reviewed on Mar 30, 2026 [](https://expedia.com/Hotel-Search?startDate=5%2F4%2F2026&endDate=5%2F5%2F2026&selected=910922&PinnedHotelID=910922&HadPinnedHotel=true®ionId=553248635976473524) [See all 2,741 properties in Uptown - Upper Duval](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=4%2F6%2F2026&endDate=4%2F7%2F2026®ionId=553248635976473524) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Uptown - Upper Duval hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976473524&startDate=2026-04-05&endDate=2026-04-06)[Apr 5 - Apr 6](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976473524&startDate=2026-04-05&endDate=2026-04-06) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976473524&startDate=2026-04-06&endDate=2026-04-07)[Apr 6 - Apr 7](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976473524&startDate=2026-04-06&endDate=2026-04-07) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976473524&startDate=4%2F10%2F2026&endDate=4%2F12%2F2026)[Apr 10 - Apr 12](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976473524&startDate=4%2F10%2F2026&endDate=4%2F12%2F2026) --- ### Other neighborhoods around Uptown - Upper Duval ![Old Town Key West](https://images.trvl-media.com/place/553248635976481920/c3895c9f-e471-4c93-ac2e-85c99f8f8fec.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Old Town Key West 4.5/5(229 area reviews) Old Town, the historic heart of Key West, boasts a central business district and numerous tourist attractions. Explore the Key West Aquarium, Ernest Hemingway House, Mallory Square, and more in this vibrant area. [](https://expedia.com/Key-West-Old-Town-Key-West.dx553248635976481920) ![Bahama Village](https://images.trvl-media.com/place/6068605/e209543d-9f52-46a8-b0de-136d3f268be5.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Bahama Village 5/5(39 area reviews) Bahama Village is noteworthy for its historic sites, and you can make a stop at top attractions like Duval Street and Key West Lighthouse and Keeper's Quarters Museum. [](https://expedia.com/Key-West-Bahama-Village.dx553248621533115696) ![Downtown Key West](https://images.trvl-media.com/place/6068616/ac9e1424-8949-4483-8a12-9063d1511aa2.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Downtown Key West If you're spending some time in Downtown Key West, Duval Street and Ernest Hemingway Home and Museum are top sights worth seeing. [](https://expedia.com/Key-West-Downtown-Key-West.dx553248635976470405) ![Key West Historic District](https://images.trvl-media.com/place/6068599/e22dc889-0174-435e-9d9b-302d362fd045.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Key West Historic District 4.5/5(4,090 area reviews) Old Town Key West boasts a rich history with 2485 historic buildings, and is home to popular attractions like Ernest Hemingway House and Mallory Square. Enjoy the lively atmosphere in the central business district. [](https://expedia.com/Key-West-Key-West-Historic-District.dx6281809) ![Casa Marina](https://images.trvl-media.com/place/1187/d0c11bd8-7e39-4ed6-b09c-d3007de4fe5e.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Casa Marina While visiting Casa Marina, you might make a stop by sights like Clarence S. Higgs Memorial Beach Park and Florida Keys Beaches. [](https://expedia.com/Key-West-Casa-Marina.dx864981993084186624) ![St. Paul's Episcopal Church, Key West ](https://images.trvl-media.com/place/553248635976482119/ebe24c59-9ab8-4963-a531-5638939859c3.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### White Street Gallery District When in White Street Gallery District, you can plan a visit to Duval Street and Clarence S. Higgs Memorial Beach Park, some noteworthy sights in the nearby area. [](https://expedia.com/Key-West-White-Street-Gallery-District.dx553248635976482119) [See our Where To Stay guide](https://expedia.com/Key-West.dx1187.Where-To-Stay?rfrr=TG.LP.Dest.Neigh.Neighborhoods) --- --- - [Stays](?pwaLob=wizard-hotel-pwa-v2) - [Packages](?pwaLob=wizard-package-pwa) - [Flights](?pwaLob=wizard-flight-pwa) - [Things to do](?pwaLob=wizard-lx-pwa) - [Cruises](?pwaLob=wizard-cruise-pwa) - [Cars](?pwaLob=wizard-car-pwa) # Uptown - Upper Duval, FL ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Key West Hotels ](https://www.expedia.com/Key-West-Hotels.d1187.Travel-Guide-Hotels) - [All-Inclusive Resorts in Key West ](https://www.expedia.com/Key-West-Hotels-All-Inclusive-Hotel.0-0-d1187-tAllinclusiveHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Key West ](https://www.expedia.com/Key-West-Hotels-Cheap-Hotels.0-0-d1187-tCheapHotels.Travel-Guide-Filter-Hotels) - [Oceanfront Hotels in Key West ](https://www.expedia.com/Key-West-Hotels-Oceanfront-Hotels.0-0-d1187-tOceanfrontHotels.Travel-Guide-Filter-Hotels) - 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