Uptown - Upper Duval, FL
Key West
Visit Uptown - Upper Duval
Popular places to visit
Southernmost Point
4.5/5(3,246 reviews)
Snap a memorable photograph from the edge of North America at this monumental landmark.
South Beach
4/5(999 reviews)
Head to the southernmost beach of the continental United States to relax and swim in the waters where famous writer Tennessee Williams once took his daily swim.
Key West Butterfly and Nature Conservatory
4.5/5(770 reviews)
With about 60 species of butterfly, an indoor waterfall and a tropical rainforest, this nature conservatory is one of the most popular attractions in Key West.
Things to do
Dolphin Watch Catamaran Sunset Sail w/ Tapas and Open Bar
$79
per adult
94% of travellers recommend
Miami to Key West Day Trip with Activity Options
$39
per adult
82% of travellers recommend
Key West Rum & Reggae: Snorkel & Sunset Sail Combo
$55
per adult
88% of travellers recommend
Sunset Dinner Cruise in Key West with Live Music & Unlimited Open Bar!
$76
per adult
88% of travellers recommend
Shipwreck Treasure Museum Tickets
$19
per adult
78% of travellers recommend
Uptown - Upper Duval Hotel Deals
Southernmost Beach Resort and Guesthouses
1319 Duval Street Key West FL
The price is $372 total per night from May 19 to May 20
$372 total
per night
May 19 - May 20
Book a stay at this beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.8/10 Excellent! (3,218 reviews)
Great location, away from the bustle of Mallery Square. Staff was awesome. 3 pools! Would highly recommend.
Reviewed on Apr 18, 2026
The Reach Key West, Curio Collection by Hilton
1435 Simonton Street Key West FL
The price is $360 total per night from May 11 to May 12
$360 total
per night
May 11 - May 12
Book a stay at this beach resort in Key West. Enjoy a full-service spa, a private beach, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.6/10 Excellent! (1,005 reviews)
The rooms and property were clean and comfortable. The staff were respectful, kind, and accommodating. The beach and pool were close and made it convenient for kids to jump from pool to beach. We loved our stay
Reviewed on Apr 16, 2026
Southwinds Motel
1321 Simonton Street Key West FL
The price is $260 total per night from Apr 27 to Apr 28
$260 total
per night
Apr 27 - Apr 28
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,305 reviews)
Clean room close the bathroom and everything
Reviewed on Apr 18, 2026
The Southernmost Inn - Adults Only
525 United Street Key West FL
The price is $224 total per night from Apr 20 to Apr 21
$224 total
per night
Apr 20 - Apr 21
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.4/10 Very Good! (1,317 reviews)
Perfect location for the price
Reviewed on Apr 17, 2026
Douglas House - Adults Only
419 Amelia St Key West FL
The price is $277 total per night from Apr 20 to Apr 21
$277 total
per night
Apr 20 - Apr 21
Stay at this guesthouse in Key West. Enjoy free WiFi, daily housekeeping, and a garden. Popular attractions Duval Street and Ernest Hemingway Home and Museum ...
9.6/10 Exceptional! (358 reviews)
Perfectly located for the ultimate Key West experience. Staff very friendly. I realize we are on ‘Island time’ however a working clock in the bedroom was important. We had a great stay. The clock was now on the fix it list. Room was very clean.
Reviewed on Apr 19, 2026
Santa Maria Suites
1401 Simonton St Key West FL
The price is $561 total per night from May 11 to May 12
$561 total
per night
May 11 - May 12
Stay at this resort in Key West. Enjoy free WiFi, 2 outdoor pools, and a fitness center. Our guests praise the pool and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (1,001 reviews)
.
Reviewed on Apr 18, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Other neighborhoods around Uptown - Upper Duval
Old Town Key West
4.5/5(229 area reviews)
Old Town, the historic heart of Key West, boasts a central business district and numerous tourist attractions. Explore the Key West Aquarium, Ernest Hemingway House, Mallory Square, and more in this vibrant area.
Bahama Village
5/5(39 area reviews)
Bahama Village is noteworthy for its historic sites, and you can make a stop at top attractions like Duval Street and Key West Lighthouse and Keeper's Quarters Museum.
Downtown Key West
If you're spending some time in Downtown Key West, Duval Street and Ernest Hemingway Home and Museum are top sights worth seeing.
Key West Historic District
4.5/5(4,090 area reviews)
Old Town Key West boasts a rich history with 2485 historic buildings, and is home to popular attractions like Ernest Hemingway House and Mallory Square. Enjoy the lively atmosphere in the central business district.
Casa Marina
While visiting Casa Marina, you might make a stop by sights like Florida Keys Beaches and Clarence S. Higgs Memorial Beach Park.
White Street Gallery District
When in White Street Gallery District, you can plan a visit to Duval Street and Clarence S. Higgs Memorial Beach Park, some noteworthy sights in the nearby area.
Uptown - Upper Duval, FL
Explore a world of travel with Expedia
- Key West Hotels
- All-Inclusive Resorts in Key West
- Cheap Hotels in Key West
- Oceanfront Hotels in Key West
- Hotels near Duval Street
- Beach Hotels in Key West
- Adults Only Resorts & in Key West
- Hotels near Key West Historic District
- Houseboats in Key West
- Pet-Friendly Hotels in Key West
- Hotels near Southernmost Point
- Condo Rentals in Key West
- Hotels near Tennessee Williams Key West Exhibit
- Hotels near Ernest Hemingway Home and Museum
- Hotels near Key West Butterfly and Nature Conservatory
- Romantic Hotels in Key West
- Family Hotels in Key West
- 4 Star Hotels in Old Town Key West
- Hotels near Old Town Key West
- Hotels near Key West Lighthouse and Keeper's Quarters Museum
- Hotels near MLK Community Pool & Community Center
- 4 Star Hotels in Key West
- Hotels near South Beach
- Hotels near Downtown Key West
- Hilton Hotels in Key West
- 5 Star Hotels in Key West
- Honeymoon Resorts & in Key West
- Hotels near Saint Mary Star of the Sea
- Resorts in Key West
- Hotels near Bahama Village
- Hotels with Restaurants in Bahama Village
- Luxury Hotels in Bahama Village
- 4 Star Hotels in Bahama Village
- Boutique Hotels in Bahama Village
- Resorts & Hotels with Spas in Bahama Village
- Hotels with Bars in Bahama Village
- Golf Hotels in Bahama Village
- Hotels near Simonton Beach
- Boutique Hotels in Key West
- Kimpton Hotels in Key West
- Cabin Rentals in Key West
- Cottages in Key West
- B&B in Key West
- Luxury Hotels in Key West
- Gay friendly Hotels in Key West
- Historic Hotels in Key West
- Hotels with Kitchenettes in Key West
- Hotels with Free Airport Shuttle in Key West
- Guest Houses in Key West
- Best Western Hotels in Key West
- Wyndham Hotels in Key West
- Hotels with smoking rooms in Key West
- Hotels near Key West Firehouse Museum
- Golf Hotels in Key West
- Vacation Homes in Key West
- Hotels with Hot Tubs in Key West
- Hotels with Free Breakfast in Key West
- Villas in Key West
- Hotels with Free Parking in Key West
- 4 Star Hotels in Key West Historic District
- Hyatt Hotels in Key West
- Hostels in Key West
- Key West Vacations
- All inclusive Vacation Packages Key West
- Visit Key West
- Visit Downtown Key West
- Visit Old Town Key West
- Ernest Hemingway Home and Museum
- Visit Bahama Village
- Visit Key West Historic District
- City Zoo Gallery
- South Beach
- Key West Butterfly and Nature Conservatory
- Tennessee Williams Key West Exhibit
- Southernmost Point
- Duval Street
- Key West Lighthouse and Keeper's Quarters Museum
- Mlk Community Pool & Community Center
- Old Town Key West Vacations
- Visit Historic Seaport
- Saint Mary Star of the Sea
- Romantic Vacation Packages Key West
- Simonton Beach
- Bahama Village Vacations
- Key West Cemetery
- Car rentals near Key West
- Car rentals near Key West Butterfly and Nature Conservatory
- Car rentals near Southernmost Point
- Car rentals near South Beach
- Car rentals near Duval Street
- Pickup Car Rentals near Duval Street
- Suv Car Rentals near Duval Street
- Hertz Rental Cars in Key West
- Budget Rental Cars in Key West
- Enterprise Rental Cars in Key West
- Mini Car Rentals in Key West
