Uptown - Upper Duval, FL
Key West
Visit Uptown - Upper Duval
Popular places to visit
Southernmost Point
Snap a memorable photograph from the edge of North America at this monumental landmark.
South Beach
Head to the southernmost beach of the continental United States to relax and swim in the waters where famous writer Tennessee Williams once took his daily swim.
Key West Butterfly and Nature Conservatory
With about 60 species of butterfly, an indoor waterfall and a tropical rainforest, this nature conservatory is one of the most popular attractions in Key West.
Things to do
Florida: Key West Overseas Highway App-Based Driving Audio Tour
$17
per traveler
78% of travellers recommend
Key West’s Old Town Treasures: A Self-Guided Audio Tour
$15
per adult
Florida Key West Self-Guided Walking Audio Tour Via App
$10
per traveler
An Audio Guide of Key West’s Journey From Village to Micro State
$12
per adult
Southernmost Key West History and Culture Small-Group Walking Tour
$40
per adult
Uptown - Upper Duval Hotel Deals
Southernmost Beach Resort and Guesthouses
1319 Duval Street, Key West, FL
$244 nightly
The price is $275 total per night from Aug 25 to Aug 26
$275 total
Aug 25 - Aug 26
Total includes taxes and fees
Stay at this 4-star beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the bar in our reviews. ...
8.6/10 Excellent! (2,656 reviews)
"Everything was perfect, except the washed up seaweed. They said a net broke, and it would be fixed eventually! Cannot wait to go back and utilize the beach area as well."
Reviewed on Jul 28, 2025
The Reach Key West, Curio Collection by Hilton
1435 Simonton Street, Key West, FL
$295 nightly
The price is $332 total per night from Aug 24 to Aug 25
$332 total
Aug 24 - Aug 25
Total includes taxes and fees
Stay at this 4-star beach resort in Key West. Enjoy a full-service spa, a private beach, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.4/10 Very Good! (1,025 reviews)
"Our room was not cleaned one day but it wasn’t a big deal. We requested more towels"
Reviewed on Jul 30, 2025
The Southernmost Inn - Adults Only
525 United Street, Key West, FL
$133 nightly
The price is $150 total per night from Jul 31 to Aug 1
$150 total
Jul 31 - Aug 1
Total includes taxes and fees
Stay at this 3-star hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.2/10 Very Good! (1,143 reviews)
"The staff was friendly and the amenities were excellent. Our room was spacious and comfortable, although a bit in disrepair. However, it did not change that we had an amazing stay!"
Reviewed on Jul 27, 2025
Southwinds Motel
1321 Simonton Street, Key West, FL
$134 nightly
The price is $151 total per night from Aug 11 to Aug 12
$151 total
Aug 11 - Aug 12
Total includes taxes and fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and a 24-hour front desk. Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,146 reviews)
"The property was great and everyone was friendly and they had music, food right across the street and around the coner."
Reviewed on Jul 28, 2025
Southernmost House
1400 Duval Street, Key West, FL
$266 nightly
The price is $299 total per night from Aug 13 to Aug 14
$299 total
Aug 13 - Aug 14
Total includes taxes and fees
Stay at this 4-star beach hotel in Key West. Enjoy free breakfast, free WiFi, and room service. Our guests praise the helpful staff and the property condition ...
9.2/10 Wonderful! (1,003 reviews)
"If you’re thinking of booking this place don’t think any further than this post and just do it! Staff was incredible, you can walk ANYWHERE. Very clean."
Reviewed on Jul 28, 2025
Orchid Key Inn - Adults Only
1004 Duval St, Key West, FL
$167 nightly
The price is $188 total per night from Aug 3 to Aug 4
$188 total
Aug 3 - Aug 4
Total includes taxes and fees
Stay at this 3.5-star hotel in Key West. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
9.8/10 Exceptional! (1,010 reviews)
"We have fallen in love with this place !!! Never had been here, came to Orchid Key for our anniversary weekend and are hooked. Local motel, quaint, clean, retro, friendly and amazing location. We have already rebooked ♥️"
Reviewed on Jul 28, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check Uptown - Upper Duval hotel availability
Other neighborhoods around Uptown - Upper Duval
Old Town Key West
4.5/5(226 area reviews)
Old Town, the historic heart of Key West, boasts a central business district and numerous tourist attractions. Explore the Key West Aquarium, Ernest Hemingway House, Mallory Square, and more in this vibrant area.
Downtown Key West
If you're spending some time in Downtown Key West, Duval Street and Ernest Hemingway Home and Museum are top sights worth seeing.
Bahama Village
5/5(38 area reviews)
Bahama Village is noteworthy for its historic sites, and you can make a stop at top attractions like Duval Street and Key West Lighthouse and Keeper's Quarters Museum.
Casa Marina
While visiting Casa Marina, you might make a stop by sights like Clarence S. Higgs Memorial Beach Park and Florida Keys Beaches.
Key West Historic District
4.5/5(4,033 area reviews)
Old Town Key West boasts a rich history with 2485 historic buildings, and is home to popular attractions like Ernest Hemingway House and Mallory Square. Enjoy the lively atmosphere in the central business district.
White Street Gallery District
When in White Street Gallery District, you can plan a visit to Duval Street and Clarence S. Higgs Memorial Beach Park, some noteworthy sights in the nearby area.
- Places of interest
- Uptown - Upper Duval Hotels by Star Rating
- Hotels in top Key West neighborhoods
- Uptown - Upper Duval Hotels by Brand
- Other vacations you might like
- Southernmost Point
- South Beach
- Key West Butterfly and Nature Conservatory
- Simonton Beach
- Duval Street
- Mallory Square
- Smathers Beach
- Ernest Hemingway Home and Museum
- Fort Zachary Taylor Historic State Park
- Stock Island Yacht Club & Marina
- Key West Golf Club
- Clarence S. Higgs Memorial Beach Park
- Boca Chica Nude Beach
- Harry S. Truman Little White House
- Florida Keys National Marine Sanctuary
- Key West Lighthouse and Keeper's Quarters Museum
- Florida Keys Eco - Discovery Center
- Key West Tropical Forest and Botanical Garden
- Audubon House and Tropical Gardens
- Mel Fisher Maritime Museum
- Boca Chica Beach
- Sugarloaf Beach
- Saint Mary Star of the Sea
- Key West Shipwreck Museum
- Robbie's
- Key West Cemetery
- Fort East Martello Museum and Gallery
Other Hotels near Uptown - Upper Duval, Key West
Uptown - Upper Duval Hotels by Brand
Expedia's Latest Trends
Hotels
- Hotels near Ernest Hemingway Home and Museum
- Old Town Key West Hotels
- 4 Star Hotels in Old Town Key West
- Hotels near Mallory Square
- 4 Star Hotels in Key West Historic District
- New Town Hotels
- Key West Historic District Hotels
- Hotels near Southernmost Point
- Hotels near Smathers Beach
- Hotels near Duval Street
- Geiger Key Hotels
Packages
- Saint Mary Star of the Sea
- Key West Lighthouse and Keeper's Quarters Museum
- Duval Street
- Clarence S. Higgs Memorial Beach Park
- Mallory Square
- Smathers Beach
- Southernmost Point
- Key West Butterfly and Nature Conservatory
- Key West Cemetery
- Ernest Hemingway Home and Museum
- Key West Shipwreck Museum
- Harry S. Truman Little White House
- South Beach