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A city skyline with a prominent arch bridge and a lit bridge over a calm river reflecting city lights.

Find all hotels by Red Roof Inn in O'Fallon, MO from $67

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    Check prices for these dates, December 13 – 14, 2026

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    Our top choices for O'Fallon Red Roof Inn

    1. Red Roof Inn St Louis - Westport/ Maryland Heights

    A hotel lobby with a reception desk, a red chair, a large window, and a wall-mounted TV.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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    Hotels recommended for families in O'Fallon

    Sleep Inn & Suites O'Fallon MO - Technology Drive

    A hotel room with a bed, a sofa, a coffee table, and wall art.

    Holiday Inn Express St. Louis West - O'Fallon by IHG

    A multi-story hotel with a mix of brick and siding exteriors, multiple windows, and a well-maintained lawn.

    Comfort Inn & Suites St. Louis - O'Fallon

    A hotel room with a large bed, a sofa, a desk, and two framed pictures on the wall.

    Staybridge Suites O'Fallon Chesterfield by IHG

    A hotel entrance with a stone facade, a wooden archway, and a paved walkway.

    Hilton Garden Inn St. Louis/O'Fallon MO

    A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

    Super 8 by Wyndham O'Fallon MO/St. Louis Area

    A hotel room with a bed, two bedside lamps, a chair, a desk with a telephone, and a large cityscape poster on the wall.

    Residence Inn by Marriott O'Fallon

    A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

    Centrally located, spacious 4 bdrm, on quiet Ct

    A modern kitchen with white cabinets, stainless steel appliances, and a wooden dining table.

    Top O'Fallon Hotel Reviews

    Holiday Inn Express & Suites St Peters by IHG

    A spacious lobby with a high ceiling, a reception desk, seating areas, and a staircase leading to an upper level.

    Hyatt Place St. Louis/Chesterfield

    A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

    Holiday Inn Express & Suites Wentzville St Louis West by IHG

    A spacious lobby with a reception desk, seating area, and a conference room.

    Residence Inn by Marriott St. Louis Chesterfield

    An outdoor patio with a built-in grill, seating area, and stone walls.

    Drury Plaza Hotel St. Louis Chesterfield

    A spacious lobby with a central round table, two sofas, and a chandelier.

    River Sirens Hotel

    A modern kitchen with a stainless steel refrigerator, a black countertop, and two stools.

    Drury Inn & Suites Southwest St. Louis

    A modern hotel lobby with a high ceiling, a central seating area with sofas and a coffee table, and a flat-screen TV mounted on the wall.

    Country Inn & Suites by Radisson, St. Charles Historic District

    A brick building with a sign reading "Country Inn & Suites."

    Pear Tree Inn St. Louis Airport

    A spacious lobby with modern seating, a reception desk, and large windows offering views of the parking area.

    Sleep Inn & Suites O'Fallon MO - Technology Drive

    A hotel room with a bed, a sofa, a coffee table, and wall art.

    Drury Plaza Hotel St. Louis Creve Coeur

    A hotel lobby with a hot tub, a pool, and outdoor seating.

    Hampton Inn St. Louis Wentzville

    A spacious hotel lobby with a long reception desk, multiple seating areas, and large windows allowing natural light.

    Hyatt Select St. Louis Airport

    A modern living room with a built-in fireplace, a large flat-screen TV, a unique hexagonal pendant light, and a patterned rug.

    Fairfield Inn & Suites Wentzville

    A modern living room with a stone fireplace, a large window, and a seating area with a coffee table.

    The Wildwood Hotel

    A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

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