Find all hotels by Marriott Hotels & Resorts in Upstate South Carolina, SC from $110

    Plan, book, stay with confidence
    bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    one key icon
    Treat yourself
    Save instantly and earn perks with One Key
    Learn about One Key
    today icon
    Change your mind
    Book hotels with free cancellation

Compare rooms and suites by Marriott Hotels & Resorts in Upstate South Carolina with rates, reviews, and availability. Most hotels are fully refundable.

Marriott Hotels & Resorts | Your Favorite Hotel Brand in Upstate South Carolina

Search for Marriott Hotels & Resorts hotel rooms in Upstate South Carolina using one of the methods below:

  • View our selection of 2491 Marriott Hotels & Resorts hotels
  • Use the map to find hotels in the Upstate South Carolina neighborhood you prefer
  • Use filters to see Marriott Hotels & Resorts hotels in a specific area of Upstate South Carolina, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Upstate South Carolina
  • Enter your travel dates to view the best deals on Upstate South Carolina Marriott Hotels & Resorts rooms - while they last

Recent reviews of Upstate South Carolina hotels
Expedia verified reviews

Comfort Inn Greenville - Haywood Mall

Comfort Inn Greenville - Haywood Mall

5/5 Excellent
Warm room great stay
"Clean and safe. Just had to turn the AC on once we arrived as it was iff in the room and was stuffy. All else was great."
A verified traveler stayed at Comfort Inn Greenville - Haywood Mall
Posted 2 days ago
Comfort Inn Greenville - Haywood Mall