Find hotels in Isle of Palms, Jacksonville from $54

When seeking a comfortable and convenient stay in Isle of Palms, the Residence Inn By Marriott Jacksonville - Mayo Clinic Area stands out with an exceptional score of 9.4. This hotel offers a delightful array of amenities, including a refreshing outdoor pool and a complimentary breakfast that caters to all tastes. Family-friendly features such as kitchenettes and grocery shopping services enhance your experience, allowing you to easily prepare meals for your loved ones while enjoying the convenience of hotel living.For families looking for spacious rooms, the TownePlace Suites by Marriott Jacksonville East is an excellent choice, rated at 9.2. The hotel boasts inviting amenities like a lovely outdoor pool and free breakfast, superb for starting your day off right. It also offers cribs at no extra charge and pet-friendly policies, making it a welcoming option for those traveling with furry friends. The nearby parking and electric car charging stations add to the convenience, ensuring a stress-free stay.Business travelers will appreciate the Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches, which holds a review score of 8.4. This hotel features well-equipped meeting rooms and a dedicated business center to accommodate any work-related needs. Guests enjoy complimentary WiFi and a fitness center to stay active during their travels, while the outdoor pool provides a relaxed environment to unwind after a day of meetings.

One Key™ - Expedia's free travel rewards program - gives you instant access to perks and Member Prices on Isle of Palms hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings.*OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.