A beach with palm trees, people relaxing on chairs, and colorful kayaks.

Find 4 Star Hotels in Florida Keys from $203

Check availability on Florida Keys 4 Star Hotels

Tonight
Oct 25 - Oct 26
Tomorrow
Oct 26 - Oct 27
Next weekend
Oct 30 - Nov 1
In two weeks
Nov 6 - Nov 8

Our top choices for Florida Keys 4-star hotels

A dining area with tables set for two, overlooking a beach with palm trees and a sunset view.
A spacious living room with large windows, comfortable seating, and decorative plants.
A beach with thatched umbrellas, palm trees, and blue lounge chairs.
An aerial view of a resort with a large pool, sun loungers, and palm trees.

1. Reefhouse Resort & Marina

Reefhouse Resort & Marina
Key Largo
United States
Manny
$259 nightly
$286 total
Oct 26 - Oct 27
Total with taxes and fees
Reefhouse Resort & Marina
A pool area with lounge chairs and umbrellas, surrounded by palm trees.
A pathway leading to a pool area with palm trees and a sunset view.
A spacious lobby with high ceilings, large windows, and a central coffee table surrounded by sofas and chairs.
An aerial view of a coastal resort with multiple white buildings, a clear turquoise sea, and lush greenery.

2. Hawks Cay Resort

Hawks Cay Resort
Marathon
United States
Antonio
$301 nightly
$337 total
Nov 15 - Nov 16
Total with taxes and fees
Hawks Cay Resort
A table with a glass pitcher, a glass with a slice of lime, and a plate with raspberries and a sprig of rosemary.
A modern kitchen with a large island, wooden cabinets, and a stainless steel refrigerator.
Restaurant
A spacious living room with a pool table, bookshelves, and comfortable seating.

3. Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton
Key Largo
United States
Alan
$294 nightly
$331 total
Nov 9 - Nov 10
Total with taxes and fees
Baker's Cay Resort Key Largo, Curio Collection by Hilton
An aerial view of a resort with two swimming pools surrounded by palm trees and sun loungers.
A paved pathway leading to a beach with palm trees and a view of the ocean.
A wooden pier leading to a beach with palm trees and a row of beach huts.
A bar area with a wooden counter, bar stools, and potted plants.

4. Islander Resort

Islander Resort
Matecumbe
United States
Bryan
$273 nightly
$308 total
Nov 15 - Nov 16
Total with taxes and fees
Islander Resort
A wooden deck with two lounge chairs, a table with two glasses of champagne and red roses, and a view of the beach and ocean.
A hotel room with a bed, a sofa, a coffee table, a desk with a lamp, and a view of the ocean.
A beach with palm trees, a dock, and lounge chairs.
A resort pool with palm trees, beach chairs, and umbrellas.

5. Amara Cay Resort

Amara Cay Resort
Matecumbe
United States
Ronald
$220 nightly
$248 total
Nov 15 - Nov 16
Total with taxes and fees
Amara Cay Resort
A balcony with wicker chairs, a small table with drinks, and a view of the beach and ocean.
A resort with a pool, beach, and ocean view.
A beach with palm trees, a clear blue sky, and a calm sea.
A coastal resort with a beach, a swimming pool, and multiple buildings.

6. Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
Islamorada
United States
Liosbel
$304 nightly
$342 total
Nov 1 - Nov 2
Total with taxes and fees
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
An aerial view of a resort with a large pool, palm trees, and a beach.
A restaurant with wooden tables and chairs, a bar area, and a view of the sea.
A beachside patio with lounge chairs, a table, and a view of the ocean.
A beach with clear water, a wooden pier, and lounge chairs under a tree.

7. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
Rock Harbor
United States
Jorge
$352 nightly
$396 total
Nov 9 - Nov 10
Total with taxes and fees
Playa Largo Resort & Spa, Autograph Collection
A swimming pool surrounded by palm trees and lounge chairs.
A wooden deck with blue chairs overlooking a beach with palm trees and the ocean.
A beach scene with a wooden deck, palm trees, and a gazebo-like structure.
An aerial view of a resort with a central swimming pool, surrounded by lush greenery and palm trees, with a view of the ocean.

8. Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort
Marathon
United Kingdom
Stuart
$264 nightly
$297 total
Nov 16 - Nov 17
Total with taxes and fees
Tranquility Bay Beachfront Hotel and Resort
A well-maintained lawn with outdoor seating and a hammock.
A bar area with a long counter, multiple stools, and a view of the marina with boats.
An outdoor dining area with round tables and chairs, string lights, and palm trees.
A pool area with lounge chairs, a lighthouse, and boats in the background.

9. Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
Marathon
United States
Rick
$180 nightly
$203 total
Nov 1 - Nov 2
Total with taxes and fees
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
A row of beachside cottages with colorful exteriors, each with a beach chair and umbrella.
A beach resort with palm trees, a thatched hut, and a purple building with a window.
A beach with colorful buildings, kayaks, and lounge chairs.
A resort with a pool surrounded by palm trees and a view of the ocean.

10. La Siesta Resort & Villas

La Siesta Resort & Villas
Matecumbe
United States
Brianne
$237 nightly
$266 total
Nov 15 - Nov 16
Total with taxes and fees
La Siesta Resort & Villas
A wooden deck with a pool and chairs overlooking a beach with palm trees.
A bar area with stools, a counter, and hanging lanterns.
A pool area with palm trees and a view of the ocean.
A hotel room with a sofa, a desk, a chair, a TV, and a balcony with curtains.

11. Grassy Flats Resort & Beach Club

Grassy Flats Resort & Beach Club
Marathon
United States
Tiffany
$237 nightly
$266 total
Nov 24 - Nov 25
Total with taxes and fees
Grassy Flats Resort & Beach Club
An aerial view of a resort with a central pool, multiple buildings, and a marina.
A modern living room with a sofa, chairs, a dining table, a TV, and a view of the ocean.
An aerial view of a resort island with a large building, a swimming pool, and a boat docked nearby.
A resort pool with palm trees and lounge chairs, surrounded by a beachfront.

12. Villas At Hawks Cay Resort

Villas At Hawks Cay Resort
Marathon
United States
Gabriela
$514 nightly
$578 total
Nov 16 - Nov 17
Total with taxes and fees
Villas At Hawks Cay Resort
A bedroom with a large bed, a ceiling fan, and a view of the outdoors through a sliding glass door.
A large hotel with a pool, multiple balconies, and palm trees.
A beachside wedding setup with wicker chairs and a white canopy, palm trees, and a sunset view.
A large, two-story hotel with a swimming pool in front.

13. Marlin Bay Resort & Marina

Marlin Bay Resort & Marina
Marathon
United States
Chardell
Marlin Bay Resort & Marina
A covered outdoor area with a wooden deck, white railings, and a view of the ocean.
A bedroom with a wooden bed, white bedding, and two bedside lamps.
A covered outdoor area with a pool, white railings, and blue chairs.
A bathroom with a granite countertop sink, two wall-mounted mirrors, and a shower area with a glass door.

14. Waterfront Luxury Villa

Waterfront Luxury Villa
Marathon Shores
Waterfront Luxury Villa
Interior
A modern kitchen with white cabinets, a microwave, and a dishwasher. There are three bar stools and a large window overlooking the ocean.
A beach with clear turquoise water, a wooden pier, and a rocky shoreline.
A modern kitchen with a central island, bar stools, and a ceiling fan.

15. Florida Keys Getaway w/ Stunning Ocean Views

Florida Keys Getaway w/ Stunning Ocean Views
Long Key
Florida Keys Getaway w/ Stunning Ocean Views
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Florida Keys.
Cheeca Lodge & Spa

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82 Islamorada FL
$226 nightly
$246 total
Nov 19 - Nov 20
Total with taxes and fees
Cheeca Lodge & Spa
Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

1 Knights Key Boulevard Marathon FL
$262 nightly
$295 total
Oct 26 - Oct 27
Total with taxes and fees
Isla Bella Beach Resort & Spa
The Islands of Islamorada

The Islands of Islamorada

82779 Old Hwy Islamorada FL
$534 nightly
$600 total
Oct 29 - Oct 30
Total with taxes and fees
The Islands of Islamorada
Still don't see what you're looking for?
See all properties in Florida Keys.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Florida Keys

Snorkel crystal-clear waters teeming with colorful fish, then feast on fresh-caught lobster at a laid-back waterfront shack. Drive the scenic Overseas Highway, stopping at Key West's Ernest Hemingway Home and Dry Tortugas National Park for island adventures.

See all hotels in Florida Keys
A beach with a historic brick fort, a small seaplane, and a group of people walking along the shore.

Top Florida Keys Hotel Reviews

Amara Cay Resort

Amara Cay Resort

10/10 Excellent
"We had a great stay here. The front desk staff greeted us with genuine warmth and made the check-in process completely seamless. The room was spotless, quiet, and very comfortable. The housekeeping team worked had to keep everything fresh and well-maintained. The bed was comfortable, and the bathroom had a great shower with quality toiletries. The range of amenities really stood out, from the reliable high-speed Wi-Fi and well-equipped fitness center to the breakfast options available in the morning. We would happily stay here again!"
Aaron 3-night trip
Posted 2 days ago
Amara Cay Resort

Find out more about Florida Keys

You'll see that you are in fine company with a visit to Florida Keys. Vacationers similar to you have made it one of our top most visited locals the past two years. However, "location, location, location" applies to more than just your vacation destination. When you want to make your next vacation extra special, it's all about where you start each new day.

Properties as Gorgeous as Florida Keys

Florida Keys saw thousands of tourists in 2016, and Expedia's comment section boast comments that highlight how fabulous these properties are. When you book a 4-star hotel you can breathe easy knowing that these properties aim to exceed your needs. You'll never have to search for to sustain your exercise routine, an energizing swim, or nice dinner during your stay, thanks to all that these hotels provide. They aim to make their facilities and grounds pleasing from the instant you step onto the property and with every step across their floors. Florida Keys has dozens of wonderful lodgings that make for the ideal holiday.

Rooms have been fashioned to keep you as comfortable as possible, with amenities like premium bedding, designer bathroom products, and in-room tea or coffee. So, sit back and decompress. Moreover, if you find that you're need of something else, you can trust the staff will do their best to ensure you continue to be pleased during your stay there. These accommodations are so lovely that you'll regret the day you have to return home.

Book a 4-Star Hotel in Florida Keys Today!

A trip to Florida Keys should be one that you'll recollect for years to come, and booking a 4-star hotel can help create memories that are fabulous. Book a 4-star hotel in Florida Keys soon, because several other people are too.

Frequently asked questions

What are the best 4-star hotels in Florida Keys?
If your Florida Keys adventure is in Key Largo, stay at Playa Largo Resort & Spa, Autograph Collection. With lots of amenities such as a firepit and a pillowtop mattress, it earns top marks from many Expedia travelers. Another sought-after option here is Bakers Cay Resort Key Largo, Curio Collection by Hilton. It's also rated 4 stars and features a steam room and a swimming pool.
How much does it cost to stay in a 4-star hotel in Florida Keys?
With Expedia's filter tool, scoring a terrific deal on a 4-star hotel in Florida Keys just got easier. Start by keying in your chosen travel dates and length of your stay. Then list the results by price and pick a property that best matches your style and budget.
  • Search for the lowest price from $246
What's the difference between 5-star and 4-star hotels in Florida Keys?
If you choose to stay at a 4-star hotel in Florida Keys, you'll typically find plenty of amenities to keep you relaxed, such as a restaurant, pool and gym. You can enjoy top-quality service and upmarket surroundings. Opt for a 5-star hotel and you'll have access to a few more perks — think concierge assistance, on-site spas and indulgent turndown services. You're likely to get more amenities and exclusive services at a 5-star getaway, but both are terrific options for luxury guests.

Explore a world of travel with Expedia