A beach with palm trees, people relaxing on chairs, and colorful kayaks.

Find 4 Star Hotels in Florida Keys from $214

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Check availability on Florida Keys 4 Star Hotels

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Oct 1 - Oct 2
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Oct 2 - Oct 3
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Oct 2 - Oct 4
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Oct 9 - Oct 11

Our top choices for Florida Keys 4-star hotels

A dining area with tables set for two, overlooking a beach with palm trees and a sunset view.
A poolside area with blue chairs and a thatched-roof structure.
A spacious bar area with high ceilings and large windows, offering views of the ocean.
A beach with thatched umbrellas, palm trees, and blue lounge chairs.

1. Reefhouse Resort & Marina

Reefhouse Resort & Marina
Key Largo
United States
Susan
$259 nightly
$286 total
Oct 4 - Oct 5
Total with taxes and fees
Reefhouse Resort & Marina
A wooden deck with a view of the ocean and a palm tree.
A spacious dining area with high ceilings, wicker furniture, and large windows.
A hammock on a sandy beach with a view of the sea and a tree overhead.
A coconut drink with a straw, a cherry, and a slice of fruit on a table by a pool with a waterfall and palm trees in the background.

2. Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton
Key Largo
United States
Micheal
$327 nightly
$368 total
Oct 12 - Oct 13
Total with taxes and fees
Baker's Cay Resort Key Largo, Curio Collection by Hilton
A pool area with lounge chairs and umbrellas, surrounded by palm trees.
A spacious lobby with high ceilings, large windows, and a central coffee table surrounded by sofas and chairs.
A modern living room with a balcony overlooking the sea, furnished with a sofa, chairs, and a dining table.
An aerial view of a coastal resort with multiple white buildings, a clear turquoise sea, and lush greenery.

3. Hawks Cay Resort

Hawks Cay Resort
Marathon
United States
Katherine
$255 nightly
$286 total
Oct 8 - Oct 9
Total with taxes and fees
Hawks Cay Resort
A wooden deck with two lounge chairs, a table with two glasses of champagne and red roses, and a view of the beach and ocean.
A beach with palm trees, a dock, and lounge chairs.
A hotel room with a bed, a sofa, a coffee table, a desk with a lamp, and a view of the ocean.
An aerial view of a resort with a swimming pool, palm trees, and a dock.

4. Amara Cay Resort

Amara Cay Resort
Matecumbe
United States
MICHAEL
$208 nightly
$234 total
Oct 5 - Oct 6
Total with taxes and fees
Amara Cay Resort
A balcony with wicker chairs, a small table with drinks, and a view of the beach and ocean.
A beach with palm trees, a clear blue sky, and a calm sea.
A coastal resort with a beach, a swimming pool, and multiple buildings.
A resort with a pool, beach, and ocean view.

5. Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
Islamorada
Canada
Eslita
$280 nightly
$315 total
Oct 18 - Oct 19
Total with taxes and fees
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
An aerial view of a resort with two swimming pools surrounded by palm trees and sun loungers.
A bar area with a wooden counter, bar stools, and potted plants.
A beachside patio with wooden furniture, a thatched roof, and a view of the ocean.
A paved pathway leading to a beach with palm trees and a view of the ocean.

6. Islander Resort

Islander Resort
Matecumbe
United States
Steven
$336 nightly
$378 total
Oct 20 - Oct 21
Total with taxes and fees
Islander Resort
An aerial view of a resort with a large pool, palm trees, and a beach.
A beachside patio with lounge chairs, a table, and a view of the ocean.
A pool area with lounge chairs and umbrellas, a clear sky, and palm trees.
A beach with clear water, a wooden pier, and lounge chairs under a tree.

7. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
Rock Harbor
United States
Tania
$312 nightly
$351 total
Oct 15 - Oct 16
Total with taxes and fees
Playa Largo Resort & Spa, Autograph Collection
A swimming pool surrounded by palm trees and lounge chairs.
A spacious living room with a wooden coffee table, a striped sofa, and a television on a wooden cabinet.
A wooden deck with blue chairs overlooking a beach with palm trees and the ocean.
A beach scene with a wooden deck, palm trees, and a gazebo-like structure.

8. Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort
Marathon
United Kingdom
Stuart
$264 nightly
$297 total
Oct 22 - Oct 23
Total with taxes and fees
Tranquility Bay Beachfront Hotel and Resort
A marina with boats docked, a lighthouse, and a resort with outdoor seating.
A bar area with a long counter, multiple bar stools, and a view of the marina with boats and palm trees.
A room with two sofas, a round coffee table, and a small side table with a vase.
An outdoor dining area with tables and chairs, a pool, and a view of the sea and boats.

9. Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
Marathon
United States
Rick
$197 nightly
$221 total
Oct 11 - Oct 12
Total with taxes and fees
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
A row of beachside cottages with colorful exteriors, each with a beach chair and umbrella.
A row of colorful beach huts with palm trees in the background.
A beach resort with palm trees, a thatched hut, and a purple building with a window.
A resort with a pool surrounded by palm trees and a view of the ocean.

10. La Siesta Resort & Villas

La Siesta Resort & Villas
Matecumbe
United States
Brianne
$252 nightly
$283 total
Nov 1 - Nov 2
Total with taxes and fees
La Siesta Resort & Villas
A wooden deck with a pool and chairs overlooking a beach with palm trees.
A beach with a wooden walkway leading to the water, palm trees, and a clear sky.
A pool area with palm trees and a view of the ocean.
A hotel room with a sofa, a desk, a chair, a TV, and a balcony with curtains.

11. Grassy Flats Resort & Beach Club

Grassy Flats Resort & Beach Club
Marathon
United States
Tiffany
$228 nightly
$257 total
Oct 5 - Oct 6
Total with taxes and fees
Grassy Flats Resort & Beach Club
A resort pool with palm trees and lounge chairs, surrounded by a beachfront.
A resort with a large pool surrounded by lounge chairs, a beach area, and a building with multiple floors.
A modern living room with a sofa, chairs, a dining table, a TV, and a view of the ocean.
A modern kitchen with white cabinetry, a stainless steel oven, and a large island with a bowl of fruit.

12. Villas At Hawks Cay Resort

Villas At Hawks Cay Resort
Marathon
United States
Gabriela
$604 nightly
$680 total
Oct 30 - Oct 31
Total with taxes and fees
Villas At Hawks Cay Resort
A large hotel with a pool, multiple balconies, and palm trees.
A beach with clear water and gentle waves.
A modern living room with a beige sectional sofa, large windows with wooden blinds, and a view of a marina and beach.
A beachside wedding setup with wicker chairs and a white canopy, palm trees, and a sunset view.

13. Marlin Bay Resort & Marina

Marlin Bay Resort & Marina
Marathon
United States
Chardell
Marlin Bay Resort & Marina
A covered outdoor area with a wooden deck, white railings, and a view of the ocean.
A spacious dining area with a long table, wicker chairs, and hanging wicker lamps.
A resort with multiple buildings, a large central pool, and a view of the ocean.
An aerial view of a coastal resort with multiple buildings, a marina, and clear blue waters.

14. Waterfront Luxury Villa

Waterfront Luxury Villa
Marathon Shores
Waterfront Luxury Villa
Interior
A beach with clear turquoise water, a wooden pier, and a rocky shoreline.
A modern kitchen with a central island, bar stools, and a ceiling fan.
A modern kitchen with white cabinets, a microwave, and a dishwasher. There are three bar stools and a large window overlooking the ocean.

15. Florida Keys Getaway w/ Stunning Ocean Views

Florida Keys Getaway w/ Stunning Ocean Views
Long Key
Florida Keys Getaway w/ Stunning Ocean Views
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Florida Keys.
Cheeca Lodge & Spa

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82 Islamorada FL
$190 nightly
$214 total
Oct 2 - Oct 3
Total with taxes and fees
Cheeca Lodge & Spa
Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

1 Knights Key Boulevard Marathon FL
$252 nightly
$283 total
Oct 4 - Oct 5
Total with taxes and fees
Isla Bella Beach Resort & Spa
The Islands of Islamorada

The Islands of Islamorada

82779 Old Hwy Islamorada FL
$534 nightly
$600 total
Oct 14 - Oct 15
Total with taxes and fees
The Islands of Islamorada
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Florida Keys

Snorkel crystal-clear waters teeming with colorful fish, then feast on fresh-caught lobster at a laid-back waterfront shack. Drive the scenic Overseas Highway, stopping at Key West's Ernest Hemingway Home and Dry Tortugas National Park for island adventures.

See all hotels in Florida Keys
A beach with palm trees, people relaxing on chairs, and colorful kayaks.

Top Florida Keys Hotel Reviews

Islander Resort

Islander Resort

10/10 Excellent
"It great amenities but pools are small."
Jaily 2-night trip
Posted 2 days ago
Islander Resort
Amara Cay Resort

Amara Cay Resort

8/10 Good
"This resort was absolutely beautiful!! The pool was amazing, a resort style pool. The resort had its own private beach area and a dock. Had plenty of seating everywhere, many cool sitting areas around the property. The only negative thing I could say is that the staff didn’t pick up trash and towels around the pool which seemed odd and it was off season so it wasn’t busy. It’s such a beautiful resort that I would think that would be a priority to keep it clean. Another cool thing is that they have a water taxi and shuttle to their 2 sister resorts which you can utilize all of those amenities as well. They also included bike rentals, paddle boards and kayaking on site which is convenient. You can also bring your private boat there and leave it at the dock for a fee. I would absolutely stay there again!"
Melissa 1-night trip
Posted 3 days ago
Amara Cay Resort
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

10/10 Excellent
"Ya’ll just need a microwave."
Nathalee 3-night trip
Posted 3 days ago
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Find out more about Florida Keys

You'll see that you are in fine company with a visit to Florida Keys. Vacationers similar to you have made it one of our top most visited locals the past two years. However, "location, location, location" applies to more than just your vacation destination. When you want to make your next vacation extra special, it's all about where you start each new day.

Properties as Gorgeous as Florida Keys

Florida Keys saw thousands of tourists in 2016, and Expedia's comment section boast comments that highlight how fabulous these properties are. When you book a 4-star hotel you can breathe easy knowing that these properties aim to exceed your needs. You'll never have to search for to sustain your exercise routine, an energizing swim, or nice dinner during your stay, thanks to all that these hotels provide. They aim to make their facilities and grounds pleasing from the instant you step onto the property and with every step across their floors. Florida Keys has dozens of wonderful lodgings that make for the ideal holiday.

Rooms have been fashioned to keep you as comfortable as possible, with amenities like premium bedding, designer bathroom products, and in-room tea or coffee. So, sit back and decompress. Moreover, if you find that you're need of something else, you can trust the staff will do their best to ensure you continue to be pleased during your stay there. These accommodations are so lovely that you'll regret the day you have to return home.

Book a 4-Star Hotel in Florida Keys Today!

A trip to Florida Keys should be one that you'll recollect for years to come, and booking a 4-star hotel can help create memories that are fabulous. Book a 4-star hotel in Florida Keys soon, because several other people are too.

Frequently asked questions

What are the best 4-star hotels in Florida Keys?
If your Florida Keys adventure is in Key Largo, stay at Playa Largo Resort & Spa, Autograph Collection. With lots of amenities such as a firepit and a pillowtop mattress, it earns top marks from many Expedia travelers. Another sought-after option here is Bakers Cay Resort Key Largo, Curio Collection by Hilton. It's also rated 4 stars and features a steam room and a swimming pool.
How much does it cost to stay in a 4-star hotel in Florida Keys?
With Expedia's filter tool, scoring a terrific deal on a 4-star hotel in Florida Keys just got easier. Start by keying in your chosen travel dates and length of your stay. Then list the results by price and pick a property that best matches your style and budget.
  • Search for the lowest price from $214
What's the difference between 5-star and 4-star hotels in Florida Keys?
If you choose to stay at a 4-star hotel in Florida Keys, you'll typically find plenty of amenities to keep you relaxed, such as a restaurant, pool and gym. You can enjoy top-quality service and upmarket surroundings. Opt for a 5-star hotel and you'll have access to a few more perks — think concierge assistance, on-site spas and indulgent turndown services. You're likely to get more amenities and exclusive services at a 5-star getaway, but both are terrific options for luxury guests.

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