Photo by Ryan Coleman

Find 5 Star Hotels in Sikeston, MO

Start date: Check-in selected.
To Date
End date: Check-out

Check availability on Sikeston 5 Star Hotels

Compare Sikeston 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Sikeston.
Davie School Inn

Davie School Inn

300 Freeman St, Anna, IL
Get rates
10/10 Exceptional! (51 reviews)
Still don't see what you're looking for?
See all properties in Sikeston.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Sikeston and related destinations

Home to Lambert's Café, the 'Home of Throwed Rolls,' where servers toss fresh bread across the room to hungry diners. Visit the historic Sikeston Depot or catch the annual rodeo where professional cowboys compete in thrilling events each August.

See all hotels in Sikeston
The best restaurant I have EVER been to! Hands down!!!
Photo by Ryan Coleman
Open Photo by Ryan Coleman

Top Sikeston Hotel Reviews

Find out more about Sikeston

Find out more about Sikeston

You enjoy the finer things in life, both at home and on vacation. Treat your every whim on your upcoming sabbatical. There's no reason to delay a getaway to Sikeston any longer. You'll join the multitudes of vacationers who have made Sikeston so fashionable recently. We should also mention, the hotels in this area are known for customer service, so you know you'll be looked after during your getaway. Don't wait any longer. Our 5-star hotels in Sikeston are the perfect places to relax in during your next chunk of time off.

Get a Great Deal on 5-Star Hotels in Sikeston

Don't be afraid to be pampered during your trip. Exceptional customer care, luxurious bedding, and deeply relaxing spa offerings are all on offer. You're sure to find exactly the accommodation you need. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What creature comforts do you want in your lodging? A concierge to help you make reservations at that outstanding restaurant? A full-body massage to help your cares fall away? Beautiful furniture, piping hot coffees, and even spectacular views...these hotels have it all.

Ready for experiences outside your hotel room? We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Sikeston are waiting for you to rest up after an exciting day. Ready to learn more? Then check out the many reviews left by previous guests -- you can take their word for it!

Make Your Escape

The results are in, and Sikeston 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. It's time to indulge yourself -- Expedia can help you land a great deal on accommodation. Choose one of the 5-star hotels in Sikeston today and settle down in complete comfort when you're ready.

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Sikeston?
How much you pay for a 5-star hotel in Sikeston depends on factors such as when you want to go and the length of your trip. Our insider tip for landing the best deal? Use our pricing filters to check out the available accommodations for your chosen dates.

  • Search for the lowest price per night

What makes a hotel 5 stars in Sikeston?
From high-end dining venues and all-day gyms to swimming pools and deluxe bedding, the 5-star experience in Sikeston is all about luxury and relaxation. But it calls for more than just upscale amenities to get a 5-star rating. Stays also have to deliver remarkable guest-centric services like in-room massages, laundry and dry cleaning and room service any time night or day.
Are there any 5-star all-inclusive resorts in Sikeston?
Find a luxury getaway that includes your lodging, meals, bar and entertainment in Sikeston with our handy filter tool. Search for properties with a 5-star rating and click on the "All inclusive" filter. Be sure to check what's included in the purchase price. That way, you're ready to take advantage of the many perks on offer when you arrive.

Explore a world of travel with Expedia

Explore a world of travel with Expedia