A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Apartments in Defiance for Rent

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Check prices for these dates

In two weeks
Oct 2 - Oct 4
In two months
Nov 13 - Nov 15
In three months
Dec 11 - Dec 13
In four months
Jan 8 - Jan 10

Our top choices for Defiance apartments

Pool

1. Great for Business Travelers! Pool + Gym

Great for Business Travelers! Pool + Gym
O'Fallon
$160 nightly
The price is $185
Oct 4 - Oct 5
Total with taxes and fees
Great for Business Travelers! Pool + Gym
Interior

2. Stylish1BRStudioCleanQuietandCozy

Stylish1BRStudioCleanQuietandCozy
Saint Charles
10.0 out of 10, Exceptional, (3 reviews)
"Room was very clean with little to no issues at all. Host was super easy to work with and get information from. This spot is within 15-20minutes OR LESS to anything you’d need to do in the ofallon and surrounding areas. I’d book it again if I needed to."
United States
Mike S.
$224 nightly
The price is $250
Sep 17 - Sep 18
Total with taxes and fees
Stylish1BRStudioCleanQuietandCozy
Exterior

3. 2nd Street -Deck Suite (back entrance)

2nd Street -Deck Suite (back entrance)
Washington
10.0 out of 10, Exceptional, (9 reviews)
"Great comfortable mini apartment style."
United States
Ozzy
$166 nightly
The price is $186
Sep 23 - Sep 24
Total with taxes and fees
2nd Street -Deck Suite (back entrance)
Property grounds

4. Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues

Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues
Ballwin
7.8 out of 10, Good, (23 reviews)
"Rooms were clean and everything we needed for our stay."
United States
Keith K.
$138 nightly
The price is $147
Sep 20 - Sep 21
Total with taxes and fees
Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues
Exterior detail

5. 2nd Street Loft - Riverview

2nd Street Loft - Riverview
Washington
10.0 out of 10, Exceptional, (17 reviews)
"Beautiful loft! Great location, walking distance to several restaurants on the river . "
United States
Christy D.
$156 nightly
The price is $175
Sep 17 - Sep 18
Total with taxes and fees
2nd Street Loft - Riverview
Interior

6. Otto's Third | River View Loft by Borgia Church

Otto's Third | River View Loft by Borgia Church
Washington
$347 nightly
The price is $389
Sep 17 - Sep 18
Total with taxes and fees
Otto's Third | River View Loft by Borgia Church
Living area

7. Family Friendly w/ Game Room in Quiet Neighborhood

Family Friendly w/ Game Room in Quiet Neighborhood
Wentzville
10.0 out of 10, Exceptional, (2 reviews)
"Nice house for our week in Lake St. Louis area. Accurate description of what you are getting and clean house. Would stay again if we are back in the area"
United States
Campbell W.
$483 nightly
The price is $483
Sep 20 - Sep 21
Total with taxes and fees
Family Friendly w/ Game Room in Quiet Neighborhood
Room

8. 1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed

1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed
Westport
9.6 out of 10, Exceptional, (41 reviews)
"Great spot!"
United States
Anonymous traveler
$59 nightly
The price is $68
Oct 1 - Oct 2
Total with taxes and fees
1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed
Interior

9. Dog-Friendly 2BR | Walk to Main Street

Dog-Friendly 2BR | Walk to Main Street
Saint Charles
8.0 out of 10, Very good, (5 reviews)
"The best price-value ratio. Quiet neighborhood, close to the city center."
United States
Tamas P.
$248 nightly
The price is $274
Sep 23 - Sep 24
Total with taxes and fees
Dog-Friendly 2BR | Walk to Main Street
Exterior

10. Historic Main Street Studio | Dog-Friendly

Historic Main Street Studio | Dog-Friendly
St. Charles Historic District
9.2 out of 10, Wonderful, (38 reviews)
"Had a wonderful stay. It was a Monday night so parking was very easy and the room was clean and comfortable. I would recommend this place 100% "
United States
Sarah C.
$205 nightly
The price is $226
Sep 20 - Sep 21
Total with taxes and fees
Historic Main Street Studio | Dog-Friendly
Living area

11. 6th street 101 - Walk to Main St

6th street 101 - Walk to Main St
St. Charles Historic District
10.0 out of 10, Exceptional, (3 reviews)
"Excellent"
United States
Scott N.
$244 nightly
The price is $274
Sep 17 - Sep 18
Total with taxes and fees
6th street 101 - Walk to Main St
Living area

12. Historic Main St 2BR | Steps to Shops

Historic Main St 2BR | Steps to Shops
St. Charles Historic District
9.4 out of 10, Exceptional, (42 reviews)
"This property has a nice renovation while keeping a lot of its original character. Very clean and comfortable beds as well. The location couldn’t be better! We really enjoyed our stay."
United States
William O.
$359 nightly
The price is $398
Sep 20 - Sep 21
Total with taxes and fees
Historic Main St 2BR | Steps to Shops
Interior

13. The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (190 reviews)
"It was great! Clean and great communication with host."
United States
Natalie H.
$259 nightly
The price is $277
Sep 20 - Sep 21
Total with taxes and fees
The Lofts of North Main Street
Living area

14. 1st Capitol Mansion - Suite 401

1st Capitol Mansion - Suite 401
St. Charles Historic District
7.4 out of 10, Good, (9 reviews)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
United States
Emily L.
$215 nightly
The price is $241
Sep 17 - Sep 18
Total with taxes and fees
1st Capitol Mansion - Suite 401
Living area

15. Prime Loft of Main Street

Prime Loft of Main Street
St. Charles Historic District
9.8 out of 10, Exceptional, (117 reviews)
"Host was great. The cutest place in the perfect spot! "
United States
Anonymous traveler
$259 nightly
The price is $277
Sep 20 - Sep 21
Total with taxes and fees
Prime Loft of Main Street
Exterior

16. Main Street 2BR - Walk to Dining & Riverfront

Main Street 2BR - Walk to Dining & Riverfront
St. Charles Historic District
9.4 out of 10, Exceptional, (3 reviews)
"This is our new favorite property in St. Charles. Between the location, size of the space and the designated parking spot, we will definitely be staying here again!"
United States
Billi G.
$297 nightly
The price is $327
Sep 20 - Sep 21
Total with taxes and fees
Main Street 2BR - Walk to Dining & Riverfront
Room

17. Walk to Main | Pet-Friendly Yard & Workspace

Walk to Main | Pet-Friendly Yard & Workspace
St. Charles Historic District
10.0 out of 10, Exceptional, (11 reviews)
"Very close to downtown St. Charles and the Kati Trail. The home is cute and bed is comfortable. Easy check in process and fenced in back yard was nice to have."
United States
Jessica S.
$251 nightly
The price is $276
Sep 23 - Sep 24
Total with taxes and fees
Walk to Main | Pet-Friendly Yard & Workspace
Private kitchen

18. Historic Main St. Customs House Upstairs Apartment

Historic Main St. Customs House Upstairs Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (39 reviews)
"Lovely place to stay!"
United States
Margaret A.
$341 nightly
The price is $376
Sep 28 - Sep 29
Total with taxes and fees
Historic Main St. Customs House Upstairs Apartment
Interior

19. Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (68 reviews)
"Lovely accommodations, very clean, well equipped, great location. "
United States
Emily B.
$259 nightly
The price is $277
Sep 20 - Sep 21
Total with taxes and fees
Amazing Renovated Historic Loft on Main Street
Living area

20. Historic Main St 1BR | Walk to Dining & Nightlife

Historic Main St 1BR | Walk to Dining & Nightlife
St. Charles Historic District
9.2 out of 10, Wonderful, (24 reviews)
"Great place, very fun. I’d stay again for sure. "
United States
Michael C.
$243 nightly
The price is $267
Sep 20 - Sep 21
Total with taxes and fees
Historic Main St 1BR | Walk to Dining & Nightlife
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

10/10 Excellent
"We only spent one night but the room was gorgeous the checking was easy and the employees were great. The food at the restaurants were also good and of course we did enjoy our time at the casino"
John 1-night trip
Posted 6 hours ago
Ameristar Casino Resort and Spa

Find out more about Defiance

Defiance Apartments information

Number of reviews
609
Accommodation
113 Apartments
Lowest Price
$68
Highest Price
$483

Frequently asked questions

What's it like to stay at an apartment in Defiance?
You'll find 10 apartments to choose from in Defiance for your stay.
Why choose an apartment versus a traditional hotel?
Often more spacious than a traditional hotel room, an apartment includes a kitchen for convenient home-cooked meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want something in a quieter part of town.
What's a favorite apartment for a stay in Defiance?
Here are some of the top apartments in the area: 2 Queen Beds | Non-Smoking, Kitchen: Situated in Maryland Heights, 18.7 mi/30.1 km from the heart of Defiance. Includes free WiFi and Smart TVs. 1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed: Located 18.7 mi/30.1 km away in Maryland Heights. Free WiFi and Smart TVs are included. The Lofts of North Main Street: Located in St. Charles, 19.2 mi/30.8 km away. Includes free WiFi, sofa beds, and Smart TVs. Access to onsite laundry facilities is available on site. Driftwood Den | Boho 2BR | Dog-Friendly: 19 mi/30.6 km away in St. Charles. Amenities include free WiFi. Historic Main Street Studio | Dog-Friendly: It's situated in St. Charles, 19.1 mi/30.8 km from Defiance.
How many apartments will I be able to find in Defiance?
Expedia has 10 apartments to book in Defiance.
What can I expect from the weather during my trip to Defiance?
Weather is only one factor, but it can really affect your travel plans, especially if you're planning an extended stay in Defiance. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.
What are the must-see places to visit in Defiance?
August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Yellow Farmhouse Winery and Chandler Hill Vineyards are other places worth a visit.
What's the best way to get to and around Defiance?
Knowing a bit about the transportation options can save you time when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. You can also search for flights into St. Louis Lambert Intl. Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to explore around the area, you may want a rental car for your journey.

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