A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Apartments in Defiance for Rent

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Our top choices for Defiance apartments

1. Great for Business Travelers! Pool + Gym

Great for Business Travelers! Pool + Gym
O'Fallon
$160 nightly
The price is $185
Sep 6 - Sep 7
Total with taxes and fees
Great for Business Travelers! Pool + Gym

2. Stylish1BRStudioCleanQuietandCozy

Stylish1BRStudioCleanQuietandCozy
Saint Charles
10.0 out of 10, Exceptional, (3 reviews)
"Room was very clean with little to no issues at all. Host was super easy to work with and get information from. This spot is within 15-20minutes OR LESS to anything you’d need to do in the ofallon and surrounding areas. I’d book it again if I needed to."
United States
Mike S.
$261 nightly
The price is $290
Sep 1 - Sep 2
Total with taxes and fees
Stylish1BRStudioCleanQuietandCozy

3. 2nd Street -Deck Suite (back entrance)

2nd Street -Deck Suite (back entrance)
Washington
10.0 out of 10, Exceptional, (9 reviews)
"Great comfortable mini apartment style."
United States
Ozzy
$157 nightly
The price is $176
Sep 1 - Sep 2
Total with taxes and fees
2nd Street -Deck Suite (back entrance)

4. Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues

Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues
Ballwin
7.8 out of 10, Good, (23 reviews)
"Nice and roomy place! The shower was a little messy when we went but everything else wemt well"
United States
alex h.
$145 nightly
The price is $155
Sep 20 - Sep 21
Total with taxes and fees
Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues

5. 2nd Street Loft - Riverview

2nd Street Loft - Riverview
Washington
10.0 out of 10, Exceptional, (15 reviews)
"Beautiful loft! Great location, walking distance to several restaurants on the river . "
United States
Christy D.
$155 nightly
The price is $174
Sep 1 - Sep 2
Total with taxes and fees
2nd Street Loft - Riverview

6. Family Friendly w/ Game Room in Quiet Neighborhood

Family Friendly w/ Game Room in Quiet Neighborhood
Wentzville
10.0 out of 10, Exceptional, (2 reviews)
"Nice house for our week in Lake St. Louis area. Accurate description of what you are getting and clean house. Would stay again if we are back in the area"
United States
Campbell W.
$474 nightly
The price is $474
Sep 3 - Sep 4
Total with taxes and fees
Family Friendly w/ Game Room in Quiet Neighborhood

7. 2 Queen Beds | Non-Smoking, Kitchen

2 Queen Beds | Non-Smoking, Kitchen
Westport
9.8 out of 10, Exceptional, (38 reviews)
"Fantastic place!"
United States
Anonymous traveler
$68 nightly
The price is $79
Sep 17 - Sep 18
Total with taxes and fees
2 Queen Beds | Non-Smoking, Kitchen

8. Dog-Friendly 2BR | Walk to Main Street

Dog-Friendly 2BR | Walk to Main Street
Saint Charles
8.0 out of 10, Very Good, (5 reviews)
"The best price-value ratio. Quiet neighborhood, close to the city center."
United States
Tamas P.
$251 nightly
The price is $277
Sep 3 - Sep 4
Total with taxes and fees
Dog-Friendly 2BR | Walk to Main Street

9. Historic Main Street Studio | Dog-Friendly

Historic Main Street Studio | Dog-Friendly
St. Charles Historic District
9.2 out of 10, Wonderful, (37 reviews)
"Had a wonderful stay. It was a Monday night so parking was very easy and the room was clean and comfortable. I would recommend this place 100% "
United States
Sarah C.
$187 nightly
The price is $206
Sep 6 - Sep 7
Total with taxes and fees
Historic Main Street Studio | Dog-Friendly

10. Pet-Friendly Duplex | Historic Main

Pet-Friendly Duplex | Historic Main
St. Charles Historic District
10.0 out of 10, Exceptional, (25 reviews)
"Great location"
United States
todd p.
$231 nightly
The price is $254
Sep 3 - Sep 4
Total with taxes and fees
Pet-Friendly Duplex | Historic Main

11. Historic Main St 2BR | Steps to Shops

Historic Main St 2BR | Steps to Shops
St. Charles Historic District
9.4 out of 10, Exceptional, (41 reviews)
"This property has a nice renovation while keeping a lot of its original character. Very clean and comfortable beds as well. The location couldn’t be better! We really enjoyed our stay."
United States
William O.
$347 nightly
The price is $382
Sep 6 - Sep 7
Total with taxes and fees
Historic Main St 2BR | Steps to Shops

12. Driftwood Den | Boho 2BR | Dog-Friendly

Driftwood Den | Boho 2BR | Dog-Friendly
St. Charles Historic District
10.0 out of 10, Exceptional, (6 reviews)
"Loved our stay here. Clean, comfortable, convenient. Couldn’t have been easier, in all aspects. Already plan to stay there again!!!"
United States
Kourtney S.
$307 nightly
The price is $338
Sep 7 - Sep 8
Total with taxes and fees
Driftwood Den | Boho 2BR | Dog-Friendly

13. Walk to Main | Pet-Friendly Yard & Workspace

Walk to Main | Pet-Friendly Yard & Workspace
St. Charles Historic District
9.8 out of 10, Exceptional, (10 reviews)
"I will stay here again. It was a great location for my visit. Lots of room and amenities. Highly recommend this location if you are visiting the St Louis area. Barely a mile to get to Hwy 70, so easy access to St Louis, St Peter's, Wentzville etc. Maybe two blocks from Historic St Charles and Ameristar Casino."
United States
Karen M.
$254 nightly
The price is $279
Sep 7 - Sep 8
Total with taxes and fees
Walk to Main | Pet-Friendly Yard & Workspace

14. The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (187 reviews)
"It was great! Clean and great communication with host."
United States
Natalie H.
$246 nightly
The price is $263
Sep 3 - Sep 4
Total with taxes and fees
The Lofts of North Main Street

15. Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (68 reviews)
"Lovely accommodations, very clean, well equipped, great location. "
United States
Emily B.
$246 nightly
The price is $263
Sep 1 - Sep 2
Total with taxes and fees
Amazing Renovated Historic Loft on Main Street

16. Prime Loft of Main Street

Prime Loft of Main Street
St. Charles Historic District
9.8 out of 10, Exceptional, (116 reviews)
"Host was great. The cutest place in the perfect spot! "
United States
Anonymous traveler
$246 nightly
The price is $263
Sep 1 - Sep 2
Total with taxes and fees
Prime Loft of Main Street

17. Historic Main St 1BR | Walk to Dining & Nightlife

Historic Main St 1BR | Walk to Dining & Nightlife
St. Charles Historic District
9.2 out of 10, Wonderful, (23 reviews)
"Great place, very fun. I’d stay again for sure. "
United States
Michael C.
$246 nightly
The price is $270
Sep 3 - Sep 4
Total with taxes and fees
Historic Main St 1BR | Walk to Dining & Nightlife

18. 1st Capitol Mansion - Suite 401

1st Capitol Mansion - Suite 401
St. Charles Historic District
7.4 out of 10, Good, (9 reviews)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
United States
Emily L.
$273 nightly
The price is $306
Sep 1 - Sep 2
Total with taxes and fees
1st Capitol Mansion - Suite 401

19. 6th street 101 - Walk to Main St

6th street 101 - Walk to Main St
St. Charles Historic District
10.0 out of 10, Exceptional, (3 reviews)
"Excellent"
United States
Scott N.
$256 nightly
The price is $287
Sep 1 - Sep 2
Total with taxes and fees
6th street 101 - Walk to Main St

20. 1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed

1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed
Westport
9.6 out of 10, Exceptional, (41 reviews)
"Great spot!"
United States
Anonymous traveler
$68 nightly
The price is $79
Sep 17 - Sep 18
Total with taxes and fees
1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Find out more about Defiance

Defiance Apartments information

Number of reviews
646
Accommodation
113 Apartments
Lowest Price
$79
Highest Price
$474

Frequently asked questions

What's it like to stay at an apartment in Defiance?
You'll find 10 apartments to choose from in Defiance for your stay.
Why choose an apartment versus a traditional hotel?
Often more spacious than a traditional hotel room, an apartment includes a kitchen for convenient home-cooked meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want something in a quieter part of town.
What's a favorite apartment for a stay in Defiance?
Here are some of the top apartments in the area: The Lofts of North Main Street: Located in St. Charles, 19.2 mi/30.8 km from the heart of Defiance. Includes free WiFi, sofa beds, and Smart TVs. Access to onsite laundry facilities is available on site. 2 Queen Beds | Non-Smoking, Kitchen: Located 18.7 mi/30.1 km away in Maryland Heights. Free WiFi and Smart TVs are included. Prime Loft of Main Street: Located in St. Charles, 19.2 mi/30.9 km away. Includes free WiFi, sofa beds, and Smart TVs. Access to onsite laundry facilities is available on site. Historic Main St 1BR | Walk to Dining & Nightlife: 19.1 mi/30.7 km away in St. Charles. Amenities include separate dining areas. The Rustic Revival | Charming 2BR Retreat: It's located in St. Charles, 19 mi/30.6 km from Defiance. Includes free WiFi.
How many apartments will I be able to find in Defiance?
Expedia has 10 apartments to book in Defiance.
What can I expect from the weather during my trip to Defiance?
Weather is only one factor, but it can really affect your travel plans, especially if you're planning an extended stay in Defiance. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.
What are the must-see places to visit in Defiance?
August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Yellow Farmhouse Winery and Chandler Hill Vineyards are other places worth a visit.
What's the best way to get to and around Defiance?
Knowing a bit about the transportation options can save you time when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. You can also search for flights into St. Louis Lambert Intl. Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to explore around the area, you may want a rental car for your journey.

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