A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Apartments in Defiance for Rent

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Check prices for these dates

In two weeks
Sep 11 - Sep 13
In two months
Oct 23 - Oct 25
In three months
Nov 20 - Nov 22
In four months
Dec 18 - Dec 20

Our top choices for Defiance apartments

A hotel lobby with a staircase, a reception desk, and a seating area.

1. 2 Queen Beds | Mobil Access Tub Nsmk Kitchen

2 Queen Beds | Mobil Access Tub Nsmk Kitchen
Westport
9.8 out of 10, Exceptional, (45 reviews)
"Great place to stay!"
United States
Anonymous traveler
$66 nightly
The price is $76
Aug 31 - Sep 1
Total with taxes and fees
2 Queen Beds | Mobil Access Tub Nsmk Kitchen
A hallway with a floral mirror and neon 'love' sign.

2. Family Home: Game Room & Huge Yard, Airport

Family Home: Game Room & Huge Yard, Airport
Maryland Heights
10.0 out of 10, Exceptional, (1 review)
"Very nice"
United States
Steven S.
$463 nightly
The price is $463
Sep 7 - Sep 8
Total with taxes and fees
Family Home: Game Room & Huge Yard, Airport
A modern kitchen with white cabinetry, a red brick accent wall, hanging pendant lights, and a central island.

3. Quiet Neighborhood-Near Eats & Shops-Airport!

Quiet Neighborhood-Near Eats & Shops-Airport!
Brookside
10.0 out of 10, Exceptional, (2 reviews)
"This was an awesome place for 9 of us- plenty of rooms to sleep and bathrooms. The renter was very kind"
United States
Janet
$471 nightly
The price is $471
Aug 30 - Aug 31
Total with taxes and fees
Quiet Neighborhood-Near Eats & Shops-Airport!
A row of multi-story buildings with commercial storefronts, including a cafe and a restaurant.

4. Historic Main Street Studio | Dog-Friendly

Historic Main Street Studio | Dog-Friendly
St. Charles Historic District
9.2 out of 10, Wonderful, (37 reviews)
"Had a wonderful stay. It was a Monday night so parking was very easy and the room was clean and comfortable. I would recommend this place 100% "
United States
Sarah C.
$184 nightly
The price is $203
Aug 31 - Sep 1
Total with taxes and fees
Historic Main Street Studio | Dog-Friendly
A hotel lobby with a staircase, a reception desk, and a chandelier.

5. 2 Queen Beds | Non-Smoking, Kitchen

2 Queen Beds | Non-Smoking, Kitchen
Westport
9.8 out of 10, Exceptional, (38 reviews)
"Fantastic place!"
United States
Anonymous traveler
$66 nightly
The price is $76
Aug 31 - Sep 1
Total with taxes and fees
2 Queen Beds | Non-Smoking, Kitchen
A modern living room with a brick fireplace, wooden flooring, a sofa, a coffee table, and a dartboard.

6. 3BR Family+Game Retreat 8 min STL Airport/Westport

3BR Family+Game Retreat 8 min STL Airport/Westport
Maryland Heights
8.8 out of 10, Excellent, (11 reviews)
"Great stay! We had everything we needed and the communication was perfect!"
United States
Melodie B.
$430 nightly
The price is $430
Aug 30 - Aug 31
Total with taxes and fees
3BR Family+Game Retreat 8 min STL Airport/Westport
A staircase with white railings and a ceiling fan.

7. Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (68 reviews)
"Lovely accommodations, very clean, well equipped, great location. "
United States
Emily B.
$246 nightly
The price is $263
Aug 30 - Aug 31
Total with taxes and fees
Amazing Renovated Historic Loft on Main Street
A hotel room with a bed, a desk, a chair, a lamp, and a telephone.

8. 1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed

1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed
Westport
9.6 out of 10, Exceptional, (41 reviews)
"Great spot!"
United States
Anonymous traveler
$66 nightly
The price is $76
Aug 31 - Sep 1
Total with taxes and fees
1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed

9. Studio | Lovely Suite Close to Edward Jones!

Studio | Lovely Suite Close to Edward Jones!
Westport
$193 nightly
The price is $220
Aug 30 - Aug 31
Total with taxes and fees
Studio | Lovely Suite Close to Edward Jones!
A cozy living room with a brick wall, a white sofa with colorful cushions, a small black table, and a potted plant.

10. Prime Loft of Main Street

Prime Loft of Main Street
St. Charles Historic District
9.8 out of 10, Exceptional, (116 reviews)
"Host was great. The cutest place in the perfect spot! "
United States
Anonymous traveler
$246 nightly
The price is $263
Aug 30 - Aug 31
Total with taxes and fees
Prime Loft of Main Street
A set of stone steps leading to a garage with a car parked inside.

11. Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues

Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues
Ballwin
7.8 out of 10, Good, (23 reviews)
"Nice and roomy place! The shower was a little messy when we went but everything else wemt well"
United States
alex h.
$145 nightly
The price is $155
Sep 20 - Sep 21
Total with taxes and fees
Studio, sleeps 4, patio, short drive to Ski Resort, Six Flags & concert venues
A modern living room with a spiral staircase, a brick wall, a dining area, and a gray sofa.

12. Historic Main St 2BR | Steps to Shops

Historic Main St 2BR | Steps to Shops
St. Charles Historic District
9.4 out of 10, Exceptional, (41 reviews)
"This property has a nice renovation while keeping a lot of its original character. Very clean and comfortable beds as well. The location couldn’t be better! We really enjoyed our stay."
United States
William O.
$348 nightly
The price is $383
Aug 31 - Sep 1
Total with taxes and fees
Historic Main St 2BR | Steps to Shops
A spacious living area with a wooden floor, a dining table with chairs, a flat-screen TV mounted on the wall, and a kitchen area with modern appliances.

13. The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (187 reviews)
"It was great! Clean and great communication with host."
United States
Natalie H.
$246 nightly
The price is $263
Aug 30 - Aug 31
Total with taxes and fees
The Lofts of North Main Street
A modern kitchen with white cabinets, a built-in microwave, a stove, and a window providing natural light.

14. Pet-Friendly Duplex | Historic Main

Pet-Friendly Duplex | Historic Main
St. Charles Historic District
10.0 out of 10, Exceptional, (25 reviews)
"Great location"
United States
todd p.
$230 nightly
The price is $253
Sep 1 - Sep 2
Total with taxes and fees
Pet-Friendly Duplex | Historic Main
A wooden deck with a green railing, brick buildings in the background, and a clear blue sky.

15. Driftwood Den | Boho 2BR | Dog-Friendly

Driftwood Den | Boho 2BR | Dog-Friendly
St. Charles Historic District
10.0 out of 10, Exceptional, (5 reviews)
"Loved our stay here. Clean, comfortable, convenient. Couldn’t have been easier, in all aspects. Already plan to stay there again!!!"
United States
Kourtney S.
$273 nightly
The price is $301
Aug 31 - Sep 1
Total with taxes and fees
Driftwood Den | Boho 2BR | Dog-Friendly
A hallway with a door, two potted plants, a doormat, and a view of a brick building through large windows.

16. Dog-Friendly 2BR | Walk to Main Street

Dog-Friendly 2BR | Walk to Main Street
Saint Charles
8.0 out of 10, Very Good, (5 reviews)
"The best price-value ratio. Quiet neighborhood, close to the city center."
United States
Tamas P.
$251 nightly
The price is $277
Aug 31 - Sep 1
Total with taxes and fees
Dog-Friendly 2BR | Walk to Main Street
A cozy living room with a brick wall, large windows, a pink sofa, a small table, and a folding chair.

17. Historic Main St 1BR | Walk to Dining & Nightlife

Historic Main St 1BR | Walk to Dining & Nightlife
St. Charles Historic District
9.0 out of 10, Wonderful, (22 reviews)
"Great place, very fun. I’d stay again for sure. "
United States
Michael C.
$246 nightly
The price is $270
Aug 31 - Sep 1
Total with taxes and fees
Historic Main St 1BR | Walk to Dining & Nightlife
A row of three-story buildings with a mix of brick and stone facades, large windows, and a brick-paved street.

18. The Oak & Aura Retreat

The Oak & Aura Retreat
St. Charles Historic District
8.0 out of 10, Very Good, (2 reviews)
"Great location, and very clean! Would stay here again!"
United States
Rachel B.
$307 nightly
The price is $338
Sep 6 - Sep 7
Total with taxes and fees
The Oak & Aura Retreat
A neatly made bed with a stack of folded towels, a bedside lamp, and a ceiling fan in a room with a large window and a wall-mounted artwork.

19. Walk to Main | Pet-Friendly Yard & Workspace

Walk to Main | Pet-Friendly Yard & Workspace
St. Charles Historic District
9.8 out of 10, Exceptional, (9 reviews)
"I will stay here again. It was a great location for my visit. Lots of room and amenities. Highly recommend this location if you are visiting the St Louis area. Barely a mile to get to Hwy 70, so easy access to St Louis, St Peter's, Wentzville etc. Maybe two blocks from Historic St Charles and Ameristar Casino."
United States
Karen M.
$254 nightly
The price is $279
Aug 31 - Sep 1
Total with taxes and fees
Walk to Main | Pet-Friendly Yard & Workspace
A modern kitchen with a central island, a dining area with a sofa, and a living room with a TV.

20. Main Street 2BR Apartment with Garage and Deck

Main Street 2BR Apartment with Garage and Deck
St. Charles Historic District
9.4 out of 10, Exceptional, (21 reviews)
"We loved our stay for Memorial Day weekend! It was the perfect space to unwind after a day of walking around historic Saint Charles. Our favorite spot was the back deck. Having the garage was so convenient and the space itself is really beautiful. The only thing we wish we had prepared for was a lack of basic kitchen cooking items. We bought breakfast food to cook but did not think to bring cooking oil/s&p. Would love to stay again sometime! We had a great weekend."
United States
Jennifer M.
$279 nightly
The price is $307
Aug 31 - Sep 1
Total with taxes and fees
Main Street 2BR Apartment with Garage and Deck
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

10/10 Excellent
"Nice spot to sleep"
Anthony 1-night trip
Posted 15 hours ago
Hampton Inn St. Charles St. Peters
Hilton St. Louis Frontenac

Hilton St. Louis Frontenac

10/10 Excellent
"The staff was very helpful"
Jerry 3-night trip
Posted 2 days ago
Hilton St. Louis Frontenac

Find out more about Defiance

Defiance Apartments information

Number of reviews
699
Accommodation
113 Apartments
Lowest Price
$76
Highest Price
$471

Frequently asked questions

What's it like to stay at an apartment in Defiance?
You'll find 10 apartments to choose from in Defiance for your stay.
Why choose an apartment versus a traditional hotel?
Often more spacious than a traditional hotel room, an apartment includes a kitchen for convenient home-cooked meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want something in a quieter part of town.
What's a favorite apartment for a stay in Defiance?
Here are some of the top apartments in the area: The Lofts of North Main Street: Located in St. Charles, 19.2 mi/30.8 km from the heart of Defiance. Includes free WiFi, sofa beds, and Smart TVs. Access to onsite laundry facilities is available on site. 2 Queen Beds | Non-Smoking, Kitchen: Located 18.7 mi/30.1 km away in Maryland Heights. Free WiFi and Smart TVs are included. Prime Loft of Main Street: Located in St. Charles, 19.2 mi/30.9 km away. Includes free WiFi, sofa beds, and Smart TVs. Access to onsite laundry facilities is available on site. Historic Main St 1BR | Walk to Dining & Nightlife: 19.1 mi/30.7 km away in St. Charles. Amenities include separate dining areas. The Rustic Revival | Charming 2BR Retreat: It's located in St. Charles, 19 mi/30.6 km from Defiance. Includes free WiFi.
How many apartments will I be able to find in Defiance?
Expedia has 10 apartments to book in Defiance.
What can I expect from the weather during my trip to Defiance?
Weather is only one factor, but it can really affect your travel plans, especially if you're planning an extended stay in Defiance. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.
What are the must-see places to visit in Defiance?
August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Yellow Farmhouse Winery and Chandler Hill Vineyards are other places worth a visit.
What's the best way to get to and around Defiance?
Knowing a bit about the transportation options can save you time when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. You can also search for flights into St. Louis Lambert Intl. Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to explore around the area, you may want a rental car for your journey.

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