Title: Best Apartments in Defiance, MO for Your Vacation from $154 | Expedia.com

[Defiance Travel Guide](https://expedia.com/Defiance.dx6353634)[Hotels in Defiance](https://expedia.com/Defiance-Hotels.d6353634.Travel-Guide-Hotels)[Vacation Rentals in Defiance](https://expedia.com/Defiance-Vacation-Rentals.d6353634.Travel-Guide-VacationRentals)[Flights to Defiance](https://expedia.com/Cheap-Flights-To-Defiance.d6353634.Travel-Guide-Flights)[Car Rentals in Defiance](https://expedia.com/Car-Rentals-In-Defiance.d6353634.Car-Rental-Guide)[Defiance Vacation Packages](https://expedia.com/Defiance.d6353634.Destination-Travel-Guides)

![A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-03-13&endDate=2026-03-15&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Apr 24 - Apr 26](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-04-24&endDate=2026-04-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[May 22 - May 24](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-05-22&endDate=2026-05-24&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jun 19 - Jun 21](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-06-19&endDate=2026-06-21&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Defiance apartments

![Exterior](https://images.trvl-media.com/lodging/68000000/67420000/67418600/67418516/w908h683x58y0-1bba5a4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/68000000/67420000/67418600/67418516/c8b25c03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/68000000/67420000/67418600/67418516/eccdc192.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books, music library, computer monitors](https://images.trvl-media.com/lodging/68000000/67420000/67418600/67418516/w1284h853x0y0-2c9a7301.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sunny SparkingClean King bed Apt- CreveCoeurPark

[](https://www.expedia.com/St-Louis-Hotels-Sunny-SparkingClean-King-Bed-Apt-CreveCoeurPark.h67418516.Hotel-Information)

Maryland Heights

9.8/10

Exceptional

(12 reviews)

"Good Stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lanai

$280 nightly

$300 total

Mar 4 - Mar 5

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Sunny-SparkingClean-King-Bed-Apt-CreveCoeurPark.h67418516.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/58000000/57120000/57115600/57115533/68484390.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/58000000/57120000/57115600/57115533/3eaa07d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/58000000/57120000/57115600/57115533/85c7ab01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/58000000/57120000/57115600/57115533/39c4586a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Great for Business Travelers! Studio Suite Near Edward Jones! Shared Pool + Free Breakfast!

[](https://www.expedia.com/St-Louis-Hotels-Great-For-Business-Travelers-Studio-Suite-Near-Edward-Jones-Shared-Pool-Free-Breakfast.h57115533.Hotel-Information)

Maryland Heights

9.6/10

Exceptional

(4 reviews)

"It was an easy experience renting this place"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Dominic M.

$141 nightly

$160 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Great-For-Business-Travelers-Studio-Suite-Near-Edward-Jones-Shared-Pool-Free-Breakfast.h57115533.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/67000000/66410000/66400800/66400703/3f60ffb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/67000000/66410000/66400800/66400703/87db6a60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/67000000/66410000/66400800/66400703/36b99900.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/67000000/66410000/66400800/66400703/f97626f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Amazing Renovated Historic Loft on Main Street

[](https://www.expedia.com/St-Louis-Hotels-Amazing-Renovated-Historic-Loft-On-Main-Street.h66400703.Hotel-Information)

St. Charles Historic District

10/10

Exceptional

(59 reviews)

"Great place and location. Owners were easy to work with."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cory M.

$259 nightly

$277 total

Mar 2 - Mar 3

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Amazing-Renovated-Historic-Loft-On-Main-Street.h66400703.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/101000000/100820000/100819200/100819176/9764dd9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100820000/100819200/100819176/e85f6ae5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/101000000/100820000/100819200/100819176/656d8a9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/101000000/100820000/100819200/100819176/54e27f5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Cul-de-Sac Retreat

[](https://www.expedia.com/St-Louis-Hotels-The-Cul-De-Sac-Retreat.h100819176.Hotel-Information)

Saint Charles

8.4/10

Very Good

(9 reviews)

"Great house, great location - close to the St. Charles convention center"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Joe H.

$251 nightly

$264 total

Feb 28 - Mar 1

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-The-Cul-De-Sac-Retreat.h100819176.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/82000000/81500000/81497000/81496999/8ce1ade3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/82000000/81500000/81497000/81496999/f417e034.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, coffee/tea maker, toaster, cookware/dishes/utensils](https://images.trvl-media.com/lodging/82000000/81500000/81497000/81496999/d5db9384.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/82000000/81500000/81497000/81496999/6aaacebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Stay on Main Historic Studio

[](https://www.expedia.com/St-Louis-Hotels-Studio-On-Historic-Main-By-StayLage.h81496999.Hotel-Information)

St. Charles Historic District

9.0/10

Wonderful

(33 reviews)

"Nice property.. Clean. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Belinda J.

$189 nightly

$208 total

Feb 27 - Feb 28

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Studio-On-Historic-Main-By-StayLage.h81496999.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/88000000/87360000/87354000/87353997/928eaf94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/88000000/87360000/87354000/87353997/87475e7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/88000000/87360000/87354000/87353997/77ac7719.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/88000000/87360000/87354000/87353997/bb7198fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Historic Main St. Customs House Upstairs Apartment

[](https://www.expedia.com/St-Louis-Hotels-Main-Street-Living-2-Bedroom-Unit-Right-On-Main.h87353997.Hotel-Information)

St. Charles Historic District

9.6/10

Exceptional

(36 reviews)

"Great Stay and great location! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Angela

$340 nightly

$375 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Main-Street-Living-2-Bedroom-Unit-Right-On-Main.h87353997.Hotel-Information)

![TV](https://images.trvl-media.com/lodging/98000000/97230000/97225700/97225622/d9b4bb4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/98000000/97230000/97225700/97225622/50375db8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Game room](https://images.trvl-media.com/lodging/98000000/97230000/97225700/97225622/959cce05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, desk, WiFi](https://images.trvl-media.com/lodging/98000000/97230000/97225700/97225622/19b2a3a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 1st Capitol Mansion - Suite 401

[](https://www.expedia.com/St-Louis-Hotels-1st-Capitol-Mansion-Suite-401.h97225622.Hotel-Information)

St. Charles Historic District

7.6/10

Good

(8 reviews)

"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Emily L.

$225 nightly

$253 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-1st-Capitol-Mansion-Suite-401.h97225622.Hotel-Information)

![TV](https://images.trvl-media.com/lodging/84000000/83400000/83393500/83393467/c3151f09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/84000000/83400000/83393500/83393467/1a5467b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/84000000/83400000/83393500/83393467/9f6898b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/84000000/83400000/83393500/83393467/42de8c9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Main Street Balcony Apartment by StayLage!

[](https://www.expedia.com/St-Louis-Hotels-Main-Street-Balcony-Apartment-By-StayLage.h83393467.Hotel-Information)

St. Charles Historic District

9.6/10

Exceptional

(36 reviews)

"Great location for shopping and a lot of restaurants nearby. Beds were very comfortable. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Brooke I.

$414 nightly

$456 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Main-Street-Balcony-Apartment-By-StayLage.h83393467.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/103000000/102400000/102390100/102390052/88a8c36e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/103000000/102400000/102390100/102390052/45cfe29b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/103000000/102400000/102390100/102390052/f3ac6df0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/103000000/102400000/102390100/102390052/215e17d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Hidden Gem - 2BR Basement Apartment on 7 Acres

[](https://www.expedia.com/Moscow-Mills-Hotels-The-Hidden-Gem-2BR-Basement-Apartment-On-7-Acres.h102390052.Hotel-Information)

Moscow Mills

10/10

Exceptional

(12 reviews)

"Great place, nice neighborhood. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Julie L.

$280 nightly

$280 total

Feb 28 - Mar 1

Total with taxes and fees

[](https://www.expedia.com/Moscow-Mills-Hotels-The-Hidden-Gem-2BR-Basement-Apartment-On-7-Acres.h102390052.Hotel-Information)

![A heated pool](https://images.trvl-media.com/lodging/84000000/83610000/83605400/83605308/7405cfec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/84000000/83610000/83605400/83605308/b209c6cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/84000000/83610000/83605400/83605308/8149b724.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Gift shop](https://images.trvl-media.com/lodging/84000000/83610000/83605400/83605308/d5077528.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Great for Business Travelers! Pool + Gym

[](https://www.expedia.com/St-Louis-Hotels-Great-For-Business-Travelers-Pool-Gym.h83605308.Hotel-Information)

O'Fallon

$134 nightly

$154 total

Feb 27 - Feb 28

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Great-For-Business-Travelers-Pool-Gym.h83605308.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879600/95879524/c37516f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/96000000/95880000/95879600/95879524/efc70ea8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879600/95879524/38a287fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/96000000/95880000/95879600/95879524/308cfe0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Historic Bricks on Main

[](https://www.expedia.com/St-Louis-Hotels-The-Historic-Bricks-On-Main.h95879524.Hotel-Information)

St. Charles Historic District

9.0/10

Wonderful

(16 reviews)

"Host was very welcoming and helpful when we have any questions no matter what time of day. The place was very quaint and comfy. We would highly recommend. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chelsea L.

$206 nightly

$227 total

Mar 9 - Mar 10

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-The-Historic-Bricks-On-Main.h95879524.Hotel-Information)

![Smart TV](https://images.trvl-media.com/lodging/69000000/68770000/68768700/68768642/779822a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/69000000/68770000/68768700/68768642/55a58440.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/69000000/68770000/68768700/68768642/2039c7b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/69000000/68770000/68768700/68768642/f288c4f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Prime Loft of Main Street

[](https://www.expedia.com/St-Louis-Hotels-Prime-Loft-Of-Main-Street.h68768642.Hotel-Information)

St. Charles Historic District

9.8/10

Exceptional

(105 reviews)

"Our host answered all my questions quickly and correctly. We found the property to be perfect for our visit. It was clean and well kept."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Anonymous traveler

$259 nightly

$277 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Prime-Loft-Of-Main-Street.h68768642.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/82000000/81510000/81509800/81509771/d1074747.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/82000000/81510000/81509800/81509771/1db5a3ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/82000000/81510000/81509800/81509771/40f19942.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/82000000/81510000/81509800/81509771/aa3bff55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 2 Bdr Upstairs Apt Walking Distance to Main St

[](https://www.expedia.com/St-Louis-Hotels-Luxurious-2-Bedroom-Abode-With-Elevated-Comforts-Near-Main-Street.h81509771.Hotel-Information)

Saint Charles

9.4/10

Exceptional

(3 reviews)

"The overall vibe struck me as a college town apartment: the building was fine, but finishes were underwhelming. The unit itself was a little small, but workable. We had a scenario where the heater seemed to be acting up; the room actually got warmer after we shut the heat off. It was a pleasant enough stay, and served the purpose we had come for: visiting our adult children. It was a bit of a walk to get to the historic district."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Greg L.

$277 nightly

$305 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Luxurious-2-Bedroom-Abode-With-Elevated-Comforts-Near-Main-Street.h81509771.Hotel-Information)

![TV](https://images.trvl-media.com/lodging/84000000/84000000/83992700/83992642/1d083e2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/84000000/84000000/83992700/83992642/b92d0bf7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/84000000/84000000/83992700/83992642/fdd1c3df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/84000000/84000000/83992700/83992642/63644275.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Back Door Guest Suite, Zia My Retreat

[](https://www.expedia.com/New-Haven-Hotels-Back-Door-Guest-Suit.h83992642.Hotel-Information)

New Haven

10/10

Exceptional

(6 reviews)

"Very comfortable, spacious, great location for canoe trip. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Carolyn B.

$208 nightly

$227 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/New-Haven-Hotels-Back-Door-Guest-Suit.h83992642.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/111000000/110650000/110646300/110646218/b34f5a36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Game room](https://images.trvl-media.com/lodging/111000000/110650000/110646300/110646218/c9f3354b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/111000000/110650000/110646300/110646218/0a6eda2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/111000000/110650000/110646300/110646218/749523e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### AK\`s STL Pearl Grey House - Game Room

[](https://www.expedia.com/St-Louis-Hotels-AKs-STL-Pearl-Grey-House-Game-Room.h110646218.Hotel-Information)

Maryland Heights

9.0/10

Wonderful

(8 reviews)

"Great stay! We had everything we needed and the communication was perfect!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Melodie B.

$419 nightly

$419 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-AKs-STL-Pearl-Grey-House-Game-Room.h110646218.Hotel-Information)

![Exterior detail](https://images.trvl-media.com/lodging/123000000/122440000/122431300/122431219/fb26db8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/123000000/122440000/122431300/122431219/0f231fae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/123000000/122440000/122431300/122431219/f2b0954b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/123000000/122440000/122431300/122431219/f71e6fd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 2nd Street Loft - Riverview

[](https://www.expedia.com/Washington-Hotels-2nd-Street-Loft-Riverview.h122431219.Hotel-Information)

Washington

10/10

Exceptional

(1 review)

"My wife and I absolutely loved this place and will definitely stay there again. The amenities were thought out very well, bed was comfortable, the kitchen area very well thought out and everything in the kitchen was handy. The bathroom was large for a loft and the entire place was very very clean. The host answered my questions in a timely manner. Cannot think of anything we would change"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mike M.

$155 nightly

$167 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Washington-Hotels-2nd-Street-Loft-Riverview.h122431219.Hotel-Information)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/100000000/99680000/99672100/99672035/899f1dbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/100000000/99680000/99672100/99672035/ee4b16a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/100000000/99680000/99672100/99672035/670f9e50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/100000000/99680000/99672100/99672035/02afa9a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Duplex Hideaway in St. Charles, MO

[](https://www.expedia.com/St-Louis-Hotels-Duplex-Hideaway-In-St-Charles.h99672035.Hotel-Information)

St. Charles Historic District

10/10

Exceptional

(5 reviews)

"I will stay here again. It was a great location for my visit. Lots of room and amenities. Highly recommend this location if you are visiting the St Louis area. Barely a mile to get to Hwy 70, so easy access to St Louis, St Peter's, Wentzville etc. Maybe two blocks from Historic St Charles and Ameristar Casino."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Karen M.

$227 nightly

$250 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Duplex-Hideaway-In-St-Charles.h99672035.Hotel-Information)

![Fridge, microwave, stovetop, toaster](https://images.trvl-media.com/lodging/100000000/99520000/99519000/99518901/c7c5c786.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/100000000/99520000/99519000/99518901/7f98cd91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/100000000/99520000/99519000/99518901/6d55ea86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, toaster](https://images.trvl-media.com/lodging/100000000/99520000/99519000/99518901/2a429583.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming Duplex on Main

[](https://www.expedia.com/St-Louis-Hotels-Charming-Duplex-On-Main.h99518901.Hotel-Information)

St. Charles Historic District

9.8/10

Exceptional

(17 reviews)

"We had an AMAZING time here and you can't beat the close walking distance to main st!! Absolutely loved our stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Wendy K.

$238 nightly

$262 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Charming-Duplex-On-Main.h99518901.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/119000000/118700000/118697800/118697721/6dd7d2ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/119000000/118700000/118697800/118697721/809955c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/119000000/118700000/118697800/118697721/08008aa1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/119000000/118700000/118697800/118697721/7b99969b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Lilly Pad House - Doddridge

[](https://www.expedia.com/St-Louis-Hotels-Sleeps-13.h118697721.Hotel-Information)

Maryland Heights

$440 nightly

$440 total

Mar 2 - Mar 3

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Sleeps-13.h118697721.Hotel-Information)

![TV](https://images.trvl-media.com/lodging/117000000/116660000/116658500/116658446/0e044ece.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/117000000/116660000/116658500/116658446/faf4ff3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/117000000/116660000/116658500/116658446/59492674.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/117000000/116660000/116658500/116658446/c76c6dba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 6th street 101 - Walk to Main St

[](https://www.expedia.com/St-Louis-Hotels-6th-Street-101-Walk-To-Main-St.h116658446.Hotel-Information)

St. Charles Historic District

10/10

Exceptional

(1 review)

$253 nightly

$284 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-6th-Street-101-Walk-To-Main-St.h116658446.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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## Find vacation rentals that suit your style

Cabins

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Apartments

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Cottages

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Private vacation homes

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Aparthotels

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Condos

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Villas

[](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-05-27&d1=2026-05-27&endDate=2026-05-30&d2=2026-05-30&lodging=VILLA)

Chalets

[](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-05-27&d1=2026-05-27&endDate=2026-05-30&d2=2026-05-30&lodging=CHALET)

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## Top Defiance Hotel Reviews

![Hampton Inn St. Charles St. Peters](https://images.trvl-media.com/lodging/1000000/30000/20200/20181/8c366380_y.jpg)

### Hampton Inn St. Charles St. Peters

10/10 Excellent

"Nice staff! They were under a remodel but kept it fairly clean. "

[](https://expedia.com/St-Louis-Hotels-Hampton-Inn-St-LouisSt-Charles.h20181.Hotel-Information)

![Country Inn & Suites by Radisson, St. Charles Historic District](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/529fe0ff_y.jpg)

### Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent

"Great location, always clean, friendly staff "

[](https://expedia.com/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information)

![Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West](https://images.trvl-media.com/lodging/2000000/1660000/1659000/1658956/ad47a940_y.jpg)

### Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

10/10 Excellent

"Great staff and location "

[](https://expedia.com/St-Louis-Hotels-Larkspur-Landing-Extended-Stay-Suites-St-Louis-Riverport-Airport-West.h1658956.Hotel-Information)

![Fairfield Inn & Suites by Marriott St. Louis Chesterfield](https://images.trvl-media.com/lodging/1000000/130000/126800/126794/b774ae26_y.jpg)

### Fairfield Inn & Suites by Marriott St. Louis Chesterfield

10/10 Excellent

" Very nice place! Clean, great breakfast, comfortable beds! "

[](https://expedia.com/St-Louis-Hotels-SpringHill-Suites-By-Marriott-St-Louis-Chesterfield.h126794.Hotel-Information)

![Ameristar Casino Resort and Spa](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/c42cf5fe_y.jpg)

### Ameristar Casino Resort and Spa

10/10 Excellent

"Large, clean rooms. Curteous, helpful staff. Great dining options"

[](https://expedia.com/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information)

![Drury Plaza Hotel St. Louis Chesterfield](https://images.trvl-media.com/lodging/2000000/1350000/1346800/1346760/c1fcfc39_y.jpg)

### Drury Plaza Hotel St. Louis Chesterfield

10/10 Excellent

"Room was clean and comfortable. Front desk staff was friendly and helpful. Very nice hotel. "

[](https://expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-Chesterfield.h1346760.Hotel-Information)

![Drury Plaza Hotel St. Louis St. Charles](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/7efb516b_y.jpg)

### Drury Plaza Hotel St. Louis St. Charles

10/10 Excellent

"Everything and everyone is great. Check in is akways fast and painless, free drinks and happy hour food is a GREAT added value, rooms always are clean and smell clean and breakfast always offers many options which is helpful for me and my wife given our different eating plans."

[](https://expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-St-Charles.h18754262.Hotel-Information)

![Comfort Suites St Charles - St Louis](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/55d0714b_y.jpg)

### Comfort Suites St Charles - St Louis

10/10 Excellent

"Very much so "

[](https://expedia.com/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information)

![Drury Inn & Suites St. Louis St. Peters](https://images.trvl-media.com/lodging/1000000/50000/41500/41453/cf4e5d0d_y.jpg)

### Drury Inn & Suites St. Louis St. Peters

10/10 Excellent

"The staff and the amenities."

[](https://expedia.com/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-St-Peters.h41453.Hotel-Information)

## Find out more about Defiance

## Defiance Apartments information

| Number of reviews | 210            |
| ----------------- | -------------- |
| Accommodation     | 103 Apartments |
| Lowest Price      | $154           |
| Highest Price     | $456           |

## Frequently asked questions

### What's it like to stay at an apartment in Defiance?

### Why choose an apartment versus a traditional hotel?

### What's a favorite apartment for a stay in Defiance?

### How many apartments will I be able to find in Defiance?

### What can I expect from the weather during my trip to Defiance?

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### What's the best way to get to and around Defiance?

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- [Weldon Spring Hotels ](https://www.expedia.com/Weldon-Spring-Hotels.d553248634983495338.Travel-Guide-Hotels)
- [Hotels near Spirit of St. Louis ](https://www.expedia.com/Spirit-Of-St-Louis-Airport-Hotels.0-aSUS-0.Travel-Guide-Filter-Hotels)
- [Hotels near Noboleis Vineyard ](https://www.expedia.com/Noboleis-Vineyard-Hotels.0-l553248621532648564-0.Travel-Guide-Filter-Hotels)

- [Flights from Saint Albans ](https://www.expedia.com/lp/flights/3000445473/flights-from-saint-albans)
- [Flights from Augusta ](https://www.expedia.com/lp/flights/6250878/flights-from-augusta)
- [Flights to Weldon Spring Heights ](https://www.expedia.com/Cheap-Flights-To-Weldon-Spring-Heights.d6252562.Travel-Guide-Flights)
- [Flights from Spirit of St. Louis ](https://www.expedia.com/lp/airports/sus/flights-from-spirit-of-st-louis-airport)
- [Flights from Poplar Bluff (POF) to St. Louis (SUS) ](https://www.expedia.com/lp/flights/pof/sus/poplar-bluff-to-st-louis)
- [Flights from St. Louis (STL) to St. Louis (SUS) ](https://www.expedia.com/lp/flights/stl/sus/st-louis-to-st-louis)
- [Flights from Mount Vernon (MVN) to St. Louis (SUS) ](https://www.expedia.com/lp/flights/mvn/sus/mount-vernon-to-st-louis)
- [Flights from Grand Rapids (GRR) to St. Louis (SUS) ](https://www.expedia.com/lp/flights/grr/sus/grand-rapids-to-st-louis)
- [Flights from Los Angeles (LAX) to St. Louis (SUS) ](https://www.expedia.com/lp/flights/lax/sus/los-angeles-to-st-louis)
- [Flights from Joplin (JLN) to St. Louis (SUS) ](https://www.expedia.com/lp/flights/jln/sus/joplin-to-st-louis)
- [Flights from Atlanta (ATL) to St. Louis (SUS) ](https://www.expedia.com/lp/flights/atl/sus/atlanta-to-st-louis)
- [Flights from Enid (WDG) to St. Louis (SUS) ](https://www.expedia.com/lp/flights/wdg/sus/enid-to-st-louis)
- [Flights from Minneapolis (MSP) to St. Louis (SUS) ](https://www.expedia.com/lp/flights/msp/sus/minneapolis-to-st-louis)
- [Flights from Detroit (DTW) to St. Louis (SUS) ](https://www.expedia.com/lp/flights/dtw/sus/detroit-to-st-louis)
- [Flights from Las Vegas (LAS) to St. Louis (SUS) ](https://www.expedia.com/lp/flights/las/sus/las-vegas-to-st-louis)
- [Flights from Lexington (LEX) to St. Louis (SUS) ](https://www.expedia.com/lp/flights/lex/sus/lexington-to-st-louis)
- [Flights from Chicago (ORD) to St. Louis (SUS) ](https://www.expedia.com/lp/flights/ord/sus/chicago-to-st-louis)
- [Flights from Kansas City (MCI) to St. Louis (SUS) ](https://www.expedia.com/lp/flights/mci/sus/kansas-city-to-st-louis)
- [Flights from Nashville (BNA) to St. Louis (SUS) ](https://www.expedia.com/lp/flights/bna/sus/nashville-to-st-louis)

- [Yellow Farmhouse Winery ](https://www.expedia.com/Yellow-Farmhouse-Winery-Defiance.d553248621532648568.Vacation-Attraction)
- [Chandler Hill Vineyards ](https://www.expedia.com/Chandler-Hill-Vineyards-Defiance.d553248621532648567.Vacation-Attraction)
- [Sugar Creek Winery ](https://www.expedia.com/Sugar-Creek-Winery-Defiance.d553248621532648612.Vacation-Attraction)
- [Visit Saint Albans ](https://www.expedia.com/Saint-Albans.dx3000445473)
- [Historic Daniel Boone Home and Heritage Center ](https://www.expedia.com/Historic-Daniel-Boone-Home-And-Heritage-Center-Defiance.d553248621532648566.Vacation-Attraction)
- [Babler State Park ](https://www.expedia.com/Babler-State-Park-St-Louis.d6293012.Vacation-Attraction)
- [Dr. Edmund A. Babler Memorial State Park ](https://www.expedia.com/Dr-Edmund-A-Babler-Memorial-State-Park-St-Louis.d553248621532648589.Vacation-Attraction)
- [Weldon Spring Site Interpretive Center ](https://www.expedia.com/Weldon-Spring-Site-Interpretive-Center-St-Louis.d553248621532648611.Vacation-Attraction)
- [Montelle Winery ](https://www.expedia.com/Montelle-Winery-Augusta.d553248621532648565.Vacation-Attraction)
- [August A. Busch Memorial Conservation Area ](https://www.expedia.com/August-A-Busch-Memorial-Conservation-Area-St-Louis.d6160337.Vacation-Attraction)
- [Broemmelsiek Park ](https://www.expedia.com/Broemmelsiek-Park-St-Louis.d553248621561876810.Vacation-Attraction)
- [Augusta Vacations ](https://www.expedia.com/Augusta.d6250878.Destination-Travel-Guides)
- [Visit Weldon Spring Heights ](https://www.expedia.com/Weldon-Spring-Heights.dx6252562)
- [St. Louis Premium Outlets ](https://www.expedia.com/St-Louis-Premium-Outlets-St-Louis.d553248621561876860.Vacation-Attraction)
- [Missouri Bluffs Golf Course ](https://www.expedia.com/Missouri-Bluffs-Golf-Course-St-Louis.d553248621532648614.Vacation-Attraction)
- [Augusta Winery ](https://www.expedia.com/Augusta-Winery-Augusta.d553248621532648562.Vacation-Attraction)

- [Car rentals near Hamburg ](https://www.expedia.com/Car-Rentals-In-Hamburg.d553248635975869538.Car-Rental-Guide)
- [Car rentals near Saint Albans ](https://www.expedia.com/Car-Rentals-In-Saint-Albans.d3000445473.Car-Rental-Guide)
- [Car rentals near Babler State Park ](https://www.expedia.com/Car-Rentals-In-Babler-State-Park.d6293012.Car-Rental-Guide)
- [Car rentals near Augusta ](https://www.expedia.com/Car-Rentals-In-Augusta.d6250878.Car-Rental-Guide)
- [Midway Car Rental Rental Cars in Augusta ](https://www.expedia.com/Midway-Car-Rental-Car-Rentals-In-Augusta.d6250878-c27.Car-Rental-Guide-Suppliers)
- [Car rentals near Weldon Spring Heights ](https://www.expedia.com/Car-Rentals-In-Weldon-Spring-Heights.d6252562.Car-Rental-Guide)
- [Car rentals near Weldon Spring ](https://www.expedia.com/Car-Rentals-In-Weldon-Spring.d553248634983495338.Car-Rental-Guide)
- [Car rental St. Louis Airport (SUS) ](https://www.expedia.com/Car-Rentals-In-Spirit-Of-St-Louis.d6024951.Car-Rental-Guide)
- [Enterprise Rental Cars in Spirit of St. Louis ](https://www.expedia.com/Enterprise-Car-Rentals-In-Spirit-Of-St-Louis.d6024951-c15.Car-Rental-Guide-Suppliers)
- [Budget Rental Cars in Spirit of St. Louis ](https://www.expedia.com/Budget-Car-Rentals-In-Spirit-Of-St-Louis.d6024951-c39.Car-Rental-Guide-Suppliers)

- [Augusta Vacation Rentals ](https://www.expedia.com/Augusta-Vacation-Rentals.d6250878.Travel-Guide-VacationRentals)
- [Weldon Spring Heights Vacation Rentals ](https://www.expedia.com/Weldon-Spring-Heights-Vacation-Rentals.d6252562.Travel-Guide-VacationRentals)

- [Things to do in Augusta ](https://www.expedia.com/Things-To-Do-In-Augusta.d6250878.Travel-Guide-Activities)