A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Apartments in Defiance for Rent

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Check prices for these dates

In two weeks
Aug 14 - Aug 16
In two months
Sep 25 - Sep 27
In three months
Oct 23 - Oct 25
In four months
Nov 20 - Nov 22

Our top choices for Defiance apartments

Exterior

The Foundry Flat | Industrial-Inspired 2-Bedroom

The Foundry Flat | Industrial-Inspired 2-Bedroom
St. Charles Historic District
$291 nightly
The price is $320
Aug 3 - Aug 4
Total with taxes and fees
The Foundry Flat | Industrial-Inspired 2-Bedroom
A heated pool

Great for Business Travelers! Pool + Gym

Great for Business Travelers! Pool + Gym
O'Fallon
$155 nightly
The price is $179
Aug 10 - Aug 11
Total with taxes and fees
Great for Business Travelers! Pool + Gym
Property grounds

Chic 1- Queen Bed, Non Smoking-Near Airport, Kitchen, Twin Bed

Chic 1- Queen Bed, Non Smoking-Near Airport, Kitchen, Twin Bed
St. Louis
9.0 out of 10, Wonderful, (13 reviews)
"This was absolutely perfect and reasonable pricing I surely will be back "
United States
David G.
$101 nightly
The price is $107
Aug 9 - Aug 10
Total with taxes and fees
Chic 1- Queen Bed, Non Smoking-Near Airport, Kitchen, Twin Bed
Interior

2 Queen Beds | Non-Smoking, Kitchen

2 Queen Beds | Non-Smoking, Kitchen
Westport
9.8 out of 10, Exceptional, (38 reviews)
"Fantastic place!"
United States
Anonymous traveler
$96 nightly
The price is $111
Aug 2 - Aug 3
Total with taxes and fees
2 Queen Beds | Non-Smoking, Kitchen
1 bedroom, WiFi, bed sheets

Duplex Hideaway in St. Charles, MO

Duplex Hideaway in St. Charles, MO
St. Charles Historic District
9.8 out of 10, Exceptional, (7 reviews)
"I will stay here again. It was a great location for my visit. Lots of room and amenities. Highly recommend this location if you are visiting the St Louis area. Barely a mile to get to Hwy 70, so easy access to St Louis, St Peter's, Wentzville etc. Maybe two blocks from Historic St Charles and Ameristar Casino."
United States
Karen M.
$241 nightly
The price is $265
Jul 29 - Jul 30
Total with taxes and fees
Duplex Hideaway in St. Charles, MO
Interior

The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (181 reviews)
"Great place to stay. Our go to when visiting St.Charles or STL"
United States
jeramy p.
$243 nightly
The price is $260
Jul 29 - Jul 30
Total with taxes and fees
The Lofts of North Main Street
TV

6th street 101 - Walk to Main St

6th street 101 - Walk to Main St
St. Charles Historic District
10.0 out of 10, Exceptional, (3 reviews)
"Excellent"
United States
Scott N.
$253 nightly
The price is $284
Jul 29 - Jul 30
Total with taxes and fees
6th street 101 - Walk to Main St
Property grounds

The Driftwood Den | Boho-Inspired 2-Bedroom

The Driftwood Den | Boho-Inspired 2-Bedroom
St. Charles Historic District
10.0 out of 10, Exceptional, (3 reviews)
"Loved our stay here. Clean, comfortable, convenient. Couldn’t have been easier, in all aspects. Already plan to stay there again!!!"
United States
Kourtney S.
$272 nightly
The price is $300
Jul 28 - Jul 29
Total with taxes and fees
The Driftwood Den | Boho-Inspired 2-Bedroom
Interior

2 Bdr Upstairs Apt Walking Distance to Main St

2 Bdr Upstairs Apt Walking Distance to Main St
Saint Charles
8.0 out of 10, Very Good, (5 reviews)
"The best price-value ratio. Quiet neighborhood, close to the city center."
United States
Tamas P.
$287 nightly
The price is $316
Jul 28 - Jul 29
Total with taxes and fees
2 Bdr Upstairs Apt Walking Distance to Main St
Exterior

Stay on Main Historic Studio

Stay on Main Historic Studio
St. Charles Historic District
9.2 out of 10, Wonderful, (36 reviews)
"Had a wonderful stay. It was a Monday night so parking was very easy and the room was clean and comfortable. I would recommend this place 100% "
United States
Sarah C.
$213 nightly
The price is $234
Aug 2 - Aug 3
Total with taxes and fees
Stay on Main Historic Studio
Exterior

2nd Street -Deck Suite (back entrance)

2nd Street -Deck Suite (back entrance)
Washington
10.0 out of 10, Exceptional, (8 reviews)
"Great comfortable mini apartment style."
United States
Ozzy
$166 nightly
The price is $186
Aug 3 - Aug 4
Total with taxes and fees
2nd Street -Deck Suite (back entrance)
Interior

Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (67 reviews)
"Lovely accommodations, very clean, well equipped, great location. "
United States
Emily B.
$244 nightly
The price is $261
Aug 3 - Aug 4
Total with taxes and fees
Amazing Renovated Historic Loft on Main Street
Fridge, microwave, stovetop, toaster

Charming Duplex on Main

Charming Duplex on Main
St. Charles Historic District
10.0 out of 10, Exceptional, (23 reviews)
"Great location"
United States
todd p.
$243 nightly
The price is $267
Aug 2 - Aug 3
Total with taxes and fees
Charming Duplex on Main
Dining

Studio | Lovely Suite Close to Edward Jones!

Studio | Lovely Suite Close to Edward Jones!
Westport
$184 nightly
The price is $210
Aug 2 - Aug 3
Total with taxes and fees
Studio | Lovely Suite Close to Edward Jones!
Smart TV

Prime Loft of Main Street

Prime Loft of Main Street
St. Charles Historic District
9.8 out of 10, Exceptional, (114 reviews)
"Host was great. The cutest place in the perfect spot! "
United States
Anonymous traveler
$243 nightly
The price is $260
Jul 28 - Jul 29
Total with taxes and fees
Prime Loft of Main Street
TV

1st Capitol Mansion - Suite 401

1st Capitol Mansion - Suite 401
St. Charles Historic District
7.4 out of 10, Good, (9 reviews)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
United States
Emily L.
$226 nightly
The price is $254
Aug 4 - Aug 5
Total with taxes and fees
1st Capitol Mansion - Suite 401
Interior

The Historic Bricks on Main

The Historic Bricks on Main
St. Charles Historic District
9.0 out of 10, Wonderful, (19 reviews)
"Great place, very fun. I’d stay again for sure. "
United States
Michael C.
$225 nightly
The price is $248
Aug 4 - Aug 5
Total with taxes and fees
The Historic Bricks on Main
TV

Walk to Main St | Pet-Friendly Apt

Walk to Main St | Pet-Friendly Apt
St. Charles Historic District
8.6 out of 10, Excellent, (16 reviews)
"Property was as advertised. Perfect for my needs, clean, quiet and convenient. Loved Historic St. Charles. Would recommend anytime! Thank you! "
United States
Brian B.
$293 nightly
The price is $323
Jul 28 - Jul 29
Total with taxes and fees
Walk to Main St | Pet-Friendly Apt
Coffee/tea maker, fridge, microwave, oven

Historic Main St. Customs House Upstairs Apartment

Historic Main St. Customs House Upstairs Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (38 reviews)
"Lovely place to stay!"
United States
Margaret A.
$359 nightly
The price is $395
Jul 29 - Jul 30
Total with taxes and fees
Historic Main St. Customs House Upstairs Apartment
Coffee/tea maker, fridge, microwave, oven

Quiet Neighborhood-Near Eats & Shops-Airport!

Quiet Neighborhood-Near Eats & Shops-Airport!
Brookside
10.0 out of 10, Exceptional, (2 reviews)
"This was an awesome place for 9 of us- plenty of rooms to sleep and bathrooms. The renter was very kind"
United States
Janet
$460 nightly
The price is $460
Aug 2 - Aug 3
Total with taxes and fees
Quiet Neighborhood-Near Eats & Shops-Airport!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

8/10 Good
"There for three nights but had no evidence of a fresh towels or wash up supplies. Hair and soap dispensers were full of mostly failed closures. We found a black cotton athletic sock. I made sure it was back where I found it. The pool needs attention. It was too dirty to bring over the grand kids for a swim."
Dean 3-night trip
Posted less than an hour ago
Wingate by Wyndham St. Louis/Fenton Route 66

Find out more about Defiance

Defiance Apartments information

Number of reviews
12,335
Accommodation
115 Apartments
Lowest Price
$78
Highest Price
$164

Frequently asked questions

What's it like to stay at an apartment in Defiance?
You'll find 10 apartments to choose from in Defiance for your stay.
Why choose an apartment versus a traditional hotel?
Often more spacious than a traditional hotel room, an apartment includes a kitchen for convenient home-cooked meals. Apartments are ideal for families who want the conveniences of home, and also for couples who want something in a quieter part of town.
What's a favorite apartment for a stay in Defiance?
Here are some of the top apartments in the area: The Lofts of North Main Street: Located in St. Charles, 19.2 mi/30.8 km from the heart of Defiance. Includes free WiFi, sofa beds, and Smart TVs. Access to onsite laundry facilities is available on site. 2 Queen Beds | Non-Smoking, Kitchen: Located 18.7 mi/30.1 km away in Maryland Heights. Free WiFi and Smart TVs are included. 1 Queen Bed | Non-Smoking, Kitchen: It's situated in Maryland Heights, 18.7 mi/30.1 km away. Includes free WiFi and Smart TVs. Prime Loft of Main Street: Located 19.2 mi/30.9 km away in St. Charles. Free WiFi, sofa beds, and Smart TVs are included. Access to onsite laundry facilities is available on site. Chic 1- Queen Bed, Non Smoking-Near Airport, Kitchen, Twin Bed: It's located in Overland, 20.7 mi/33.2 km from Defiance. Includes free WiFi, private balconies, and Smart TVs.
How many apartments will I be able to find in Defiance?
Expedia has 10 apartments to book in Defiance.
What can I expect from the weather during my trip to Defiance?
Weather is only one factor, but it can really affect your travel plans, especially if you're planning an extended stay in Defiance. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.
What are the must-see places to visit in Defiance?
August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. While here, Chandler Hill Vineyards and Sugar Creek Winery are other places worth a visit.
What's the best way to get to and around Defiance?
Knowing a bit about the transportation options can save you time when you get to your destination. Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) from the heart of the city. You can also search for flights into St. Louis Lambert Intl. Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to explore around the area, you may want a rental car for your journey.

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