La Mesa Vacation Rentals

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Check prices for these dates

In two weeks
Nov 27 - Nov 29
In two months
Jan 8 - Jan 10
In three months
Feb 5 - Feb 7
In four months
Mar 5 - Mar 7

Our top choices for La Mesa vacation rentals

A modern hotel room with a large bed, a bedside table, a built-in TV, and a shower area.

1. 1 King Bed | Non-Smoking, Micfridge

1 King Bed | Non-Smoking, Micfridge
La Mesa
10.0 out of 10, Exceptional, (54 reviews)
"Beds were soft but supportive, good rest every night!"
United States
Anonymous traveler
$96 nightly
The price is $106
Nov 15 - Nov 16
Total with taxes and fees
1 King Bed | Non-Smoking, Micfridge
A hotel reception area with a counter, a digital tablet, and a poster on the wall.

2. 1 Queen Bed | Mini Fridge

1 Queen Bed | Mini Fridge
La Mesa
10.0 out of 10, Exceptional, (2 reviews)
"Room included a fridge, shower, and free WiFi in public areas."
United States
Anonymous traveler
$115 nightly
The price is $127
Nov 16 - Nov 17
Total with taxes and fees
1 Queen Bed | Mini Fridge
A modern kitchen with stainless steel appliances, white cabinetry, and a wooden floor.

3. Cozy Casa | Private Modern Studio · La Mesa

Cozy Casa | Private Modern Studio · La Mesa
La Mesa
$322 nightly
The price is $322
Nov 20 - Nov 21
Total with taxes and fees
Cozy Casa | Private Modern Studio · La Mesa
A modern living room with a sofa, a chair, a coffee table, and a ceiling fan.

4. Entire Private Home w/ 4BR 3Bath, King Bed, Large Yard & Prime Area, Ranch Style

Entire Private Home w/ 4BR 3Bath, King Bed, Large Yard & Prime Area, Ranch Style
La Mesa
10.0 out of 10, Exceptional, (1 review)
"Great overall experience, clean room."
United States
Warren B.
$335 nightly
The price is $377
Nov 16 - Nov 17
Total with taxes and fees
Entire Private Home w/ 4BR 3Bath, King Bed, Large Yard & Prime Area, Ranch Style
A modern living room with a flat-screen TV, a sofa, and a dining area with a table set for four.

5. Entire Private House with 4 Bedroom 3 Bath Ranch Style w Gated Yard, Parking

Entire Private House with 4 Bedroom 3 Bath Ranch Style w Gated Yard, Parking
La Mesa
$352 nightly
The price is $352
Nov 17 - Nov 18
Total with taxes and fees
Entire Private House with 4 Bedroom 3 Bath Ranch Style w Gated Yard, Parking
A modern two-story house with a well-maintained lawn and a pathway leading to the front door.

6. Entire Private House with 4 Beds, Gated Yard, Parking, Ranch Style in La Mesa

Entire Private House with 4 Beds, Gated Yard, Parking, Ranch Style in La Mesa
La Mesa
$343 nightly
The price is $376
Nov 29 - Nov 30
Total with taxes and fees
Entire Private House with 4 Beds, Gated Yard, Parking, Ranch Style in La Mesa
A modern living room with a sofa, a dining area, and a kitchen.

7. 25% off, Chic Casita • Hot tub • BBQ • 4 min to SDSU

25% off, Chic Casita • Hot tub • BBQ • 4 min to SDSU
La Mesa
10.0 out of 10, Exceptional, (9 reviews)
"Great stay. Clean, beautiful and great communication with property manager."
United States
Kate K.
$415 nightly
The price is $415
Nov 23 - Nov 24
Total with taxes and fees
25% off, Chic Casita • Hot tub • BBQ • 4 min to SDSU
A modern kitchen with a large island, stainless steel appliances, and pendant lighting.

8. Modern SD Escape: SDSU/Downtown <10 Min, GameRoom, Fire Pit, Easy Freeway Access

Modern SD Escape: SDSU/Downtown <10 Min, GameRoom, Fire Pit, Easy Freeway Access
La Mesa
9.0 out of 10, Wonderful, (10 reviews)
"We had a wonderful stay! The home is lovely, clean and exactly as described. Jonathan is very nice and easy to communicate with. We loved staying here to celebrate our son’s graduation from SDSU!"
United States
Anonymous traveler
$498 nightly
The price is $498
Nov 15 - Nov 16
Total with taxes and fees
Modern SD Escape: SDSU/Downtown <10 Min, GameRoom, Fire Pit, Easy Freeway Access
Interior

9. Mountain top view getaway loft

Mountain top view getaway loft
Casa de Oro-Mount Helix
10.0 out of 10, Exceptional, (1 review)
$374 nightly
The price is $374
Nov 14 - Nov 15
Total with taxes and fees
Mountain top view getaway loft
A hotel reception area with a counter, a digital tablet, and a poster on the wall.

10. Cozy Queen Bed|Free Parking|WiFi

Cozy Queen Bed|Free Parking|WiFi
La Mesa
10.0 out of 10, Exceptional, (2 reviews)
"After a long drive, I felt quite at ease here, the room had a cozy but practical feel."
United States
Anonymous traveler
$112 nightly
The price is $123
Nov 16 - Nov 17
Total with taxes and fees
Cozy Queen Bed|Free Parking|WiFi
A hotel reception area with a counter, a digital tablet, and a poster on the wall.

11. Cozy ADA Queen bed|Free Parking|Wifi

Cozy ADA Queen bed|Free Parking|Wifi
La Mesa
10.0 out of 10, Exceptional, (2 reviews)
"Conveniently located near campus providing easy access when exploring local spots or heading back after busy days ."
United States
Anonymous traveler
$112 nightly
The price is $123
Nov 16 - Nov 17
Total with taxes and fees
Cozy ADA Queen bed|Free Parking|Wifi
A hotel room with two beds, a desk, and a window with curtains.

12. 2 Queen Beds | Non-Smoking, Micfridge

2 Queen Beds | Non-Smoking, Micfridge
La Mesa
10.0 out of 10, Exceptional, (47 reviews)
"We found the space decent for our small group and liked having parking on site."
United States
Anonymous traveler
$106 nightly
The price is $116
Nov 15 - Nov 16
Total with taxes and fees
2 Queen Beds | Non-Smoking, Micfridge
A hotel room with two beds, a nightstand with a lamp, and a window with patterned curtains.

13. Cozy 2-Bed Queen|Free Parking|Wifi

Cozy 2-Bed Queen|Free Parking|Wifi
La Mesa
10.0 out of 10, Exceptional, (2 reviews)
"Getting around town from here was easy on my own. Parking was hassle-free and several eateries were within walking distance as well."
United States
Anonymous traveler
$126 nightly
The price is $139
Nov 16 - Nov 17
Total with taxes and fees
Cozy 2-Bed Queen|Free Parking|Wifi
A hotel reception area with a counter, a digital tablet, and a poster on the wall.

14. 2 Queen Beds | Mini Fridge

2 Queen Beds | Mini Fridge
La Mesa
5.4 out of 10, (3 reviews)
"Being close to San Diego State University helped me get around quickly during this short trip. The fridge also came handy for keeping snacks fresh!"
United States
Anonymous traveler
$131 nightly
The price is $144
Nov 19 - Nov 20
Total with taxes and fees
2 Queen Beds | Mini Fridge
An outdoor patio with a table and chairs, string lights, and a grill.

15. 3 Bedroom House - Fire Pit Table, BBQ - 10 Guests

3 Bedroom House - Fire Pit Table, BBQ - 10 Guests
La Mesa
9.2 out of 10, Wonderful, (15 reviews)
"Adam was great! Communicated regularly and ensured I was good to go from the start. "
United States
Beth H.
3 Bedroom House - Fire Pit Table, BBQ - 10 Guests
A modern kitchen with white cabinets, a stainless steel refrigerator, and a dining area with a table and chairs.

16. Splendid 1-bedroom apartment in delightful La Mesa with AC and Laundry

Splendid 1-bedroom apartment in delightful La Mesa with AC and Laundry
Mid-City
10.0 out of 10, Exceptional, (9 reviews)
"Our stay was lovely at Neric's place. Nice decor, clean, comfortable, & quiet. The AC worked well to keep the home at the perfect temp for us. We will stay here again!"
United States
Katherine S.
$143 nightly
The price is $143
Nov 17 - Nov 18
Total with taxes and fees
Splendid 1-bedroom apartment in delightful La Mesa with AC and Laundry
A kitchen with a stove, pots, pans, and various utensils.

17. Lake Murray 3BR Retreat with AC and Skylight

Lake Murray 3BR Retreat with AC and Skylight
La Mesa
10.0 out of 10, Exceptional, (18 reviews)
"Our stay was fantastic and it had everything we need for our 1 week stay. I recommend this location. "
United States
Rosa C.
$297 nightly
The price is $297
Nov 16 - Nov 17
Total with taxes and fees
Lake Murray 3BR Retreat with AC and Skylight
A room with a dining table, chairs, a fan, and a closed door.

18. Cozy Private Studio in El Cajon

Cozy Private Studio in El Cajon
Mount Helix
8.8 out of 10, Excellent, (29 reviews)
"The host was very helpful"
United States
Bri S.
$125 nightly
The price is $125
Nov 15 - Nov 16
Total with taxes and fees
Cozy Private Studio in El Cajon
An outdoor patio with wicker furniture and a wooden fence.

19. The Vintage Hideway

The Vintage Hideway
Lemon Grove
9.8 out of 10, Exceptional, (21 reviews)
"Convenient location with everything we needed to enjoy our stay."
United States
Steve E.
$334 nightly
The price is $334
Nov 16 - Nov 17
Total with taxes and fees
The Vintage Hideway
A narrow, enclosed walkway with wooden railings and a metal grid barrier, leading to a building entrance.

20. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (245 reviews)
"Excellent location, near little Italy, zoo and airport. Be aware that you are near airport so expect more noise than normal"
United States
Willie
$157 nightly
The price is $177
Nov 29 - Nov 30
Total with taxes and fees
City24 Hotel Little Italy Mission Hills
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top La Mesa Hotel Reviews

A spacious lobby with a modern design, featuring a large seating area, a reception desk, and large windows offering views of the city.
Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
Otay Ranch

10/10 Excellent

Excellent customer service. Very clean throughout the hotel and inside room and bathroom. Room and bathroom is spacious. Tub shower is excellent. Water pressure is super. The family loved the Pool and hot tub area. Also outdoor area is available and there’s an outdoor bar that opens in the evening. Breakfast in the morning was delicious with waffles, pancakes, eggs, a protein and potatoes. Can also request for kitchen staff to make an omelet if you prefer. Will definitely recommend this hotel.
United States
Madeline
Reviewed June 21, 2025
Ayres Hotel San Diego South - Chula Vista

Find out more about La Mesa

Everything you need to know about La Mesa vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the La Mesa vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect La Mesa vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

La Mesa vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in La Mesa. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit La Mesa in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $105 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on La Mesa rentals

At Expedia, we put the best La Mesa vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top La Mesa rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream La Mesa vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around La Mesa. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently Asked Questions

Are there vacation rentals in La Mesa?

Yes, you can find vacation rentals in La Mesa near La Mesa Memorial Fine Arts Center, or you can choose a secluded option if you'd like a relaxing place to stay. Visitors like the top-notch restaurants and shops in La Mesa. Leave some time to check out the zoo and entertainment venues during your trip.

What are some of the best vacation rentals that La Mesa has to offer?

Luxurious Estate Home-Sumptuous Views - Resort Like!!!: This La Mesa vacation home rental offers a balcony, a garden, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. You and your friends and family can relax into your vacation with amenities like a hot tub.

How many vacation rentals are there in La Mesa?

With 65 Expedia vacation rentals, you're sure to find just the right place for your La Mesa stay.

What can I see and do in La Mesa?

While exploring the area, visit family-friendly sights like San Diego Zoo, or get outside and enjoy nature at Mission Bay. While in the area, you can also visit popular places like Petco Park and Port of San Diego.

What are vacation rentals like in La Mesa?

Vacation rentals are privately owned properties you can book for several days or more in La Mesa. Vacation rentals feature amenities such as WiFi and washers and dryers so you'll have everything you need. If you're concerned about a clean environment, vacation rentals can provide a sense of safety away from shared hotel elevators and busy lobbies while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great choice for families.

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