Title: Ladys Island, SC Inns from $406 | Expedia.com [Ladys Island Travel Guide](https://expedia.com/Ladys-Island.dx6301860)[Hotels in Ladys Island](https://expedia.com/Ladys-Island-Hotels.d6301860.Travel-Guide-Hotels)[Vacation Rentals in Ladys Island](https://expedia.com/Ladys-Island-Vacation-Rentals.d6301860.Travel-Guide-VacationRentals)[Flights to Ladys Island](https://expedia.com/Cheap-Flights-To-Ladys-Island.d6301860.Travel-Guide-Flights)[Car Rentals in Ladys Island](https://expedia.com/Car-Rentals-In-Ladys-Island.d6301860.Car-Rental-Guide)[Ladys Island Vacation Packages](https://expedia.com/Ladys-Island.d6301860.Destination-Travel-Guides) ![Gotta love some marsh grass at sunset. ](https://images.trvl-media.com/place/6057941/0fe828ca-372c-4f3e-bc68-41f396c3d6ec.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Michael Schuier ![](https://images.trvl-media.com/place/6057941/0fe828ca-372c-4f3e-bc68-41f396c3d6ec.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_bundle_and_save.svg) ### Bundle & Save Get more, spend less whenever you see Bundle & Save deals - ![](https://a.travel-assets.com/travel-assets-manager/pictograms-expedia/light__onekey.svg) ### OneKeyCash Earn OneKeyCash on all your eligible bookings - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_ftc.svg) ### Upfront pricing We are not like the others - we include taxes and fees ## Check prices for these dates Next weekend [Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=6301860&startDate=2026-02-27&endDate=2026-03-01&adults=2&lodging=INN&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=6301860&startDate=2026-03-06&endDate=2026-03-08&adults=2&lodging=INN&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6301860&startDate=2026-03-20&endDate=2026-03-22&adults=2&lodging=INN&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=6301860&startDate=2026-04-17&endDate=2026-04-19&adults=2&lodging=INN&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Ladys Island inns ![Dining](https://images.trvl-media.com/lodging/5000000/4770000/4762400/4762348/6c376095.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/5000000/4770000/4762400/4762348/92cd7c8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/5000000/4770000/4762400/4762348/deec1ba4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Suite, 1 King Bed with Sofa bed, Fireplace, Bay View (Not Pet Friendly) | Egyptian cotton sheets, premium bedding, memory foam beds, in-room safe](https://images.trvl-media.com/lodging/5000000/4770000/4762400/4762348/f0a875b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cuthbert House [](https://www.expedia.com/Beaufort-Hotels-The-Cuthbert-House-Inn.h4762348.Hotel-Information) Downtown Beaufort 9.2/10 Wonderful (951 reviews) "Lovely B&B in a wonderful location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ivan $369 nightly $406 total Feb 23 - Feb 24 Total with taxes and fees [](https://www.expedia.com/Beaufort-Hotels-The-Cuthbert-House-Inn.h4762348.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-08&endDate=2026-03-09®ionId=6301860&adults=2&lodging=INN&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=AA_SPRING_PROMO_6301860) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLadys-Island-Inns.d6301860-aaInns.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLadys-Island-Inns.d6301860-aaInns.Travel-Guide-Accommodation) ## Top Ladys Island Hotel Reviews ![Beach House Resort Hilton Head](https://images.trvl-media.com/lodging/1000000/30000/20700/20657/b454fbd2_y.jpg) ### Beach House Resort Hilton Head 10/10 Excellent "Front desk gentleman was so nice and beautiful place!" [](https://expedia.com/Hilton-Head-Island-Hotels-Beach-House-Hilton-Head.h20657.Hotel-Information) ![Holiday Inn Express Hilton Head Island by IHG](https://images.trvl-media.com/lodging/1000000/10000/1400/1341/e21613a3_y.jpg) ### Holiday Inn Express Hilton Head Island by IHG 10/10 Excellent "Great location! Clean room, good breakfast. " [](https://expedia.com/Hilton-Head-Hotels-Holiday-Inn-Express-Hilton-Head-Island.h1341.Hotel-Information) ![Holiday Inn Hotel & Suites Beaufort at Highway 21 by IHG](https://images.trvl-media.com/lodging/2000000/1650000/1647600/1647509/80bdfa73_y.jpg) ### Holiday Inn Hotel & Suites Beaufort at Highway 21 by IHG 10/10 Excellent "Staff and the size of the room. Comfortable bed. " [](https://expedia.com/Beaufort-Hotels-Holiday-Inn-Hotel-Suites-Beaufort-At-Highway-21.h1647509.Hotel-Information) ![Hilton Beachfront Resort & Spa Hilton Head Island](https://images.trvl-media.com/lodging/1000000/590000/583400/583363/484680bc_y.jpg) ### Hilton Beachfront Resort & Spa Hilton Head Island 10/10 Excellent "Yes" [](https://expedia.com/Hilton-Head-Hotels-Marriott-Hilton-Head-Resort-Spa.h583363.Hotel-Information) ![Spark By Hilton Hilton Head Island](https://images.trvl-media.com/lodging/13000000/12430000/12427700/12427670/35eaaa78_y.jpg) ### Spark By Hilton Hilton Head Island 10/10 Excellent "Room was great for our little family. Friendly staff at check in" [](https://expedia.com/Hilton-Head-Hotels-Best-Western-Ocean-Breeze-Inn.h12427670.Hotel-Information) ![Sonesta Resort Hilton Head Island](https://images.trvl-media.com/lodging/1000000/10000/2700/2618/220ad345_y.jpg) ### Sonesta Resort Hilton Head Island 10/10 Excellent "Excellent stay. Room was spotless and the staff is amazing. " [](https://expedia.com/Hilton-Head-Hotels-Sonesta-Resort-Hilton-Head-Island.h2618.Hotel-Information) ![Holiday Inn Express Bluffton at Hilton Head Area by IHG](https://images.trvl-media.com/lodging/1000000/900000/892200/892177/bf3e7e4b_y.jpg) ### Holiday Inn Express Bluffton at Hilton Head Area by IHG 10/10 Excellent "The young Lady who checked us in was delightful and friendly. Clean room, nice area convenient location " [](https://expedia.com/Hilton-Head-Hotels-Holiday-Inn-Express-Bluffton-At-Hilton-Head-Area.h892177.Hotel-Information) ![Beaufort Inn](https://images.trvl-media.com/lodging/3000000/2170000/2169500/2169413/1b8cc041_y.jpg) ### Beaufort Inn 10/10 Excellent "Great place. First time visiting Beaufort and it was super nice. " [](https://expedia.com/Beaufort-Hotels-Beaufort-Inn.h2169413.Hotel-Information) ![Palmera Inn and Suites](https://images.trvl-media.com/lodging/1000000/570000/564600/564590/28eae64d_y.jpg) ### Palmera Inn and Suites 10/10 Excellent "The room was immaculate and well appointed with a refrigerator, microwave, coffee maker, toaster, and even a little two-eye stovetop, full plates/bowls/cups/silverware, pillows out the wazoo, comfy beds, and a small table. We had the hot tub to ourselves on Valentine's night and the checkin/checkout process was effortless. Location was amazing for shopping, out of the way. Not a beachgoer location, but we weren't there for the beach." [](https://expedia.com/Hilton-Head-Hotels-Palmera-Inn-And-Suites.h564590.Hotel-Information) ## Find out more about Ladys Island ## Ladys Island Inns information | Number of reviews | 951 | | ----------------- | ------ | | Accommodation | 1 Inns | | Lowest Price | $406 | | Highest Price | $406 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Beaufort Hotels ](https://www.expedia.com/Beaufort-Hotels.d6057941.Travel-Guide-Hotels) - [Hotels near Newpoint ](https://www.expedia.com/Newpoint-Beaufort-Hotels.0-n553248635976470303-0.Travel-Guide-Filter-Hotels) - [Houseboats in Beaufort County ](https://www.expedia.com/Beaufort-County-Houseboats.d553248635996711332-aaHouseboats.Travel-Guide-Accommodation) - [Rv Parks in Beaufort County ](https://www.expedia.com/Beaufort-County-RV-Parks.d553248635996711332-aaRVParks.Travel-Guide-Accommodation) - [Motels in Beaufort County ](https://www.expedia.com/Beaufort-County-Motels.d553248635996711332-aaMotels.Travel-Guide-Accommodation) - 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