
Popular airlines from Columbia, MO (COU-Columbia Regional) to Greenville-Spartanburg Intl. Airport (GSP)
- American Airlines
American Airlines
 - United
United
 
Cheap Flights from Columbia to Greenville (COU-GSP)
Prices were available within the past 7 days and start at $233 for one-way flights and $270 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.










Frequently asked questions
Travel information
Origin airport  | Columbia Regional | 
|---|---|
Destination airport  | Greenville-Spartanburg Intl. | 
Airlines serving  | American Airlines, United | 
Roundtrip price  | $269 | 
Distance  | 615 mi | 
Book with confidence
Columbia to Greenville Flights
The cheapest times to fly from Columbia to Greenville
On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Columbia to Greenville are during the month of April. You can find some of the cheapest flights from Columbia to Greenville with Expedia's search tool and vast selection of airlines.
The best time to book a flight from Columbia to Greenville
Sunday is one of the best days to book for cheap flights from Columbia to Greenville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.
How to find cheap round-trip tickets from Columbia to Greenville
Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Columbia to Greenville in 2025. You can also book with separate airlines for your outbound and return journeys, from $233 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.
Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Columbia to Greenville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.
You could also save big by booking one of Expedia's vacation packages. Bundling together your Columbia to Greenville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.
*Terms apply.
Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.
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Top Routes from Columbia
- Columbia to Chicago (COU - ORD)
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Top Routes to Greenville
- Chicago to Greenville (ORD - GSP)
 - Newark Liberty Intl. Airport to Greenville (EWR - GSP)
 - Chicago to Greenville (MDW - GSP)
 - Los Angeles to Greenville (LAX - GSP)
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 - Tampa to Greenville (TPA - GSP)
 - New York to Greenville (LGA - GSP)
 - Boston to Greenville (BOS - GSP)
 - Hartford to Greenville (BDL - GSP)
 - Denver to Greenville (DEN - GSP)
 - New York to Greenville (JFK - GSP)
 - Seattle to Greenville (SEA - GSP)
 
Top Routes to Greenville
- Delta Chicago to Greenville
 - Delta Los Angeles to Greenville
 - American Airlines Washington to Greenville
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Airlines Operating
Asheville
Nearby Airports
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