$171 Cheap Flights from Melbourne (MLB) to Des Moines (DSM)

View $171 flight on Thu, Jan 1, 2026Opens in a new window

Popular airlines from Melbourne Orlando Intl. Airport (MLB) to Des Moines International Airport (DSM)

Cheap Flights from Melbourne to Des Moines (MLB-DSM)

Prices were available within the past 7 days and start at $171 for one-way flights and $374 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Fri, Oct 31 - Tue, Nov 18
MLB
Melbourne
DSM
Des Moines
$374 Roundtrip, found 1 day ago
$374
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Oct 31 from Melbourne to Des Moines, returning Tue, Nov 18, priced at $374 found 1 day ago
Delta
Fri, Oct 31 - Wed, Nov 12
MLB
Melbourne
DSM
Des Moines
$379 Roundtrip, found 1 day ago
$379
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Oct 31 from Melbourne to Des Moines, returning Wed, Nov 12, priced at $379 found 1 day ago
Delta
Fri, Oct 31 - Mon, Nov 17
MLB
Melbourne
DSM
Des Moines
$384 Roundtrip, found 1 day ago
$384
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Oct 31 from Melbourne to Des Moines, returning Mon, Nov 17, priced at $384 found 1 day ago
Delta
Fri, Oct 31 - Thu, Nov 13
MLB
Melbourne
DSM
Des Moines
$394 Roundtrip, found 1 day ago
$394
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Oct 31 from Melbourne to Des Moines, returning Thu, Nov 13, priced at $394 found 1 day ago
Delta
Tue, Nov 11 - Tue, Nov 18
MLB
Melbourne
DSM
Des Moines
$412 Roundtrip, found 1 day ago
$412
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Nov 11 from Melbourne to Des Moines, returning Tue, Nov 18, priced at $412 found 1 day ago
Delta
Tue, Nov 11 - Sat, Nov 15
MLB
Melbourne
DSM
Des Moines
$417 Roundtrip, found 1 day ago
$417
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Nov 11 from Melbourne to Des Moines, returning Sat, Nov 15, priced at $417 found 1 day ago
Delta
Tue, Nov 11 - Mon, Nov 17
MLB
Melbourne
DSM
Des Moines
$422 Roundtrip, found 1 day ago
$422
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Nov 11 from Melbourne to Des Moines, returning Mon, Nov 17, priced at $422 found 1 day ago
Delta
Fri, Oct 31 - Sat, Nov 1
MLB
Melbourne
DSM
Des Moines
$424 Roundtrip, found 22 hours ago
$424
Roundtrip
found 22 hours ago
Select Delta flight, departing Fri, Oct 31 from Melbourne to Des Moines, returning Sat, Nov 1, priced at $424 found 22 hours ago
Delta
Mon, Nov 10 - Tue, Nov 18
MLB
Melbourne
DSM
Des Moines
$427 Roundtrip, found 1 day ago
$427
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Nov 10 from Melbourne to Des Moines, returning Tue, Nov 18, priced at $427 found 1 day ago
American Airlines
Thu, Nov 13 - Sun, Nov 16
MLB
Melbourne
DSM
Des Moines
$447 Roundtrip, found 1 day ago
$447
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Nov 13 from Melbourne to Des Moines, returning Sun, Nov 16, priced at $447 found 1 day ago

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $553
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $553
Flights from Melbourne (MLB) to Des Moines (DSM)
Origin airport
Orlando Melbourne Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta
Roundtrip price
$373
Distance
1183 mi

Melbourne to Des Moines Flights

The cheapest times to fly from Melbourne to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Melbourne to Des Moines are during the month of October. You can find some of the cheapest flights from Melbourne to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Melbourne to Des Moines

Sunday is one of the best days to book for cheap flights from Melbourne to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Melbourne to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Melbourne to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $171 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Melbourne to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Melbourne to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Orlando Melbourne Intl. Airport (MLB) to Des Moines Intl. Airport (DSM) cost?
Snag a cheap one-way flight from $171 or cheap return flight from $374 from Orlando Melbourne Intl. Airport (MLB) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Orlando Melbourne Intl. Airport (MLB) to Des Moines Intl. Airport (DSM)?
Flying in October is a good way to save, as it's the cheapest month for flights between MLB and DSM. You'll usually find the lowest fares during the off-season.
Which airlines fly direct from Orlando Melbourne Intl. Airport (MLB) to Des Moines Intl. Airport (DSM)?
While Melbourne, FL (MLB-Orlando Melbourne Intl.) doesn't have any direct flights to Des Moines Intl. Airport (DSM), other airports have nonstop options. Jetting off from Orlando Intl. Airport (MCO) will get you to Des Moines without any layovers.
What is the cheapest airline that flies from Orlando Melbourne Intl. Airport (MLB) to Des Moines Intl. Airport (DSM)?
To find the cheapest airline flying from MLB to DSM, use Expedia's filter tool. Tailor your search based on your travel needs, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Orlando Melbourne Intl. Airport (MLB) to Des Moines Intl. Airport (DSM)?
Nonstop flights from Orlando Melbourne Intl. Airport (MLB) to Des Moines Intl. Airport (DSM) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MLB to DSM?
You'll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Orlando Melbourne Intl. Airport (MLB) to Des Moines Intl. Airport (DSM)?
Select a flight from Orlando Melbourne Intl. Airport (MLB) to Des Moines Intl. Airport (DSM) that leaves before 3 PM to reduce the risk of cancellations and delays. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Orlando Melbourne Intl. Airport (MLB) to Des Moines Intl. Airport (DSM) last-minute?
Booking your flight from MLB to DSM right before your journey is usually more expensive. However, if you're flexible with your schedule, you could snag a cheap last-minute fare.
Is it cheaper to book a MLB to DSM flight and hotel package?
You'll typically save money by booking a MLB to DSM flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one place. After selecting your preferred accommodations and flights, consider other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from Orlando Melbourne Intl. Airport (MLB) to Des Moines Intl. Airport (DSM)?
If you reserved your MLB to DSM flight in the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for further details.

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*Available to One Key members.