$97 Cheap Flights from Knoxville (TYS) to Des Moines (DSM)

View $97 flight on Sat, Oct 18, 2025Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to Des Moines International Airport (DSM)

Cheap Flights from Knoxville to Des Moines (TYS-DSM)

Prices were available within the past 7 days and start at $97 for one-way flights and $193 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Dec 16 - Wed, Dec 31
TYS
Knoxville
DSM
Des Moines
$193 Roundtrip, found 1 day ago
$193
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Dec 16 from Knoxville to Des Moines, returning Wed, Dec 31, priced at $193 found 1 day ago
United
Tue, Dec 16 - Wed, Dec 31
TYS
Knoxville
DSM
Des Moines
$193 Roundtrip, found 1 day ago
$193
Roundtrip
found 1 day ago
Select United flight, departing Tue, Dec 16 from Knoxville to Des Moines, returning Wed, Dec 31, priced at $193 found 1 day ago
American Airlines
Tue, Dec 16 - Wed, Dec 31
TYS
Knoxville
DSM
Des Moines
$194 Roundtrip, found 1 day ago
$194
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Dec 16 from Knoxville to Des Moines, returning Wed, Dec 31, priced at $194 found 1 day ago
Delta
Tue, Dec 16 - Wed, Dec 31
TYS
Knoxville
DSM
Des Moines
$206 Roundtrip, found 1 day ago
$206
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Dec 16 from Knoxville to Des Moines, returning Wed, Dec 31, priced at $206 found 1 day ago
Delta
Tue, Jan 6 - Wed, Jan 21
TYS
Knoxville
DSM
Des Moines
$217 Roundtrip, found 5 hours ago
$217
Roundtrip
found 5 hours ago
Select Delta flight, departing Tue, Jan 6 from Knoxville to Des Moines, returning Wed, Jan 21, priced at $217 found 5 hours ago
United
Tue, Dec 16 - Wed, Dec 31
TYS
Knoxville
DSM
Des Moines
$230 Roundtrip, found 1 day ago
$230
Roundtrip
found 1 day ago
Select United flight, departing Tue, Dec 16 from Knoxville to Des Moines, returning Wed, Dec 31, priced at $230 found 1 day ago
United
Tue, Dec 16 - Wed, Dec 31
TYS
Knoxville
DSM
Des Moines
$231 Roundtrip, found 1 day ago
$231
Roundtrip
found 1 day ago
Select United flight, departing Tue, Dec 16 from Knoxville to Des Moines, returning Wed, Dec 31, priced at $231 found 1 day ago
United
Tue, Dec 16 - Wed, Dec 31
TYS
Knoxville
DSM
Des Moines
$233 Roundtrip, found 1 day ago
$233
Roundtrip
found 1 day ago
Select United flight, departing Tue, Dec 16 from Knoxville to Des Moines, returning Wed, Dec 31, priced at $233 found 1 day ago
Frontier Airlines
Thu, Oct 16 - Thu, Oct 23
TYS
Knoxville
DSM
Des Moines
$284 Roundtrip, found 2 days ago
$284
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Thu, Oct 16 from Knoxville to Des Moines, returning Thu, Oct 23, priced at $284 found 2 days ago
Southwest Airlines
Mon, Apr 20 - Mon, Apr 27
TYS
Knoxville
DSM
Des Moines
$353 Roundtrip, found 1 day ago
$353
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Mon, Apr 20 from Knoxville to Des Moines, returning Mon, Apr 27, priced at $353 found 1 day ago

Find the cheapest month to fly from Knoxville (TYS) to Des Moines (DSM)

February is typically the cheapest month to fly

From $223 - $816 per traveler.

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $307
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $307
Flights from Knoxville (TYS) to Des Moines (DSM)
Origin airport
McGhee Tyson
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Frontier Airlines, Southwest Airlines, United
Roundtrip price
$192
Distance
653 mi

Knoxville to Des Moines Flights

The cheapest times to fly from Knoxville to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Des Moines are during the month of December. You can find some of the cheapest flights from Knoxville to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to Des Moines

Sunday is one of the best days to book for cheap flights from Knoxville to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $97 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to Des Moines Intl. Airport (DSM) cost?
Lock in a cheap one-way flight from $97 or cheap return flight from $193 from McGhee Tyson Airport (TYS) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from McGhee Tyson Airport (TYS) to Des Moines Intl. Airport (DSM)?
Planning your getaway for December may help you find better deals, as it's the cheapest month for flights between TYS and DSM. You'll often find the lowest prices during off-peak months.
What is the cheapest airline that flies from McGhee Tyson Airport (TYS) to Des Moines Intl. Airport (DSM)?
Expedia's filter tool lets you easily compare different airlines, departure times and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest TYS to DSM flight.
How many flights per day from McGhee Tyson Airport (TYS) to Des Moines Intl. Airport (DSM)?
You'll have to take a flight with a layover if you're traveling from McGhee Tyson Airport (TYS) to Des Moines Intl. Airport (DSM). There are no daily direct flights on this route. However, just filter your search to include one or more stops to discover the best option for your trip.
What day of the week has the most flights from TYS to DSM?
Generally you'll find the largest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* But this can vary based on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What airline has the least delays from TYS to DSM?
With 100% of flights typically landing on schedule, Delta Air Lines has the best on-time performance for nonstop flights from McGhee Tyson Airport (TYS) to Des Moines Intl. Airport (DSM). To check your flight status and get notified if anything changes, head to the Expedia App.
What is the best time to fly from McGhee Tyson Airport (TYS) to Des Moines Intl. Airport (DSM)?
Opt for a flight from McGhee Tyson Airport (TYS) to Des Moines Intl. Airport (DSM) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures after this time are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to Des Moines Intl. Airport (DSM) last-minute?
Waiting until right before your break to book a ticket from TYS to DSM generally means paying more. While you might find some last-minute deals, they aren't always guaranteed. Allow some flexibility in your schedule to maximize your chances of getting a bargain.
Is it cheaper to book a TYS to DSM flight and hotel package?
You can save money by booking a TYS to DSM flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. Once you've selected your ideal accommodations and flights, consider adding extras including car rentals, activities and tours.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to Des Moines Intl. Airport (DSM)?
In most cases, you can modify or cancel your TYS to DSM flight. However, additional charges may apply, especially if your booking was made more than 24 hours ago. Double-check your itinerary for the airline's fees and guidelines on flight changes, or if you'd like further information, head to our Customer Service portal.

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*Available to One Key members.