$359 Cheap Flights from Zacatecas (ZCL) to Des Moines (DSM)

View $359 flight on Mon, Nov 24, 2025Opens in a new window

Popular airlines from Zacatecas, Zacatecas (ZCL-General Leobardo C. Ruiz Intl.) to Des Moines International Airport (DSM)

Cheap Flights from Zacatecas to Des Moines (ZCL-DSM)

Prices were available within the past 7 days and start at $359 for one-way flights and $703 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Sep 2 - Thu, Sep 11
ZCL
Zacatecas
DSM
Des Moines
$703 Roundtrip, found 6 days ago
$703
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Sep 2 from Zacatecas to Des Moines, returning Thu, Sep 11, priced at $703 found 6 days ago
American Airlines
Tue, Sep 2 - Mon, Sep 8
ZCL
Zacatecas
DSM
Des Moines
$729 Roundtrip, found 16 hours ago
$729
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Tue, Sep 2 from Zacatecas to Des Moines, returning Mon, Sep 8, priced at $729 found 16 hours ago
American Airlines
Thu, Aug 28 - Mon, Sep 8
ZCL
Zacatecas
DSM
Des Moines
$768 Roundtrip, found 16 hours ago
$768
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Thu, Aug 28 from Zacatecas to Des Moines, returning Mon, Sep 8, priced at $768 found 16 hours ago
American Airlines
Tue, Sep 2 - Sun, Sep 7
ZCL
Zacatecas
DSM
Des Moines
$776 Roundtrip, found 16 hours ago
$776
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Tue, Sep 2 from Zacatecas to Des Moines, returning Sun, Sep 7, priced at $776 found 16 hours ago
American Airlines
Sun, Aug 31 - Mon, Sep 8
ZCL
Zacatecas
DSM
Des Moines
$794 Roundtrip, found 16 hours ago
$794
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Sun, Aug 31 from Zacatecas to Des Moines, returning Mon, Sep 8, priced at $794 found 16 hours ago
Aeromexico
Tue, Sep 2 - Tue, Sep 9
ZCL
Zacatecas
DSM
Des Moines
$805 Roundtrip, found 16 hours ago
$805
Roundtrip
found 16 hours ago
Select Aeromexico flight, departing Tue, Sep 2 from Zacatecas to Des Moines, returning Tue, Sep 9, priced at $805 found 16 hours ago
American Airlines
Thu, Aug 28 - Sun, Sep 7
ZCL
Zacatecas
DSM
Des Moines
$815 Roundtrip, found 16 hours ago
$815
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Thu, Aug 28 from Zacatecas to Des Moines, returning Sun, Sep 7, priced at $815 found 16 hours ago
Delta
Fri, Aug 29 - Tue, Sep 9
ZCL
Zacatecas
DSM
Des Moines
$900 Roundtrip, found 16 hours ago
$900
Roundtrip
found 16 hours ago
Select Delta flight, departing Fri, Aug 29 from Zacatecas to Des Moines, returning Tue, Sep 9, priced at $900 found 16 hours ago

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $815
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $815
Flights from Zacatecas (ZCL) to Des Moines (DSM)
Origin airport
General Leobardo C. Ruiz Intl.
Destination airport
Des Moines Intl.
Airlines serving
Aeromexico, American Airlines, Delta
Roundtrip price
$703
Distance
1389 mi

Zacatecas to Des Moines Flights

The cheapest times to fly from Zacatecas to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Zacatecas to Des Moines are during the month of September. You can find some of the cheapest flights from Zacatecas to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Zacatecas to Des Moines

Sunday is one of the best days to book for cheap flights from Zacatecas to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Zacatecas to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Zacatecas to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $359 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Zacatecas to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Zacatecas to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from General Leobardo C. Ruiz Intl. Airport (ZCL) to Des Moines Intl. Airport (DSM) cost?
Snag a cheap one-way flight from $359 or cheap return flight from $703 from General Leobardo C. Ruiz Intl. Airport (ZCL) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from General Leobardo C. Ruiz Intl. Airport (ZCL) to Des Moines Intl. Airport (DSM)?
September is the cheapest month to fly from ZCL to DSM. Traveling during quieter months is often the key to scoring lower fares.
What is the cheapest airline that flies from General Leobardo C. Ruiz Intl. Airport (ZCL) to Des Moines Intl. Airport (DSM)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest ZCL to DSM flight.
How many flights per day from General Leobardo C. Ruiz Intl. Airport (ZCL) to Des Moines Intl. Airport (DSM)?
You'll need to catch a flight with a layover when traveling from General Leobardo C. Ruiz Intl. Airport (ZCL) to Des Moines Intl. Airport (DSM). Direct flights don't operate daily on this route. However, just filter your search to include one or more stops to find an option that works for you.
What day of the week has the most flights from ZCL to DSM?
You'll usually find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from General Leobardo C. Ruiz Intl. Airport (ZCL) to Des Moines Intl. Airport (DSM)?
To land at Des Moines Intl. Airport (DSM) on time, choose a flight that leaves from General Leobardo C. Ruiz Intl. Airport (ZCL) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from General Leobardo C. Ruiz Intl. Airport (ZCL) to Des Moines Intl. Airport (DSM) last-minute?
Waiting until just before your trip to book a flight from ZCL to DSM generally means paying more. While you may come across some last-minute offers, they're not always guaranteed. Be flexible with your travel plans for the best chance of landing a bargain.
Is it cheaper to book a ZCL to DSM flight and hotel package?
Compared with arranging hotels and flights separately, booking a ZCL to DSM flight and hotel package with Expedia could result in significant savings. Better still, having everything in one easy place takes the hassle out of planning your trip. Just secure your flights and choose from our wide range of hotels, then customize your trip with other add-ons like activities and car rentals.
Can I cancel or change the date of my flight from General Leobardo C. Ruiz Intl. Airport (ZCL) to Des Moines Intl. Airport (DSM)?
Typically, it's possible to cancel or reschedule your ZCL to DSM flight. However, if it's been more than 24 hours since booking, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find more details on our Customer Service portal.

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*Available to One Key members.