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Discover 4,700 Downtown South San Francisco hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.
Our top choices for Downtown South San Francisco hotels

Hotel des Arts
Hotel des Arts

Alpine Inn And Suites
Alpine Inn And Suites

Gateway Inn & Suites San Francisco SFO Airport
Gateway Inn & Suites San Francisco SFO Airport

Inn By The SFO
Inn By The SFO

Miller Apartments
Miller Apartments

Airport Inn
Airport Inn
Where to stay in Downtown South San Francisco

Fisherman's Wharf
Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.

Union Square
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

Downtown San Francisco
Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.

South of Market
From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

Nob Hill
Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.
Top Downtown South San Francisco Hotel Reviews
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