Find hotels near San Diego Santa Fe Depot, San Diego from $60
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Our top choices for San Diego Santa Fe Depot hotels
9.6 out of 10, Exceptional, (783)
"Good place to stay "
sai
$52 nightly
The price is $60
Dec 16 - Dec 17
Total with taxes and fees
City24 Hotel Little Italy Mission Hills
City24 Hotel Little Italy Mission Hills1.2 mi from San Diego Santa Fe Depot
9.6 out of 10, Exceptional, (104)
"would definitely go back and stay there again "
Kounwick
$166 nightly
The price is $187
Dec 18 - Dec 19
Total with taxes and fees
Marriott Vacation Club®, San Diego
Marriott Vacation Club®, San Diego0.7 mi from San Diego Santa Fe Depot
9.4 out of 10, Exceptional, (1001)
"I like the Hotel!!"
Karla
$135 nightly
The price is $157
Dec 24 - Dec 25
Total with taxes and fees
Staypineapple, Hotel Z, Gaslamp San Diego
Staypineapple, Hotel Z, Gaslamp San DiegoGaslamp Quarter, 0.7 mi from San Diego Santa Fe Depot
9.4 out of 10, Exceptional, (1000)
"Great location "
Mohammad
$137 nightly
The price is $159
Dec 26 - Dec 27
Total with taxes and fees
Springhill Suites San Diego Downtown/Bayfront
Springhill Suites San Diego Downtown/Bayfront0.1 mi from San Diego Santa Fe Depot
9.2 out of 10, Wonderful, (1000)
"Great place to stay"
Kimberly
$188 nightly
The price is $218
Jan 5 - Jan 6, 2026
Total with taxes and fees
InterContinental San Diego by IHG
InterContinental San Diego by IHG0.2 mi from San Diego Santa Fe Depot
9.2 out of 10, Wonderful, (1113)
"Excellent location prior to a cruise."
Joan
$265 nightly
The price is $307
Jan 4 - Jan 5, 2026
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top San Diego Santa Fe Depot Hotel Reviews
Lafayette Hotel & Club
10/10 Excellent
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