$749 Cheap Flights from Milan (MXP) to Des Moines (DSM)

View $749 flight on Fri, Jan 30, 2026Opens in a new window

Popular airlines from Milan Malpensa Airport (MXP) to Des Moines International Airport (DSM)

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Cheap Flights from Milan to Des Moines (MXP-DSM)

Prices were available within the past 7 days and start at $749 for one-way flights and $767 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Oct 8 - Wed, Oct 15
MXP
Milan
DSM
Des Moines
$767 Roundtrip, found 6 hours ago
$767
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Wed, Oct 8 from Milan to Des Moines, returning Wed, Oct 15, priced at $767 found 6 hours ago
Delta
Wed, Oct 8 - Wed, Oct 15
MXP
Milan
DSM
Des Moines
$793 Roundtrip, found 6 hours ago
$793
Roundtrip
found 6 hours ago
Select Delta flight, departing Wed, Oct 8 from Milan to Des Moines, returning Wed, Oct 15, priced at $793 found 6 hours ago
Delta
Wed, Oct 8 - Wed, Oct 15
MXP
Milan
DSM
Des Moines
$817 Roundtrip, found 6 hours ago
$817
Roundtrip
found 6 hours ago
Select Delta flight, departing Wed, Oct 8 from Milan to Des Moines, returning Wed, Oct 15, priced at $817 found 6 hours ago
Air France
Wed, Oct 8 - Wed, Oct 15
MXP
Milan
DSM
Des Moines
$824 Roundtrip, found 6 hours ago
$824
Roundtrip
found 6 hours ago
Select Air France flight, departing Wed, Oct 8 from Milan to Des Moines, returning Wed, Oct 15, priced at $824 found 6 hours ago
Air France
Wed, Oct 8 - Wed, Oct 15
MXP
Milan
DSM
Des Moines
$841 Roundtrip, found 6 hours ago
$841
Roundtrip
found 6 hours ago
Select Air France flight, departing Wed, Oct 8 from Milan to Des Moines, returning Wed, Oct 15, priced at $841 found 6 hours ago
Air France
Wed, Oct 8 - Wed, Oct 15
MXP
Milan
DSM
Des Moines
$843 Roundtrip, found 6 hours ago
$843
Roundtrip
found 6 hours ago
Select Air France flight, departing Wed, Oct 8 from Milan to Des Moines, returning Wed, Oct 15, priced at $843 found 6 hours ago
KLM
Wed, Oct 8 - Wed, Oct 15
MXP
Milan
DSM
Des Moines
$845 Roundtrip, found 6 hours ago
$845
Roundtrip
found 6 hours ago
Select KLM flight, departing Wed, Oct 8 from Milan to Des Moines, returning Wed, Oct 15, priced at $845 found 6 hours ago
Air France
Wed, Oct 8 - Wed, Oct 15
MXP
Milan
DSM
Des Moines
$847 Roundtrip, found 6 hours ago
$847
Roundtrip
found 6 hours ago
Select Air France flight, departing Wed, Oct 8 from Milan to Des Moines, returning Wed, Oct 15, priced at $847 found 6 hours ago
Delta
Wed, Oct 8 - Wed, Oct 15
MXP
Milan
DSM
Des Moines
$862 Roundtrip, found 6 hours ago
$862
Roundtrip
found 6 hours ago
Select Delta flight, departing Wed, Oct 8 from Milan to Des Moines, returning Wed, Oct 15, priced at $862 found 6 hours ago
Air Canada
Wed, Oct 8 - Wed, Oct 15
MXP
Milan
DSM
Des Moines
$873 Roundtrip, found 6 hours ago
$873
Roundtrip
found 6 hours ago
Select Air Canada flight, departing Wed, Oct 8 from Milan to Des Moines, returning Wed, Oct 15, priced at $873 found 6 hours ago
Flights from Milan (MXP) to Des Moines (DSM)
Origin airport
Malpensa Intl.
Destination airport
Des Moines Intl.
Airlines serving
Air Canada, Air France, American Airlines, Delta, KLM, Lufthansa, United
Roundtrip price
$767
Distance
4752 mi

Milan to Des Moines Flights

The cheapest times to fly from Milan to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Milan to Des Moines are during the month of October. You can find some of the cheapest flights from Milan to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Milan to Des Moines

Sunday is one of the best days to book for cheap flights from Milan to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Milan to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Milan to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $749 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Milan to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Milan to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Malpensa Intl. Airport (MXP) to Des Moines Intl. Airport (DSM) cost?
Discover the latest flight deals from MXP to DSM by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MXP to DSM?
The cheapest flights from MXP to DSM are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from MXP to DSM?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from MXP to DSM. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Malpensa Intl. Airport (MXP) to Des Moines Intl. Airport (DSM)?
You'll have to hop on a flight with a layover if you're traveling from Malpensa Intl. Airport (MXP) to Des Moines Intl. Airport (DSM). There are no daily direct flights on this route. However, just filter your search to include one or more stops to find an option that works for you.
What day of the week has the most flights from MXP to DSM?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can vary depending on a number of factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Malpensa Intl. Airport (MXP) to Des Moines Intl. Airport (DSM)?
To avoid potential delays on the Malpensa Intl. Airport (MXP) to Des Moines Intl. Airport (DSM) route, fly before 3 PM. Later departures have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Malpensa Intl. Airport (MXP) to Des Moines Intl. Airport (DSM) last-minute?
Waiting until just before your departure to book a flight from MXP to DSM often results in higher prices. Although you may find some last-minute discounts, there's no guarantee. Keep your travel plans flexible to boost your chances of getting a bargain.
Is it cheaper to book a MXP to DSM flight and hotel package?
You'll generally save money by booking a MXP to DSM flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one convenient place. Once you've chosen your preferred accommodations and flights, you can add extras such as car rentals, tours and activities.
Can I cancel or change the date of my flight from Malpensa Intl. Airport (MXP) to Des Moines Intl. Airport (DSM)?
If you booked your MXP to DSM flight in the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the type of fare you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal if you'd like more information.

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*Available to One Key members.