
Popular airlines from Santiago Intl. Airport (SCL) to Santa Cruz (VVI-Viru Viru Intl.)
- LATAM Airlines Group
LATAM Airlines Group
- GOL Linhas Aereas S.A.
GOL Linhas Aereas S.A.
- Aerolineas Argentinas
Aerolineas Argentinas
- Plan, book, fly with confidence
trending down icon Be in the knowGet alerts if flight prices drop or rise*bex rewards loyalty icon Book smarterSave up to 30% on select hotels after you book a flight*one key icon
Cheap Flights from Santiago to Santa Cruz (SCL-VVI)
Prices were available within the past 7 days and start at $141 for one-way flights and $297 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.










Alternative airports near Santa Cruz
Prices were available within the past 7 days. Prices and availability are subject to change.
Origin airport | Arturo Merino Benitez |
Destination airport | Viru Viru Intl. |
Airlines serving | Aerolineas Argentinas, GOL Linhas Aereas S.A., LATAM Airlines Group |
Roundtrip price | $297 |
Distance | 1187 mi |
Santiago to Santa Cruz Flights
The cheapest times to fly from Santiago to Santa Cruz
On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santiago to Santa Cruz are during the month of August. You can find some of the cheapest flights from Santiago to Santa Cruz with Expedia's search tool and vast selection of airlines.
The best time to book a flight from Santiago to Santa Cruz
Sunday is one of the best days to book for cheap flights from Santiago to Santa Cruz: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.
How to find cheap round-trip tickets from Santiago to Santa Cruz
Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santiago to Santa Cruz in 2025. You can also book with separate airlines for your outbound and return journeys, from $141 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.
Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santiago to Santa Cruz flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.
You could also save big by booking one of Expedia's vacation packages. Bundling together your Santiago to Santa Cruz airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.
*Terms apply.
Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.
Frequently asked questions
Explore a world of travel with Expedia
Top Routes from Santiago
- Santiago to Newark Liberty Intl. Airport (SCL - EWR)
- Santiago to Los Angeles (SCL - LAX)
- Santiago to Miami (SCL - MIA)
- Santiago to Rio de Janeiro (SCL - GIG)
- Santiago to Punta Cana (SCL - PUJ)
- Santiago to Rio de Janeiro (SCL - SDU)
- Santiago to New York (SCL - LGA)
- Santiago to Florianópolis (SCL - FLN)
- Santiago to Buenos Aires (SCL - AEP)
- Santiago to Barcelona (SCL - BCN)
- Santiago to Punta Arenas (SCL - PUQ)
- Santiago to New York (SCL - JFK)
Top Routes to Santa Cruz
- Chicago to Santa Cruz (ORD - VVI)
- Newark Liberty Intl. Airport to Santa Cruz (EWR - VVI)
- Los Angeles to Santa Cruz (LAX - VVI)
- Washington to Santa Cruz (DCA - VVI)
- Asuncion to Santa Cruz (ASU - VVI)
- Miami to Santa Cruz (MIA - VVI)
- New York to Santa Cruz (LGA - VVI)
- Fort Lauderdale to Santa Cruz (FLL - VVI)
- Boston to Santa Cruz (BOS - VVI)
- São Paulo to Santa Cruz (GRU - VVI)
- Washington to Santa Cruz (IAD - VVI)
- New York to Santa Cruz (JFK - VVI)
Top Flight Destinations
- Flights to La Paz
- Flights to Santa Cruz
- Flights to Uyuni
- Flights to Cochabamba
- Flights to Sucre
- Flights to Copacabana
- Flights to Tarija
- Flights to Coroico
- Flights to Potosi
- Flights to Colcha K
- Flights to Samaipata
- Flights to Isla del Sol
- Flights to Oruro
- Flights to Rurrenabaque
- Flights to Tupiza
- Flights to Tiwanaku
- Flights to Colchani
- Flights to Villa Tunari
- Flights to Coquesa
- Flights to San Jose de Chiquitos
Expedia's Latest Trends
- The Mozart Prague by Accor
- La Quinta Resort & Club, Curio Collection by Hilton
- Tampa Golf Hotels
- Hotel Rooms in Bridgeton
- Hampton Inn Galax
- Wyndham Grand Desert - Las Vegas - 1 Bedroom Deluxe
- Florence Pet-friendly Hotels
- Best Western Plus Rivershore Hotel
- Best Western Plus Castle Rock
- Springhill Suites Milford
- B&B Eureka Springs
- SpringHill Suites Scottsdale North
- UH Suite The Jongno
- Oakland (OAK) to Santa Cruz (SRZ) Flights
- Anchorage (ANC) to Minneapolis (MSP) Flights
- Flights to AVL
- Miami (MIA) to Bucharest (OTP) Flights
- Stockton (SCK) to Santa Cruz (SRZ) Flights
- Cheap Flights from El Trompillo Airport
- San Diego (SAN) to Santa Cruz (SRZ) Flights
- Tulsa (TUL) to Orange County (SNA) Flights
- San Luis Obispo (SBP) to Santa Cruz (SRZ) Flights
- Flights to NYC
- United Fort Lauderdale (FLL) to Newark (EWR) flights
- Reno (RNO) to Santa Cruz (SRZ) Flights