$116 Cheap Flights from McAllen (MFE) to Des Moines (DSM)

View $116 flight on Tue, Jan 20, 2026Opens in a new window

Popular airlines from Miller Intl. Airport (MFE) to Des Moines International Airport (DSM)

Cheap Flights from McAllen to Des Moines (MFE-DSM)

Prices were available within the past 7 days and start at $116 for one-way flights and $259 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Mon, Jan 12 - Sat, Jan 17
MFE
McAllen
DSM
Des Moines
$259 Roundtrip, found 22 hours ago
$259
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Mon, Jan 12 from McAllen to Des Moines, returning Sat, Jan 17, priced at $259 found 22 hours ago
Delta
Tue, Dec 16 - Thu, Jan 1
MFE
McAllen
DSM
Des Moines
$260 Roundtrip, found 2 days ago
$260
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Dec 16 from McAllen to Des Moines, returning Thu, Jan 1, priced at $260 found 2 days ago
Delta
Sat, Feb 14 - Tue, Feb 24
MFE
McAllen
DSM
Des Moines
$265 Roundtrip, found 3 days ago
$265
Roundtrip
found 3 days ago
Select Delta flight, departing Sat, Feb 14 from McAllen to Des Moines, returning Tue, Feb 24, priced at $265 found 3 days ago
Delta
Wed, Jan 21 - Tue, Jan 27
MFE
McAllen
DSM
Des Moines
$269 Roundtrip, found 8 hours ago
$269
Roundtrip
found 8 hours ago
Select Delta flight, departing Wed, Jan 21 from McAllen to Des Moines, returning Tue, Jan 27, priced at $269 found 8 hours ago
American Airlines
Tue, Nov 11 - Tue, Nov 18
MFE
McAllen
DSM
Des Moines
$284 Roundtrip, found 1 day ago
$284
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Nov 11 from McAllen to Des Moines, returning Tue, Nov 18, priced at $284 found 1 day ago
Delta
Thu, Dec 11 - Thu, Jan 1
MFE
McAllen
DSM
Des Moines
$287 Roundtrip, found 2 days ago
$287
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Dec 11 from McAllen to Des Moines, returning Thu, Jan 1, priced at $287 found 2 days ago
American Airlines
Thu, Nov 13 - Sat, Nov 15
MFE
McAllen
DSM
Des Moines
$289 Roundtrip, found 2 days ago
$289
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Nov 13 from McAllen to Des Moines, returning Sat, Nov 15, priced at $289 found 2 days ago
Delta
Sun, Dec 14 - Thu, Jan 1
MFE
McAllen
DSM
Des Moines
$290 Roundtrip, found 2 days ago
$290
Roundtrip
found 2 days ago
Select Delta flight, departing Sun, Dec 14 from McAllen to Des Moines, returning Thu, Jan 1, priced at $290 found 2 days ago
Delta
Mon, Feb 2 - Tue, Feb 17
MFE
McAllen
DSM
Des Moines
$292 Roundtrip, found 3 days ago
$292
Roundtrip
found 3 days ago
Select Delta flight, departing Mon, Feb 2 from McAllen to Des Moines, returning Tue, Feb 17, priced at $292 found 3 days ago
United
Thu, Nov 13 - Sat, Nov 15
MFE
McAllen
DSM
Des Moines
$294 Roundtrip, found 2 days ago
$294
Roundtrip
found 2 days ago
Select United flight, departing Thu, Nov 13 from McAllen to Des Moines, returning Sat, Nov 15, priced at $294 found 2 days ago

Find the cheapest month to fly from McAllen (MFE) to Des Moines (DSM)

May is typically the cheapest month to fly

From $228 - $528 per traveler.

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $354
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $354

Frequently asked questions

How much does a flight from Miller Intl. Airport (MFE) to Des Moines Intl. Airport (DSM) cost?
Get a cheap one-way flight from $116 or cheap return flight from $259 from Miller Intl. Airport (MFE) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Miller Intl. Airport (MFE) to Des Moines Intl. Airport (DSM)?
Planning your trip for January is a good way to save, as it's the cheapest month for flights between MFE and DSM. You'll often find the lowest prices during off-peak months.
What is the cheapest airline that flies from Miller Intl. Airport (MFE) to Des Moines Intl. Airport (DSM)?
Use the filter tool on Expedia to compare different airlines and find the most affordable carrier that'll take you from MFE to DSM. Then, sort your results by "Price (lowest to highest)" to pick up a great deal.
How many flights per day from Miller Intl. Airport (MFE) to Des Moines Intl. Airport (DSM)?
Nonstop flights from Miller Intl. Airport (MFE) to Des Moines Intl. Airport (DSM) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and click on either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MFE to DSM?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can vary depending on a number of factors, such as the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Miller Intl. Airport (MFE) to Des Moines Intl. Airport (DSM)?
To avoid potential delays on the Miller Intl. Airport (MFE) to Des Moines Intl. Airport (DSM) route, travel before 3 PM. Flights after this time are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Miller Intl. Airport (MFE) to Des Moines Intl. Airport (DSM) last-minute?
Last-minute bookings from MFE to DSM are usually more expensive. For the cheapest rates, start searching for flights as early as possible. That being said, if you're flexible with your travel dates, it's possible to score a cheap ticket right before your journey.
Is it cheaper to book a MFE to DSM flight and hotel package?
Compared with arranging hotels and flights separately, booking a MFE to DSM flight and hotel package with Expedia could lead to significant savings. Better yet, having everything in one convenient place takes the hassle out of travel planning. Simply pick your flights and select from our wide range of stays, then customize your trip with extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Miller Intl. Airport (MFE) to Des Moines Intl. Airport (DSM)?
In most cases, you're able to cancel or reschedule your MFE to DSM flight. However, additional fees may apply, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline's fees and rules on flight changes, or if you'd like further information, go to our Customer Service portal.

Travel information

Origin airport
Miller Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$258
Distance
1092 mi

Book with confidence

McAllen to Des Moines Flights

The cheapest times to fly from McAllen to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from McAllen to Des Moines are during the month of January. You can find some of the cheapest flights from McAllen to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from McAllen to Des Moines

Sunday is one of the best days to book for cheap flights from McAllen to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from McAllen to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from McAllen to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $116 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap McAllen to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your McAllen to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

McAllen to Des Moines Flights

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*Available to One Key members.