$225 Cheap Flights from Medford (MFR) to Des Moines (DSM)

View $225 flight on Tue, Jan 6, 2026Opens in a new window

Popular airlines from Rogue Valley Intl. Airport (MFR) to Des Moines International Airport (DSM)

Cheap Flights from Medford to Des Moines (MFR-DSM)

Prices were available within the past 7 days and start at $225 for one-way flights and $269 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Dec 12 - Sun, Dec 14
MFR
Medford
DSM
Des Moines
$269 Roundtrip, found 12 hours ago
$269
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Fri, Dec 12 from Medford to Des Moines, returning Sun, Dec 14, priced at $269 found 12 hours ago
United
Wed, Dec 10 - Sun, Dec 14
MFR
Medford
DSM
Des Moines
$269 Roundtrip, found 13 hours ago
$269
Roundtrip
found 13 hours ago
Select United flight, departing Wed, Dec 10 from Medford to Des Moines, returning Sun, Dec 14, priced at $269 found 13 hours ago
Delta
Fri, Dec 12 - Sun, Dec 14
MFR
Medford
DSM
Des Moines
$279 Roundtrip, found 12 hours ago
$279
Roundtrip
found 12 hours ago
Select Delta flight, departing Fri, Dec 12 from Medford to Des Moines, returning Sun, Dec 14, priced at $279 found 12 hours ago
United
Wed, Dec 10 - Sun, Dec 14
MFR
Medford
DSM
Des Moines
$293 Roundtrip, found 13 hours ago
$293
Roundtrip
found 13 hours ago
Select United flight, departing Wed, Dec 10 from Medford to Des Moines, returning Sun, Dec 14, priced at $293 found 13 hours ago
Delta
Wed, Dec 10 - Sat, Dec 13
MFR
Medford
DSM
Des Moines
$304 Roundtrip, found 2 days ago
$304
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Dec 10 from Medford to Des Moines, returning Sat, Dec 13, priced at $304 found 2 days ago
Delta
Wed, Nov 19 - Sun, Nov 23
MFR
Medford
DSM
Des Moines
$314 Roundtrip, found 3 days ago
$314
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Nov 19 from Medford to Des Moines, returning Sun, Nov 23, priced at $314 found 3 days ago
American Airlines
Tue, Dec 9 - Tue, Dec 16
MFR
Medford
DSM
Des Moines
$329 Roundtrip, found 18 hours ago
$329
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Tue, Dec 9 from Medford to Des Moines, returning Tue, Dec 16, priced at $329 found 18 hours ago
Delta
Wed, Dec 10 - Sun, Dec 14
MFR
Medford
DSM
Des Moines
$329 Roundtrip, found 13 hours ago
$329
Roundtrip
found 13 hours ago
Select Delta flight, departing Wed, Dec 10 from Medford to Des Moines, returning Sun, Dec 14, priced at $329 found 13 hours ago
Delta
Wed, Dec 10 - Sun, Dec 14
MFR
Medford
DSM
Des Moines
$339 Roundtrip, found 13 hours ago
$339
Roundtrip
found 13 hours ago
Select Delta flight, departing Wed, Dec 10 from Medford to Des Moines, returning Sun, Dec 14, priced at $339 found 13 hours ago
Alaska Airlines
Sat, Dec 13 - Tue, Dec 16
MFR
Medford
DSM
Des Moines
$359 Roundtrip, found 2 days ago
$359
Roundtrip
found 2 days ago
Select Alaska Airlines flight, departing Sat, Dec 13 from Medford to Des Moines, returning Tue, Dec 16, priced at $359 found 2 days ago

Find the cheapest month to fly from Medford (MFR) to Des Moines (DSM)

October is typically the cheapest month to fly

From $268 - $733 per traveler.

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $379
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $379

Frequently asked questions

How much does a flight from Rogue Valley Intl. Airport (MFR) to Des Moines Intl. Airport (DSM) cost?
Get a cheap one-way flight from $225 or cheap return flight from $269 from Rogue Valley Intl. Airport (MFR) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Rogue Valley Intl. Airport (MFR) to Des Moines Intl. Airport (DSM)?
Traveling in December is a good way to save, as it's the cheapest month for flights between MFR and DSM. You'll typically find the lowest prices during the off-season.
What is the cheapest airline that flies from Rogue Valley Intl. Airport (MFR) to Des Moines Intl. Airport (DSM)?
Use the filters on Expedia to compare different airlines and find the cheapest carrier that'll fly you from MFR to DSM. Then, sort your results by "Price (lowest to highest)" to snag a good deal.
How many flights per day from Rogue Valley Intl. Airport (MFR) to Des Moines Intl. Airport (DSM)?
Nonstop flights from Rogue Valley Intl. Airport (MFR) to Des Moines Intl. Airport (DSM) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MFR to DSM?
You'll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Rogue Valley Intl. Airport (MFR) to Des Moines Intl. Airport (DSM)?
To reach Des Moines Intl. Airport (DSM) without delays, select a flight that leaves from Rogue Valley Intl. Airport (MFR) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Rogue Valley Intl. Airport (MFR) to Des Moines Intl. Airport (DSM) last-minute?
Last-minute bookings from MFR to DSM are generally more expensive. To lock in the cheapest rates, start searching for flights as soon as possible. That said, if your travel plans are flexible, it's possible to score a cheap ticket right before your journey.
Is it cheaper to book a MFR to DSM flight and hotel package?
You can save money by securing a MFR to DSM flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one place. After selecting your ideal flights and accommodations, consider adding extras including activities, tours and car rentals.
Can I cancel or change the date of my flight from Rogue Valley Intl. Airport (MFR) to Des Moines Intl. Airport (DSM)?
Typically, it's possible to reschedule or cancel your MFR to DSM flight. However, if it's been more than 24 hours since booking, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find more information on our Customer Service portal.

Travel information

Origin airport
Rogue Valley Intl.
Destination airport
Des Moines Intl.
Airlines serving
Alaska Airlines, American Airlines, Delta, United
Roundtrip price
$268
Distance
1495 mi

Book with confidence

Medford to Des Moines Flights

The cheapest times to fly from Medford to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medford to Des Moines are during the month of December. You can find some of the cheapest flights from Medford to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medford to Des Moines

Sunday is one of the best days to book for cheap flights from Medford to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medford to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medford to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $225 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medford to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medford to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Medford to Des Moines Flights

Explore a world of travel with Expedia

*Available to One Key members.