$273 Cheap Flights from Monroe (MLU) to Des Moines (DSM)

View $273 flight on Tue, Jan 13, 2026Opens in a new window

Popular airlines from Monroe, LA (MLU-Monroe Regional) to Des Moines International Airport (DSM)

Cheap Flights from Monroe to Des Moines (MLU-DSM)

Prices were available within the past 7 days and start at $273 for one-way flights and $378 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Oct 3 - Mon, Oct 6
MLU
Monroe
DSM
Des Moines
$378 Roundtrip, found 3 days ago
$378
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 3 from Monroe to Des Moines, returning Mon, Oct 6, priced at $378 found 3 days ago
Delta
Tue, Sep 30 - Sat, Oct 4
MLU
Monroe
DSM
Des Moines
$393 Roundtrip, found 3 days ago
$393
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Sep 30 from Monroe to Des Moines, returning Sat, Oct 4, priced at $393 found 3 days ago
American Airlines
Thu, Oct 9 - Mon, Oct 13
MLU
Monroe
DSM
Des Moines
$398 Roundtrip, found 3 days ago
$398
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Oct 9 from Monroe to Des Moines, returning Mon, Oct 13, priced at $398 found 3 days ago
American Airlines
Fri, Oct 3 - Mon, Oct 6
MLU
Monroe
DSM
Des Moines
$448 Roundtrip, found 3 days ago
$448
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 3 from Monroe to Des Moines, returning Mon, Oct 6, priced at $448 found 3 days ago
Delta
Fri, Oct 3 - Mon, Oct 6
MLU
Monroe
DSM
Des Moines
$458 Roundtrip, found 3 days ago
$458
Roundtrip
found 3 days ago
Select Delta flight, departing Fri, Oct 3 from Monroe to Des Moines, returning Mon, Oct 6, priced at $458 found 3 days ago
American Airlines
Tue, Sep 30 - Sun, Oct 5
MLU
Monroe
DSM
Des Moines
$463 Roundtrip, found 3 days ago
$463
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Sep 30 from Monroe to Des Moines, returning Sun, Oct 5, priced at $463 found 3 days ago
American Airlines
Thu, Oct 9 - Mon, Oct 13
MLU
Monroe
DSM
Des Moines
$468 Roundtrip, found 3 days ago
$468
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Oct 9 from Monroe to Des Moines, returning Mon, Oct 13, priced at $468 found 3 days ago
Delta
Wed, Oct 1 - Mon, Oct 6
MLU
Monroe
DSM
Des Moines
$473 Roundtrip, found 3 days ago
$473
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Oct 1 from Monroe to Des Moines, returning Mon, Oct 6, priced at $473 found 3 days ago
American Airlines
Thu, Oct 9 - Mon, Oct 13
MLU
Monroe
DSM
Des Moines
$493 Roundtrip, found 3 days ago
$493
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Oct 9 from Monroe to Des Moines, returning Mon, Oct 13, priced at $493 found 3 days ago
American Airlines
Thu, Oct 2 - Thu, Oct 9
MLU
Monroe
DSM
Des Moines
$518 Roundtrip, found 3 days ago
$518
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Oct 2 from Monroe to Des Moines, returning Thu, Oct 9, priced at $518 found 3 days ago
Flights from Monroe (MLU) to Des Moines (DSM)
Origin airport
Monroe Regional
Destination airport
Des Moines Intl.
Roundtrip price
$378
Distance
629 mi

Monroe to Des Moines Flights

The cheapest times to fly from Monroe to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Monroe to Des Moines are during the month of October. You can find some of the cheapest flights from Monroe to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Monroe to Des Moines

Sunday is one of the best days to book for cheap flights from Monroe to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Monroe to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Monroe to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $273 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Monroe to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Monroe to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Monroe Regional Airport (MLU) to Des Moines Intl. Airport (DSM) cost?
Snag a cheap one-way flight from $273 or cheap return flight from $378 from Monroe Regional Airport (MLU) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Monroe Regional Airport (MLU) to Des Moines Intl. Airport (DSM)?
October is the least expensive month to fly from MLU to DSM. Traveling during an off-peak travel window is often the key to scoring lower fares.
What is the cheapest airline that flies from Monroe Regional Airport (MLU) to Des Moines Intl. Airport (DSM)?
To find the cheapest airline that'll fly you from MLU to DSM, use Expedia's filter tool. Customize your search based on what matters most to you, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Monroe Regional Airport (MLU) to Des Moines Intl. Airport (DSM)?
There aren't any daily direct flights departing from Monroe Regional Airport (MLU) to Des Moines Intl. Airport (DSM). But you can book flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be cruising above the clouds before you know it.
What day of the week has the most flights from MLU to DSM?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can change depending on various factors, including the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Monroe Regional Airport (MLU) to Des Moines Intl. Airport (DSM)?
To arrive at Des Moines Intl. Airport (DSM) on schedule, choose a flight that leaves from Monroe Regional Airport (MLU) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Monroe Regional Airport (MLU) to Des Moines Intl. Airport (DSM) last-minute?
Booking your plane ticket from MLU to DSM shortly before your trip is usually more expensive. However, if there's some wiggle room with your schedule, you could grab a cheap last-minute fare.
Is it cheaper to book a MLU to DSM flight and hotel package?
Booking a MLU to DSM flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip in one place. Choose from our impressive range of accommodations and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Monroe Regional Airport (MLU) to Des Moines Intl. Airport (DSM)?
It's usually possible to cancel or reschedule your MLU to DSM flight. However, if it's been more than 24 hours since booking, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find more details on our Customer Service portal.

Explore a world of travel with Expedia

*Available to One Key members.