$387 Cheap Flights from Mobile (MOB) to Florence (FLO)

View $387 flight on Sun, Jan 4, 2026Opens in a new window

Popular airlines from Mobile Regional Airport (MOB) to Florence, SC (FLO-Florence Regional)

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Cheap Flights from Mobile to Florence (MOB-FLO)

Prices were available within the past 7 days and start at $387 for one-way flights and $487 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Jan 1 - Tue, Jan 13
MOB
Mobile
FLO
Florence
$487 Roundtrip, found 6 days ago
$487
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Jan 1 from Mobile to Florence, returning Tue, Jan 13, priced at $487 found 6 days ago
American Airlines
Sun, Jan 4 - Sun, Jan 11
MOB
Mobile
FLO
Florence
$517 Roundtrip, found 6 days ago
$517
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Jan 4 from Mobile to Florence, returning Sun, Jan 11, priced at $517 found 6 days ago
American Airlines
Thu, Jan 1 - Thu, Jan 8
MOB
Mobile
FLO
Florence
$532 Roundtrip, found 6 days ago
$532
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Jan 1 from Mobile to Florence, returning Thu, Jan 8, priced at $532 found 6 days ago
American Airlines
Thu, Jan 1 - Sat, Jan 10
MOB
Mobile
FLO
Florence
$537 Roundtrip, found 6 days ago
$537
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Jan 1 from Mobile to Florence, returning Sat, Jan 10, priced at $537 found 6 days ago
American Airlines
Sat, Jan 3 - Tue, Jan 13
MOB
Mobile
FLO
Florence
$544 Roundtrip, found 6 days ago
$544
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Jan 3 from Mobile to Florence, returning Tue, Jan 13, priced at $544 found 6 days ago
American Airlines
Fri, Jan 2 - Tue, Jan 13
MOB
Mobile
FLO
Florence
$562 Roundtrip, found 6 days ago
$562
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Jan 2 from Mobile to Florence, returning Tue, Jan 13, priced at $562 found 6 days ago
American Airlines
Wed, Jan 7 - Sat, Jan 10
MOB
Mobile
FLO
Florence
$567 Roundtrip, found 6 days ago
$567
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Jan 7 from Mobile to Florence, returning Sat, Jan 10, priced at $567 found 6 days ago
American Airlines
Sun, Jan 4 - Sun, Jan 11
MOB
Mobile
FLO
Florence
$587 Roundtrip, found 6 days ago
$587
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Jan 4 from Mobile to Florence, returning Sun, Jan 11, priced at $587 found 6 days ago
American Airlines
Sat, Jan 3 - Thu, Jan 8
MOB
Mobile
FLO
Florence
$589 Roundtrip, found 6 days ago
$589
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Jan 3 from Mobile to Florence, returning Thu, Jan 8, priced at $589 found 6 days ago
American Airlines
Sat, Jan 3 - Sat, Jan 10
MOB
Mobile
FLO
Florence
$594 Roundtrip, found 6 days ago
$594
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Jan 3 from Mobile to Florence, returning Sat, Jan 10, priced at $594 found 6 days ago
American Airlines
Sun, Jan 4 - Sun, Jan 11
MOB
Mobile
FLO
Florence
$597 Roundtrip, found 6 days ago
$597
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Jan 4 from Mobile to Florence, returning Sun, Jan 11, priced at $597 found 6 days ago
American Airlines
Thu, Jan 1 - Fri, Jan 9
MOB
Mobile
FLO
Florence
$600 Roundtrip, found 6 days ago
$600
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Jan 1 from Mobile to Florence, returning Fri, Jan 9, priced at $600 found 6 days ago
American Airlines
Fri, Jan 2 - Thu, Jan 8
MOB
Mobile
FLO
Florence
$607 Roundtrip, found 6 days ago
$607
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Jan 2 from Mobile to Florence, returning Thu, Jan 8, priced at $607 found 6 days ago
American Airlines
Fri, Jan 2 - Sat, Jan 10
MOB
Mobile
FLO
Florence
$612 Roundtrip, found 6 days ago
$612
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Jan 2 from Mobile to Florence, returning Sat, Jan 10, priced at $612 found 6 days ago
American Airlines
Tue, Jan 6 - Sat, Jan 10
MOB
Mobile
FLO
Florence
$617 Roundtrip, found 6 days ago
$617
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Jan 6 from Mobile to Florence, returning Sat, Jan 10, priced at $617 found 6 days ago
American Airlines
Sat, Jan 3 - Fri, Jan 9
MOB
Mobile
FLO
Florence
$657 Roundtrip, found 6 days ago
$657
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Jan 3 from Mobile to Florence, returning Fri, Jan 9, priced at $657 found 6 days ago
American Airlines
Sun, Jan 4 - Tue, Jan 13
MOB
Mobile
FLO
Florence
$662 Roundtrip, found 6 days ago
$662
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Jan 4 from Mobile to Florence, returning Tue, Jan 13, priced at $662 found 6 days ago

Frequently asked questions

How much does a flight from Mobile Regional Airport (MOB) to Florence Regional Airport (FLO) cost?
Get a cheap one-way flight from $387 or cheap return flight from $487 from Mobile Regional Airport (MOB) to Florence Regional Airport (FLO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Mobile Regional Airport (MOB) to Florence Regional Airport (FLO)?
Traveling in January is a great way to save, as it's the cheapest month for flights between MOB and FLO. You'll typically find the lowest fares during the off-season.
What is the cheapest airline that flies from Mobile Regional Airport (MOB) to Florence Regional Airport (FLO)?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from MOB to FLO. Then, sort your results by "Price (lowest to highest)" to score the best deal available.
How many flights per day from Mobile Regional Airport (MOB) to Florence Regional Airport (FLO)?
You'll have to catch a flight with a layover when traveling from Mobile Regional Airport (MOB) to Florence Regional Airport (FLO). There are no daily direct flights on this route. However, simply filter your search to include one or more stops to discover an option that works for you.
What day of the week has the most flights from MOB to FLO?
You'll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Mobile Regional Airport (MOB) to Florence Regional Airport (FLO)?
To avoid potential delays on the Mobile Regional Airport (MOB) to Florence Regional Airport (FLO) route, aim to travel before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Mobile Regional Airport (MOB) to Florence Regional Airport (FLO) last-minute?
Booking your flight from MOB to FLO right before your journey is typically more expensive. But if you're flexible with your travel times and dates, you could bag a cheap last-minute fare.
Is it cheaper to book a MOB to FLO flight and hotel package?
You'll typically save money by booking a MOB to FLO flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. Once you've chosen your ideal flights and accommodations, you can add extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Mobile Regional Airport (MOB) to Florence Regional Airport (FLO)?
If you reserved your MOB to FLO flight within the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more information.

Travel information

Origin airport
Mobile Regional
Destination airport
Florence Regional
Roundtrip price
$486
Distance
552 mi

Book with confidence

Mobile to Florence Flights

The cheapest times to fly from Mobile to Florence

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Mobile to Florence are during the month of January. You can find some of the cheapest flights from Mobile to Florence with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Mobile to Florence

Sunday is one of the best days to book for cheap flights from Mobile to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Mobile to Florence

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Mobile to Florence in 2026. You can also book with separate airlines for your outbound and return journeys, from $387 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Mobile to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Mobile to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Mobile to Florence Flights

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*Available to One Key members.